股本结构
单位:万股
| 公告日期 | 2025-11-06 | 2025-11-06 | 2025-08-07 | 2025-08-07 | 2025-05-08 | 2025-05-08 |
|---|---|---|---|---|---|---|
| 证券总股本 | 16918.18 | 16914.60 | 16871.22 | 16860.79 | 16736.19 | 16711.60 |
| 普通股本 | 16918.18 | 16914.60 | 16871.22 | 16860.79 | 16736.19 | 16711.60 |
| 优先股 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2025-10-29 | 2025-09-30 | 2025-07-30 | 2025-06-30 | 2025-04-30 | 2025-03-31 |
注释:中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本(万股) | 变动后优先股(万股) | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2025-11-06 | 16918.18 | 未披露 | 定期报告 | 2025-10-29 |
| 2025-11-06 | 16914.60 | 未披露 |
更多>>
From June 30, 2025 to September 30, 2025
Issuance of common stock from exercise of stock options and units
Stock-based compensation
|
2025-09-30 |
| 2025-08-07 | 16871.22 | 未披露 | 定期报告 | 2025-07-30 |
| 2025-08-07 | 16860.79 | 未披露 | 定期报告 | 2025-06-30 |
| 2025-05-08 | 16736.19 | 未披露 | 定期报告 | 2025-04-30 |
| 2025-04-25 | 16733.34 | 未披露 | 定期报告 | 2025-04-22 |
| 2025-05-08 | 16711.60 | 未披露 | 定期报告 | 2025-03-31 |
| 2025-04-25 | 16678.85 | 未披露 | 定期报告 | 2025-02-15 |
| 2025-02-27 | 16670.89 | 未披露 |
更多>>
From December 31, 2023 to December 31, 2024
Issuance of common stock from exercise of stock options and units
Issuance of common stock pursuant to employee stock purchase plan
|
2024-12-31 |
| 2024-11-07 | 16639.19 | 未披露 | 定期报告 | 2024-10-29 |
| 2024-11-07 | 16635.17 | 未披露 | 定期报告 | 2024-09-30 |
| 2024-08-07 | 16587.61 | 未披露 | 定期报告 | 2024-07-31 |
| 2024-08-07 | 16585.33 | 未披露 | 定期报告 | 2024-06-30 |
| 2024-05-09 | 16522.09 | 未披露 | 定期报告 | 2024-04-30 |
| 2024-04-26 | 16520.35 | 未披露 | 定期报告 | 2024-04-22 |
| 2024-05-09 | 16495.97 | 未披露 | 定期报告 | 2024-03-31 |
| 2024-02-28 | 16477.15 | 未披露 | 定期报告 | 2024-02-21 |
| 2024-04-26 | 16476.76 | 未披露 | 定期报告 | 2024-02-15 |
| 2024-02-28 | 16465.02 | 未披露 |
更多>>
From December 31, 2022 to December 31, 2023
Issuance of common stock from exercise of stock options and units
Issuance of common stock pursuant to employee stock purchase plan
|
2023-12-31 |
| 2023-11-03 | 16418.04 | 未披露 | 定期报告 | 2023-10-25 |
| 2023-11-03 | 16396.89 | 未披露 | 定期报告 | 2023-09-30 |
| 2023-08-03 | 16372.89 | 未披露 | 定期报告 | 2023-07-26 |
| 2023-08-03 | 16335.58 | 未披露 | 定期报告 | 2023-06-30 |
| 2023-05-08 | 16262.54 | 未披露 | 定期报告 | 2023-04-26 |
| 2023-05-08 | 16238.42 | 未披露 | 定期报告 | 2023-03-31 |
| 2023-02-28 | 16223.02 | 未披露 | 定期报告 | 2023-02-21 |
| 2023-02-28 | 16206.49 | 未披露 |
更多>>
From December 31, 2021 to December 31, 2022
Issuance of common stock from exercise of stock options and units
Issuance of common stock pursuant to employee stock purchase plan
|
2022-12-31 |
| 2022-11-03 | 16193.10 | 未披露 | 定期报告 | 2022-10-21 |
| 2022-11-03 | 16187.18 | 未披露 | 定期报告 | 2022-09-30 |
| 2022-08-09 | 16184.32 | 未披露 | 定期报告 | 2022-07-28 |
| 2022-08-09 | 16184.24 | 未披露 | 定期报告 | 2022-06-30 |
| 2022-05-25 | 16178.53 | 未披露 | 定期报告 | 2022-05-23 |
| 2022-05-05 | 16142.94 | 未披露 | 定期报告 | 2022-04-28 |
| 2022-04-29 | 16142.85 | 未披露 | 定期报告 | 2022-04-22 |
| 2022-05-05 | 16138.18 | 未披露 | 定期报告 | 2022-03-31 |
| 2022-05-13 | 16133.07 | 未披露 | 定期报告 | 2022-02-28 |
| 2022-03-01 | 16120.37 | 未披露 | 定期报告 | 2022-02-15 |
| 2022-03-01 | 16101.27 | 未披露 |
更多>>
From December 31, 2020 to December 31, 2021
Issuance of common stock from exercise of stock options and units
Issuance of common stock pursuant to employee stock purchase plan
|
2021-12-31 |
| 2021-11-09 | 16075.60 | 未披露 | 定期报告 | 2021-10-25 |
| 2021-11-09 | 16069.09 | 未披露 | 定期报告 | 2021-09-30 |
| 2021-08-05 | 16064.33 | 未披露 | 定期报告 | 2021-07-28 |
| 2021-08-05 | 16062.27 | 未披露 | 定期报告 | 2021-06-30 |
| 2021-05-06 | 16017.90 | 未披露 | 定期报告 | 2021-04-27 |
| 2021-04-30 | 16017.85 | 未披露 | 定期报告 | 2021-04-26 |
| 2021-05-06 | 16017.22 | 未披露 | 定期报告 | 2021-03-31 |
| 2021-04-30 | 16005.47 | 未披露 | 定期报告 | 2021-02-28 |
| 2021-02-25 | 16004.75 | 未披露 | 定期报告 | 2021-02-10 |
| 2021-02-25 | 15963.78 | 未披露 |
更多>>
From December 31, 2019 to December 31, 2020
Issuance of common stock in connection with asset acquisition
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to employee stock purchase plan
|
2020-12-31 |
| 2020-11-04 | 15897.81 | 未披露 | 定期报告 | 2020-10-22 |
| 2020-11-04 | 15886.35 | 未披露 |
更多>>
From June 30, 2020 to September 30, 2020
Issuance of common stock from exercise of stock options and units
Issuance of common stock in public offering, net of issuance
|
2020-09-30 |
| 2020-08-06 | 15768.08 | 未披露 | 定期报告 | 2020-07-22 |
| 2020-08-06 | 15738.34 | 未披露 | 定期报告 | 2020-06-30 |
| 2020-04-29 | 15586.14 | 未披露 | 定期报告 | 2020-04-24 |
| 2020-05-08 | 15572.41 | 未披露 | 定期报告 | 2020-04-22 |
| 2020-05-08 | 15544.11 | 未披露 | 定期报告 | 2020-03-31 |
| 2020-04-29 | 15536.37 | 未披露 | 定期报告 | 2020-02-07 |
| 2020-02-27 | 15533.97 | 未披露 | 定期报告 | 2020-01-31 |
| 2020-02-27 | 15527.53 | 未披露 |
更多>>
from December 31, 2018 to December 31, 2019
Issuance of common stock in public offering, net of issuance costs
Issuance of common stock from exercise of stock options and units
Issuance of common stock pursuant to employee stock purchase plan
|
2019-12-31 |
| 2019-10-31 | 15402.55 | 未披露 | 定期报告 | 2019-10-23 |
| 2019-10-31 | 15353.92 | 未披露 |
更多>>
from June 30, 2019 to September 30, 2019
Issuance of common stock in public offering, net of issuance costs
|
2019-09-30 |
| 2019-09-20 | 15070.41 | 未披露 | 定期报告 | 2019-09-20 |
| 2019-08-01 | 14448.74 | 未披露 | 定期报告 | 2019-07-24 |
| 2019-08-01 | 14445.41 | 未披露 | 定期报告 | 2019-06-30 |
| 2019-05-02 | 14416.59 | 未披露 | 定期报告 | 2019-04-24 |
| 2019-05-02 | 14412.76 | 未披露 | 定期报告 | 2019-03-31 |
| 2019-04-30 | 14390.80 | 未披露 | 定期报告 | 2019-02-08 |
| 2019-02-27 | 14388.24 | 未披露 | 定期报告 | 2019-01-31 |
| 2019-02-27 | 14385.36 | 未披露 |
更多>>
from December 31, 2017 to December 31, 2018
Issuance of common stock in public offering, net of issuance costs
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock from exercise of warrants on a net issuance basis
|
2018-12-31 |
| 2018-11-06 | 12507.46 | 未披露 | 定期报告 | 2018-10-31 |
| 2018-11-06 | 12502.30 | 未披露 | 定期报告 | 2018-09-30 |
| 2018-08-08 | 12500.67 | 未披露 | 定期报告 | 2018-07-31 |
| 2018-08-08 | 12499.94 | 未披露 | 定期报告 | 2018-06-30 |
| 2018-05-04 | 12482.60 | 未披露 | 定期报告 | 2018-04-30 |
| 2018-04-30 | 12482.45 | 未披露 | 定期报告 | 2018-04-13 |
| 2018-05-04 | 12479.95 | 未披露 | 定期报告 | 2018-03-31 |
| 2018-04-30 | 12470.94 | 未披露 | 定期报告 | 2018-02-14 |
| 2018-02-27 | 12470.19 | 未披露 | 定期报告 | 2018-01-31 |
| 2018-02-27 | 12441.06 | 未披露 |
更多>>
from December 31, 2016 to December 31, 2017
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock from exercise of warrants on a net issuance basis
|
2017-12-31 |
| 2017-11-07 | 12420.56 | 未披露 | 定期报告 | 2017-10-31 |
| 2017-11-07 | 12271.70 | 未披露 | 定期报告 | 2017-09-30 |
| 2017-08-08 | 12240.03 | 未披露 | 定期报告 | 2017-07-31 |
| 2017-08-08 | 12233.66 | 未披露 | 定期报告 | 2017-06-30 |
| 2017-05-09 | 12204.64 | 未披露 | 定期报告 | 2017-05-03 |
| 2017-04-27 | 12202.06 | 未披露 | 定期报告 | 2017-04-19 |
| 2017-05-09 | 12198.68 | 未披露 | 定期报告 | 2017-03-31 |
| 2017-04-27 | 12169.45 | 未披露 | 定期报告 | 2017-02-17 |
| 2017-02-28 | 12140.76 | 未披露 | 定期报告 | 2017-01-31 |
| 2017-02-28 | 12136.72 | 未披露 |
更多>>
from December 31, 2015 to December 31, 2016
Issuance of common stock in public offering, net of issuance costs
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to employee stock purchase plan
|
2016-12-31 |
| 2016-11-07 | 12111.38 | 未披露 | 定期报告 | 2016-10-31 |
| 2016-11-07 | 12110.72 | 未披露 | 定期报告 | 2016-09-30 |
| 2016-08-04 | 11400.57 | 未披露 | 定期报告 | 2016-07-29 |
| 2016-08-04 | 11368.60 | 未披露 | 定期报告 | 2016-06-30 |
| 2016-05-05 | 11316.30 | 未披露 | 定期报告 | 2016-04-28 |
| 2016-04-29 | 11311.29 | 未披露 | 定期报告 | 2016-04-22 |
| 2016-05-05 | 11277.33 | 未披露 | 定期报告 | 2016-03-31 |
| 2016-02-29 | 11263.65 | 未披露 | 定期报告 | 2016-01-29 |
| 2016-02-29 | 10193.87 | 未披露 |
更多>>
From December 31, 2014 to December 31, 2015
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to employee stock purchase plan
|
2015-12-31 |
| 2015-11-05 | 10091.16 | 未披露 | 定期报告 | 2015-10-30 |
| 2015-11-05 | 10089.62 | 未披露 | 定期报告 | 2015-09-30 |
| 2015-08-06 | 10071.49 | 未披露 | 定期报告 | 2015-07-31 |
| 2015-08-06 | 10052.24 | 未披露 | 定期报告 | 2015-06-30 |
| 2015-05-07 | 10029.74 | 未披露 | 定期报告 | 2015-04-30 |
| 2015-04-29 | 10029.37 | 未披露 | 定期报告 | 2015-04-16 |
| 2015-05-07 | 10028.24 | 未披露 | 定期报告 | 2015-03-31 |
| 2015-02-26 | 10017.17 | 未披露 | 定期报告 | 2015-01-30 |
| 2015-02-26 | 10004.73 | 未披露 |
更多>>
from December 31, 2013 to December 31, 2014
Issuance of common stock in public offering, net of issuance costs
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to employee stock purchase plan
|
2014-12-31 |
| 2014-11-10 | 9977.03 | 未披露 | 定期报告 | 2014-10-31 |
| 2014-11-10 | 9970.16 | 未披露 | 定期报告 | 2014-09-30 |
| 2014-08-05 | 9943.68 | 未披露 | 定期报告 | 2014-07-31 |
| 2014-08-05 | 9930.07 | 未披露 | 定期报告 | 2014-06-30 |
| 2014-05-06 | 9897.63 | 未披露 | 定期报告 | 2014-04-30 |
| 2014-04-23 | 9888.74 | 未披露 | 定期报告 | 2014-04-08 |
| 2014-05-06 | 9883.56 | 未披露 | 定期报告 | 2014-03-31 |
| 2014-02-27 | 9134.85 | 未披露 | 定期报告 | 2014-01-31 |
| 2014-02-27 | 9110.26 | 未披露 |
更多>>
from December 31, 2012 to December 31, 2013
Issuance of common stock and warrants, net of issuance costs
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock from exercise of warrants on a net issuance basis
Reclassification to redeemable common stock
|
2013-12-31 |
| 2013-11-06 | 9086.65 | 未披露 | 定期报告 | 2013-10-31 |
| 2013-11-06 | 9082.80 | 未披露 | 定期报告 | 2013-09-30 |
| 2013-08-06 | 8878.38 | 未披露 | 定期报告 | 2013-07-31 |
| 2013-08-06 | 8877.70 | 未披露 | 定期报告 | 2013-06-30 |
| 2013-05-07 | 7916.49 | 未披露 | 定期报告 | 2013-04-29 |
| 2013-04-25 | 7888.38 | 未披露 | 定期报告 | 2013-04-09 |
| 2013-05-07 | 7880.30 | 未披露 | 定期报告 | 2013-03-31 |
| 2013-03-12 | 7875.80 | 未披露 | 定期报告 | 2013-03-01 |
| 2013-03-12 | 7868.14 | 未披露 |
更多>>
from December 31, 2011 to December 31, 2012
Issuance of common stock and warrants, net of issuance costs
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock from exercise of warrants on a net issuance basis
Issuance of common stock under ATM Agreement, net of issuance costs
Reclassification to redeemable common stock
|
2012-12-31 |
| 2012-11-05 | 5662.16 | 未披露 | 定期报告 | 2012-10-31 |
| 2012-11-05 | 5658.94 | 未披露 | 定期报告 | 2012-09-30 |
| 2012-08-08 | 5303.00 | 未披露 | 定期报告 | 2012-06-30 |
| 2012-05-08 | 5292.71 | 未披露 | 定期报告 | 2012-04-30 |
| 2012-05-08 | 5292.19 | 未披露 | 定期报告 | 2012-03-31 |
| 2012-03-06 | 5290.35 | 未披露 | 定期报告 | 2012-03-01 |
| 2012-03-06 | 5289.87 | 未披露 |
更多>>
from December 31, 2010 to December 31, 2011
Issuance of common stock and warrants, net of issuance costs
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock in connection with lease termination
|
2011-12-31 |
| 2011-11-09 | 5280.09 | 未披露 | 定期报告 | 2011-09-30 |
| 2011-08-10 | 5279.96 | 未披露 | 定期报告 | 2011-06-30 |
| 2011-05-10 | 5270.75 | 未披露 | 定期报告 | 2011-04-30 |
| 2011-03-10 | 5192.18 | 未披露 | 定期报告 | 2011-03-01 |
| 2011-03-10 | 3935.06 | 未披露 |
更多>>
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock under Committed Equity Financing Facility, net of issuance costs
|
2010-12-31 |
| 2010-11-09 | 3929.93 | 未披露 | 定期报告 | 2010-10-29 |
| 2010-11-09 | 3882.63 | 未披露 | 定期报告 | 2010-09-30 |
| 2010-08-09 | 3837.27 | 未披露 | 定期报告 | 2010-06-30 |
| 2010-05-10 | 3833.64 | 未披露 | 定期报告 | 2010-04-30 |
| 2010-05-10 | 3833.54 | 未披露 | 定期报告 | 2010-03-31 |
| 2010-03-09 | 3833.21 | 未披露 |
更多>>
from December 31, 2008 to December 31, 2009
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to Employee Stock Purchase Plan
Issuance of common stock under Committed Equity Financing Facility, net of issuance costs
Issuance of common stock upon exercise of warrant
|
2009-12-31 |
| 2009-03-10 | 3717.91 | 未披露 | 定期报告 | 2009-03-02 |
| 2009-03-10 | 3717.79 | 未披露 |
更多>>
from December 31, 2007 to December 31, 2008
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to Employee Stock Purchase Plan
|
2008-12-31 |
| 2008-03-05 | 3705.92 | 未披露 | 定期报告 | 2008-02-29 |
| 2008-03-05 | 3703.54 | 未披露 |
更多>>
from December 31, 2006 to December 31, 2007
Issuance of common stock to collaborator, net of issuance costs
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to Employee Stock Purchase Plan
|
2007-12-31 |
| 2007-03-09 | 2995.22 | 未披露 | 定期报告 | 2007-02-28 |
| 2007-03-09 | 2994.05 | 未披露 |
更多>>
from December 31, 2005 to December 31, 2006
Issuance of common stock to collaborator, net of issuance costs
Issuance of common stock and warrants, net of issuance costs
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to Employee Stock Purchase Plan
|
2006-12-31 |
| 2006-03-15 | 2434.99 | 未披露 | 定期报告 | 2006-02-28 |
| 2006-03-15 | 2351.79 | 未披露 |
更多>>
from December 31, 2004 to December 31, 2005
Issuance of common stock to collaborator, net of issuance costs
Issuance of common stock and warrants, net of issuance costs
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to Employee Stock Purchase Plan
Repurchase of restricted common stock
|
2005-12-31 |
| 2005-03-18 | 1805.12 | 未披露 | 定期报告 | 2005-03-14 |
| 2005-03-18 | 1692.29 | 未披露 |
更多>>
from December 31, 2003 to December 31, 2004
Issuance of common stock in initial public offering, net of issuance costs
Conversion of preferred stock to common stock
Issuance of common stock from conversion of debt
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to Employee Stock Purchase Plan
On May 25, 2004, the Company effected a 1-for-2 reverse stock split of the outstanding preferred stock and common stock. The accompanying financial statements give retroactive effect to the 1-for-2 reverse stock split for all periods presented.
|
2004-12-31 |
| 2005-03-18 | 146.21 | 990.09 |
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from December 31, 2002 to December 31, 2003
Issuance of Series F preferred stock, net of issuance costs
Issuance of Series E preferred stock in connection with Series F offering
Issuance of common stock from exercise of stock options
|
2003-12-31 |
From June 30, 2025 to September 30, 2025
Issuance of common stock from exercise of stock options and units
Stock-based compensation
From December 31, 2023 to December 31, 2024
Issuance of common stock from exercise of stock options and units
Issuance of common stock pursuant to employee stock purchase plan
From December 31, 2022 to December 31, 2023
Issuance of common stock from exercise of stock options and units
Issuance of common stock pursuant to employee stock purchase plan
From December 31, 2021 to December 31, 2022
Issuance of common stock from exercise of stock options and units
Issuance of common stock pursuant to employee stock purchase plan
From December 31, 2020 to December 31, 2021
Issuance of common stock from exercise of stock options and units
Issuance of common stock pursuant to employee stock purchase plan
From December 31, 2019 to December 31, 2020
Issuance of common stock in connection with asset acquisition
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to employee stock purchase plan
From June 30, 2020 to September 30, 2020
Issuance of common stock from exercise of stock options and units
Issuance of common stock in public offering, net of issuance
from December 31, 2018 to December 31, 2019
Issuance of common stock in public offering, net of issuance costs
Issuance of common stock from exercise of stock options and units
Issuance of common stock pursuant to employee stock purchase plan
from June 30, 2019 to September 30, 2019
Issuance of common stock in public offering, net of issuance costs
from December 31, 2017 to December 31, 2018
Issuance of common stock in public offering, net of issuance costs
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock from exercise of warrants on a net issuance basis
from December 31, 2016 to December 31, 2017
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock from exercise of warrants on a net issuance basis
from December 31, 2015 to December 31, 2016
Issuance of common stock in public offering, net of issuance costs
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to employee stock purchase plan
From December 31, 2014 to December 31, 2015
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to employee stock purchase plan
from December 31, 2013 to December 31, 2014
Issuance of common stock in public offering, net of issuance costs
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to employee stock purchase plan
from December 31, 2012 to December 31, 2013
Issuance of common stock and warrants, net of issuance costs
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock from exercise of warrants on a net issuance basis
Reclassification to redeemable common stock
from December 31, 2011 to December 31, 2012
Issuance of common stock and warrants, net of issuance costs
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock from exercise of warrants on a net issuance basis
Issuance of common stock under ATM Agreement, net of issuance costs
Reclassification to redeemable common stock
from December 31, 2010 to December 31, 2011
Issuance of common stock and warrants, net of issuance costs
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock in connection with lease termination
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock under Committed Equity Financing Facility, net of issuance costs
from December 31, 2008 to December 31, 2009
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to Employee Stock Purchase Plan
Issuance of common stock under Committed Equity Financing Facility, net of issuance costs
Issuance of common stock upon exercise of warrant
from December 31, 2007 to December 31, 2008
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to Employee Stock Purchase Plan
from December 31, 2006 to December 31, 2007
Issuance of common stock to collaborator, net of issuance costs
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to Employee Stock Purchase Plan
from December 31, 2005 to December 31, 2006
Issuance of common stock to collaborator, net of issuance costs
Issuance of common stock and warrants, net of issuance costs
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to Employee Stock Purchase Plan
from December 31, 2004 to December 31, 2005
Issuance of common stock to collaborator, net of issuance costs
Issuance of common stock and warrants, net of issuance costs
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to Employee Stock Purchase Plan
Repurchase of restricted common stock
from December 31, 2003 to December 31, 2004
Issuance of common stock in initial public offering, net of issuance costs
Conversion of preferred stock to common stock
Issuance of common stock from conversion of debt
Issuance of common stock from exercise of stock options
Issuance of common stock pursuant to Employee Stock Purchase Plan
On May 25, 2004, the Company effected a 1-for-2 reverse stock split of the outstanding preferred stock and common stock. The accompanying financial statements give retroactive effect to the 1-for-2 reverse stock split for all periods presented.
from December 31, 2002 to December 31, 2003
Issuance of Series F preferred stock, net of issuance costs
Issuance of Series E preferred stock in connection with Series F offering
Issuance of common stock from exercise of stock options