JOINT FILER INFORMATION Name：Frost Gamma Investments Trust Address：4400 Biscayne Blvd. Miami，FL 33137 Designated Filer：Phillip Frost，M.D. Issuer Name and Ticker Symbol：OPKO保健，Inc.（OPK）Date of Earliest Transaction：August 9,2023 Relationship to Issuer：10% Owner FROST GAMMA INVESTMENTS TRUST By：/s/Phillip Frost，M.D.，as Trustee Phillip Frost，M.D.，Trustee