股本结构
单位：万股
| 公告日期 | 2025-11-04 | 2025-11-04 | 2025-09-19 | 2025-09-09 | 2025-08-08 | 2025-08-08 |
|---|---|---|---|---|---|---|
| 证券总股本 | 18336.25 | 18332.40 | 18331.44 | 18331.47 | 15329.18 | 15325.30 |
| 普通股本 | 18336.25 | 18332.40 | 18331.44 | 18331.47 | 15329.18 | 15325.30 |
| 优先股 | 未披露 | 52.40 | 未披露 | 52.41 | 未披露 | 未披露 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2025-10-30 | 2025-09-30 | 2025-09-11 | 2025-09-03 | 2025-07-31 | 2025-06-30 |
注释：中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本（万股） | 变动后优先股（万股） | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2025-11-04 | 18336.25 | 未披露 | 定期报告 | 2025-10-30 |
| 2025-11-04 | 18332.40 | 52.40 |
更多>>
From June 30, 2025 to September 30, 2025
Issuance of common stock under equity incentive plan
Issuance of common stock in settlement of 2026 Convertible Notes
Issuance of common stock in a private placement equity offering
|
2025-09-30 |
| 2025-09-19 | 18331.44 | 未披露 | 定期报告 | 2025-09-11 |
| 2025-09-09 | 18331.47 | 52.41 | 定期报告 | 2025-09-03 |
| 2025-08-08 | 15329.18 | 未披露 | 定期报告 | 2025-07-31 |
| 2025-08-08 | 15325.30 | 未披露 |
更多>>
From March 31, 2025 to June 30, 2025
Issuance of common stock under equity incentive plan
Issuance of common stock under the employee stock purchase plan
|
2025-06-30 |
| 2025-05-06 | 15256.36 | 未披露 | 定期报告 | 2025-05-01 |
| 2025-04-30 | 15253.07 | 未披露 | 定期报告 | 2025-04-15 |
| 2025-05-06 | 15242.70 | 未披露 |
更多>>
From December 31,2024 to March 31,2025
Issuance of common stock under equity incentive plan
|
2025-03-31 |
| 2025-02-27 | 15232.96 | 未披露 | 定期报告 | 2025-02-13 |
| 2025-02-27 | 15212.79 | 未披露 |
更多>>
From December 31, 2023 to December 31, 2024
Issuance of common stock under Employee Stock Purchase Plan
Issuance of common stock under equity incentive plan
|
2024-12-31 |
| 2024-11-12 | 15209.49 | 未披露 | 定期报告 | 2024-11-07 |
| 2024-11-12 | 15170.20 | 未披露 |
更多>>
From June 30, 2024 to September 30, 2024
Issuance of common stock under equity incentive plan
|
2024-09-30 |
| 2024-08-06 | 15166.80 | 未披露 | 定期报告 | 2024-08-01 |
| 2024-08-06 | 15157.80 | 未披露 |
更多>>
From March 31, 2024 to June 30, 2024
Issuance of common stock under equity incentive plan
Issuance of common stock under the employee stock purchase plan
|
2024-06-30 |
| 2024-05-07 | 15065.32 | 未披露 | 定期报告 | 2024-05-02 |
| 2024-04-29 | 15063.70 | 未披露 | 定期报告 | 2024-04-26 |
| 2024-05-07 | 15036.27 | 未披露 |
更多>>
From December 31, 2023 to March 31, 2024
Issuance of common stock under equity incentive plan
|
2024-03-31 |
| 2024-03-12 | 15032.86 | 未披露 | 定期报告 | 2024-02-28 |
| 2024-03-12 | 15028.50 | 未披露 |
更多>>
From December 31, 2022 to December 31, 2023
Issuance of common stock under Employee Stock Purchase Plan
Issuance of common stock in a private placement
Issuance of common stock on exercise of pre-funded warrants
Issuance of common stock under equity incentive plan
|
2023-12-31 |
| 2023-11-14 | 15007.26 | 未披露 | 定期报告 | 2023-11-10 |
| 2023-11-14 | 14110.10 | 未披露 |
更多>>
From June 30, 2023 to September 30, 2023
Issuance of common stock under equity incentive plan
Issuance of common stock in private placement
|
2023-09-30 |
| 2023-08-14 | 14075.93 | 未披露 | 定期报告 | 2023-07-25 |
| 2023-05-11 | 11971.46 | 未披露 | 定期报告 | 2023-05-01 |
| 2023-05-01 | 11928.00 | 未披露 | 定期报告 | 2023-04-18 |
| 2023-05-11 | 11928.00 | 未披露 |
更多>>
From December 31, 2022 to March 31, 2023
Issuance of common stock under equity incentive plan
|
2023-03-31 |
| 2023-03-29 | 11925.93 | 未披露 | 定期报告 | 2023-03-14 |
| 2023-03-29 | 11915.50 | 未披露 |
更多>>
From December 31, 2021 to December 31, 2022
Issuance of common stock under equity incentive plan
Issuance of common stock under Employee Stock Purchase Plan
Issuance of common stock in a private placement
|
2022-12-31 |
| 2022-11-08 | 11888.81 | 未披露 | 定期报告 | 2022-11-01 |
| 2022-11-08 | 11877.39 | 未披露 |
更多>>
From June 30, 2022 to September 30, 2022
Issuance of common stock in a private placement, net
Issuance of common stock under equity incentive plan
|
2022-09-30 |
| 2022-08-19 | 12244.51 | 未披露 | 定期报告 | 2022-08-19 |
| 2022-08-09 | 10263.22 | 未披露 | 定期报告 | 2022-08-01 |
| 2022-08-09 | 10249.80 | 未披露 |
更多>>
From March 31, 2022 to June 30, 2022
Issuance of common stock under equity incentive plan
Issuance of common stock on under the employee stock purchase plan
|
2022-06-30 |
| 2022-05-09 | 10247.96 | 未披露 | 定期报告 | 2022-05-03 |
| 2022-04-25 | 10227.84 | 未披露 | 定期报告 | 2022-04-14 |
| 2022-05-09 | 10214.30 | 未披露 |
更多>>
From December 31, 2021 to March 31, 2022
Issuance of common stock under equity incentive plan
|
2022-03-31 |
| 2022-02-28 | 10214.07 | 未披露 | 定期报告 | 2022-02-04 |
| 2022-02-28 | 10200.50 | 未披露 |
更多>>
From December 31, 2020 to December 31, 2021
Issuance of common stock under Employee Stock Purchase Plan
Issuance of common stock under equity incentive plan
Issuance of common stock on exercise of warrants
Issuance of common stock on conversion of Convertible Notes
|
2021-12-31 |
| 2021-11-03 | 10193.54 | 未披露 | 定期报告 | 2021-10-28 |
| 2021-11-03 | 10191.20 | 未披露 |
更多>>
from June 30, 2021 to September 30, 2021
Issuance of common stock under equity incentive plan
|
2021-09-30 |
| 2021-08-09 | 10190.95 | 未披露 | 定期报告 | 2021-07-29 |
| 2021-08-09 | 10187.40 | 未披露 |
更多>>
From March 31, 2021 to June 30, 2021
Issuance of common stock under equity incentive plan
Issuance of common stock on under the employee stock purchase plan
Issuance of common stock on exercise of warrants
Issuance of common stock on conversion of notes
|
2021-06-30 |
| 2021-05-28 | 10182.95 | 未披露 | 定期报告 | 2021-05-27 |
| 2021-05-10 | 10182.91 | 未披露 | 定期报告 | 2021-05-04 |
| 2021-04-22 | 9167.46 | 未披露 | 定期报告 | 2021-04-20 |
| 2021-05-25 | 9140.71 | 未披露 |
更多>>
From December 31, 2020 To March 31, 2021
Issuance of common stock under equity incentive plan
|
2021-03-31 |
| 2021-02-24 | 9139.65 | 未披露 | 定期报告 | 2021-02-05 |
| 2021-02-24 | 9131.00 | 未披露 |
更多>>
From December 31,2019 to December 31,2020
Issuance of common stock under Employee Stock Purchase Plan
Issuance of common stock on exercise of stock options
Issuance of common stock on exercise of warrants
|
2020-12-31 |
| 2020-11-05 | 9085.53 | 未披露 | 定期报告 | 2020-10-29 |
| 2020-11-05 | 9085.50 | 未披露 |
更多>>
From June 30, 2020 to September 30, 2020
Issuance of common stock on exercise of stock
|
2020-09-30 |
| 2020-08-05 | 9085.53 | 未披露 | 定期报告 | 2020-07-29 |
| 2020-08-05 | 9082.00 | 未披露 |
更多>>
From March 31, 2020 to June 30, 2020
Issuance of common stock on exercise of stock options
Issuance of common stock under the employee stock purchase plan
|
2020-06-30 |
| 2020-04-23 | 9064.22 | 未披露 | 定期报告 | 2020-04-20 |
| 2020-05-06 | 9064.20 | 未披露 |
更多>>
from December 31, 2019 to March 31, 2020
Issuance of common stock on exercise of stock options
Issuance of common stock on exercise of warrants
|
2020-03-31 |
| 2020-03-02 | 9037.43 | 未披露 | 定期报告 | 2020-02-03 |
| 2020-03-02 | 9030.40 | 未披露 |
更多>>
from December 31, 2018 to December 31, 2019
Issuance of common stock on exercise of warrants
Issuance of common stock under Employee Stock Purchase Plan
Issuance of common stock on exercise of stock options
Issuance of common stock in public offerings, net
Issuance of common stock on conversion of Convertible Notes
|
2019-12-31 |
| 2019-11-12 | 9005.15 | 未披露 | 定期报告 | 2019-10-30 |
| 2019-11-12 | 8003.00 | 未披露 |
更多>>
from June 30, 2019 to September 30, 2019
Issuance of common stock on exercise of stock options
|
2019-09-30 |
| 2019-08-05 | 7981.64 | 未披露 | 定期报告 | 2019-07-17 |
| 2019-08-05 | 7977.90 | 未披露 |
更多>>
from March 31, 2019 to June 30, 2019
Issuance of common stock on exercise of stock options
Issuance of common stock on under the employee stock purchase plan
|
2019-06-30 |
| 2019-04-26 | 7919.42 | 未披露 | 定期报告 | 2019-04-22 |
| 2019-05-09 | 7906.95 | 未披露 | 定期报告 | 2019-04-18 |
| 2019-05-09 | 7890.60 | 未披露 |
更多>>
from December 31, 2018 to March 31, 2019
Issuance of common stock on exercise of stock options
|
2019-03-31 |
| 2019-02-22 | 7818.17 | 未披露 | 定期报告 | 2019-02-01 |
| 2019-02-22 | 7817.40 | 未披露 |
更多>>
from December 31, 2017 to December 31, 2018
Issuance of common stock in public offerings, net
Issuance of common stock under Employee Stock Purchase Plan
Issuance of common stock on exercise of stock options
|
2018-12-31 |
| 2018-11-07 | 7801.90 | 未披露 | 定期报告 | 2018-10-26 |
| 2018-08-08 | 7773.43 | 未披露 | 定期报告 | 2018-07-24 |
| 2018-04-30 | 7195.10 | 未披露 | 定期报告 | 2018-04-23 |
| 2018-02-27 | 6464.84 | 未披露 | 定期报告 | 2018-02-01 |
| 2018-02-27 | 6460.90 | 未披露 |
更多>>
from December 31, 2016 to December 31, 2017
Issuance of common stock in public offerings, net
Issuance of common stock under Employee Stock Purchase Plan
Issuance of common stock on exercise of stock options
Issuance of common stock on exercise of warrants
|
2017-12-31 |
| 2017-11-06 | 5450.46 | 未披露 | 定期报告 | 2017-10-25 |
| 2017-08-09 | 5413.87 | 未披露 | 定期报告 | 2017-07-26 |
| 2017-04-26 | 5369.69 | 未披露 | 定期报告 | 2017-04-17 |
| 2017-02-23 | 5357.45 | 未披露 | 定期报告 | 2017-02-03 |
| 2017-02-23 | 3935.50 | 未披露 |
更多>>
From December 31, 2015 to December 31, 2016
Issuance of common stock under Employee Stock Purchase Plan
Issuance of common stock upon exercise of stock options
Issuance of common stock upon exercise of warrants
|
2016-12-31 |
| 2016-11-08 | 3918.76 | 未披露 | 定期报告 | 2016-10-27 |
| 2016-08-08 | 3905.06 | 未披露 | 定期报告 | 2016-07-29 |
| 2016-05-05 | 3665.81 | 未披露 | 定期报告 | 2016-04-26 |
| 2016-04-29 | 3665.36 | 未披露 | 定期报告 | 2016-04-25 |
| 2016-07-29 | 3634.87 | 未披露 | 定期报告 | 2016-03-31 |
| 2016-02-19 | 3623.17 | 未披露 | 定期报告 | 2016-02-04 |
| 2016-02-19 | 3610.60 | 未披露 |
更多>>
From December 31, 2014 to December 31, 2015
Issuance of common stock in a public offering, net
Issuance of common stock under Employee Stock Purchase Plan
Issuance of common stock upon exercise of stock options
Issuance of common stock upon exercise of warrants
|
2015-12-31 |
| 2015-11-06 | 3597.10 | 未披露 | 定期报告 | 2015-10-26 |
| 2015-08-07 | 3568.57 | 未披露 | 定期报告 | 2015-06-30 |
| 2015-05-08 | 2963.25 | 未披露 | 定期报告 | 2015-04-28 |
| 2015-04-28 | 2963.05 | 未披露 | 定期报告 | 2015-04-15 |
| 2015-03-13 | 2953.12 | 未披露 | 定期报告 | 2015-03-02 |
| 2015-03-13 | 2922.70 | 未披露 |
更多>>
from December 31, 2013 to December 31, 2014
Issuance of common stock and pre-funded warrants in a public offering, net
Issuance of common stock under Employee Stock Purchase Plan
Issuance of common stock upon exercise of stock options
Issuance of common stock upon exercise of warrants
Effective January 13, 2014, we effected a 1-for-20 reverse split of our outstanding common stock
|
2014-12-31 |
| 2014-11-06 | 2918.01 | 未披露 | 定期报告 | 2014-10-29 |
| 2014-09-19 | 2891.07 | 未披露 | 定期报告 | 2014-07-29 |
| 2014-05-12 | 2390.15 | 未披露 | 定期报告 | 2014-04-28 |
| 2014-04-24 | 2389.71 | 未披露 | 定期报告 | 2014-04-07 |
| 2014-03-07 | 2372.40 | 未披露 | 定期报告 | 2014-02-28 |
| 2014-06-27 | 2839.60 | 未披露 | 定期报告 | 2014-01-23 |
| 2014-03-07 | 2357.20 | 未披露 |
更多>>
from DECEMBER 31, 2012 to January 14, 2014
Common stock issued in private placement, net of issuance costs
Common stock issued to employees under ESPP
Common stock issued for stock option exercises
Warrant exercise
Effective January 13, 2014, we effected a 1-for-20 reverse split of our outstanding common stock
|
2014-01-14 |
| 2013-11-12 | 31361.64 | 未披露 | 定期报告 | 2013-10-31 |
| 2011-05-16 | 3996.83 | 未披露 | 定期报告 | 2011-04-29 |
| 2011-03-28 | 4006.42 | 未披露 | 定期报告 | 2011-02-28 |
| 2011-03-28 | 4014.32 | 未披露 |
更多>>
from DECEMBER 31, 2009 to DECEMBER 31, 2010
Fair value of stock-based compensation issued to directors for restricted stock awards
Common stock issued upon exercise of stock options
Common stock issued to employees under ESPP
|
2010-12-31 |
| 2010-11-15 | 4011.30 | 未披露 | 定期报告 | 2010-10-31 |
| 2010-08-16 | 4011.42 | 未披露 | 定期报告 | 2010-07-31 |
| 2010-05-17 | 3951.33 | 未披露 | 定期报告 | 2010-04-30 |
| 2010-03-15 | 3942.60 | 未披露 | 定期报告 | 2010-02-28 |
| 2010-03-15 | 3993.52 | 未披露 |
更多>>
from DECEMBER 31, 2008 to DECEMBER 31, 2009
Common stock and warrants issued in private placement, net of issuance costs
Fair value of stock-based compensation issued to directors for restricted stock awards
Common stock issued upon exercise of stock options
Common stock issued to employees under the ESPP
Stock issued in lieu of bonus
|
2009-12-31 |
| 2009-03-31 | 3094.11 | 未披露 |
更多>>
from DECEMBER 31, 2007 to DECEMBER 31, 2008
Common stock issued upon exercise of stock options
Fair value of stock-based compensation issued to directors for restricted stock awards
Common stock issued to employees under the ESPP
|
2008-12-31 |
| 2008-03-31 | 3080.97 | 未披露 | 定期报告 | 2008-02-29 |
| 2008-03-31 | 3079.15 | 未披露 |
更多>>
from DECEMBER 31, 2006 to DECEMBER 31, 2007
Common stock issued in public offering, net of issuance costs
Fair value of stock based compensation issued to directors for restricted stock awards
Common stock issued to employees under the Employee Stock Purchase Plan
|
2007-12-31 |
| 2007-03-30 | 2543.87 | 未披露 | 定期报告 | 2007-02-28 |
| 2007-03-30 | 2543.87 | 未披露 |
更多>>
from DECEMBER 31, 2005 to DECEMBER 31, 2006
Common stock issued upon exercise of stock options
Fair value of stock based compensation issued to directors for services and to employees for restricted stock Awards
Common stock issued to employees under the Employee Stock Purchase Plan
|
2006-12-31 |
| 2006-03-31 | 2528.00 | 未披露 |
更多>>
from DECEMBER 31, 2004 to DECEMBER 31, 2005
Common stock issued upon exercise of stock options
Fair value of stock based compensation issued to directors for services and to employees for restricted stock awards
Common stock issued to employees under the Employee Stock Purchase Plan
|
2005-12-31 |
| 2005-03-15 | 2504.04 | 未披露 | 定期报告 | 2005-02-28 |
| 2005-03-15 | 2503.39 | 未披露 |
更多>>
from DECEMBER 31, 2003 to DECEMBER 31, 2004
Common stock issuance, net of issuance costs
Common stock issued upon exercise of stock options
Fair value of common stock issued to directors for services
Common stock issued to employees under the Employee Stock Purchase Plan
|
2004-12-31 |
| 2004-03-26 | 2064.19 | 未披露 |
更多>>
from DECEMBER 31, 2002 to DECEMBER 31, 2003
Common stock issued upon exercise of stock options
Fair value of common stock issued to directors for services
Common stock issued to employees under the Employee Stock Purchase Plan
|
2003-12-31 |
| 2003-03-28 | 2049.04 | 未披露 | 定期报告 | 2003-02-28 |
| 2003-03-28 | 2046.74 | 未披露 |
更多>>
from DECEMBER 31, 2001 to DECEMBER 31, 2002
Fair value of common stock issued to non-employees for services and restricted stock awards
Common stock issued to employees under the Employee Stock Purchase Plan
|
2002-12-31 |
| 2002-03-28 | 2036.57 | 未披露 | 定期报告 | 2002-02-28 |
| 2002-03-28 | 2035.71 | 未披露 |
更多>>
from DECEMBER 31, 2000 to DECEMBER 31, 2001
Restricted stock awards
Fair value of common stock issued to non-employees for services
Common stock issued to employees under the Employee Stock Purchase Plan
|
2001-12-31 |
| 2001-03-26 | 2020.61 | 未披露 | 定期报告 | 2001-02-28 |
| 2001-03-26 | 2020.61 | 未披露 |
更多>>
from DECEMBER 31, 1999 to DECEMBER 31, 2000
Fair value of stock issued to non-employees
Common stock issued to employees under the Employee Stock Purchase Plan
Warrants exercised
|
2000-12-31 |
| 2000-04-28 | 2016.29 | 未披露 | 定期报告 | 2000-04-20 |
| 2000-03-28 | 2011.90 | 未披露 |
更多>>
from DECEMBER 31, 1998 to DECEMBER 31, 1999
Options exercised
Fair value of stock issued to non-employees
Common stock issued to employees under the Employee Stock Purchase Plan
Warrants exercised
|
1999-12-31 |
| 1999-03-30 | 1999.33 | 未披露 |
更多>>
from DECEMBER 31, 1997 to DECEMBER 31, 1998
Options exercised
Restricted stock awards
Common stock issued to employees under the Employee Stock Purchase Plan
Warrants exercised
|
1998-12-31 |
| 1998-03-30 | 1946.50 | 未披露 | 定期报告 | 1998-02-28 |
| 1998-03-30 | 1946.48 | 未披露 |
更多>>
from DECEMBER 31, 1996 to DECEMBER 31, 1997
Options exercised
Common stock issued to employees under the Employee Stock Purchase Plan
Warrants exercised
|
1997-12-31 |
| 1997-03-28 | 1841.26 | 未披露 | 定期报告 | 1997-02-28 |
| 1997-03-28 | 1835.97 | 未披露 |
更多>>
from DECEMBER 31, 1995 to DECEMBER 31, 1996
Options exercised
Shares retired
Private Placement,net of $62,149 in offering costs
Common stock to be issued in connection with the agreement with Johnson & Johnson
Common stock issued in connection with the agreement with Johnson & Johnson
Common stock issued in connection with the agreement with Lander Company, net of $39,547 in offering costs
Common stock issued to Dow Corning, net of $4,000 in offering costs
Common stock issued to Biosource
Securities issued in debt financing arrangements
Warrants exercised
|
1996-12-31 |
| 1996-03-27 | 1713.93 | 未披露 | 定期报告 | 1996-02-29 |
| 1996-03-27 | 1702.67 | 未披露 |
更多>>
from DECEMBER 31, 1994 to DECEMBER 31, 1995
Options exercised
Private placement, net of $112,383 in offering costs
Securities issued in debt financing arrangements
Common Stock to be issued in connection with the agreement with Johnson & Johnson
|
1995-12-31 |
From June 30, 2025 to September 30, 2025
Issuance of common stock under equity incentive plan
Issuance of common stock in settlement of 2026 Convertible Notes
Issuance of common stock in a private placement equity offering
From March 31, 2025 to June 30, 2025
Issuance of common stock under equity incentive plan
Issuance of common stock under the employee stock purchase plan
From December 31,2024 to March 31,2025
Issuance of common stock under equity incentive plan
From December 31, 2023 to December 31, 2024
Issuance of common stock under Employee Stock Purchase Plan
Issuance of common stock under equity incentive plan
From June 30, 2024 to September 30, 2024
Issuance of common stock under equity incentive plan
From March 31, 2024 to June 30, 2024
Issuance of common stock under equity incentive plan
Issuance of common stock under the employee stock purchase plan
From December 31, 2023 to March 31, 2024
Issuance of common stock under equity incentive plan
From December 31, 2022 to December 31, 2023
Issuance of common stock under Employee Stock Purchase Plan
Issuance of common stock in a private placement
Issuance of common stock on exercise of pre-funded warrants
Issuance of common stock under equity incentive plan
From June 30, 2023 to September 30, 2023
Issuance of common stock under equity incentive plan
Issuance of common stock in private placement
From December 31, 2022 to March 31, 2023
Issuance of common stock under equity incentive plan
From December 31, 2021 to December 31, 2022
Issuance of common stock under equity incentive plan
Issuance of common stock under Employee Stock Purchase Plan
Issuance of common stock in a private placement
From June 30, 2022 to September 30, 2022
Issuance of common stock in a private placement, net
Issuance of common stock under equity incentive plan
From March 31, 2022 to June 30, 2022
Issuance of common stock under equity incentive plan
Issuance of common stock on under the employee stock purchase plan
From December 31, 2021 to March 31, 2022
Issuance of common stock under equity incentive plan
From December 31, 2020 to December 31, 2021
Issuance of common stock under Employee Stock Purchase Plan
Issuance of common stock under equity incentive plan
Issuance of common stock on exercise of warrants
Issuance of common stock on conversion of Convertible Notes
from June 30, 2021 to September 30, 2021
Issuance of common stock under equity incentive plan
From March 31, 2021 to June 30, 2021
Issuance of common stock under equity incentive plan
Issuance of common stock on under the employee stock purchase plan
Issuance of common stock on exercise of warrants
Issuance of common stock on conversion of notes
From December 31, 2020 To March 31, 2021
Issuance of common stock under equity incentive plan
From December 31,2019 to December 31,2020
Issuance of common stock under Employee Stock Purchase Plan
Issuance of common stock on exercise of stock options
Issuance of common stock on exercise of warrants
From June 30, 2020 to September 30, 2020
Issuance of common stock on exercise of stock
From March 31, 2020 to June 30, 2020
Issuance of common stock on exercise of stock options
Issuance of common stock under the employee stock purchase plan
from December 31, 2019 to March 31, 2020
Issuance of common stock on exercise of stock options
Issuance of common stock on exercise of warrants
from December 31, 2018 to December 31, 2019
Issuance of common stock on exercise of warrants
Issuance of common stock under Employee Stock Purchase Plan
Issuance of common stock on exercise of stock options
Issuance of common stock in public offerings, net
Issuance of common stock on conversion of Convertible Notes
from June 30, 2019 to September 30, 2019
Issuance of common stock on exercise of stock options
from March 31, 2019 to June 30, 2019
Issuance of common stock on exercise of stock options
Issuance of common stock on under the employee stock purchase plan
from December 31, 2018 to March 31, 2019
Issuance of common stock on exercise of stock options
from December 31, 2017 to December 31, 2018
Issuance of common stock in public offerings, net
Issuance of common stock under Employee Stock Purchase Plan
Issuance of common stock on exercise of stock options
from December 31, 2016 to December 31, 2017
Issuance of common stock in public offerings, net
Issuance of common stock under Employee Stock Purchase Plan
Issuance of common stock on exercise of stock options
Issuance of common stock on exercise of warrants
From December 31, 2015 to December 31, 2016
Issuance of common stock under Employee Stock Purchase Plan
Issuance of common stock upon exercise of stock options
Issuance of common stock upon exercise of warrants
From December 31, 2014 to December 31, 2015
Issuance of common stock in a public offering, net
Issuance of common stock under Employee Stock Purchase Plan
Issuance of common stock upon exercise of stock options
Issuance of common stock upon exercise of warrants
from December 31, 2013 to December 31, 2014
Issuance of common stock and pre-funded warrants in a public offering, net
Issuance of common stock under Employee Stock Purchase Plan
Issuance of common stock upon exercise of stock options
Issuance of common stock upon exercise of warrants
Effective January 13, 2014, we effected a 1-for-20 reverse split of our outstanding common stock
from DECEMBER 31, 2012 to January 14, 2014
Common stock issued in private placement, net of issuance costs
Common stock issued to employees under ESPP
Common stock issued for stock option exercises
Warrant exercise
Effective January 13, 2014, we effected a 1-for-20 reverse split of our outstanding common stock
from DECEMBER 31, 2009 to DECEMBER 31, 2010
Fair value of stock-based compensation issued to directors for restricted stock awards
Common stock issued upon exercise of stock options
Common stock issued to employees under ESPP
from DECEMBER 31, 2008 to DECEMBER 31, 2009
Common stock and warrants issued in private placement, net of issuance costs
Fair value of stock-based compensation issued to directors for restricted stock awards
Common stock issued upon exercise of stock options
Common stock issued to employees under the ESPP
Stock issued in lieu of bonus
from DECEMBER 31, 2007 to DECEMBER 31, 2008
Common stock issued upon exercise of stock options
Fair value of stock-based compensation issued to directors for restricted stock awards
Common stock issued to employees under the ESPP
from DECEMBER 31, 2006 to DECEMBER 31, 2007
Common stock issued in public offering, net of issuance costs
Fair value of stock based compensation issued to directors for restricted stock awards
Common stock issued to employees under the Employee Stock Purchase Plan
from DECEMBER 31, 2005 to DECEMBER 31, 2006
Common stock issued upon exercise of stock options
Fair value of stock based compensation issued to directors for services and to employees for restricted stock Awards
Common stock issued to employees under the Employee Stock Purchase Plan
from DECEMBER 31, 2004 to DECEMBER 31, 2005
Common stock issued upon exercise of stock options
Fair value of stock based compensation issued to directors for services and to employees for restricted stock awards
Common stock issued to employees under the Employee Stock Purchase Plan
from DECEMBER 31, 2003 to DECEMBER 31, 2004
Common stock issuance, net of issuance costs
Common stock issued upon exercise of stock options
Fair value of common stock issued to directors for services
Common stock issued to employees under the Employee Stock Purchase Plan
from DECEMBER 31, 2002 to DECEMBER 31, 2003
Common stock issued upon exercise of stock options
Fair value of common stock issued to directors for services
Common stock issued to employees under the Employee Stock Purchase Plan
from DECEMBER 31, 2001 to DECEMBER 31, 2002
Fair value of common stock issued to non-employees for services and restricted stock awards
Common stock issued to employees under the Employee Stock Purchase Plan
from DECEMBER 31, 2000 to DECEMBER 31, 2001
Restricted stock awards
Fair value of common stock issued to non-employees for services
Common stock issued to employees under the Employee Stock Purchase Plan
from DECEMBER 31, 1999 to DECEMBER 31, 2000
Fair value of stock issued to non-employees
Common stock issued to employees under the Employee Stock Purchase Plan
Warrants exercised
from DECEMBER 31, 1998 to DECEMBER 31, 1999
Options exercised
Fair value of stock issued to non-employees
Common stock issued to employees under the Employee Stock Purchase Plan
Warrants exercised
from DECEMBER 31, 1997 to DECEMBER 31, 1998
Options exercised
Restricted stock awards
Common stock issued to employees under the Employee Stock Purchase Plan
Warrants exercised
from DECEMBER 31, 1996 to DECEMBER 31, 1997
Options exercised
Common stock issued to employees under the Employee Stock Purchase Plan
Warrants exercised
from DECEMBER 31, 1995 to DECEMBER 31, 1996
Options exercised
Shares retired
Private Placement,net of $62,149 in offering costs
Common stock to be issued in connection with the agreement with Johnson & Johnson
Common stock issued in connection with the agreement with Johnson & Johnson
Common stock issued in connection with the agreement with Lander Company, net of $39,547 in offering costs
Common stock issued to Dow Corning, net of $4,000 in offering costs
Common stock issued to Biosource
Securities issued in debt financing arrangements
Warrants exercised
from DECEMBER 31, 1994 to DECEMBER 31, 1995
Options exercised
Private placement, net of $112,383 in offering costs
Securities issued in debt financing arrangements
Common Stock to be issued in connection with the agreement with Johnson & Johnson