股本结构

单位:万股
公告日期 2025-12-11 2025-11-10 2025-11-10 2025-07-30 2025-07-30 2025-06-23
证券总股本 18560.28 16718.18 16028.85 15914.05 15567.33 15556.27
普通股本 18560.28 16718.18 16028.85 15914.05 15567.33 15556.27
优先股 未披露 未披露 390.13 未披露 390.13 未披露
其他 未披露 未披露 未披露 未披露 未披露 未披露
变动日期 2025-12-11 2025-11-07 2025-09-30 2025-07-24 2025-06-30 2025-06-06
注释:中概股证券总股本=普通股股本/ 存托凭证比例

历史变动

公告日期 变动后普通股本(万股) 变动后优先股(万股) 变动原因 变动日期
2025-12-11 18560.28 未披露
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Common Stock offered 15,789,475 shares by the company The underwriters exercised their option to purchase ordinary share 2,631,578 shares
2025-12-11
2025-11-10 16718.18 未披露 定期报告 2025-11-07
2025-11-10 16028.85 390.13
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From June 30, 2025 to September 30, 2025 Issuance of ordinary shares pursuant to the “at-the-market” equity program, net Vesting of RSUs Option exercises Issuance of ordinary shares under the ESPP
2025-09-30
2025-07-30 15914.05 未披露 定期报告 2025-07-24
2025-07-30 15567.33 390.13
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From March 31, 2025 to June 30, 2025 Issuance of ordinary shares pursuant to the “at-the-market”equity program, net Vesting of RSUs Option exercises
2025-06-30
2025-06-23 15556.27 未披露 定期报告 2025-06-06
2025-05-08 15413.41 未披露 定期报告 2025-05-02
2025-05-08 15409.33 390.13
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From December 31, 2024 to March 31, 2025 Issuance of ordinary shares pursuant to the “at-the-market”equity program, net Vesting of RSUs Option exercises Issuance of ordinary shares under the ESPP
2025-03-31
2025-03-04 15348.60 未披露 定期报告 2025-02-24
2025-03-04 15303.73 390.13
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From December 31, 2023 to December 31, 2024 Option exercises Issuance of ordinary shares under the ESPP Issuance of ordinary shares pursuant to the at-the-market equity program, net Issuance of ordinary shares, net of offering costs Vesting of RSUs
2024-12-31
2024-11-12 15251.98 未披露 定期报告 2024-11-07
2024-11-12 14839.29 390.13
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From June 30, 2024 to September 30, 2024 Option exercises Issuance of ordinary shares under the ESPP Issuance of ordinary shares, net of offering costs Vesting of RSUs Issuance of ordinary shares pursuant to the “at-the-market” equity program, net
2024-09-30
2024-10-01 15161.29 未披露
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Ordinary shares offered 23,125,001 ordinary shares by the company(the underwriters exercise their option to purchase 3,750,000 additional ordinary shares in full)
2024-09-27
2024-08-08 12473.79 未披露 定期报告 2024-08-07
2024-08-08 12247.93 390.13
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From March 31, 2024 to June 30, 2024 Vesting of RSUs Option exercises Issuance of ordinary shares pursuant to the at-the-market equity program, net
2024-06-30
2024-06-21 12247.51 未披露 定期报告 2024-06-05
2024-05-10 12246.02 未披露 定期报告 2024-05-07
2024-05-10 12232.14 390.13
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From December 31, 2023 to March 31, 2024 Option exercises Issuance of ordinary shares under the ESPP Issuance of ordinary shares, net of offering costs Vesting of RSUs
2024-03-31
2024-04-29 12231.86 未披露 定期报告 2024-03-27
2024-03-06 12228.41 未披露 定期报告 2024-02-28
2024-03-06 11916.22 390.13
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From December 31,2022 to December 31,2023 Issuance of ordinary shares,net of offering costs Issuance of ordinary shares,pursuant to the GSK Collaboration Agreement Issuance of ordinary shares pursuant to the at-the-market equity program, net Share-based compensation Vesting of RSUs Option exercises Issuance of ordinary shares under the ESPP
2023-12-31
2023-12-08 11905.39 未披露
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Ordinary shares offered 20,000,000 ordinary shares by the company
2023-12-11
2023-11-09 9905.39 未披露 定期报告 2023-11-01
2023-11-09 9901.19 390.13
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From June 30, 2023 to September 30, 2023 Option exercises Issuance of ordinary shares under the ESPP Vesting of RSUs Issuance of ordinary shares pursuant to the at-the-market equity program, net
2023-09-30
2023-08-03 9898.33 未披露 定期报告 2023-07-27
2023-08-03 9856.68 390.13
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From March 31, 2023 to June 30, 2023 Issuance of ordinary shares pursuant to the at-the-market equity program, net Vesting of RSUs Option exercises
2023-06-30
2023-06-26 9843.74 未披露 定期报告 2023-06-12
2023-05-03 9837.19 未披露 定期报告 2023-04-25
2023-05-03 9810.48 390.13
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From December 31, 2022 to March 31, 2023 Option exercises Issuance of ordinary shares under the ESPP Issuance of ordinary shares Vesting of RSUs
2023-03-31
2023-03-23 9810.48 未披露 定期报告 2023-03-10
2023-03-23 8692.46 390.13
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From December 31, 2021 to December 31, 2022 Option exercises Issuance of ordinary shares under the ESPP Issuance of ordinary shares pursuant to the at-the-market equity program, net Issuance of ordinary shares, net of offering costs Vesting of RSUs
2022-12-31
2022-11-10 8690.07 未披露 定期报告 2022-11-01
2022-11-10 8684.15 390.13
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From June 30, 2022 to September 30, 2022 Vesting of RSUs Option exercises Issuance of ordinary shares under the ESPP
2022-09-30
2022-08-11 8682.01 未披露 定期报告 2022-08-03
2022-08-11 8672.47 390.13
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From March 31, 2022 to June 30, 2022 Issuance of ordinary shares,net of offering costs Vesting of RSUs
2022-06-30
2022-06-28 8672.47 未披露 定期报告 2022-06-22
2022-06-16 8632.45 390.13
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1.Ordinary shares offered by 25,464,483 ordinary shares 2.The number of ordinary shares to be outstanding after this offering is based on an aggregate of 60,859,968 ordinary shares outstanding as of March 31, 2022
2022-06-16
2022-05-12 6124.92 未披露 定期报告 2022-05-09
2022-05-12 6086.00 390.13
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From December 31, 2021 to March 31, 2022 Issuance of ordinary shares pursuant to the at-the-market equity program, net Vesting of RSUs Option exercises Issuance of ordinary shares under the ESPP
2022-03-31
2022-04-28 6086.00 未披露 定期报告 2022-03-25
2022-03-03 6084.45 390.13 定期报告 2022-02-25
2022-03-03 5984.11 390.13
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From December 31, 2020 to December 31, 2021 Issuance of ordinary shares pursuant to the at-the-market pursuant to the at-the-market Vesting of RSUs Option exercises Issuance of ordinary shares under the ESPP
2021-12-31
2021-11-10 5883.25 未披露 定期报告 2021-11-01
2021-11-10 5199.80 390.13 定期报告 2021-09-30
2021-08-05 5076.61 未披露 定期报告 2021-07-29
2021-08-05 5057.65 390.13
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From March 31, 2021 to June 30, 2021 Issuance of ordinary shares pursuant to the at-the-market equity program, net Vesting of RSUs
2021-06-30
2021-06-28 5031.34 未披露 定期报告 2021-06-17
2021-05-13 4985.74 未披露 定期报告 2021-05-05
2021-04-30 4985.58 未披露 定期报告 2021-04-10
2021-05-13 4985.47 390.13
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From December 31, 2020 to March 31, 2021 Issuance of ordinary shares pursuant to the at-the-market equity program, net Vesting of RSUs Option exercises Issuance of ordinary shares under the ESPP
2021-03-31
2021-03-04 4899.74 未披露 定期报告 2021-02-22
2021-03-04 4877.87 390.13
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From December 31,2019 to December 31,2020 Issuance of ordinary shares,net of offering costs Issuance of ordinary shares pursuant to the at-the-market equity program, net Vesting of RSUs Option exercises Issuance of ordinary shares under the ESPP
2020-12-31
2020-11-09 4877.78 未披露 定期报告 2020-11-01
2020-11-09 4876.90 390.13
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From June 30, 2020 to September 30, 2020 Issuance of ordinary shares,net of offering costs Issuance of ordinary shares pursuant to the at-the-market equity program,net Vesting of RSUs Option exercises Issuance of ordinary shares under the ESPP
2020-09-30
2020-09-25 4406.55 390.13
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1.Ordinary shares offered by the company 8,333,334 ordinary shares. 2.The number of ordinary shares to be outstanding after this offering is based on an aggregate of 35,732,154 ordinary shares outstanding as of June 30, 2020.
2020-09-25
2020-08-10 3645.40 未披露 定期报告 2020-08-01
2020-08-10 3573.22 390.13
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From March 31, 2020 to June 30, 2020 Issuance of ordinary shares pursuant to the at-the-market equity program, net Vesting of RSUs Option exercises
2020-06-30
2020-06-26 3573.22 未披露 定期报告 2020-06-15
2020-05-11 3489.26 未披露 定期报告 2020-05-01
2020-04-29 3469.08 未披露 定期报告 2020-04-10
2020-05-11 3460.16 390.13
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From December 31, 2019 to March 31, 2020 Issuance of ordinary shares,net of offering costs Vesting of RSUs Option exercises
2020-03-31
2020-03-02 3454.15 未披露 定期报告 2020-02-21
2020-03-02 3434.07 390.13
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from December 31, 2018 to December 31, 2019 Issuance of ordinary shares Vesting of RSUs Option exercises
2019-12-31
2019-11-05 3428.98 未披露 定期报告 2019-11-01
2019-11-05 3428.42 390.13
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from June 30, 2019 to September 30, 2019 Option exercises
2019-09-30
2019-08-06 3428.06 未披露 定期报告 2019-08-01
2019-08-06 3426.63 390.13
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From March 31, 2019 to June 30, 2019 Option exercises
2019-06-30
2019-06-26 3426.46 未披露 定期报告 2019-06-17
2019-06-26 3426.16 未披露 定期报告 2019-06-10
2019-05-10 3426.02 未披露 定期报告 2019-05-01
2019-05-10 3425.54 390.13
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from January 1, 2019 to March 31, 2019 Issuance of ordinary shares Vesting of RSUs Option exercises
2019-03-31
2019-03-01 3419.21 未披露 定期报告 2019-02-26
2019-03-01 2947.22 390.13
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from December 31, 2017 to December 31, 2018 Issuance of ordinary shares Vesting of RSUs Option exercises
2018-12-31
2018-11-09 2946.37 未披露 定期报告 2018-11-01
2018-11-09 2942.62 390.13 定期报告 2018-09-30
2018-08-09 2932.03 未披露 定期报告 2018-08-01
2018-08-09 2929.34 390.13 定期报告 2018-06-30
2018-06-28 2929.31 未披露 定期报告 2018-06-15
2018-05-09 2910.55 未披露 定期报告 2018-05-01
2018-04-27 2909.02 未披露 定期报告 2018-04-02
2018-05-09 2799.33 390.13 定期报告 2018-03-31
2018-03-12 2799.22 未披露 定期报告 2018-03-01
2018-03-12 2782.91 390.13
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from December 31, 2016 to December 31, 2017 Issuance of ordinary shares, net of issuance costs of $491 Vesting of RSUs Option exercises
2017-12-31
2017-11-09 2779.00 未披露 定期报告 2017-11-01
2017-11-09 2776.79 390.13 定期报告 2017-09-30
2017-08-15 2773.14 未披露 定期报告 2017-08-10
2017-08-09 2776.02 未披露 定期报告 2017-08-01
2017-08-09 2773.14 390.13 定期报告 2017-06-30
2017-07-06 2773.14 未披露 定期报告 2017-06-22
2017-04-28 2771.77 未披露 定期报告 2017-04-18
2017-05-10 2355.11 390.13 定期报告 2017-03-31
2017-03-16 2354.26 未披露 定期报告 2017-03-01
2017-03-16 2350.22 390.13
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from December 31, 2015 to December 31, 2016 Issuance of ordinary shares Option exercises
2016-12-31
2016-11-09 2347.55 未披露 定期报告 2016-11-01
2016-11-09 2347.44 390.13 定期报告 2016-09-30
2016-08-15 2344.04 未披露 定期报告 2016-08-01
2016-08-15 2343.29 390.13 定期报告 2016-06-30
2016-05-16 2342.64 未披露 定期报告 2016-05-09
2016-03-30 2155.14 390.13
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from December 31, 2014 to December 31, 2015 Issuance of ordinary shares, net of issuance costs of $169 Stock-based compensation Issuance of Series B preferred, net of issuance costs of $3,468 Reclassification of Series A preferred shares Issuance of ordinary shares upon initial public offering, net of issuance costs of $3,702 Conversion of Series B preferred shares into ordinary shares upon initial public offering On November 1, 2015, the Company effectuated a 4.0415917-for-1 forward share split of its issued and outstanding ordinary shares, Series A preferred shares and Series B preferred shares.
2015-12-31
2015-12-17 2155.14 未披露 定期报告 2015-12-17
2015-11-12 2093.33 390.13
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a 4.0415917-for-1 forward share split of our ordinary shares, our Series A preferred shares and our Series B preferred shares effected on November 1, 2015
2015-11-11
2015-12-17 922.34 923.62
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from December 31, 2014 to November 2, 2015 Reclassification of Series A preferred shares Issuance of Series B preferred, net of issuance costs of $3,357 Issuance of ordinary shares, net of issuance costs of $169 Stock-based compensation On November 1, 2015, the Company effectuated a 4.0415917-for-1 forward share split of its issued and outstanding ordinary shares, Series A preferred shares and Series B preferred shares.
2015-11-02
2015-10-09 360.21 未披露
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the conversion of all outstanding Series B preferred shares into 1,320,000 ordinary shares
2015-08-15
2015-10-09 228.21 96.53
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from December 31, 2014 to June 30, 2015 Share-based compensation, including issuance of ordinary shares to an employee (unaudited) Issuance of ordinary shares, net of offering costs of $169 (unaudited)
2015-06-30
Common Stock offered 15,789,475 shares by the company The underwriters exercised their option to purchase ordinary share 2,631,578 shares
From June 30, 2025 to September 30, 2025 Issuance of ordinary shares pursuant to the “at-the-market” equity program, net Vesting of RSUs Option exercises Issuance of ordinary shares under the ESPP
From March 31, 2025 to June 30, 2025 Issuance of ordinary shares pursuant to the “at-the-market”equity program, net Vesting of RSUs Option exercises
From December 31, 2024 to March 31, 2025 Issuance of ordinary shares pursuant to the “at-the-market”equity program, net Vesting of RSUs Option exercises Issuance of ordinary shares under the ESPP
From December 31, 2023 to December 31, 2024 Option exercises Issuance of ordinary shares under the ESPP Issuance of ordinary shares pursuant to the at-the-market equity program, net Issuance of ordinary shares, net of offering costs Vesting of RSUs
From June 30, 2024 to September 30, 2024 Option exercises Issuance of ordinary shares under the ESPP Issuance of ordinary shares, net of offering costs Vesting of RSUs Issuance of ordinary shares pursuant to the “at-the-market” equity program, net
Ordinary shares offered 23,125,001 ordinary shares by the company(the underwriters exercise their option to purchase 3,750,000 additional ordinary shares in full)
From March 31, 2024 to June 30, 2024 Vesting of RSUs Option exercises Issuance of ordinary shares pursuant to the at-the-market equity program, net
From December 31, 2023 to March 31, 2024 Option exercises Issuance of ordinary shares under the ESPP Issuance of ordinary shares, net of offering costs Vesting of RSUs
From December 31,2022 to December 31,2023 Issuance of ordinary shares,net of offering costs Issuance of ordinary shares,pursuant to the GSK Collaboration Agreement Issuance of ordinary shares pursuant to the at-the-market equity program, net Share-based compensation Vesting of RSUs Option exercises Issuance of ordinary shares under the ESPP
Ordinary shares offered 20,000,000 ordinary shares by the company
From June 30, 2023 to September 30, 2023 Option exercises Issuance of ordinary shares under the ESPP Vesting of RSUs Issuance of ordinary shares pursuant to the at-the-market equity program, net
From March 31, 2023 to June 30, 2023 Issuance of ordinary shares pursuant to the at-the-market equity program, net Vesting of RSUs Option exercises
From December 31, 2022 to March 31, 2023 Option exercises Issuance of ordinary shares under the ESPP Issuance of ordinary shares Vesting of RSUs
From December 31, 2021 to December 31, 2022 Option exercises Issuance of ordinary shares under the ESPP Issuance of ordinary shares pursuant to the at-the-market equity program, net Issuance of ordinary shares, net of offering costs Vesting of RSUs
From June 30, 2022 to September 30, 2022 Vesting of RSUs Option exercises Issuance of ordinary shares under the ESPP
From March 31, 2022 to June 30, 2022 Issuance of ordinary shares,net of offering costs Vesting of RSUs
1.Ordinary shares offered by 25,464,483 ordinary shares 2.The number of ordinary shares to be outstanding after this offering is based on an aggregate of 60,859,968 ordinary shares outstanding as of March 31, 2022
From December 31, 2021 to March 31, 2022 Issuance of ordinary shares pursuant to the at-the-market equity program, net Vesting of RSUs Option exercises Issuance of ordinary shares under the ESPP
From December 31, 2020 to December 31, 2021 Issuance of ordinary shares pursuant to the at-the-market pursuant to the at-the-market Vesting of RSUs Option exercises Issuance of ordinary shares under the ESPP
From March 31, 2021 to June 30, 2021 Issuance of ordinary shares pursuant to the at-the-market equity program, net Vesting of RSUs
From December 31, 2020 to March 31, 2021 Issuance of ordinary shares pursuant to the at-the-market equity program, net Vesting of RSUs Option exercises Issuance of ordinary shares under the ESPP
From December 31,2019 to December 31,2020 Issuance of ordinary shares,net of offering costs Issuance of ordinary shares pursuant to the at-the-market equity program, net Vesting of RSUs Option exercises Issuance of ordinary shares under the ESPP
From June 30, 2020 to September 30, 2020 Issuance of ordinary shares,net of offering costs Issuance of ordinary shares pursuant to the at-the-market equity program,net Vesting of RSUs Option exercises Issuance of ordinary shares under the ESPP
1.Ordinary shares offered by the company 8,333,334 ordinary shares. 2.The number of ordinary shares to be outstanding after this offering is based on an aggregate of 35,732,154 ordinary shares outstanding as of June 30, 2020.
From March 31, 2020 to June 30, 2020 Issuance of ordinary shares pursuant to the at-the-market equity program, net Vesting of RSUs Option exercises
From December 31, 2019 to March 31, 2020 Issuance of ordinary shares,net of offering costs Vesting of RSUs Option exercises
from December 31, 2018 to December 31, 2019 Issuance of ordinary shares Vesting of RSUs Option exercises
from June 30, 2019 to September 30, 2019 Option exercises
From March 31, 2019 to June 30, 2019 Option exercises
from January 1, 2019 to March 31, 2019 Issuance of ordinary shares Vesting of RSUs Option exercises
from December 31, 2017 to December 31, 2018 Issuance of ordinary shares Vesting of RSUs Option exercises
from December 31, 2016 to December 31, 2017 Issuance of ordinary shares, net of issuance costs of $491 Vesting of RSUs Option exercises
from December 31, 2015 to December 31, 2016 Issuance of ordinary shares Option exercises
from December 31, 2014 to December 31, 2015 Issuance of ordinary shares, net of issuance costs of $169 Stock-based compensation Issuance of Series B preferred, net of issuance costs of $3,468 Reclassification of Series A preferred shares Issuance of ordinary shares upon initial public offering, net of issuance costs of $3,702 Conversion of Series B preferred shares into ordinary shares upon initial public offering On November 1, 2015, the Company effectuated a 4.0415917-for-1 forward share split of its issued and outstanding ordinary shares, Series A preferred shares and Series B preferred shares.
a 4.0415917-for-1 forward share split of our ordinary shares, our Series A preferred shares and our Series B preferred shares effected on November 1, 2015
from December 31, 2014 to November 2, 2015 Reclassification of Series A preferred shares Issuance of Series B preferred, net of issuance costs of $3,357 Issuance of ordinary shares, net of issuance costs of $169 Stock-based compensation On November 1, 2015, the Company effectuated a 4.0415917-for-1 forward share split of its issued and outstanding ordinary shares, Series A preferred shares and Series B preferred shares.
the conversion of all outstanding Series B preferred shares into 1,320,000 ordinary shares
from December 31, 2014 to June 30, 2015 Share-based compensation, including issuance of ordinary shares to an employee (unaudited) Issuance of ordinary shares, net of offering costs of $169 (unaudited)