股本结构
单位：万股
| 公告日期 | 2025-10-30 | 2025-10-30 | 2025-07-31 | 2025-07-31 | 2025-05-01 | 2025-05-01 |
|---|---|---|---|---|---|---|
| 证券总股本 | 13211.38 | 13179.10 | 13107.90 | 13097.70 | 13038.84 | 13031.10 |
| 普通股本 | 13211.38 | 13179.10 | 13107.90 | 13097.70 | 13038.84 | 13031.10 |
| 优先股 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2025-10-24 | 2025-09-30 | 2025-07-25 | 2025-06-30 | 2025-04-25 | 2025-03-31 |
注释：中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本（万股） | 变动后优先股（万股） | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2025-10-30 | 13211.38 | 未披露 | 定期报告 | 2025-10-24 |
| 2025-10-30 | 13179.10 | 未披露 |
更多>>
From June 30, 2025 to September 30, 2025
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
|
2025-09-30 |
| 2025-07-31 | 13107.90 | 未披露 | 定期报告 | 2025-07-25 |
| 2025-07-31 | 13097.70 | 未披露 |
更多>>
From March 31, 2025 to June 30, 2025
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
|
2025-06-30 |
| 2025-05-01 | 13038.84 | 未披露 | 定期报告 | 2025-04-25 |
| 2025-05-01 | 13031.10 | 未披露 |
更多>>
From December 31, 2024 to March 31, 2025
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
|
2025-03-31 |
| 2025-03-24 | 13008.49 | 未披露 | 定期报告 | 2025-03-10 |
| 2025-02-13 | 12945.72 | 未披露 | 定期报告 | 2025-02-06 |
| 2025-03-24 | 12942.66 | 未披露 | 定期报告 | 2025-01-31 |
| 2025-02-13 | 12929.40 | 未披露 |
更多>>
From December 31, 2023 to December 31, 2024
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
|
2024-12-31 |
| 2024-10-31 | 12898.09 | 未披露 | 定期报告 | 2024-10-25 |
| 2024-10-31 | 12884.10 | 未披露 |
更多>>
From June 30, 2024 to September 30, 2024
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
|
2024-09-30 |
| 2024-08-01 | 12838.05 | 未披露 | 定期报告 | 2024-07-26 |
| 2024-08-01 | 12802.10 | 未披露 |
更多>>
From March 31, 2024 to June 30, 2024
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
|
2024-06-30 |
| 2024-05-02 | 12649.18 | 未披露 | 定期报告 | 2024-04-26 |
| 2024-05-02 | 12646.30 | 未披露 |
更多>>
From December 31, 2023 to March 31, 2024
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
|
2024-03-31 |
| 2024-04-01 | 12645.21 | 未披露 | 定期报告 | 2024-03-22 |
| 2024-02-15 | 12594.58 | 未披露 | 定期报告 | 2024-02-09 |
| 2024-04-01 | 12593.39 | 未披露 | 定期报告 | 2024-01-31 |
| 2024-02-15 | 12579.40 | 未披露 |
更多>>
From December 31, 2022 to December 31, 2023
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
|
2023-12-31 |
| 2023-11-02 | 12549.29 | 未披露 | 定期报告 | 2023-10-27 |
| 2023-11-02 | 12545.40 | 未披露 |
更多>>
From June 30, 2023 to September 30, 2023
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
|
2023-09-30 |
| 2023-08-03 | 12500.07 | 未披露 | 定期报告 | 2023-07-28 |
| 2023-08-03 | 12490.10 | 未披露 |
更多>>
From March 31, 2023 to June 30, 2023
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
|
2023-06-30 |
| 2023-05-04 | 12452.57 | 未披露 | 定期报告 | 2023-04-28 |
| 2023-05-04 | 12424.10 | 未披露 |
更多>>
From December 31, 2022 to March 31, 2023
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
|
2023-03-31 |
| 2023-04-03 | 12422.35 | 未披露 | 定期报告 | 2023-03-24 |
| 2023-02-23 | 12413.10 | 未披露 | 定期报告 | 2023-02-17 |
| 2023-04-03 | 12392.49 | 未披露 | 定期报告 | 2023-01-31 |
| 2023-02-23 | 12392.50 | 未披露 |
更多>>
From December 31, 2021 to December 31, 2022
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
|
2022-12-31 |
| 2022-10-27 | 12302.82 | 未披露 | 定期报告 | 2022-10-21 |
| 2022-10-27 | 12299.10 | 未披露 |
更多>>
From June 30, 2022 to September 30, 2022
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
|
2022-09-30 |
| 2022-07-28 | 12002.66 | 未披露 | 定期报告 | 2022-07-22 |
| 2022-07-28 | 12099.20 | 未披露 |
更多>>
From March 31, 2022 to June 30, 2022
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
|
2022-06-30 |
| 2022-04-28 | 12081.36 | 未披露 | 定期报告 | 2022-04-22 |
| 2022-04-28 | 12072.90 | 未披露 |
更多>>
From December 31, 2021 to March 31, 2022
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
|
2022-03-31 |
| 2022-04-05 | 12071.85 | 未披露 | 定期报告 | 2022-03-28 |
| 2022-02-10 | 12021.05 | 未披露 | 定期报告 | 2022-02-04 |
| 2022-04-05 | 12020.13 | 未披露 | 定期报告 | 2022-01-31 |
| 2022-02-10 | 12018.20 | 未披露 |
更多>>
From December 31, 2020 to December 31, 2021
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
|
2021-12-31 |
| 2021-10-28 | 11960.12 | 未披露 | 定期报告 | 2021-10-22 |
| 2021-10-28 | 11948.00 | 未披露 |
更多>>
From June 30, 2021 to September 30, 2021
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
|
2021-09-30 |
| 2021-08-03 | 11884.77 | 未披露 | 定期报告 | 2021-07-30 |
| 2021-08-03 | 11859.60 | 未披露 |
更多>>
From March 31, 2021 to June 30, 2021
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
|
2021-06-30 |
| 2021-04-29 | 11754.50 | 未披露 | 定期报告 | 2021-04-23 |
| 2021-04-29 | 11732.10 | 未披露 |
更多>>
From December 31, 2020 to March 31, 2021
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
|
2021-03-31 |
| 2021-04-02 | 11732.01 | 未披露 | 定期报告 | 2021-03-29 |
| 2021-02-11 | 11700.20 | 未披露 | 定期报告 | 2021-02-05 |
| 2021-04-02 | 11699.16 | 未披露 | 定期报告 | 2021-01-31 |
| 2021-02-11 | 11642.70 | 未披露 |
更多>>
From December 31, 2019 to December 31, 2020
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
Issuance of common stock to strategic partners, net of closing costs
|
2020-12-31 |
| 2020-11-05 | 11618.08 | 未披露 | 定期报告 | 2020-10-30 |
| 2020-11-05 | 11614.30 | 未披露 |
更多>>
From June 30, 2020 to September 30, 2020
Exercise of common stock options,net of tax withholdings
Issuance of common stock under equity plans
|
2020-09-30 |
| 2020-08-06 | 11596.98 | 未披露 | 定期报告 | 2020-07-31 |
| 2020-08-06 | 11564.70 | 未披露 |
更多>>
From March 31, 2020 to June 30, 2020
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
Issuance of common stock to strategic partners, net of closing costs
|
2020-06-30 |
| 2020-06-05 | 11535.70 | 未披露 | 定期报告 | 2020-06-04 |
| 2020-05-06 | 11481.92 | 未披露 | 定期报告 | 2020-04-30 |
| 2020-05-06 | 11316.80 | 未披露 |
更多>>
from December 31, 2019 to March 31, 2020
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
|
2020-03-31 |
| 2020-03-23 | 11307.24 | 未披露 | 定期报告 | 2020-03-09 |
| 2020-02-13 | 11258.40 | 未披露 | 定期报告 | 2020-02-07 |
| 2020-02-13 | 11218.80 | 未披露 |
更多>>
from December 31, 2018 to December 31, 2019
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
Issuance of common stock under benefit plans
Issuance of common stock, net of offering costs
|
2019-12-31 |
| 2019-10-31 | 11148.97 | 未披露 | 定期报告 | 2019-10-25 |
| 2019-10-31 | 11132.50 | 未披露 |
更多>>
from June 30, 2019 to September 30, 2019
Exercise of common stock options, net of tax withholdings
Issuance of common stock under other types of equity plans
Issuance of common stock under benefit plans
|
2019-09-30 |
| 2019-08-06 | 11120.77 | 未披露 | 定期报告 | 2019-07-31 |
| 2019-08-06 | 11111.40 | 未披露 |
更多>>
from March 31, 2019 to June 30,2019
Exercise of common stock options, net of tax withholdings
Issuance of common stock under other types of equity plans
Stock-based compensation expense related to equity-classified awards
Issuance of common stock, net of offering costs
|
2019-06-30 |
| 2019-05-02 | 10653.68 | 未披露 | 定期报告 | 2019-04-30 |
| 2019-05-02 | 10640.00 | 未披露 |
更多>>
from December 31, 2018 to March 31, 2019
Exercise of common stock options, net of tax withholdings
Issuance of common stock under other types of equity plans
Issuance of common stock under equity plans, net of tax withholdings
Issuance of common stock, net of offering costs
|
2019-03-31 |
| 2019-03-21 | 10630.44 | 未披露 | 定期报告 | 2019-03-01 |
| 2019-03-21 | 10630.62 | 未披露 | 定期报告 | 2019-02-28 |
| 2019-02-14 | 10625.83 | 未披露 | 定期报告 | 2019-01-31 |
| 2019-02-14 | 10117.70 | 未披露 |
更多>>
from December 31, 2017 to December 31, 2018
Exercise of common stock options, net of tax withholdings
Issuance of common stock under other types of equity plans
Issuance of common stock under equity plans, net of tax withholdings
|
2018-12-31 |
| 2018-11-07 | 10103.04 | 未披露 | 定期报告 | 2018-10-31 |
| 2018-11-07 | 10096.81 | 未披露 | 定期报告 | 2018-09-30 |
| 2018-08-02 | 10066.61 | 未披露 | 定期报告 | 2018-07-31 |
| 2018-08-02 | 10056.90 | 未披露 | 定期报告 | 2018-06-30 |
| 2018-05-04 | 10052.24 | 未披露 | 定期报告 | 2018-04-30 |
| 2018-05-04 | 10046.81 | 未披露 | 定期报告 | 2018-03-31 |
| 2018-03-23 | 10017.14 | 未披露 | 定期报告 | 2018-03-15 |
| 2018-03-23 | 9992.53 | 未披露 | 定期报告 | 2018-02-28 |
| 2018-02-15 | 9986.78 | 未披露 | 定期报告 | 2018-01-31 |
| 2018-02-15 | 9966.65 | 未披露 |
更多>>
from December 31, 2016 to December 31, 2017
Exercise of common stock options
Issuance of common stock under other types of equity plans
Issuance of common stock under equity plans, net of tax withholdings
Issuance of common stock to Sanofi Genzyme
Issuance of common stock, net of offering costs
|
2017-12-31 |
| 2017-11-07 | 9273.08 | 未披露 | 定期报告 | 2017-10-31 |
| 2017-11-07 | 9236.79 | 未披露 | 定期报告 | 2017-09-30 |
| 2017-08-09 | 9173.34 | 未披露 | 定期报告 | 2017-07-31 |
| 2017-08-09 | 9170.14 | 未披露 | 定期报告 | 2017-06-30 |
| 2017-05-05 | 8619.02 | 未披露 | 定期报告 | 2017-04-28 |
| 2017-05-05 | 8606.81 | 未披露 | 定期报告 | 2017-03-31 |
| 2017-03-17 | 8605.26 | 未披露 | 定期报告 | 2017-03-10 |
| 2017-02-15 | 8601.38 | 未披露 | 定期报告 | 2017-01-31 |
| 2017-02-15 | 8594.13 | 未披露 |
更多>>
from December 31, 2015 to December 31, 2016
Exercise of common stock options, net of tax withholdings
Issuance of common stock under other types of equity plans
Issuance of common stock under equity plans, net of tax withholdings
Issuance of common stock to Sanofi Genzyme
|
2016-12-31 |
| 2016-11-03 | 8581.39 | 未披露 | 定期报告 | 2016-10-31 |
| 2016-11-03 | 8576.62 | 未披露 | 定期报告 | 2016-09-30 |
| 2016-08-04 | 8572.46 | 未披露 | 定期报告 | 2016-07-29 |
| 2016-08-04 | 8557.28 | 未披露 | 定期报告 | 2016-06-30 |
| 2016-05-04 | 8556.05 | 未披露 | 定期报告 | 2016-04-29 |
| 2016-05-02 | 8546.33 | 未披露 | 定期报告 | 2016-03-31 |
| 2016-03-17 | 8535.53 | 未披露 | 定期报告 | 2016-03-11 |
| 2016-02-12 | 8513.86 | 未披露 | 定期报告 | 2016-01-29 |
| 2016-02-12 | 8509.10 | 未披露 |
更多>>
From December 31, 2014 to December 31, 2015
Exercise of common stock options
Issuance of common stock under other types of equity plans
Issuance of common stock under equity plans, net of tax withholdings
Issuance of common stock to Sanofi Genzyme
Issuance of common stock, net of offering costs
|
2015-12-31 |
| 2015-11-09 | 8473.57 | 未披露 | 定期报告 | 2015-10-30 |
| 2015-11-09 | 8470.85 | 未披露 | 定期报告 | 2015-09-30 |
| 2015-08-07 | 8461.51 | 未披露 | 定期报告 | 2015-07-31 |
| 2015-08-07 | 8453.38 | 未披露 | 定期报告 | 2015-06-30 |
| 2015-05-08 | 8428.27 | 未披露 | 定期报告 | 2015-04-30 |
| 2015-05-08 | 8421.43 | 未披露 | 定期报告 | 2015-03-31 |
| 2015-03-10 | 8399.09 | 未披露 | 定期报告 | 2015-03-04 |
| 2015-02-13 | 8376.01 | 未披露 | 定期报告 | 2015-01-30 |
| 2015-02-13 | 7720.28 | 未披露 |
更多>>
From December 31, 2013 to December 31, 2014
Exercise of common stock options
Issuance of common stock under other types of equity plans
Tax withholdings and cancellations of restricted stock, net of issuances of new awards
Issuance of common stock to Genzyme
Issuance of common stock in connection with an asset acquisition
|
2014-12-31 |
| 2014-11-06 | 7693.11 | 未披露 | 定期报告 | 2014-10-31 |
| 2014-11-06 | 7667.70 | 未披露 | 定期报告 | 2014-09-30 |
| 2014-08-08 | 7635.48 | 未披露 | 定期报告 | 2014-07-31 |
| 2014-08-08 | 7632.41 | 未披露 | 定期报告 | 2014-06-30 |
| 2014-05-09 | 7555.34 | 未披露 | 定期报告 | 2014-04-30 |
| 2014-05-09 | 7548.48 | 未披露 | 定期报告 | 2014-03-31 |
| 2014-02-20 | 6391.68 | 未披露 | 定期报告 | 2014-01-31 |
| 2014-02-20 | 6374.16 | 未披露 |
更多>>
from December 31, 2012 to December 31, 2013
Exercise of common stock options
Issuance of common stock under other types of equity plans
Tax withholdings and cancellations of restricted stock, net of issuances of new awards
Issuance of common stock, net of offering costs
|
2013-12-31 |
| 2013-11-07 | 6343.01 | 未披露 | 定期报告 | 2013-10-31 |
| 2013-11-07 | 6323.62 | 未披露 | 定期报告 | 2013-09-30 |
| 2013-08-09 | 6296.00 | 未披露 | 定期报告 | 2013-07-31 |
| 2013-08-08 | 6250.00 | 未披露 | 定期报告 | 2013-06-30 |
| 2013-05-07 | 6217.10 | 未披露 | 定期报告 | 2013-04-30 |
| 2013-04-24 | 6213.99 | 未披露 | 定期报告 | 2013-04-19 |
| 2013-05-07 | 6213.28 | 未披露 | 定期报告 | 2013-03-31 |
| 2013-02-19 | 6186.68 | 未披露 | 定期报告 | 2013-01-31 |
| 2013-02-19 | 5248.99 | 未披露 |
更多>>
from December 31, 2011 to December 31, 2012
Exercise of common stock options
Issuance of common stock under other types of equity plans
Issuance of restricted stock, net of cancellations and tax withholdings
Issuance of common stock, net of offering costs
|
2012-12-31 |
| 2012-11-05 | 5241.44 | 未披露 | 定期报告 | 2012-10-31 |
| 2012-11-05 | 5237.89 | 未披露 | 定期报告 | 2012-09-30 |
| 2012-08-08 | 5224.49 | 未披露 | 定期报告 | 2012-07-31 |
| 2012-08-08 | 5199.56 | 未披露 | 定期报告 | 2012-06-30 |
| 2012-05-03 | 5194.99 | 未披露 | 定期报告 | 2012-04-30 |
| 2012-05-03 | 5189.33 | 未披露 | 定期报告 | 2012-03-31 |
| 2012-02-13 | 4320.85 | 未披露 | 定期报告 | 2012-01-31 |
| 2012-02-13 | 4272.19 | 未披露 |
更多>>
from December 31, 2010 to December 31, 2011
Exercise of common stock options
Issuance of common stock
Issuance of restricted stock
|
2011-12-31 |
| 2011-11-03 | 4272.70 | 未披露 | 定期报告 | 2011-10-31 |
| 2011-11-03 | 4268.79 | 未披露 | 定期报告 | 2011-09-30 |
| 2011-08-03 | 4265.18 | 未披露 | 定期报告 | 2011-07-29 |
| 2011-08-03 | 4265.39 | 未披露 | 定期报告 | 2011-06-30 |
| 2011-05-05 | 4240.82 | 未披露 | 定期报告 | 2011-05-02 |
| 2011-05-05 | 4235.93 | 未披露 | 定期报告 | 2011-03-31 |
| 2011-02-18 | 4234.36 | 未披露 | 定期报告 | 2011-01-31 |
| 2011-02-18 | 4234.34 | 未披露 |
更多>>
Exercise of common stock options
Issuance of common stock
Issuance of restricted stock
|
2010-12-31 |
| 2010-11-04 | 4219.98 | 未披露 | 定期报告 | 2010-10-29 |
| 2010-11-04 | 4216.04 | 未披露 | 定期报告 | 2010-09-30 |
| 2010-08-05 | 4209.67 | 未披露 | 定期报告 | 2010-06-30 |
From June 30, 2025 to September 30, 2025
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
From March 31, 2025 to June 30, 2025
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
From December 31, 2024 to March 31, 2025
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
From December 31, 2023 to December 31, 2024
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
From June 30, 2024 to September 30, 2024
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
From March 31, 2024 to June 30, 2024
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
From December 31, 2023 to March 31, 2024
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
From December 31, 2022 to December 31, 2023
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
From June 30, 2023 to September 30, 2023
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
From March 31, 2023 to June 30, 2023
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
From December 31, 2022 to March 31, 2023
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
From December 31, 2021 to December 31, 2022
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
From June 30, 2022 to September 30, 2022
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
From March 31, 2022 to June 30, 2022
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
From December 31, 2021 to March 31, 2022
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
From December 31, 2020 to December 31, 2021
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
From June 30, 2021 to September 30, 2021
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
From March 31, 2021 to June 30, 2021
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
From December 31, 2020 to March 31, 2021
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
From December 31, 2019 to December 31, 2020
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
Issuance of common stock to strategic partners, net of closing costs
From June 30, 2020 to September 30, 2020
Exercise of common stock options,net of tax withholdings
Issuance of common stock under equity plans
From March 31, 2020 to June 30, 2020
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
Issuance of common stock to strategic partners, net of closing costs
from December 31, 2019 to March 31, 2020
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
from December 31, 2018 to December 31, 2019
Exercise of common stock options, net of tax withholdings
Issuance of common stock under equity plans
Issuance of common stock under benefit plans
Issuance of common stock, net of offering costs
from June 30, 2019 to September 30, 2019
Exercise of common stock options, net of tax withholdings
Issuance of common stock under other types of equity plans
Issuance of common stock under benefit plans
from March 31, 2019 to June 30,2019
Exercise of common stock options, net of tax withholdings
Issuance of common stock under other types of equity plans
Stock-based compensation expense related to equity-classified awards
Issuance of common stock, net of offering costs
from December 31, 2018 to March 31, 2019
Exercise of common stock options, net of tax withholdings
Issuance of common stock under other types of equity plans
Issuance of common stock under equity plans, net of tax withholdings
Issuance of common stock, net of offering costs
from December 31, 2017 to December 31, 2018
Exercise of common stock options, net of tax withholdings
Issuance of common stock under other types of equity plans
Issuance of common stock under equity plans, net of tax withholdings
from December 31, 2016 to December 31, 2017
Exercise of common stock options
Issuance of common stock under other types of equity plans
Issuance of common stock under equity plans, net of tax withholdings
Issuance of common stock to Sanofi Genzyme
Issuance of common stock, net of offering costs
from December 31, 2015 to December 31, 2016
Exercise of common stock options, net of tax withholdings
Issuance of common stock under other types of equity plans
Issuance of common stock under equity plans, net of tax withholdings
Issuance of common stock to Sanofi Genzyme
From December 31, 2014 to December 31, 2015
Exercise of common stock options
Issuance of common stock under other types of equity plans
Issuance of common stock under equity plans, net of tax withholdings
Issuance of common stock to Sanofi Genzyme
Issuance of common stock, net of offering costs
From December 31, 2013 to December 31, 2014
Exercise of common stock options
Issuance of common stock under other types of equity plans
Tax withholdings and cancellations of restricted stock, net of issuances of new awards
Issuance of common stock to Genzyme
Issuance of common stock in connection with an asset acquisition
from December 31, 2012 to December 31, 2013
Exercise of common stock options
Issuance of common stock under other types of equity plans
Tax withholdings and cancellations of restricted stock, net of issuances of new awards
Issuance of common stock, net of offering costs
from December 31, 2011 to December 31, 2012
Exercise of common stock options
Issuance of common stock under other types of equity plans
Issuance of restricted stock, net of cancellations and tax withholdings
Issuance of common stock, net of offering costs
from December 31, 2010 to December 31, 2011
Exercise of common stock options
Issuance of common stock
Issuance of restricted stock
Exercise of common stock options
Issuance of common stock
Issuance of restricted stock