主要股东
注：以下部分股东代表特定权益共同体，直接或间接持有上市公司股份
| 序号 | 股东名称 | 是否机构 | 持股数(股) | 持股比例 | 持股变动数(股) | 持股数变动比例 | 投票权比例 |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Healthcare Fund, L.P. | 是 | 440.15万 | 8.64% | 新增 | 新增 | -- |
| 2 | Perceptive Advisors LLC | 是 | 347.19万 | 6.81% | 新增 | 新增 | -- |
| 3 | Andrew Moin | 否 | 219.85万 | 4.31% |
|
|
4.3148% |
| 4 | Eddie J. Sullivan | 否 | 72.27万 | 1.41% |
|
|
1.4184% |
| 5 | Samuel J. Reich | 否 | 45.16万 | 0.89% |
|
|
0.8863% |
| 6 | Christoph Bausch | 否 | 16.37万 | 0.32% |
|
|
0.3213% |
| 7 | Alexandra Kropotova | 否 | 11.54万 | 0.23% |
|
|
0.2265% |
| 8 | Lucy To | 否 | 5.21万 | 0.10% |
|
|
0.1022% |
| 9 | David Link | 否 | 3.50万 | 0.07% | 不变 | 不变 | 0.0688% |
| 10 | William Polvino | 否 | 3.09万 | 0.06% | 不变 | 不变 | 0.0607% |
| 11 | Katie Ellias | 否 | 2.17万 | 0.04% | 新增 | 新增 | 0.0425% |
| 12 | Jay S. Skyler | 否 | 2.17万 | 0.04% | 不变 | 不变 | 0.0425% |
| 13 | Erick Lucera | 否 | 1.25万 | 0.02% |
|
|
0.0245% |
| 14 | Scott Giberson | 否 | 1.25万 | 0.02% | 不变 | 不变 | 0.0245% |
| 序号 | 股东名称 | 是否机构 | 持股数(股) | 持股比例 | 持股变动数(股) | 持股数变动比例 | 投票权比例 |
|---|---|---|---|---|---|---|---|
| 1 | Christine Hamilton | 否 | 89.59万 | 8.53% |
|
|
-- |
| 2 | Eddie J. Sullivan | 否 | 68.61万 | 6.49% |
|
|
-- |
| 3 | Andrew Moin | 否 | 45.85万 | 4.40% | 不变 | 不变 | -- |
| 4 | Samuel J. Reich | 否 | 36.78万 | 3.44% |
|
|
-- |
| 5 | Christoph Bausch | 否 | 13.10万 | 1.24% |
|
|
-- |
| 6 | Alexandra Kropotova | 否 | 8.81万 | -- |
|
|
-- |
| 7 | Jeffrey G. Spragens | 否 | 5.98万 | -- |
|
|
-- |
| 8 | David Link | 否 | 3.50万 | -- |
|
|
-- |
| 9 | Lucy To | 否 | 3.39万 | -- | 新增 | 新增 | -- |
| 10 | William Polvino | 否 | 3.09万 | -- |
|
|
-- |
| 11 | Jay S. Skyler | 否 | 2.17万 | -- |
|
|
-- |
| 12 | Scott Giberson | 否 | 1.25万 | -- |
|
|
-- |
| 13 | Erick Lucera | 否 | 1.20万 | -- |
|
|
-- |
| 序号 | 股东名称 | 是否机构 | 持股数(股) | 持股比例 | 持股变动数(股) | 持股数变动比例 | 投票权比例 |
|---|---|---|---|---|---|---|---|
| 1 | Christine Hamilton | 否 | 88.36万 | 9.44% |
|
|
-- |
| 2 | Eddie J. Sullivan | 否 | 66.04万 | 7.01% |
|
|
-- |
| 3 | Andrew Moin | 否 | 45.85万 | 4.94% | 不变 | 不变 | -- |
| 4 | Samuel J. Reich | 否 | 30.34万 | 3.19% |
|
|
-- |
| 5 | Christoph Bausch | 否 | 10.33万 | 1.10% |
|
|
-- |
| 6 | Alexandra Kropotova | 否 | 6.98万 | -- |
|
|
-- |
| 7 | Jeffrey G. Spragens | 否 | 4.98万 | -- | 不变 | 不变 | -- |
| 8 | David Link | 否 | 2.04万 | -- | 不变 | 不变 | -- |
| 9 | William Polvino | 否 | 1.40万 | -- | 不变 | 不变 | -- |
| 10 | Jay S. Skyler | 否 | 1.17万 | -- | 新增 | 新增 | -- |
| 11 | Scott Giberson | 否 | 0.24万 | -- |
|
|
-- |
| 12 | Erick Lucera | 否 | 0.17万 | -- |
|
|
-- |
| 序号 | 股东名称 | 是否机构 | 持股数(股) | 持股比例 | 持股变动数(股) | 持股数变动比例 | 投票权比例 |
|---|---|---|---|---|---|---|---|
| 1 | Christine Hamilton | 否 | 88.12万 | 9.48% |
|
|
-- |
| 2 | Eddie J. Sullivan | 否 | 59.21万 | 6.37% |
|
|
-- |
| 3 | Andrew Moin | 否 | 45.85万 | 4.97% |
|
|
-- |
| 4 | Katie Ellias | 否 | 28.57万 | 3.10% |
|
|
-- |
| 5 | Samuel J. Reich | 否 | 14.89万 | 1.60% |
|
|
-- |
| 6 | Christoph Bausch | 否 | 4.99万 | -- | 新增 | 新增 | -- |
| 7 | Jeffrey G. Spragens | 否 | 4.98万 | -- |
|
|
-- |
| 8 | Alexandra Kropotova | 否 | 2.56万 | -- | 新增 | 新增 | -- |
| 9 | David Link | 否 | 2.04万 | -- |
|
|
-- |
| 10 | William Polvino | 否 | 1.40万 | -- |
|
|
-- |
| 11 | Scott Giberson | 否 | 0.17万 | -- |
|
|
-- |
| 12 | Erick Lucera | 否 | 0.10万 | -- |
|
|
-- |
| 13 | Michael G. King, Jr. | 否 | 0.05万 | -- | 新增 | 新增 | -- |
| 序号 | 股东名称 | 是否机构 | 持股数(股) | 持股比例 | 持股变动数(股) | 持股数变动比例 | 投票权比例 |
|---|---|---|---|---|---|---|---|
| 1 | Entities Managed by RTW Investments, LP | 是 | 917.83万 | 9.95% | 新增 | 新增 | -- |
| 2 | Entities affiliated with BVF Partners | 是 | 917.83万 | 9.95% | 新增 | 新增 | -- |
| 3 | Christine Hamilton | 否 | 881.25万 | 9.48% | 不变 | 不变 | -- |
| 4 | Eddie J. Sullivan | 否 | 575.37万 | 6.20% |
|
|
-- |
| 5 | Andrew Moin | 否 | 458.46万 | 4.97% | 新增 | 新增 | -- |
| 6 | Katie Ellias | 否 | 285.71万 | 3.10% | 新增 | 新增 | -- |
| 7 | Samuel J. Reich | 否 | 122.12万 | 1.32% |
|
|
-- |
| 8 | Jeffrey G. Spragens | 否 | 49.79万 | -- | 不变 | 不变 | -- |
| 9 | David Link | 否 | 20.40万 | -- | 不变 | 不变 | -- |
| 10 | William Polvino | 否 | 13.96万 | -- | 不变 | 不变 | -- |
| 11 | Alexandra Kropotva | 否 | 13.11万 | -- | 新增 | 新增 | -- |
| 12 | Scott Giberson | 否 | 1.25万 | -- |
|
|
-- |
| 13 | Erick Lucera | 否 | 0.69万 | -- |
|
|
-- |
机构持股汇总
| 主力进出\报告期 | 2026-06-11 | 2026-06-04 | 2026-06-03 | 2026-05-15 | 2026-05-14 | 2026-05-13 |
|---|---|---|---|---|---|---|
| 机构数量(家) | 81 | 80 | 81 | 81 | 69 | 65 |
| 累计持有数量(万股) | 7181.39 | 7131.39 | 7181.39 | 7142.01 | 4482.06 | 4201.71 |
| 累计市值(亿) | 2.38 | 2.47 | 2.50 | 2.64 | 1.74 | 1.66 |
| 持仓比例(%) | 94.49% | 93.83% | 94.49% | 93.97% | 58.97% | 55.29% |
| 净交易量(万股) |
注：若当期数据无主力机构持仓或公司定期报告未披露完毕，则不显示。
非主要股东机构持股变动
| 机构或基金名称 | 持有数量 | 持股市值(亿美元) | 持股变动(万股) | 变动比例(%) |
|---|---|---|---|---|
|
Adage Capital Partners Gp, L.L.C.
|
340.56万股 | - | 340.56 | 不足0.01 |
|
Ameriprise Financial Inc
|
147.61万股 | - | 119.25 | 420.41 |
|
Balyasny Asset Management L.P.
|
376.04万股 | - | 328.50 | 690.94 |
|
Blackstone Inc.
|
86.02万股 | - | -128.34 | -59.87 |
|
Boothbay Fund Management, Llc
|
148.17万股 | - | 148.17 | 不足0.01 |
|
Caligan Partners Lp
|
796.72万股 | - | 796.72 | 不足0.01 |
|
Commodore Capital Lp
|
440.15万股 | - | - | 不足0.01 |
|
Ensign Peak Advisors, Inc
|
137.56万股 | - | 137.56 | 不足0.01 |
|
Exoduspoint Capital Management, Lp
|
76.86万股 | - | 68.25 | 792.58 |
|
Jefferies Financial Group Inc.
|
90.31万股 | - | 32.28 | 55.62 |
|
Millennium Management Llc
|
303.27万股 | - | 270.86 | 835.76 |
|
Perceptive Advisors Llc
|
643.17万股 | - | 562.85 | 700.76 |
|
Propel Bio Management, Llc
|
101.28万股 | - | 35.99 | 55.13 |
|
Ra Capital Management, L.P.
|
440.15万股 | - | - | 不足0.01 |
|
Sessa Capital Im, L.P.
|
219.85万股 | - | - | 不足0.01 |
|
Soleus Capital Management, L.P.
|
105.00万股 | - | 105.00 | 不足0.01 |
|
Spruce Street Capital Lp
|
219.85万股 | - | - | 不足0.01 |
|
Vanguard Capital Management Llc
|
249.37万股 | - | 249.37 | 不足0.01 |
|
Vivo Capital, Llc
|
1142.00万股 | - | - | 不足0.01 |
|
Woodline Partners Lp
|
285.18万股 | - | 0.09 | 0.03 |
| 机构或基金名称 | 持有数量 | 持股市值(亿美元) | 持股变动(万股) | 变动比例(%) |
|---|---|---|---|---|
|
Adage Capital Partners Gp, L.L.C.
|
340.56万股 | - | 340.56 | 不足0.01 |
|
Ameriprise Financial Inc
|
147.61万股 | - | 119.25 | 420.41 |
|
Balyasny Asset Management L.P.
|
376.04万股 | - | 328.50 | 690.94 |
|
Blackstone Inc.
|
86.02万股 | - | -128.34 | -59.87 |
|
Boothbay Fund Management, Llc
|
148.17万股 | - | 148.17 | 不足0.01 |
|
Caligan Partners Lp
|
796.72万股 | - | 796.72 | 不足0.01 |
|
Commodore Capital Lp
|
440.15万股 | - | - | 不足0.01 |
|
Ensign Peak Advisors, Inc
|
137.56万股 | - | 137.56 | 不足0.01 |
|
Exoduspoint Capital Management, Lp
|
76.86万股 | - | 68.25 | 792.58 |
|
Jefferies Financial Group Inc.
|
90.31万股 | - | 32.28 | 55.62 |
|
Millennium Management Llc
|
303.27万股 | - | 270.86 | 835.76 |
|
Perceptive Advisors Llc
|
643.17万股 | - | 562.85 | 700.76 |
|
Propel Bio Management, Llc
|
101.28万股 | - | 35.99 | 55.13 |
|
Ra Capital Management, L.P.
|
440.15万股 | - | - | 不足0.01 |
|
Sessa Capital Im, L.P.
|
219.85万股 | - | - | 不足0.01 |
|
Soleus Capital Management, L.P.
|
105.00万股 | - | 105.00 | 不足0.01 |
|
Spruce Street Capital Lp
|
219.85万股 | - | - | 不足0.01 |
|
Vanguard Capital Management Llc
|
249.37万股 | - | 249.37 | 不足0.01 |
|
Vivo Capital, Llc
|
1142.00万股 | - | - | 不足0.01 |
|
Woodline Partners Lp
|
285.18万股 | - | 0.09 | 0.03 |
| 机构或基金名称 | 持有数量 | 持股市值(亿美元) | 持股变动(万股) | 变动比例(%) |
|---|---|---|---|---|
|
Adage Capital Partners Gp, L.L.C.
|
340.56万股 | - | 340.56 | 不足0.01 |
|
Ameriprise Financial Inc
|
147.61万股 | - | 119.25 | 420.41 |
|
Balyasny Asset Management L.P.
|
376.04万股 | - | 328.50 | 690.94 |
|
Blackstone Inc.
|
86.02万股 | - | -128.34 | -59.87 |
|
Boothbay Fund Management, Llc
|
148.17万股 | - | 148.17 | 不足0.01 |
|
Caligan Partners Lp
|
796.72万股 | - | 796.72 | 不足0.01 |
|
Commodore Capital Lp
|
440.15万股 | - | - | 不足0.01 |
|
Ensign Peak Advisors, Inc
|
137.56万股 | - | 137.56 | 不足0.01 |
|
Exoduspoint Capital Management, Lp
|
76.86万股 | - | 68.25 | 792.58 |
|
Jefferies Financial Group Inc.
|
90.31万股 | - | 32.28 | 55.62 |
|
Millennium Management Llc
|
303.27万股 | - | 270.86 | 835.76 |
|
Perceptive Advisors Llc
|
643.17万股 | - | 562.85 | 700.76 |
|
Propel Bio Management, Llc
|
101.28万股 | - | 35.99 | 55.13 |
|
Ra Capital Management, L.P.
|
440.15万股 | - | - | 不足0.01 |
|
Sessa Capital Im, L.P.
|
219.85万股 | - | - | 不足0.01 |
|
Soleus Capital Management, L.P.
|
105.00万股 | - | 105.00 | 不足0.01 |
|
Spruce Street Capital Lp
|
219.85万股 | - | - | 不足0.01 |
|
Vanguard Capital Management Llc
|
249.37万股 | - | 249.37 | 不足0.01 |
|
Vivo Capital, Llc
|
1142.00万股 | - | - | 不足0.01 |
|
Woodline Partners Lp
|
285.18万股 | - | 0.09 | 0.03 |
| 机构或基金名称 | 持有数量 | 持股市值(亿美元) | 持股变动(万股) | 变动比例(%) |
|---|---|---|---|---|
|
Adage Capital Partners Gp, L.L.C.
|
340.56万股 | - | 340.56 | 不足0.01 |
|
Ameriprise Financial Inc
|
147.61万股 | - | 119.25 | 420.41 |
|
Balyasny Asset Management L.P.
|
376.04万股 | - | 328.50 | 690.94 |
|
Blackstone Inc.
|
86.02万股 | - | -128.34 | -59.87 |
|
Boothbay Fund Management, Llc
|
148.17万股 | - | 148.17 | 不足0.01 |
|
Caligan Partners Lp
|
796.72万股 | - | 796.72 | 不足0.01 |
|
Commodore Capital Lp
|
440.15万股 | - | - | 不足0.01 |
|
Ensign Peak Advisors, Inc
|
137.56万股 | - | 137.56 | 不足0.01 |
|
Exoduspoint Capital Management, Lp
|
76.86万股 | - | 68.25 | 792.58 |
|
Jefferies Financial Group Inc.
|
90.31万股 | - | 32.28 | 55.62 |
|
Millennium Management Llc
|
303.27万股 | - | 270.86 | 835.76 |
|
Perceptive Advisors Llc
|
643.17万股 | - | 562.85 | 700.76 |
|
Propel Bio Management, Llc
|
101.28万股 | - | 35.99 | 55.13 |
|
Ra Capital Management, L.P.
|
440.15万股 | - | - | 不足0.01 |
|
Sessa Capital Im, L.P.
|
219.85万股 | - | - | 不足0.01 |
|
Soleus Capital Management, L.P.
|
105.00万股 | - | 105.00 | 不足0.01 |
|
Spruce Street Capital Lp
|
219.85万股 | - | - | 不足0.01 |
|
Vanguard Capital Management Llc
|
249.37万股 | - | 249.37 | 不足0.01 |
|
Vivo Capital, Llc
|
1142.00万股 | - | - | 不足0.01 |
|
Woodline Partners Lp
|
285.18万股 | - | 0.09 | 0.03 |
| 机构或基金名称 | 持有数量 | 持股市值(亿美元) | 持股变动(万股) | 变动比例(%) |
|---|---|---|---|---|
|
Blackrock, Inc.
|
30.13万股 | - | 28.41 | 1647.93 |
|
Ensign Peak Advisors, Inc
|
137.56万股 | - | 137.56 | 不足0.01 |
|
Hb Wealth Management, Llc
|
30.75万股 | - | - | 不足0.01 |
|
Jefferies Financial Group Inc.
|
90.31万股 | - | 32.28 | 55.62 |
|
Kestra Advisory Services, Llc
|
6.17万股 | - | 5.02 | 434.55 |
|
Monashee Investment Management Llc
|
50.00万股 | - | 50.00 | 不足0.01 |
|
Persistent Asset Partners Ltd
|
6.97万股 | - | 4.99 | 252.36 |
|
Propel Bio Management, Llc
|
101.28万股 | - | 35.99 | 55.13 |
|
Seven Grand Managers, Llc
|
27.50万股 | - | 27.50 | 不足0.01 |
|
Simplify Asset Management Inc.
|
18.72万股 | - | -2.10 | -10.08 |
|
Soleus Capital Management, L.P.
|
105.00万股 | - | 105.00 | 不足0.01 |
|
Vanguard Capital Management Llc
|
249.37万股 | - | 249.37 | 不足0.01 |
|
Vanguard Fiduciary Trust Co
|
19.76万股 | - | 19.76 | 不足0.01 |
|
Affinity Asset Advisors, Llc
|
57.50万股 | - | 57.50 | 不足0.01 |
|
Exoduspoint Capital Management, Lp
|
76.86万股 | - | 68.25 | 792.58 |
|
Spruce Street Capital Lp
|
219.85万股 | - | - | 不足0.01 |
内部人交易
| 日期 | 股东名称 | 变动股数(万股) | 交易后持股数量(万股) | 交易价格 | 是否直接持有 | 内部人类型 |
|---|---|---|---|---|---|---|
| 2026-03-24 | Kropotova Alexandra |
|
4.33 | -- | 是 | CHIEF MEDICAL OFFICER |
| 2025-12-11 | Kropotova Alexandra |
|
4.43 | -- | 是 | CHIEF MEDICAL OFFICER |
| 2025-09-19 | Kropotova Alexandra |
|
4.53 | -- | 是 | CHIEF MEDICAL OFFICER |
| 2025-03-27 | Kropotova Alexandra |
|
4.72 | -- | 是 | CHIEF MEDICAL OFFICER |
| 2024-12-18 | Kropotova Alexandra |
|
4.84 | -- | 是 | CHIEF MEDICAL OFFICER |