股本结构
单位：万股
| 公告日期 | 2025-11-12 | 2025-11-12 | 2025-08-11 | 2025-08-11 | 2025-05-13 | 2025-05-13 |
|---|---|---|---|---|---|---|
| 证券总股本 | 5568.15 | 5449.50 | 5371.38 | 5362.42 | 4546.88 | 4408.91 |
| 普通股本 | 5568.15 | 5449.50 | 5371.38 | 5362.42 | 4546.88 | 4408.91 |
| 优先股 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2025-11-06 | 2025-09-30 | 2025-08-05 | 2025-06-30 | 2025-05-06 | 2025-03-31 |
注释：中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本（万股） | 变动后优先股（万股） | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2025-11-12 | 5568.15 | 未披露 | 定期报告 | 2025-11-06 |
| 2025-11-12 | 5449.50 | 未披露 |
更多>>
From June 30, 2025 to September 30, 2025
Issuance of common stock in connection with the ATM offerings, net
|
2025-09-30 |
| 2025-08-11 | 5371.38 | 未披露 | 定期报告 | 2025-08-05 |
| 2025-08-11 | 5362.42 | 未披露 |
更多>>
From March 31, 2025 to June 30, 2025
Issuance of common stock and warrants in private placement offering, net
Issuance of common stock in connection with the ATM offerings, net
Issuance of common stock on exercise of stock options and vesting of restricted stock units
|
2025-06-30 |
| 2025-05-13 | 4546.88 | 未披露 | 定期报告 | 2025-05-06 |
| 2025-04-23 | 4412.29 | 未披露 | 定期报告 | 2025-04-16 |
| 2025-05-13 | 4408.91 | 未披露 |
更多>>
From December 31, 2024 to March 31, 2025
Issuance of common stock on exercise of stock options
|
2025-03-31 |
| 2025-03-24 | 4400.16 | 未披露 |
更多>>
From December 31, 2023 to December 31, 2024
Issuance of common stock on exercise of stock options and vesting of restricted stock units
Release of indemnity holdback shares in connection with acquisition of EryDel S.p.A
|
2024-12-31 |
| 2024-11-13 | 4400.16 | 未披露 | 定期报告 | 2024-11-05 |
| 2024-08-13 | 4327.66 | 未披露 |
更多>>
From March 31, 2024 to June 30, 2024
Issuance of common stock on exercise of stock options and vesting of restricted stock units
|
2024-06-30 |
| 2024-05-13 | 4321.52 | 未披露 |
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From January 1, 2024 to March 31, 2024
Issuance of common stock on exercise of stock options and vesting of restricted stock units
|
2024-03-31 |
| 2024-04-01 | 4321.52 | 未披露 | 定期报告 | 2024-03-25 |
| 2024-04-01 | 4297.32 | 未披露 |
更多>>
From December 31, 2022 to December 31, 2023
Issuance of common stock on exercise of stock options and vesting of restricted stock units
Share issuance in connection with acquisition of EryDel S.p.A.
Restricted stock award forfeiture
|
2023-12-31 |
| 2023-11-14 | 4286.89 | 未披露 | 定期报告 | 2023-11-06 |
| 2023-11-14 | 3634.36 | 未披露 |
更多>>
From June 30, 2023 to September 30, 2023
Issuance of common stock on exercise of stock options and vesting of restricted stock units
Restricted stock award retirement
|
2023-09-30 |
| 2023-08-03 | 3638.30 | 未披露 | 定期报告 | 2023-07-28 |
| 2023-08-03 | 3632.80 | 未披露 |
更多>>
From March 31, 2023 to June 30, 2023
Issuance of common stock on exercise of stock options and vesting of restricted stock units
Restricted stock award retirement
|
2023-06-30 |
| 2023-05-15 | 3626.99 | 未披露 | 定期报告 | 2023-05-05 |
| 2023-05-15 | 3627.84 | 未披露 |
更多>>
From January 1, 2023 to March 31, 2023
Issuance of common stock on exercise of stock options and vesting of restricted stock units
|
2023-03-31 |
| 2023-03-15 | 3627.69 | 未披露 | 定期报告 | 2023-03-10 |
| 2023-03-15 | 3613.65 | 未披露 |
更多>>
From December 31, 2021 to December 31, 2022
Issuance of common stock in connection with open market sales agreement, net of issuance costs of $19
Issuance of common stock on exercise of stock options and vesting of restricted stock units
Share issuance in connection with acquisition of Novosteo, Inc.
|
2022-12-31 |
| 2022-11-09 | 3613.03 | 未披露 |
更多>>
From June 30, 2022 to September 30, 2022
Issuance of common stock on exercise of stock options and vesting of restricted stock units
|
2022-09-30 |
| 2022-08-09 | 3610.41 | 未披露 | 定期报告 | 2022-08-03 |
| 2022-08-09 | 3597.77 | 未披露 |
更多>>
From March 31, 2022 to June 30, 2022
Issuance of common stock on exercise of stock options and vesting of restricted stock units
Share issuance in connection with acquisition of Novosteo, Inc.
|
2022-06-30 |
| 2022-04-27 | 3015.08 | 未披露 | 定期报告 | 2022-04-20 |
| 2022-05-10 | 3014.96 | 未披露 |
更多>>
From January 1, 2022 to March 31, 2022
Exercise of stock options
|
2022-03-31 |
| 2022-03-01 | 3014.55 | 未披露 | 定期报告 | 2022-02-24 |
| 2022-04-27 | 3013.37 | 未披露 | 定期报告 | 2022-01-31 |
| 2022-03-01 | 3007.44 | 未披露 |
更多>>
From December 31, 2020 to December 31, 2021
Exercise of stock options
|
2021-12-31 |
| 2021-10-29 | 2987.76 | 未披露 | 定期报告 | 2021-10-25 |
| 2021-10-29 | 2986.73 | 未披露 |
更多>>
From June 30, 2021 to September 30, 2021
Exercise of stock options
|
2021-09-30 |
| 2021-08-06 | 2968.58 | 未披露 | 定期报告 | 2021-08-03 |
| 2021-08-06 | 2965.58 | 未披露 |
更多>>
From March 31, 2021 to June 30, 2021
Exercise of stock options
|
2021-06-30 |
| 2021-04-30 | 2958.85 | 未披露 | 定期报告 | 2021-04-20 |
| 2021-05-06 | 2957.59 | 未披露 |
更多>>
from December 31, 2020 to March 31, 2021
Exercise of stock options
|
2021-03-31 |
| 2021-03-01 | 2955.21 | 未披露 | 定期报告 | 2021-02-24 |
| 2021-03-01 | 2954.32 | 未披露 |
更多>>
From December 31,2019 to December 31,2020
Issuance of common stock in connection with private placement, net of issuance costs of $7,372
Exercise of stock options
|
2020-12-31 |
| 2020-11-12 | 2949.80 | 未披露 | 定期报告 | 2020-11-11 |
| 2020-11-12 | 2949.42 | 未披露 |
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From June 30, 2020 to September 30, 2020
Exercise of stock options
|
2020-09-30 |
| 2020-08-14 | 2948.77 | 未披露 | 定期报告 | 2020-08-12 |
| 2020-08-14 | 2948.63 | 未披露 |
更多>>
From March 31, 2020 to June 30, 2020
Exercise of stock options
|
2020-06-30 |
| 2020-05-12 | 2941.73 | 未披露 | 定期报告 | 2020-05-11 |
| 2020-04-22 | 2941.01 | 未披露 | 定期报告 | 2020-04-09 |
| 2020-05-12 | 2940.45 | 未披露 |
更多>>
From January 1, 2020 to March 31, 2020
Issuance of common stock in connection with private placement, net of issuance costs of $7,310
Exercise of stock options
|
2020-03-31 |
| 2020-03-16 | 2940.22 | 未披露 | 定期报告 | 2020-03-13 |
| 2020-03-16 | 2686.94 | 未披露 |
更多>>
From December 31, 2018 to December 31, 2019
Conversion of redeemable convertible preferred stock to common stock
Initial public offering of common stock, net of issuance costs
Exercise of stock warrant
Exercise of stock options
|
2019-12-31 |
| 2019-11-12 | 2685.25 | 未披露 | 定期报告 | 2019-11-12 |
| 2019-08-09 | 2684.11 | 未披露 |
更多>>
From March 31, 2019 to June 30, 2019
Conversion of redeemable convertible preferred stock to common stock
Initial public offering of common stock, net of issuance costs
Exercise of stock warrant
|
2019-06-30 |
| 2019-06-12 | 2684.11 | 未披露 | 定期报告 | 2019-06-12 |
| 2019-05-09 | 2601.33 | 未披露 |
更多>>
1.Common stock offered 4,412,000 shares
2.Except as otherwise indicated, all information in this prospectus is based upon 21,601,334 shares of our common stock outstanding as of December 31, 2018
3.a one-for-0.367647 reverse stock split of our capital stock on April 25, 2019
|
2019-05-09 |
| 2019-06-12 | 356.69 | 1816.10 |
更多>>
From January 1, 2019 To March 31, 2019
Vesting of Series B redeemable convertible preferred stock in lieu of rent
Exercise of stock options
|
2019-03-31 |
From June 30, 2025 to September 30, 2025
Issuance of common stock in connection with the ATM offerings, net
From March 31, 2025 to June 30, 2025
Issuance of common stock and warrants in private placement offering, net
Issuance of common stock in connection with the ATM offerings, net
Issuance of common stock on exercise of stock options and vesting of restricted stock units
From December 31, 2024 to March 31, 2025
Issuance of common stock on exercise of stock options
From December 31, 2023 to December 31, 2024
Issuance of common stock on exercise of stock options and vesting of restricted stock units
Release of indemnity holdback shares in connection with acquisition of EryDel S.p.A
From March 31, 2024 to June 30, 2024
Issuance of common stock on exercise of stock options and vesting of restricted stock units
From January 1, 2024 to March 31, 2024
Issuance of common stock on exercise of stock options and vesting of restricted stock units
From December 31, 2022 to December 31, 2023
Issuance of common stock on exercise of stock options and vesting of restricted stock units
Share issuance in connection with acquisition of EryDel S.p.A.
Restricted stock award forfeiture
From June 30, 2023 to September 30, 2023
Issuance of common stock on exercise of stock options and vesting of restricted stock units
Restricted stock award retirement
From March 31, 2023 to June 30, 2023
Issuance of common stock on exercise of stock options and vesting of restricted stock units
Restricted stock award retirement
From January 1, 2023 to March 31, 2023
Issuance of common stock on exercise of stock options and vesting of restricted stock units
From December 31, 2021 to December 31, 2022
Issuance of common stock in connection with open market sales agreement, net of issuance costs of $19
Issuance of common stock on exercise of stock options and vesting of restricted stock units
Share issuance in connection with acquisition of Novosteo, Inc.
From June 30, 2022 to September 30, 2022
Issuance of common stock on exercise of stock options and vesting of restricted stock units
From March 31, 2022 to June 30, 2022
Issuance of common stock on exercise of stock options and vesting of restricted stock units
Share issuance in connection with acquisition of Novosteo, Inc.
From January 1, 2022 to March 31, 2022
Exercise of stock options
From December 31, 2020 to December 31, 2021
Exercise of stock options
From June 30, 2021 to September 30, 2021
Exercise of stock options
From March 31, 2021 to June 30, 2021
Exercise of stock options
from December 31, 2020 to March 31, 2021
Exercise of stock options
From December 31,2019 to December 31,2020
Issuance of common stock in connection with private placement, net of issuance costs of $7,372
Exercise of stock options
From June 30, 2020 to September 30, 2020
Exercise of stock options
From March 31, 2020 to June 30, 2020
Exercise of stock options
From January 1, 2020 to March 31, 2020
Issuance of common stock in connection with private placement, net of issuance costs of $7,310
Exercise of stock options
From December 31, 2018 to December 31, 2019
Conversion of redeemable convertible preferred stock to common stock
Initial public offering of common stock, net of issuance costs
Exercise of stock warrant
Exercise of stock options
From March 31, 2019 to June 30, 2019
Conversion of redeemable convertible preferred stock to common stock
Initial public offering of common stock, net of issuance costs
Exercise of stock warrant
1.Common stock offered 4,412,000 shares
2.Except as otherwise indicated, all information in this prospectus is based upon 21,601,334 shares of our common stock outstanding as of December 31, 2018
3.a one-for-0.367647 reverse stock split of our capital stock on April 25, 2019
From January 1, 2019 To March 31, 2019
Vesting of Series B redeemable convertible preferred stock in lieu of rent
Exercise of stock options