主要股东
注：以下部分股东代表特定权益共同体，直接或间接持有上市公司股份
| 序号 | 股东名称 | 是否机构 | 持股数(股) | 持股比例 | 持股变动数(股) | 持股数变动比例 | 投票权比例 |
|---|---|---|---|---|---|---|---|
| 1 | Deerfield Management Company, Lp | 是 | 1446.92万 | 18.50% | 新增 | 新增 | -- |
| 2 | Palo Alto Investors, Llc | 是 | 1203.66万 | 15.20% | 新增 | 新增 | -- |
| 3 | Armistice Capital, LLC | 是 | 693.60万 | 9.90% | 新增 | 新增 | -- |
| 4 | venBio Select Advisors LLC | 是 | 624.16万 | 8.90% | 新增 | 新增 | -- |
| 5 | BAVP, LP | 是 | 385.21万 | 5.50% | 新增 | 新增 | -- |
| 6 | Brian K. Halak | 否 | 378.25万 | 5.40% | 新增 | 新增 | -- |
| 7 | Stonepine Capital Management, LLC | 是 | 355.99万 | 5.10% | 新增 | 新增 | -- |
| 8 | HBM Healthcare Investments (Cayman) Ltd. | 是 | 350.00万 | 5.00% | 新增 | 新增 | -- |
机构持股汇总
| 主力进出\报告期 | 2024-09-13 | 2024-08-14 | 2024-08-13 | 2024-08-12 | 2024-08-09 | 2024-08-08 |
|---|---|---|---|---|---|---|
| 机构数量(家) | 65 | 63 | 54 | 51 | 49 | 47 |
| 累计持有数量(万股) | 4635.75 | 4893.30 | 4848.27 | 4791.93 | 4696.90 | 4661.13 |
| 累计市值(亿) | 2.57 | 2.74 | 2.72 | 2.68 | 2.63 | 2.60 |
| 持仓比例(%) | 85.85% | 90.62% | 89.78% | 88.74% | 86.98% | 86.32% |
| 净交易量(万股) |
注：若当期数据无主力机构持仓或公司定期报告未披露完毕，则不显示。
非主要股东机构持股变动
| 机构或基金名称 | 持有数量 | 持股市值(亿美元) | 持股变动(万股) | 变动比例(%) |
|---|---|---|---|---|
|
Altium Capital Management Lp
|
215.00万股 | 0.24 | -40.00 | -15.69 |
|
Bank Of New York Mellon Corp
|
6.19万股 | 0.0070 | 6.19 | 不足0.01 |
|
Blackrock Inc.
|
138.54万股 | 0.16 | 90.21 | 186.67 |
|
Boothbay Fund Management, Llc
|
319.87万股 | 0.36 | - | 不足0.01 |
|
Bridgeway Capital Management, Llc
|
13.91万股 | 0.02 | - | 不足0.01 |
|
Caligan Partners Lp
|
1683.52万股 | 1.90 | - | 不足0.01 |
|
Deltec Asset Management Llc
|
12.42万股 | 0.01 | 12.42 | 不足0.01 |
|
Gabelli Funds Llc
|
10.80万股 | 0.01 | 10.80 | 不足0.01 |
|
Geode Capital Management, Llc
|
63.84万股 | 0.07 | 26.02 | 68.78 |
|
Glazer Capital, Llc
|
55.15万股 | 0.06 | 55.15 | 不足0.01 |
|
Jpmorgan Chase & Co
|
100.36万股 | 0.11 | 98.15 | 4434.07 |
|
Morgan Stanley
|
51.53万股 | 0.06 | 1.36 | 2.70 |
|
Northern Trust Corp
|
8.63万股 | 0.0098 | 1.29 | 17.55 |
|
Qube Research & Technologies Ltd
|
9.77万股 | 0.01 | 5.11 | 109.39 |
|
Renaissance Technologies Llc
|
18.17万股 | 0.02 | 0.69 | 3.95 |
|
State Street Corp
|
37.45万股 | 0.04 | 24.15 | 181.57 |
|
Stonepine Capital Management, Llc
|
351.18万股 | 0.40 | -53.93 | -13.31 |
|
Vanguard Group Inc
|
117.77万股 | 0.13 | 13.23 | 12.65 |
|
Velan Capital Investment Management Lp
|
1360.85万股 | 1.54 | - | 不足0.01 |
|
Virtu Financial Llc
|
6.23万股 | 0.0070 | 6.23 | 不足0.01 |
| 机构或基金名称 | 持有数量 | 持股市值(亿美元) | 持股变动(万股) | 变动比例(%) |
|---|---|---|---|---|
|
Altium Capital Management Lp
|
215.00万股 | 0.24 | -40.00 | -15.69 |
|
Bank Of New York Mellon Corp
|
6.19万股 | 0.0070 | 6.19 | 不足0.01 |
|
Blackrock Inc.
|
138.54万股 | 0.16 | 90.21 | 186.67 |
|
Boothbay Fund Management, Llc
|
319.87万股 | 0.36 | - | 不足0.01 |
|
Bridgeway Capital Management, Llc
|
13.91万股 | 0.02 | - | 不足0.01 |
|
Caligan Partners Lp
|
1683.52万股 | 1.90 | - | 不足0.01 |
|
Deltec Asset Management Llc
|
12.42万股 | 0.01 | 12.42 | 不足0.01 |
|
Gabelli Funds Llc
|
10.80万股 | 0.01 | 10.80 | 不足0.01 |
|
Geode Capital Management, Llc
|
63.84万股 | 0.07 | 26.02 | 68.78 |
|
Glazer Capital, Llc
|
55.15万股 | 0.06 | 55.15 | 不足0.01 |
|
Jpmorgan Chase & Co
|
100.36万股 | 0.11 | 98.15 | 4434.07 |
|
Morgan Stanley
|
51.53万股 | 0.06 | 1.36 | 2.70 |
|
Northern Trust Corp
|
8.63万股 | 0.0098 | 1.29 | 17.55 |
|
Qube Research & Technologies Ltd
|
9.77万股 | 0.01 | 5.11 | 109.39 |
|
Renaissance Technologies Llc
|
18.17万股 | 0.02 | 0.69 | 3.95 |
|
State Street Corp
|
37.45万股 | 0.04 | 24.15 | 181.57 |
|
Stonepine Capital Management, Llc
|
351.18万股 | 0.40 | -53.93 | -13.31 |
|
Vanguard Group Inc
|
117.77万股 | 0.13 | 13.23 | 12.65 |
|
Velan Capital Investment Management Lp
|
1360.85万股 | 1.54 | - | 不足0.01 |
|
Virtu Financial Llc
|
6.23万股 | 0.0070 | 6.23 | 不足0.01 |
| 机构或基金名称 | 持有数量 | 持股市值(亿美元) | 持股变动(万股) | 变动比例(%) |
|---|---|---|---|---|
|
Altium Capital Management Lp
|
215.00万股 | 0.24 | -40.00 | -15.69 |
|
Bank Of New York Mellon Corp
|
6.19万股 | 0.0070 | 6.19 | 不足0.01 |
|
Blackrock Inc.
|
138.54万股 | 0.16 | 90.21 | 186.67 |
|
Boothbay Fund Management, Llc
|
319.87万股 | 0.36 | - | 不足0.01 |
|
Bridgeway Capital Management, Llc
|
13.91万股 | 0.02 | - | 不足0.01 |
|
Caligan Partners Lp
|
1683.52万股 | 1.90 | - | 不足0.01 |
|
Deltec Asset Management Llc
|
12.42万股 | 0.01 | 12.42 | 不足0.01 |
|
Gabelli Funds Llc
|
10.80万股 | 0.01 | 10.80 | 不足0.01 |
|
Geode Capital Management, Llc
|
63.84万股 | 0.07 | 26.02 | 68.78 |
|
Glazer Capital, Llc
|
55.15万股 | 0.06 | 55.15 | 不足0.01 |
|
Jpmorgan Chase & Co
|
100.36万股 | 0.11 | 98.15 | 4434.07 |
|
Morgan Stanley
|
51.53万股 | 0.06 | 1.36 | 2.70 |
|
Northern Trust Corp
|
8.63万股 | 0.0098 | 1.29 | 17.55 |
|
Qube Research & Technologies Ltd
|
9.77万股 | 0.01 | 5.11 | 109.39 |
|
Renaissance Technologies Llc
|
18.17万股 | 0.02 | 0.69 | 3.95 |
|
State Street Corp
|
37.45万股 | 0.04 | 24.15 | 181.57 |
|
Stonepine Capital Management, Llc
|
351.18万股 | 0.40 | -53.93 | -13.31 |
|
Vanguard Group Inc
|
117.77万股 | 0.13 | 13.23 | 12.65 |
|
Velan Capital Investment Management Lp
|
1360.85万股 | 1.54 | - | 不足0.01 |
|
Virtu Financial Llc
|
6.23万股 | 0.0070 | 6.23 | 不足0.01 |
| 机构或基金名称 | 持有数量 | 持股市值(亿美元) | 持股变动(万股) | 变动比例(%) |
|---|---|---|---|---|
|
Altium Capital Management Lp
|
215.00万股 | 0.24 | -40.00 | -15.69 |
|
Bank Of New York Mellon Corp
|
6.19万股 | 0.0070 | 6.19 | 不足0.01 |
|
Blackrock Inc.
|
138.54万股 | 0.16 | 90.21 | 186.67 |
|
Boothbay Fund Management, Llc
|
319.87万股 | 0.36 | - | 不足0.01 |
|
Bridgeway Capital Management, Llc
|
13.91万股 | 0.02 | - | 不足0.01 |
|
Caligan Partners Lp
|
1683.52万股 | 1.90 | - | 不足0.01 |
|
Deltec Asset Management Llc
|
12.42万股 | 0.01 | 12.42 | 不足0.01 |
|
Gabelli Funds Llc
|
10.80万股 | 0.01 | 10.80 | 不足0.01 |
|
Geode Capital Management, Llc
|
63.84万股 | 0.07 | 26.02 | 68.78 |
|
Glazer Capital, Llc
|
55.15万股 | 0.06 | 55.15 | 不足0.01 |
|
Jpmorgan Chase & Co
|
100.36万股 | 0.11 | 98.15 | 4434.07 |
|
Morgan Stanley
|
51.53万股 | 0.06 | 1.36 | 2.70 |
|
Northern Trust Corp
|
8.63万股 | 0.0098 | 1.29 | 17.55 |
|
Qube Research & Technologies Ltd
|
9.77万股 | 0.01 | 5.11 | 109.39 |
|
Renaissance Technologies Llc
|
18.17万股 | 0.02 | 0.69 | 3.95 |
|
State Street Corp
|
37.45万股 | 0.04 | 24.15 | 181.57 |
|
Stonepine Capital Management, Llc
|
351.18万股 | 0.40 | -53.93 | -13.31 |
|
Vanguard Group Inc
|
117.77万股 | 0.13 | 13.23 | 12.65 |
|
Velan Capital Investment Management Lp
|
1360.85万股 | 1.54 | - | 不足0.01 |
|
Virtu Financial Llc
|
6.23万股 | 0.0070 | 6.23 | 不足0.01 |
| 机构或基金名称 | 持有数量 | 持股市值(亿美元) | 持股变动(万股) | 变动比例(%) |
|---|---|---|---|---|
|
Altium Capital Management Lp
|
215.00万股 | 0.24 | -40.00 | -15.69 |
|
Bank Of New York Mellon Corp
|
6.19万股 | 0.0070 | 6.19 | 不足0.01 |
|
Blackrock Inc.
|
138.54万股 | 0.16 | 90.21 | 186.67 |
|
Boothbay Fund Management, Llc
|
319.87万股 | 0.36 | - | 不足0.01 |
|
Bridgeway Capital Management, Llc
|
13.91万股 | 0.02 | - | 不足0.01 |
|
Caligan Partners Lp
|
1683.52万股 | 1.90 | - | 不足0.01 |
|
Deltec Asset Management Llc
|
12.42万股 | 0.01 | 12.42 | 不足0.01 |
|
Gabelli Funds Llc
|
10.80万股 | 0.01 | 10.80 | 不足0.01 |
|
Geode Capital Management, Llc
|
63.84万股 | 0.07 | 26.02 | 68.78 |
|
Glazer Capital, Llc
|
55.15万股 | 0.06 | 55.15 | 不足0.01 |
|
Jpmorgan Chase & Co
|
100.36万股 | 0.11 | 98.15 | 4434.07 |
|
Morgan Stanley
|
51.53万股 | 0.06 | 1.36 | 2.70 |
|
Northern Trust Corp
|
8.63万股 | 0.0098 | 1.29 | 17.55 |
|
Qube Research & Technologies Ltd
|
9.77万股 | 0.01 | 5.11 | 109.39 |
|
Renaissance Technologies Llc
|
18.17万股 | 0.02 | 0.69 | 3.95 |
|
State Street Corp
|
37.45万股 | 0.04 | 24.15 | 181.57 |
|
Stonepine Capital Management, Llc
|
351.18万股 | 0.40 | -53.93 | -13.31 |
|
Vanguard Group Inc
|
117.77万股 | 0.13 | 13.23 | 12.65 |
|
Velan Capital Investment Management Lp
|
1360.85万股 | 1.54 | - | 不足0.01 |
|
Virtu Financial Llc
|
6.23万股 | 0.0070 | 6.23 | 不足0.01 |
内部人交易
| 日期 | 股东名称 | 变动股数(万股) | 交易后持股数量(万股) | 交易价格 | 是否直接持有 | 内部人类型 |
|---|---|---|---|---|---|---|
| 2024-03-26 | Ashman Philip |
|
11.83 | 3.83 | 是 | President of Int'l Operations |