股本结构

单位:万股
公告日期 2025-11-06 2025-11-06 2025-08-07 2025-08-07 2025-05-08 2025-05-08
证券总股本 16918.18 16914.60 16871.22 16860.79 16736.19 16711.60
普通股本 16918.18 16914.60 16871.22 16860.79 16736.19 16711.60
优先股 未披露 未披露 未披露 未披露 未披露 未披露
其他 未披露 未披露 未披露 未披露 未披露 未披露
变动日期 2025-10-29 2025-09-30 2025-07-30 2025-06-30 2025-04-30 2025-03-31
注释:中概股证券总股本=普通股股本/ 存托凭证比例

历史变动

公告日期 变动后普通股本(万股) 变动后优先股(万股) 变动原因 变动日期
2025-11-06 16918.18 未披露 定期报告 2025-10-29
2025-11-06 16914.60 未披露
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From June 30, 2025 to September 30, 2025 Issuance of common stock from exercise of stock options and units Stock-based compensation
2025-09-30
2025-08-07 16871.22 未披露 定期报告 2025-07-30
2025-08-07 16860.79 未披露 定期报告 2025-06-30
2025-05-08 16736.19 未披露 定期报告 2025-04-30
2025-04-25 16733.34 未披露 定期报告 2025-04-22
2025-05-08 16711.60 未披露 定期报告 2025-03-31
2025-04-25 16678.85 未披露 定期报告 2025-02-15
2025-02-27 16670.89 未披露
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From December 31, 2023 to December 31, 2024 Issuance of common stock from exercise of stock options and units Issuance of common stock pursuant to employee stock purchase plan
2024-12-31
2024-11-07 16639.19 未披露 定期报告 2024-10-29
2024-11-07 16635.17 未披露 定期报告 2024-09-30
2024-08-07 16587.61 未披露 定期报告 2024-07-31
2024-08-07 16585.33 未披露 定期报告 2024-06-30
2024-05-09 16522.09 未披露 定期报告 2024-04-30
2024-04-26 16520.35 未披露 定期报告 2024-04-22
2024-05-09 16495.97 未披露 定期报告 2024-03-31
2024-02-28 16477.15 未披露 定期报告 2024-02-21
2024-04-26 16476.76 未披露 定期报告 2024-02-15
2024-02-28 16465.02 未披露
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From December 31, 2022 to December 31, 2023 Issuance of common stock from exercise of stock options and units Issuance of common stock pursuant to employee stock purchase plan
2023-12-31
2023-11-03 16418.04 未披露 定期报告 2023-10-25
2023-11-03 16396.89 未披露 定期报告 2023-09-30
2023-08-03 16372.89 未披露 定期报告 2023-07-26
2023-08-03 16335.58 未披露 定期报告 2023-06-30
2023-05-08 16262.54 未披露 定期报告 2023-04-26
2023-05-08 16238.42 未披露 定期报告 2023-03-31
2023-02-28 16223.02 未披露 定期报告 2023-02-21
2023-02-28 16206.49 未披露
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From December 31, 2021 to December 31, 2022 Issuance of common stock from exercise of stock options and units Issuance of common stock pursuant to employee stock purchase plan
2022-12-31
2022-11-03 16193.10 未披露 定期报告 2022-10-21
2022-11-03 16187.18 未披露 定期报告 2022-09-30
2022-08-09 16184.32 未披露 定期报告 2022-07-28
2022-08-09 16184.24 未披露 定期报告 2022-06-30
2022-05-25 16178.53 未披露 定期报告 2022-05-23
2022-05-05 16142.94 未披露 定期报告 2022-04-28
2022-04-29 16142.85 未披露 定期报告 2022-04-22
2022-05-05 16138.18 未披露 定期报告 2022-03-31
2022-05-13 16133.07 未披露 定期报告 2022-02-28
2022-03-01 16120.37 未披露 定期报告 2022-02-15
2022-03-01 16101.27 未披露
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From December 31, 2020 to December 31, 2021 Issuance of common stock from exercise of stock options and units Issuance of common stock pursuant to employee stock purchase plan
2021-12-31
2021-11-09 16075.60 未披露 定期报告 2021-10-25
2021-11-09 16069.09 未披露 定期报告 2021-09-30
2021-08-05 16064.33 未披露 定期报告 2021-07-28
2021-08-05 16062.27 未披露 定期报告 2021-06-30
2021-05-06 16017.90 未披露 定期报告 2021-04-27
2021-04-30 16017.85 未披露 定期报告 2021-04-26
2021-05-06 16017.22 未披露 定期报告 2021-03-31
2021-04-30 16005.47 未披露 定期报告 2021-02-28
2021-02-25 16004.75 未披露 定期报告 2021-02-10
2021-02-25 15963.78 未披露
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From December 31, 2019 to December 31, 2020 Issuance of common stock in connection with asset acquisition Issuance of common stock from exercise of stock options Issuance of common stock pursuant to employee stock purchase plan
2020-12-31
2020-11-04 15897.81 未披露 定期报告 2020-10-22
2020-11-04 15886.35 未披露
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From June 30, 2020 to September 30, 2020 Issuance of common stock from exercise of stock options and units Issuance of common stock in public offering, net of issuance
2020-09-30
2020-08-06 15768.08 未披露 定期报告 2020-07-22
2020-08-06 15738.34 未披露 定期报告 2020-06-30
2020-04-29 15586.14 未披露 定期报告 2020-04-24
2020-05-08 15572.41 未披露 定期报告 2020-04-22
2020-05-08 15544.11 未披露 定期报告 2020-03-31
2020-04-29 15536.37 未披露 定期报告 2020-02-07
2020-02-27 15533.97 未披露 定期报告 2020-01-31
2020-02-27 15527.53 未披露
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from December 31, 2018 to December 31, 2019 Issuance of common stock in public offering, net of issuance costs Issuance of common stock from exercise of stock options and units Issuance of common stock pursuant to employee stock purchase plan
2019-12-31
2019-10-31 15402.55 未披露 定期报告 2019-10-23
2019-10-31 15353.92 未披露
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from June 30, 2019 to September 30, 2019 Issuance of common stock in public offering, net of issuance costs
2019-09-30
2019-09-20 15070.41 未披露 定期报告 2019-09-20
2019-08-01 14448.74 未披露 定期报告 2019-07-24
2019-08-01 14445.41 未披露 定期报告 2019-06-30
2019-05-02 14416.59 未披露 定期报告 2019-04-24
2019-05-02 14412.76 未披露 定期报告 2019-03-31
2019-04-30 14390.80 未披露 定期报告 2019-02-08
2019-02-27 14388.24 未披露 定期报告 2019-01-31
2019-02-27 14385.36 未披露
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from December 31, 2017 to December 31, 2018 Issuance of common stock in public offering, net of issuance costs Issuance of common stock from exercise of stock options Issuance of common stock pursuant to employee stock purchase plan Issuance of common stock from exercise of warrants on a net issuance basis
2018-12-31
2018-11-06 12507.46 未披露 定期报告 2018-10-31
2018-11-06 12502.30 未披露 定期报告 2018-09-30
2018-08-08 12500.67 未披露 定期报告 2018-07-31
2018-08-08 12499.94 未披露 定期报告 2018-06-30
2018-05-04 12482.60 未披露 定期报告 2018-04-30
2018-04-30 12482.45 未披露 定期报告 2018-04-13
2018-05-04 12479.95 未披露 定期报告 2018-03-31
2018-04-30 12470.94 未披露 定期报告 2018-02-14
2018-02-27 12470.19 未披露 定期报告 2018-01-31
2018-02-27 12441.06 未披露
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from December 31, 2016 to December 31, 2017 Issuance of common stock from exercise of stock options Issuance of common stock pursuant to employee stock purchase plan Issuance of common stock from exercise of warrants on a net issuance basis
2017-12-31
2017-11-07 12420.56 未披露 定期报告 2017-10-31
2017-11-07 12271.70 未披露 定期报告 2017-09-30
2017-08-08 12240.03 未披露 定期报告 2017-07-31
2017-08-08 12233.66 未披露 定期报告 2017-06-30
2017-05-09 12204.64 未披露 定期报告 2017-05-03
2017-04-27 12202.06 未披露 定期报告 2017-04-19
2017-05-09 12198.68 未披露 定期报告 2017-03-31
2017-04-27 12169.45 未披露 定期报告 2017-02-17
2017-02-28 12140.76 未披露 定期报告 2017-01-31
2017-02-28 12136.72 未披露
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from December 31, 2015 to December 31, 2016 Issuance of common stock in public offering, net of issuance costs Issuance of common stock from exercise of stock options Issuance of common stock pursuant to employee stock purchase plan
2016-12-31
2016-11-07 12111.38 未披露 定期报告 2016-10-31
2016-11-07 12110.72 未披露 定期报告 2016-09-30
2016-08-04 11400.57 未披露 定期报告 2016-07-29
2016-08-04 11368.60 未披露 定期报告 2016-06-30
2016-05-05 11316.30 未披露 定期报告 2016-04-28
2016-04-29 11311.29 未披露 定期报告 2016-04-22
2016-05-05 11277.33 未披露 定期报告 2016-03-31
2016-02-29 11263.65 未披露 定期报告 2016-01-29
2016-02-29 10193.87 未披露
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From December 31, 2014 to December 31, 2015 Issuance of common stock from exercise of stock options Issuance of common stock pursuant to employee stock purchase plan
2015-12-31
2015-11-05 10091.16 未披露 定期报告 2015-10-30
2015-11-05 10089.62 未披露 定期报告 2015-09-30
2015-08-06 10071.49 未披露 定期报告 2015-07-31
2015-08-06 10052.24 未披露 定期报告 2015-06-30
2015-05-07 10029.74 未披露 定期报告 2015-04-30
2015-04-29 10029.37 未披露 定期报告 2015-04-16
2015-05-07 10028.24 未披露 定期报告 2015-03-31
2015-02-26 10017.17 未披露 定期报告 2015-01-30
2015-02-26 10004.73 未披露
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from December 31, 2013 to December 31, 2014 Issuance of common stock in public offering, net of issuance costs Issuance of common stock from exercise of stock options Issuance of common stock pursuant to employee stock purchase plan
2014-12-31
2014-11-10 9977.03 未披露 定期报告 2014-10-31
2014-11-10 9970.16 未披露 定期报告 2014-09-30
2014-08-05 9943.68 未披露 定期报告 2014-07-31
2014-08-05 9930.07 未披露 定期报告 2014-06-30
2014-05-06 9897.63 未披露 定期报告 2014-04-30
2014-04-23 9888.74 未披露 定期报告 2014-04-08
2014-05-06 9883.56 未披露 定期报告 2014-03-31
2014-02-27 9134.85 未披露 定期报告 2014-01-31
2014-02-27 9110.26 未披露
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from December 31, 2012 to December 31, 2013 Issuance of common stock and warrants, net of issuance costs Issuance of common stock from exercise of stock options Issuance of common stock pursuant to employee stock purchase plan Issuance of common stock from exercise of warrants on a net issuance basis Reclassification to redeemable common stock
2013-12-31
2013-11-06 9086.65 未披露 定期报告 2013-10-31
2013-11-06 9082.80 未披露 定期报告 2013-09-30
2013-08-06 8878.38 未披露 定期报告 2013-07-31
2013-08-06 8877.70 未披露 定期报告 2013-06-30
2013-05-07 7916.49 未披露 定期报告 2013-04-29
2013-04-25 7888.38 未披露 定期报告 2013-04-09
2013-05-07 7880.30 未披露 定期报告 2013-03-31
2013-03-12 7875.80 未披露 定期报告 2013-03-01
2013-03-12 7868.14 未披露
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from December 31, 2011 to December 31, 2012 Issuance of common stock and warrants, net of issuance costs Issuance of common stock from exercise of stock options Issuance of common stock pursuant to employee stock purchase plan Issuance of common stock from exercise of warrants on a net issuance basis Issuance of common stock under ATM Agreement, net of issuance costs Reclassification to redeemable common stock
2012-12-31
2012-11-05 5662.16 未披露 定期报告 2012-10-31
2012-11-05 5658.94 未披露 定期报告 2012-09-30
2012-08-08 5303.00 未披露 定期报告 2012-06-30
2012-05-08 5292.71 未披露 定期报告 2012-04-30
2012-05-08 5292.19 未披露 定期报告 2012-03-31
2012-03-06 5290.35 未披露 定期报告 2012-03-01
2012-03-06 5289.87 未披露
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from December 31, 2010 to December 31, 2011 Issuance of common stock and warrants, net of issuance costs Issuance of common stock from exercise of stock options Issuance of common stock pursuant to employee stock purchase plan Issuance of common stock in connection with lease termination
2011-12-31
2011-11-09 5280.09 未披露 定期报告 2011-09-30
2011-08-10 5279.96 未披露 定期报告 2011-06-30
2011-05-10 5270.75 未披露 定期报告 2011-04-30
2011-03-10 5192.18 未披露 定期报告 2011-03-01
2011-03-10 3935.06 未披露
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Issuance of common stock from exercise of stock options Issuance of common stock pursuant to employee stock purchase plan Issuance of common stock under Committed Equity Financing Facility, net of issuance costs
2010-12-31
2010-11-09 3929.93 未披露 定期报告 2010-10-29
2010-11-09 3882.63 未披露 定期报告 2010-09-30
2010-08-09 3837.27 未披露 定期报告 2010-06-30
2010-05-10 3833.64 未披露 定期报告 2010-04-30
2010-05-10 3833.54 未披露 定期报告 2010-03-31
2010-03-09 3833.21 未披露
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from December 31, 2008 to December 31, 2009 Issuance of common stock from exercise of stock options Issuance of common stock pursuant to Employee Stock Purchase Plan Issuance of common stock under Committed Equity Financing Facility, net of issuance costs Issuance of common stock upon exercise of warrant
2009-12-31
2009-03-10 3717.91 未披露 定期报告 2009-03-02
2009-03-10 3717.79 未披露
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from December 31, 2007 to December 31, 2008 Issuance of common stock from exercise of stock options Issuance of common stock pursuant to Employee Stock Purchase Plan
2008-12-31
2008-03-05 3705.92 未披露 定期报告 2008-02-29
2008-03-05 3703.54 未披露
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from December 31, 2006 to December 31, 2007 Issuance of common stock to collaborator, net of issuance costs Issuance of common stock from exercise of stock options Issuance of common stock pursuant to Employee Stock Purchase Plan
2007-12-31
2007-03-09 2995.22 未披露 定期报告 2007-02-28
2007-03-09 2994.05 未披露
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from December 31, 2005 to December 31, 2006 Issuance of common stock to collaborator, net of issuance costs Issuance of common stock and warrants, net of issuance costs Issuance of common stock from exercise of stock options Issuance of common stock pursuant to Employee Stock Purchase Plan
2006-12-31
2006-03-15 2434.99 未披露 定期报告 2006-02-28
2006-03-15 2351.79 未披露
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from December 31, 2004 to December 31, 2005 Issuance of common stock to collaborator, net of issuance costs Issuance of common stock and warrants, net of issuance costs Issuance of common stock from exercise of stock options Issuance of common stock pursuant to Employee Stock Purchase Plan Repurchase of restricted common stock
2005-12-31
2005-03-18 1805.12 未披露 定期报告 2005-03-14
2005-03-18 1692.29 未披露
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from December 31, 2003 to December 31, 2004 Issuance of common stock in initial public offering, net of issuance costs Conversion of preferred stock to common stock Issuance of common stock from conversion of debt Issuance of common stock from exercise of stock options Issuance of common stock pursuant to Employee Stock Purchase Plan On May 25, 2004, the Company effected a 1-for-2 reverse stock split of the outstanding preferred stock and common stock. The accompanying financial statements give retroactive effect to the 1-for-2 reverse stock split for all periods presented.
2004-12-31
2005-03-18 146.21 990.09
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from December 31, 2002 to December 31, 2003 Issuance of Series F preferred stock, net of issuance costs Issuance of Series E preferred stock in connection with Series F offering Issuance of common stock from exercise of stock options
2003-12-31
From June 30, 2025 to September 30, 2025 Issuance of common stock from exercise of stock options and units Stock-based compensation
From December 31, 2023 to December 31, 2024 Issuance of common stock from exercise of stock options and units Issuance of common stock pursuant to employee stock purchase plan
From December 31, 2022 to December 31, 2023 Issuance of common stock from exercise of stock options and units Issuance of common stock pursuant to employee stock purchase plan
From December 31, 2021 to December 31, 2022 Issuance of common stock from exercise of stock options and units Issuance of common stock pursuant to employee stock purchase plan
From December 31, 2020 to December 31, 2021 Issuance of common stock from exercise of stock options and units Issuance of common stock pursuant to employee stock purchase plan
From December 31, 2019 to December 31, 2020 Issuance of common stock in connection with asset acquisition Issuance of common stock from exercise of stock options Issuance of common stock pursuant to employee stock purchase plan
From June 30, 2020 to September 30, 2020 Issuance of common stock from exercise of stock options and units Issuance of common stock in public offering, net of issuance
from December 31, 2018 to December 31, 2019 Issuance of common stock in public offering, net of issuance costs Issuance of common stock from exercise of stock options and units Issuance of common stock pursuant to employee stock purchase plan
from June 30, 2019 to September 30, 2019 Issuance of common stock in public offering, net of issuance costs
from December 31, 2017 to December 31, 2018 Issuance of common stock in public offering, net of issuance costs Issuance of common stock from exercise of stock options Issuance of common stock pursuant to employee stock purchase plan Issuance of common stock from exercise of warrants on a net issuance basis
from December 31, 2016 to December 31, 2017 Issuance of common stock from exercise of stock options Issuance of common stock pursuant to employee stock purchase plan Issuance of common stock from exercise of warrants on a net issuance basis
from December 31, 2015 to December 31, 2016 Issuance of common stock in public offering, net of issuance costs Issuance of common stock from exercise of stock options Issuance of common stock pursuant to employee stock purchase plan
From December 31, 2014 to December 31, 2015 Issuance of common stock from exercise of stock options Issuance of common stock pursuant to employee stock purchase plan
from December 31, 2013 to December 31, 2014 Issuance of common stock in public offering, net of issuance costs Issuance of common stock from exercise of stock options Issuance of common stock pursuant to employee stock purchase plan
from December 31, 2012 to December 31, 2013 Issuance of common stock and warrants, net of issuance costs Issuance of common stock from exercise of stock options Issuance of common stock pursuant to employee stock purchase plan Issuance of common stock from exercise of warrants on a net issuance basis Reclassification to redeemable common stock
from December 31, 2011 to December 31, 2012 Issuance of common stock and warrants, net of issuance costs Issuance of common stock from exercise of stock options Issuance of common stock pursuant to employee stock purchase plan Issuance of common stock from exercise of warrants on a net issuance basis Issuance of common stock under ATM Agreement, net of issuance costs Reclassification to redeemable common stock
from December 31, 2010 to December 31, 2011 Issuance of common stock and warrants, net of issuance costs Issuance of common stock from exercise of stock options Issuance of common stock pursuant to employee stock purchase plan Issuance of common stock in connection with lease termination
Issuance of common stock from exercise of stock options Issuance of common stock pursuant to employee stock purchase plan Issuance of common stock under Committed Equity Financing Facility, net of issuance costs
from December 31, 2008 to December 31, 2009 Issuance of common stock from exercise of stock options Issuance of common stock pursuant to Employee Stock Purchase Plan Issuance of common stock under Committed Equity Financing Facility, net of issuance costs Issuance of common stock upon exercise of warrant
from December 31, 2007 to December 31, 2008 Issuance of common stock from exercise of stock options Issuance of common stock pursuant to Employee Stock Purchase Plan
from December 31, 2006 to December 31, 2007 Issuance of common stock to collaborator, net of issuance costs Issuance of common stock from exercise of stock options Issuance of common stock pursuant to Employee Stock Purchase Plan
from December 31, 2005 to December 31, 2006 Issuance of common stock to collaborator, net of issuance costs Issuance of common stock and warrants, net of issuance costs Issuance of common stock from exercise of stock options Issuance of common stock pursuant to Employee Stock Purchase Plan
from December 31, 2004 to December 31, 2005 Issuance of common stock to collaborator, net of issuance costs Issuance of common stock and warrants, net of issuance costs Issuance of common stock from exercise of stock options Issuance of common stock pursuant to Employee Stock Purchase Plan Repurchase of restricted common stock
from December 31, 2003 to December 31, 2004 Issuance of common stock in initial public offering, net of issuance costs Conversion of preferred stock to common stock Issuance of common stock from conversion of debt Issuance of common stock from exercise of stock options Issuance of common stock pursuant to Employee Stock Purchase Plan On May 25, 2004, the Company effected a 1-for-2 reverse stock split of the outstanding preferred stock and common stock. The accompanying financial statements give retroactive effect to the 1-for-2 reverse stock split for all periods presented.
from December 31, 2002 to December 31, 2003 Issuance of Series F preferred stock, net of issuance costs Issuance of Series E preferred stock in connection with Series F offering Issuance of common stock from exercise of stock options