股本结构
单位：万股
| 公告日期 | 2025-11-05 | 2025-11-05 | 2025-07-30 | 2025-07-30 | 2025-04-28 | 2025-05-09 |
|---|---|---|---|---|---|---|
| 证券总股本 | 1442.12 | 1442.10 | 1441.81 | 1441.80 | 1434.14 | 1433.60 |
| 普通股本 | 1442.12 | 1442.10 | 1441.81 | 1441.80 | 1434.14 | 1433.60 |
| 优先股 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2025-10-29 | 2025-09-30 | 2025-07-23 | 2025-06-30 | 2025-04-21 | 2025-03-31 |
注释：中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本（万股） | 变动后优先股（万股） | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2025-11-05 | 1442.12 | 未披露 | 定期报告 | 2025-10-29 |
| 2025-11-05 | 1442.10 | 未披露 |
更多>>
From June 30, 2025 to September 30, 2025
Vesting of restricted stock units
Retirement of common stock for minimum tax withholdings
|
2025-09-30 |
| 2025-07-30 | 1441.81 | 未披露 | 定期报告 | 2025-07-23 |
| 2025-07-30 | 1441.80 | 未披露 |
更多>>
From March 31, 2025 to June 30, 2025
Vesting of restricted stock units
Issuance of ESPP shares
Retirement of common stock for minimum tax withholdings
|
2025-06-30 |
| 2025-04-28 | 1434.14 | 未披露 | 定期报告 | 2025-04-21 |
| 2025-05-09 | 1433.60 | 未披露 |
更多>>
From January 1, 2025 to March 31, 2025
Vesting of restricted stock units
Retirement of common stock for minimum tax withholdings
Repurchase of common stock
|
2025-03-31 |
| 2025-03-17 | 1417.60 | 未披露 | 定期报告 | 2025-03-06 |
| 2025-03-17 | 1441.60 | 未披露 |
更多>>
From December 31, 2023 to December 31, 2024
Retirement of common stock for minimum tax withholdings
Issuance of common stock from employee purchase plan
Issuance of common stock for equity awards
Vesting of restricted stock units
Repurchase of common stock
|
2024-12-31 |
| 2024-11-04 | 1464.56 | 未披露 | 定期报告 | 2024-10-28 |
| 2024-11-04 | 1469.40 | 未披露 |
更多>>
From June 30, 2024 to September 30, 2024
Vesting of restricted stock units
Repurchase of common stock
Retirement of common stock for minimum tax withholdings
|
2024-09-30 |
| 2024-08-08 | 1479.67 | 未披露 | 定期报告 | 2024-07-29 |
| 2024-08-08 | 1483.90 | 未披露 |
更多>>
From March 31, 2024 to June 30, 2024
Vesting of restricted stock units
Repurchase of common stock
Issuance of ESPP shares
Retirement of common stock for minimum tax withholdings
Issuance of common stock for equity awards
|
2024-06-30 |
| 2024-06-11 | 1485.74 | 未披露 | 定期报告 | 2024-05-17 |
| 2024-04-26 | 1482.85 | 未披露 | 定期报告 | 2024-04-22 |
| 2024-05-08 | 1482.10 | 未披露 |
更多>>
From January 1, 2024 to March 31, 2024
Issuance of common stock for equity awards
Vesting of restricted stock units
Retirement of common stock for minimum tax withholdings
|
2024-03-31 |
| 2024-03-15 | 1484.99 | 未披露 | 定期报告 | 2024-03-06 |
| 2024-03-15 | 1466.00 | 未披露 |
更多>>
From December 31, 2022 to December 31, 2023
Repurchase of common stock
Vesting of restricted stock units
Issuance of common stock for equity awards
Retirement of common stock for minimum tax withholdings
Issuance of common stock from employee purchase plan
|
2023-12-31 |
| 2023-11-03 | 1464.09 | 未披露 | 定期报告 | 2023-10-26 |
| 2023-11-03 | 1463.70 | 未披露 |
更多>>
From June 30, 2023 to September 30, 2023
Retirement of common stock for minimum tax withholdings
Vesting of restricted stock units
Repurchase of common stock
|
2023-09-30 |
| 2023-08-08 | 1463.11 | 未披露 | 定期报告 | 2023-07-31 |
| 2023-05-09 | 1475.72 | 未披露 | 定期报告 | 2023-04-30 |
| 2023-05-01 | 1474.35 | 未披露 | 定期报告 | 2023-04-20 |
| 2023-05-09 | 1474.10 | 未披露 |
更多>>
From January 1, 2023 to March 31, 2023
Vesting of restricted stock units
Retirement of common stock for minimum tax withholdings
Issuance of common stock for equity awards
|
2023-03-31 |
| 2023-03-16 | 1463.29 | 未披露 | 定期报告 | 2023-03-08 |
| 2023-03-16 | 1462.50 | 未披露 |
更多>>
From December 31, 2021 to December 31, 2022
Retirement of common stock for minimum tax withholdings
Vesting of restricted stock units
Issuance of common stock from employee purchase plan
|
2022-12-31 |
| 2022-11-09 | 1460.97 | 未披露 | 定期报告 | 2022-10-31 |
| 2022-11-09 | 1460.70 | 未披露 |
更多>>
From June 30, 2022 to September 30, 2022
Retirement of common stock for minimum tax withholdings
Vesting of restricted stock units
|
2022-09-30 |
| 2022-08-04 | 1459.99 | 未披露 | 定期报告 | 2022-07-29 |
| 2022-08-04 | 1459.80 | 未披露 |
更多>>
From March 31, 2022 to June 30, 2022
Vesting of restricted stock units
Issuance of ESPP shares
Retirement of common stock for minimum tax withholdings
|
2022-06-30 |
| 2022-05-06 | 1454.39 | 未披露 | 定期报告 | 2022-04-28 |
| 2022-04-27 | 1451.93 | 未披露 | 定期报告 | 2022-04-13 |
| 2022-05-06 | 1451.80 | 未披露 |
更多>>
From January 1, 2022 to March 31, 2022
Issuance of common stock for equity awards
Vesting of restricted stock units
Retirement of common stock for minimum tax withholdings
|
2022-03-31 |
| 2022-03-11 | 1446.70 | 未披露 | 定期报告 | 2022-03-02 |
| 2022-03-11 | 1444.10 | 未披露 |
更多>>
From December 31, 2020 to December 31, 2021
Issuance of common stock for equity awards
Vesting of restricted stock units
Retirement of common stock for minimum tax withholdings
Vesting of restricted stock units
|
2021-12-31 |
| 2021-11-05 | 1443.68 | 未披露 | 定期报告 | 2021-10-25 |
| 2021-11-05 | 1443.60 | 未披露 |
更多>>
From June 30, 2021 to September 30, 2021
Issuance of common stock for equity awards
Vesting of restricted stock units
Retirement of common stock for minimum tax withholdings
|
2021-09-30 |
| 2021-08-06 | 1442.30 | 未披露 | 定期报告 | 2021-07-26 |
| 2021-08-06 | 1441.80 | 未披露 |
更多>>
From March 31, 2021 to June 30, 2021
Issuance of common stock for equity awards
Vesting of restricted stock units
Retirement of common stock for minimum tax withholdings
|
2021-06-30 |
| 2021-05-07 | 1439.13 | 未披露 | 定期报告 | 2021-04-30 |
| 2021-04-26 | 1436.67 | 未披露 | 定期报告 | 2021-04-20 |
| 2021-05-07 | 1436.60 | 未披露 |
更多>>
From January 1, 2021 To March 31, 2021
Vesting of restricted stock units
Retirement of common stock for minimum tax withholdings
|
2021-03-31 |
| 2021-03-05 | 1432.96 | 未披露 | 定期报告 | 2021-02-24 |
| 2021-03-05 | 1432.90 | 未披露 |
更多>>
From December 31, 2019 to December 31, 2020
Issuance of common stock for equity awards
Vesting of restricted stock units
Forfeiture of restricted stock awards
Retirement of common stock for minimum tax withholdings
Repurchase of common stock
|
2020-12-31 |
| 2020-11-05 | 1421.45 | 未披露 | 定期报告 | 2020-10-26 |
| 2020-11-05 | 1420.80 | 未披露 |
更多>>
From June 30, 2020 to September 30, 2020
Vesting of restricted stock units
|
2020-09-30 |
| 2020-08-07 | 1420.74 | 未披露 | 定期报告 | 2020-07-27 |
| 2020-08-07 | 1420.40 | 未披露 |
更多>>
from March 31, 2020 to June 30, 2020
Issuance of common stock for equity awards
Vesting of restricted stock units
Retirement of common stock for minimum tax withholdings
|
2020-06-30 |
| 2020-05-22 | 1420.23 | 未披露 | 定期报告 | 2020-05-19 |
| 2020-04-29 | 1419.79 | 未披露 | 定期报告 | 2020-04-20 |
| 2020-05-22 | 1419.80 | 未披露 |
更多>>
from January 1, 2020 to March 31, 2020
Vesting of restricted stock units
Forfeiture of restricted stock awards
Retirement of common stock for minimum tax withholdings
Repurchase of common stock
|
2020-03-31 |
| 2020-03-06 | 1416.81 | 未披露 | 定期报告 | 2020-02-24 |
| 2020-03-06 | 1430.80 | 未披露 |
更多>>
from December 31, 2018 to December 31, 2019
Issuance of common stock for equity awards
Vesting of restricted stock units
Forfeiture of restricted stock awards
Retirement of common stock for minimum tax withholdings
Repurchase of common stock
|
2019-12-31 |
| 2019-10-28 | 1426.94 | 未披露 | 定期报告 | 2019-10-17 |
| 2019-10-28 | 1426.90 | 未披露 |
更多>>
from June 30, 2019 to September 30, 2019
Issuance of common stock for equity awards
Forfeiture of restricted stock
Retirement of common stock for minimum tax withholdings
|
2019-09-30 |
| 2019-07-26 | 1378.29 | 未披露 | 定期报告 | 2019-07-18 |
| 2019-07-26 | 1378.50 | 未披露 |
更多>>
from March 31, 2019 to June 30,2019
Issuance of common stock for equity awards
Forfeiture of restricted stock
Repurchase of common stock
|
2019-06-30 |
| 2019-04-25 | 1420.69 | 未披露 | 定期报告 | 2019-04-22 |
| 2019-05-06 | 1421.40 | 未披露 |
更多>>
from January 1, 2019 to March 31, 2019
Issuance of common stock for equity awards
Retirement of common stock for minimum tax withholdings
|
2019-03-31 |
| 2019-02-27 | 1421.17 | 未披露 | 定期报告 | 2019-02-10 |
| 2019-02-27 | 1421.00 | 未披露 |
更多>>
from December 31, 2017 to December 31, 2018
Issuance of common stock for equity awards
Retirement of common stock for minimum tax withholdings
Repurchase of common stock
|
2018-12-31 |
| 2018-10-26 | 1421.15 | 未披露 | 定期报告 | 2018-10-18 |
| 2018-10-26 | 1421.10 | 未披露 | 定期报告 | 2018-09-30 |
| 2018-07-31 | 1458.36 | 未披露 | 定期报告 | 2018-07-25 |
| 2018-07-31 | 1458.40 | 未披露 | 定期报告 | 2018-06-30 |
| 2018-04-17 | 1474.52 | 未披露 | 定期报告 | 2018-04-02 |
| 2018-05-10 | 1474.50 | 未披露 | 定期报告 | 2018-03-31 |
| 2018-02-27 | 1469.39 | 未披露 | 定期报告 | 2018-02-09 |
| 2018-02-27 | 1468.80 | 未披露 |
更多>>
from December 31, 2016 to December 31, 2017
Issuance of common stock for equity awards
|
2017-12-31 |
| 2017-10-27 | 1466.18 | 未披露 | 定期报告 | 2017-10-17 |
| 2017-10-25 | 1466.20 | 未披露 | 定期报告 | 2017-09-30 |
| 2017-07-28 | 1465.84 | 未披露 | 定期报告 | 2017-07-20 |
| 2017-07-26 | 1465.80 | 未披露 | 定期报告 | 2017-06-30 |
| 2017-04-28 | 1465.46 | 未披露 | 定期报告 | 2017-04-17 |
| 2017-05-04 | 1465.50 | 未披露 | 定期报告 | 2017-03-31 |
| 2017-02-24 | 1463.89 | 未披露 | 定期报告 | 2017-02-21 |
| 2017-02-24 | 1462.70 | 未披露 |
更多>>
from December 31, 2015 to December 31, 2016
Issuance of common stock for equity awards
Repurchase of common stock
|
2016-12-31 |
| 2016-10-26 | 1462.32 | 未披露 | 定期报告 | 2016-09-30 |
| 2016-07-27 | 1477.77 | 未披露 | 定期报告 | 2016-06-30 |
| 2016-05-03 | 1433.06 | 未披露 | 定期报告 | 2016-04-28 |
| 2016-04-27 | 1476.83 | 未披露 | 定期报告 | 2016-03-31 |
| 2016-03-10 | 1433.02 | 未披露 | 定期报告 | 2016-03-04 |
| 2016-03-10 | 1503.68 | 未披露 |
更多>>
From December 31, 2014 to December 31, 2015
Issuance of common stock for equity awards
|
2015-12-31 |
| 2015-11-03 | 1463.77 | 未披露 | 定期报告 | 2015-10-29 |
| 2015-10-28 | 1501.15 | 未披露 | 定期报告 | 2015-09-30 |
| 2015-08-04 | 1463.21 | 未披露 | 定期报告 | 2015-07-31 |
| 2015-07-29 | 1500.37 | 未披露 | 定期报告 | 2015-06-30 |
| 2015-05-04 | 1462.67 | 未披露 | 定期报告 | 2015-04-30 |
| 2015-05-04 | 1500.31 | 未披露 | 定期报告 | 2015-03-31 |
| 2015-03-13 | 1454.63 | 未披露 | 定期报告 | 2015-03-09 |
| 2015-03-13 | 1485.17 | 未披露 |
更多>>
from December 31, 2013 to December 31, 2014
Issuance of common stock for employee equity awards
Retirement of common stock for minimum tax withholdings
|
2014-12-31 |
| 2014-11-06 | 1450.40 | 未披露 | 定期报告 | 2014-10-31 |
| 2014-10-29 | 1480.05 | 未披露 | 定期报告 | 2014-09-30 |
| 2014-08-04 | 1448.65 | 未披露 | 定期报告 | 2014-08-01 |
| 2014-07-30 | 1479.81 | 未披露 | 定期报告 | 2014-06-30 |
| 2014-05-05 | 1442.14 | 未披露 | 定期报告 | 2014-05-01 |
| 2014-04-23 | 1460.85 | 未披露 | 定期报告 | 2014-04-07 |
| 2014-04-29 | 1462.00 | 未披露 | 定期报告 | 2014-03-31 |
| 2014-03-13 | 1432.49 | 未披露 | 定期报告 | 2014-03-10 |
| 2014-03-13 | 1428.93 | 未披露 |
更多>>
from December 31, 2012 to December 31, 2013
Issuance of common stock for employee equity awards
|
2013-12-31 |
| 2013-11-05 | 1382.55 | 未披露 | 定期报告 | 2013-10-31 |
| 2013-10-30 | 1426.61 | 未披露 | 定期报告 | 2013-09-30 |
| 2013-08-06 | 1366.21 | 未披露 | 定期报告 | 2013-08-01 |
| 2013-07-31 | 1401.73 | 未披露 | 定期报告 | 2013-06-30 |
| 2013-04-23 | 1399.63 | 未披露 | 定期报告 | 2013-04-19 |
| 2013-05-06 | 1400.61 | 未披露 | 定期报告 | 2013-03-31 |
| 2013-03-14 | 1391.92 | 未披露 | 定期报告 | 2013-03-08 |
| 2013-03-14 | 1386.61 | 未披露 |
更多>>
from December 31, 2011 to December 31, 2012
Issuance of common stock for employee equity awards
|
2012-12-31 |
| 2012-11-08 | 1381.27 | 未披露 | 定期报告 | 2012-11-01 |
| 2012-10-30 | 1380.50 | 未披露 | 定期报告 | 2012-09-30 |
| 2012-08-07 | 1380.26 | 未披露 | 定期报告 | 2012-08-03 |
| 2012-08-02 | 1376.60 | 未披露 | 定期报告 | 2012-06-30 |
| 2012-05-07 | 1376.39 | 未披露 | 定期报告 | 2012-05-03 |
| 2012-05-03 | 1376.32 | 未披露 | 定期报告 | 2012-03-31 |
| 2012-03-13 | 1366.95 | 未披露 | 定期报告 | 2012-03-09 |
| 2012-03-13 | 1363.06 | 未披露 |
更多>>
from December 31, 2010 to December 31, 2011
Issuance of common stock for employee equity awards
|
2011-12-31 |
| 2011-11-04 | 1362.50 | 未披露 | 定期报告 | 2011-11-01 |
| 2011-11-04 | 1362.23 | 未披露 | 定期报告 | 2011-09-30 |
| 2011-08-05 | 1362.15 | 未披露 | 定期报告 | 2011-08-03 |
| 2011-08-04 | 1362.23 | 未披露 | 定期报告 | 2011-06-30 |
| 2011-05-06 | 1349.55 | 未披露 | 定期报告 | 2011-05-04 |
| 2011-05-06 | 1350.58 | 未披露 | 定期报告 | 2011-03-31 |
| 2011-03-16 | 1345.82 | 未披露 | 定期报告 | 2011-03-14 |
| 2011-03-16 | 1348.24 | 未披露 |
更多>>
from December 31, 2009 to December 31, 2010
Issuance of common stock for employee equity awards
|
2010-12-31 |
| 2010-11-09 | 1348.13 | 未披露 | 定期报告 | 2010-11-08 |
| 2010-11-09 | 1348.13 | 未披露 | 定期报告 | 2010-09-30 |
| 2010-08-09 | 1348.13 | 未披露 | 定期报告 | 2010-07-30 |
| 2010-08-09 | 1347.76 | 未披露 | 定期报告 | 2010-06-30 |
| 2010-03-16 | 1344.92 | 未披露 | 定期报告 | 2010-03-01 |
| 2010-03-16 | 1341.88 | 未披露 |
更多>>
from December 31, 2008 to December 31, 2009
Issuance of common stock for employee equity awards
Acquisition of Fidia Advanced Biopolymers S.r.l.
|
2009-12-31 |
| 2009-03-09 | 1137.76 | 未披露 |
更多>>
from December 31, 2007 to December 31, 2008
Issuance of common stock for employee equity awards
|
2008-12-31 |
| 2008-03-12 | 1122.75 | 未披露 | 定期报告 | 2008-03-01 |
| 2008-03-12 | 1122.33 | 未披露 |
更多>>
from December 31, 2006 to December 31, 2007
Issuance of common stock for employee equity awards
|
2007-12-31 |
| 2007-03-13 | 1090.63 | 未披露 | 定期报告 | 2007-03-01 |
| 2007-03-13 | 1077.27 | 未披露 |
更多>>
from December 31, 2005 to December 31, 2006
Exercise of common stock options
|
2006-12-31 |
| 2006-03-09 | 1052.93 | 未披露 | 定期报告 | 2006-03-01 |
| 2006-03-09 | 1050.04 | 未披露 |
更多>>
from December 31, 2004 to December 31, 2005
Exercise of common stock options
|
2005-12-31 |
| 2005-03-16 | 1029.62 | 未披露 | 定期报告 | 2005-03-04 |
| 2005-03-16 | 999.19 | 未披露 |
更多>>
from December 31, 2003 to December 31, 2004
Exercise of common stock options
|
2004-12-31 |
| 2004-03-30 | 999.05 | 未披露 | 定期报告 | 2004-03-18 |
| 2004-03-30 | 998.64 | 未披露 |
更多>>
from December 31, 2002 to December 31, 2003
Exercise of common stock options
|
2003-12-31 |
| 2001-04-02 | 993.43 | 未披露 |
更多>>
from December 31, 1999 to December 31, 2000
Exercise of common stock options
|
2000-12-31 |
| 2000-03-30 | 979.56 | 未披露 | 定期报告 | 2000-03-20 |
| 2000-03-30 | 979.11 | 未披露 |
更多>>
from December 31, 1998 to December 31, 1999
Exercise of common stock options
Purchase of 402,600 shares of common stock
|
1999-12-31 |
| 1999-03-31 | 931.42 | 未披露 | 定期报告 | 1999-03-19 |
| 1999-03-31 | 964.74 | 未披露 |
更多>>
from December 31, 1997 to December 31, 1998
Exercise of common stock options
Exercise of common stock warrants
Purchase of 359,500 shares of common stock
|
1998-12-31 |
| 1999-03-31 | 969.11 | 未披露 |
更多>>
from December 31, 1996 to December 31, 1997
Exercise of common stock options
Sale of common stock, net of issuance costs of $2,043,519
Issuance of common stock to 401(k) plan
Issuance of common stock to Board of Directors
Conversion of redeemable convertible preferred stock
|
1997-12-31 |
From June 30, 2025 to September 30, 2025
Vesting of restricted stock units
Retirement of common stock for minimum tax withholdings
From March 31, 2025 to June 30, 2025
Vesting of restricted stock units
Issuance of ESPP shares
Retirement of common stock for minimum tax withholdings
From January 1, 2025 to March 31, 2025
Vesting of restricted stock units
Retirement of common stock for minimum tax withholdings
Repurchase of common stock
From December 31, 2023 to December 31, 2024
Retirement of common stock for minimum tax withholdings
Issuance of common stock from employee purchase plan
Issuance of common stock for equity awards
Vesting of restricted stock units
Repurchase of common stock
From June 30, 2024 to September 30, 2024
Vesting of restricted stock units
Repurchase of common stock
Retirement of common stock for minimum tax withholdings
From March 31, 2024 to June 30, 2024
Vesting of restricted stock units
Repurchase of common stock
Issuance of ESPP shares
Retirement of common stock for minimum tax withholdings
Issuance of common stock for equity awards
From January 1, 2024 to March 31, 2024
Issuance of common stock for equity awards
Vesting of restricted stock units
Retirement of common stock for minimum tax withholdings
From December 31, 2022 to December 31, 2023
Repurchase of common stock
Vesting of restricted stock units
Issuance of common stock for equity awards
Retirement of common stock for minimum tax withholdings
Issuance of common stock from employee purchase plan
From June 30, 2023 to September 30, 2023
Retirement of common stock for minimum tax withholdings
Vesting of restricted stock units
Repurchase of common stock
From January 1, 2023 to March 31, 2023
Vesting of restricted stock units
Retirement of common stock for minimum tax withholdings
Issuance of common stock for equity awards
From December 31, 2021 to December 31, 2022
Retirement of common stock for minimum tax withholdings
Vesting of restricted stock units
Issuance of common stock from employee purchase plan
From June 30, 2022 to September 30, 2022
Retirement of common stock for minimum tax withholdings
Vesting of restricted stock units
From March 31, 2022 to June 30, 2022
Vesting of restricted stock units
Issuance of ESPP shares
Retirement of common stock for minimum tax withholdings
From January 1, 2022 to March 31, 2022
Issuance of common stock for equity awards
Vesting of restricted stock units
Retirement of common stock for minimum tax withholdings
From December 31, 2020 to December 31, 2021
Issuance of common stock for equity awards
Vesting of restricted stock units
Retirement of common stock for minimum tax withholdings
Vesting of restricted stock units
From June 30, 2021 to September 30, 2021
Issuance of common stock for equity awards
Vesting of restricted stock units
Retirement of common stock for minimum tax withholdings
From March 31, 2021 to June 30, 2021
Issuance of common stock for equity awards
Vesting of restricted stock units
Retirement of common stock for minimum tax withholdings
From January 1, 2021 To March 31, 2021
Vesting of restricted stock units
Retirement of common stock for minimum tax withholdings
From December 31, 2019 to December 31, 2020
Issuance of common stock for equity awards
Vesting of restricted stock units
Forfeiture of restricted stock awards
Retirement of common stock for minimum tax withholdings
Repurchase of common stock
From June 30, 2020 to September 30, 2020
Vesting of restricted stock units
from March 31, 2020 to June 30, 2020
Issuance of common stock for equity awards
Vesting of restricted stock units
Retirement of common stock for minimum tax withholdings
from January 1, 2020 to March 31, 2020
Vesting of restricted stock units
Forfeiture of restricted stock awards
Retirement of common stock for minimum tax withholdings
Repurchase of common stock
from December 31, 2018 to December 31, 2019
Issuance of common stock for equity awards
Vesting of restricted stock units
Forfeiture of restricted stock awards
Retirement of common stock for minimum tax withholdings
Repurchase of common stock
from June 30, 2019 to September 30, 2019
Issuance of common stock for equity awards
Forfeiture of restricted stock
Retirement of common stock for minimum tax withholdings
from March 31, 2019 to June 30,2019
Issuance of common stock for equity awards
Forfeiture of restricted stock
Repurchase of common stock
from January 1, 2019 to March 31, 2019
Issuance of common stock for equity awards
Retirement of common stock for minimum tax withholdings
from December 31, 2017 to December 31, 2018
Issuance of common stock for equity awards
Retirement of common stock for minimum tax withholdings
Repurchase of common stock
from December 31, 2016 to December 31, 2017
Issuance of common stock for equity awards
from December 31, 2015 to December 31, 2016
Issuance of common stock for equity awards
Repurchase of common stock
From December 31, 2014 to December 31, 2015
Issuance of common stock for equity awards
from December 31, 2013 to December 31, 2014
Issuance of common stock for employee equity awards
Retirement of common stock for minimum tax withholdings
from December 31, 2012 to December 31, 2013
Issuance of common stock for employee equity awards
from December 31, 2011 to December 31, 2012
Issuance of common stock for employee equity awards
from December 31, 2010 to December 31, 2011
Issuance of common stock for employee equity awards
from December 31, 2009 to December 31, 2010
Issuance of common stock for employee equity awards
from December 31, 2008 to December 31, 2009
Issuance of common stock for employee equity awards
Acquisition of Fidia Advanced Biopolymers S.r.l.
from December 31, 2007 to December 31, 2008
Issuance of common stock for employee equity awards
from December 31, 2006 to December 31, 2007
Issuance of common stock for employee equity awards
from December 31, 2005 to December 31, 2006
Exercise of common stock options
from December 31, 2004 to December 31, 2005
Exercise of common stock options
from December 31, 2003 to December 31, 2004
Exercise of common stock options
from December 31, 2002 to December 31, 2003
Exercise of common stock options
from December 31, 1999 to December 31, 2000
Exercise of common stock options
from December 31, 1998 to December 31, 1999
Exercise of common stock options
Purchase of 402,600 shares of common stock
from December 31, 1997 to December 31, 1998
Exercise of common stock options
Exercise of common stock warrants
Purchase of 359,500 shares of common stock
from December 31, 1996 to December 31, 1997
Exercise of common stock options
Sale of common stock, net of issuance costs of $2,043,519
Issuance of common stock to 401(k) plan
Issuance of common stock to Board of Directors
Conversion of redeemable convertible preferred stock