主要股东
注:以下部分股东代表特定权益共同体,直接或间接持有上市公司股份
| 序号 | 股东名称 | 是否机构 | 持股数(股) | 持股比例 | 持股变动数(股) | 持股数变动比例 | 投票权比例 |
|---|---|---|---|---|---|---|---|
| 1 | Entities affiliated with BVF Partners L.P. | 是 | 232.67万 | 16.90% | 新增 | 新增 | -- |
| 2 | Steven Perrin | 否 | 139.71万 | 10.14% | 新增 | 新增 | -- |
| 3 | Entities affiliated with Cormorant Global Healthcare Master Fund L.P. | 是 | 139.17万 | 9.90% | 新增 | 新增 | -- |
| 4 | ALS Therapy Development Institute | 是 | 132.56万 | 9.60% | 新增 | 新增 | -- |
| 5 | David Alexandre C. Gros | 否 | 76.77万 | 5.30% | 新增 | 新增 | -- |
| 序号 | 股东名称 | 是否机构 | 持股数(股) | 持股比例 | 持股变动数(股) | 持股数变动比例 | 投票权比例 |
|---|---|---|---|---|---|---|---|
| 1 | Entities affiliated with OrbiMed Israel GP Ltd. | 是 | 253.71万 | 26.90% | 不变 | 不变 | -- |
| 2 | Entities affiliated with LifeSci Venture Partners I, L.P. | 是 | 115.11万 | 12.20% | 不变 | 不变 | -- |
| 3 | Pontifax Management Fund III L.P. | 是 | 78.73万 | 8.30% | 不变 | 不变 | -- |
| 4 | Peregrine Ventures Management Ltd. | 是 | 61.77万 | 6.50% | 不变 | 不变 | -- |
| 5 | Novartis Bioventures Ltd. | 是 | 49.93万 | 5.30% | 不变 | 不变 | -- |
| 序号 | 股东名称 | 是否机构 | 持股数(股) | 持股比例 | 持股变动数(股) | 持股数变动比例 | 投票权比例 |
|---|---|---|---|---|---|---|---|
| 1 | Entities affiliated with OrbiMed Israel GP Ltd. | 是 | 253.71万 | 27.00% | 新增 | 新增 | -- |
| 2 | Entities affiliated with LifeSci Venture Partners I, L.P. | 是 | 115.11万 | 12.20% | 新增 | 新增 | -- |
| 3 | Entities affiliated with Apple Tree Partners | 是 | 90.27万 | 9.60% | 新增 | 新增 | -- |
| 4 | Pontifax Management Fund III L.P. | 是 | 78.73万 | 8.40% | 新增 | 新增 | -- |
| 5 | Peregrine Ventures Management Ltd. | 是 | 61.77万 | 6.60% | 新增 | 新增 | -- |
| 6 | Novartis Bioventures Ltd. | 是 | 49.93万 | 5.30% | 新增 | 新增 | -- |
机构持股汇总
| 主力进出\报告期 | 2025-12-26 | 2025-11-19 | 2025-11-14 | 2025-11-13 |
|---|---|---|---|---|
| 机构数量(家) | 107 | 106 | 106 | 111 |
| 累计持有数量(万股) | 3649.16 | 3649.14 | 3742.49 | 4186.06 |
| 累计市值(亿) | 0.58 | 0.57 | 0.66 | 0.74 |
| 持仓比例(%) | 48.66% | 60.82% | 62.37% | 69.77% |
| 净交易量(万股) |
注:若当期数据无主力机构持仓或公司定期报告未披露完毕,则不显示。
非主要股东机构持股变动
| 机构或基金名称 | 持有数量 | 持股市值(亿美元) | 持股变动(万股) | 变动比例(%) |
|---|---|---|---|---|
|
22nw, Lp
|
63.64万股 | 0.07 | - | 不足0.01 |
|
Blackrock, Inc.
|
346.51万股 | 0.36 | 21.09 | 6.48 |
|
Blue Owl Capital Holdings Lp
|
97.99万股 | 0.10 | -35.00 | -26.32 |
|
Bvf Inc
|
629.33万股 | 0.65 | - | 不足0.01 |
|
Catalio Capital Management, Lp
|
106.11万股 | 0.11 | 106.11 | 不足0.01 |
|
Cm Management, Llc
|
60.00万股 | 0.06 | 22.50 | 60.00 |
|
Ensign Peak Advisors, Inc
|
126.49万股 | 0.13 | - | 不足0.01 |
|
Geode Capital Management, Llc
|
136.89万股 | 0.14 | -1.50 | -1.08 |
|
Kovitz Investment Group Partners, Llc
|
73.30万股 | 0.08 | 73.30 | 不足0.01 |
|
Nantahala Capital Management, Llc
|
114.12万股 | 0.12 | - | 不足0.01 |
|
Northern Trust Corp
|
42.86万股 | 0.04 | -2.55 | -5.62 |
|
Ra Capital Management, L.P.
|
356.63万股 | 0.37 | - | 不足0.01 |
|
Sanofi
|
81.50万股 | 0.08 | - | 不足0.01 |
|
Siren, L.L.C.
|
207.28万股 | 0.21 | 138.26 | 200.33 |
|
Sphera Funds Management Ltd.
|
128.02万股 | 0.13 | -67.94 | -34.67 |
|
State Street Corp
|
65.55万股 | 0.07 | 5.01 | 8.28 |
|
Vanguard Group Inc
|
326.78万股 | 0.34 | -5.06 | -1.53 |
|
Wellington Management Group Llp
|
128.39万股 | 0.13 | 128.39 | 不足0.01 |
|
Woodline Partners Lp
|
80.08万股 | 0.08 | -87.10 | -52.10 |
|
Zimmer Partners, Lp
|
182.50万股 | 0.19 | 84.43 | 86.10 |
| 机构或基金名称 | 持有数量 | 持股市值(亿美元) | 持股变动(万股) | 变动比例(%) |
|---|---|---|---|---|
|
22nw, Lp
|
63.64万股 | 0.07 | - | 不足0.01 |
|
Blackrock, Inc.
|
346.51万股 | 0.36 | 21.09 | 6.48 |
|
Blue Owl Capital Holdings Lp
|
97.99万股 | 0.10 | -35.00 | -26.32 |
|
Bvf Inc
|
629.33万股 | 0.65 | - | 不足0.01 |
|
Catalio Capital Management, Lp
|
106.11万股 | 0.11 | 106.11 | 不足0.01 |
|
Cm Management, Llc
|
60.00万股 | 0.06 | 22.50 | 60.00 |
|
Ensign Peak Advisors, Inc
|
126.49万股 | 0.13 | - | 不足0.01 |
|
Geode Capital Management, Llc
|
136.89万股 | 0.14 | -1.50 | -1.08 |
|
Kovitz Investment Group Partners, Llc
|
73.30万股 | 0.08 | 73.30 | 不足0.01 |
|
Nantahala Capital Management, Llc
|
114.12万股 | 0.12 | - | 不足0.01 |
|
Northern Trust Corp
|
42.86万股 | 0.04 | -2.55 | -5.62 |
|
Ra Capital Management, L.P.
|
356.63万股 | 0.37 | - | 不足0.01 |
|
Sanofi
|
81.50万股 | 0.08 | - | 不足0.01 |
|
Siren, L.L.C.
|
207.28万股 | 0.21 | 138.26 | 200.33 |
|
Sphera Funds Management Ltd.
|
128.02万股 | 0.13 | -67.94 | -34.67 |
|
State Street Corp
|
65.55万股 | 0.07 | 5.01 | 8.28 |
|
Vanguard Group Inc
|
326.78万股 | 0.34 | -5.06 | -1.53 |
|
Wellington Management Group Llp
|
128.39万股 | 0.13 | 128.39 | 不足0.01 |
|
Woodline Partners Lp
|
80.08万股 | 0.08 | -87.10 | -52.10 |
|
Zimmer Partners, Lp
|
182.50万股 | 0.19 | 84.43 | 86.10 |
| 机构或基金名称 | 持有数量 | 持股市值(亿美元) | 持股变动(万股) | 变动比例(%) |
|---|---|---|---|---|
|
22nw, Lp
|
63.64万股 | 0.07 | - | 不足0.01 |
|
Blackrock, Inc.
|
346.51万股 | 0.36 | 21.09 | 6.48 |
|
Blue Owl Capital Holdings Lp
|
97.99万股 | 0.10 | -35.00 | -26.32 |
|
Bvf Inc
|
629.33万股 | 0.65 | - | 不足0.01 |
|
Catalio Capital Management, Lp
|
106.11万股 | 0.11 | 106.11 | 不足0.01 |
|
Cm Management, Llc
|
60.00万股 | 0.06 | 22.50 | 60.00 |
|
Ensign Peak Advisors, Inc
|
126.49万股 | 0.13 | - | 不足0.01 |
|
Geode Capital Management, Llc
|
136.89万股 | 0.14 | -1.50 | -1.08 |
|
Kovitz Investment Group Partners, Llc
|
73.30万股 | 0.08 | 73.30 | 不足0.01 |
|
Nantahala Capital Management, Llc
|
114.12万股 | 0.12 | - | 不足0.01 |
|
Northern Trust Corp
|
42.86万股 | 0.04 | -2.55 | -5.62 |
|
Ra Capital Management, L.P.
|
356.63万股 | 0.37 | - | 不足0.01 |
|
Sanofi
|
81.50万股 | 0.08 | - | 不足0.01 |
|
Siren, L.L.C.
|
207.28万股 | 0.21 | 138.26 | 200.33 |
|
Sphera Funds Management Ltd.
|
128.02万股 | 0.13 | -67.94 | -34.67 |
|
State Street Corp
|
65.55万股 | 0.07 | 5.01 | 8.28 |
|
Vanguard Group Inc
|
326.78万股 | 0.34 | -5.06 | -1.53 |
|
Wellington Management Group Llp
|
128.39万股 | 0.13 | 128.39 | 不足0.01 |
|
Woodline Partners Lp
|
80.08万股 | 0.08 | -87.10 | -52.10 |
|
Zimmer Partners, Lp
|
182.50万股 | 0.19 | 84.43 | 86.10 |
| 机构或基金名称 | 持有数量 | 持股市值(亿美元) | 持股变动(万股) | 变动比例(%) |
|---|---|---|---|---|
|
22nw, Lp
|
63.64万股 | 0.07 | - | 不足0.01 |
|
Blackrock, Inc.
|
346.51万股 | 0.36 | 21.09 | 6.48 |
|
Blue Owl Capital Holdings Lp
|
97.99万股 | 0.10 | -35.00 | -26.32 |
|
Bvf Inc
|
629.33万股 | 0.65 | - | 不足0.01 |
|
Catalio Capital Management, Lp
|
106.11万股 | 0.11 | 106.11 | 不足0.01 |
|
Cm Management, Llc
|
60.00万股 | 0.06 | 22.50 | 60.00 |
|
Ensign Peak Advisors, Inc
|
126.49万股 | 0.13 | - | 不足0.01 |
|
Geode Capital Management, Llc
|
136.89万股 | 0.14 | -1.50 | -1.08 |
|
Kovitz Investment Group Partners, Llc
|
73.30万股 | 0.08 | 73.30 | 不足0.01 |
|
Nantahala Capital Management, Llc
|
114.12万股 | 0.12 | - | 不足0.01 |
|
Northern Trust Corp
|
42.86万股 | 0.04 | -2.55 | -5.62 |
|
Ra Capital Management, L.P.
|
356.63万股 | 0.37 | - | 不足0.01 |
|
Sanofi
|
81.50万股 | 0.08 | - | 不足0.01 |
|
Siren, L.L.C.
|
207.28万股 | 0.21 | 138.26 | 200.33 |
|
Sphera Funds Management Ltd.
|
128.02万股 | 0.13 | -67.94 | -34.67 |
|
State Street Corp
|
65.55万股 | 0.07 | 5.01 | 8.28 |
|
Vanguard Group Inc
|
326.78万股 | 0.34 | -5.06 | -1.53 |
|
Wellington Management Group Llp
|
128.39万股 | 0.13 | 128.39 | 不足0.01 |
|
Woodline Partners Lp
|
80.08万股 | 0.08 | -87.10 | -52.10 |
|
Zimmer Partners, Lp
|
182.50万股 | 0.19 | 84.43 | 86.10 |
| 机构或基金名称 | 持有数量 | 持股市值(亿美元) | 持股变动(万股) | 变动比例(%) |
|---|---|---|---|---|
|
22nw, Lp
|
63.64万股 | 0.07 | - | 不足0.01 |
|
Blackrock, Inc.
|
346.51万股 | 0.36 | 21.09 | 6.48 |
|
Blue Owl Capital Holdings Lp
|
97.99万股 | 0.10 | -35.00 | -26.32 |
|
Bvf Inc
|
629.33万股 | 0.65 | - | 不足0.01 |
|
Catalio Capital Management, Lp
|
106.11万股 | 0.11 | 106.11 | 不足0.01 |
|
Cm Management, Llc
|
60.00万股 | 0.06 | 22.50 | 60.00 |
|
Ensign Peak Advisors, Inc
|
126.49万股 | 0.13 | - | 不足0.01 |
|
Geode Capital Management, Llc
|
136.89万股 | 0.14 | -1.50 | -1.08 |
|
Kovitz Investment Group Partners, Llc
|
73.30万股 | 0.08 | 73.30 | 不足0.01 |
|
Nantahala Capital Management, Llc
|
114.12万股 | 0.12 | - | 不足0.01 |
|
Northern Trust Corp
|
42.86万股 | 0.04 | -2.55 | -5.62 |
|
Ra Capital Management, L.P.
|
356.63万股 | 0.37 | - | 不足0.01 |
|
Sanofi
|
81.50万股 | 0.08 | - | 不足0.01 |
|
Siren, L.L.C.
|
207.28万股 | 0.21 | 138.26 | 200.33 |
|
Sphera Funds Management Ltd.
|
128.02万股 | 0.13 | -67.94 | -34.67 |
|
State Street Corp
|
65.55万股 | 0.07 | 5.01 | 8.28 |
|
Vanguard Group Inc
|
326.78万股 | 0.34 | -5.06 | -1.53 |
|
Wellington Management Group Llp
|
128.39万股 | 0.13 | 128.39 | 不足0.01 |
|
Woodline Partners Lp
|
80.08万股 | 0.08 | -87.10 | -52.10 |
|
Zimmer Partners, Lp
|
182.50万股 | 0.19 | 84.43 | 86.10 |
内部人交易
| 日期 | 股东名称 | 变动股数(万股) | 交易后持股数量(万股) | 交易价格 | 是否直接持有 | 内部人类型 |
|---|---|---|---|---|---|---|
| 2024-05-09 | BVF PARTNERS L P/IL |
|
336.18 | 2.37 | 是 | -- |
| 2024-05-09 | BVF PARTNERS L P/IL |
|
263.37 | 2.37 | 是 | -- |
| 2024-05-09 | BVF PARTNERS L P/IL |
|
22.05 | 2.37 | 是 | -- |