股本结构
单位：万股
| 公告日期 | 2025-12-30 | 2025-11-12 | 2025-11-12 | 2025-08-11 | 2025-08-11 | 2025-05-12 |
|---|---|---|---|---|---|---|
| 证券总股本 | 2841.43 | 2841.25 | 2723.50 | 2715.45 | 2714.80 | 2712.10 |
| 普通股本 | 2841.43 | 2841.25 | 2723.50 | 2715.45 | 2714.80 | 2712.10 |
| 优先股 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2025-12-24 | 2025-11-05 | 2025-09-30 | 2025-08-08 | 2025-06-30 | 2025-03-31 |
注释：中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本（万股） | 变动后优先股（万股） | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2025-12-30 | 2841.43 | 未披露 | 定期报告 | 2025-12-24 |
| 2025-11-12 | 2841.25 | 未披露 | 定期报告 | 2025-11-05 |
| 2025-11-12 | 2723.50 | 未披露 |
更多>>
From June 30, 2025 to September 30, 2025
Issuance of common stock under equity plans
Issuance of common stock upon exercise of stock options
|
2025-09-30 |
| 2025-08-11 | 2715.45 | 未披露 | 定期报告 | 2025-08-08 |
| 2025-08-11 | 2714.80 | 未披露 |
更多>>
From March 31, 2025 to June 30, 2025
Issuance of common stock upon exercise of stock options
|
2025-06-30 |
| 2025-04-25 | 2712.06 | 未披露 | 定期报告 | 2025-04-14 |
| 2025-05-12 | 2712.10 | 未披露 |
更多>>
From December 31, 2024 to March 31, 2025
Issuance of common stock upon exercise of stock options
|
2025-03-31 |
| 2025-03-06 | 2711.98 | 未披露 | 定期报告 | 2025-03-04 |
| 2025-03-06 | 2709.60 | 未披露 |
更多>>
From December 31, 2023 to December 31, 2024
Issuance of common stock under equity plans
Issuance of common stock upon exercise of stock options
|
2024-12-31 |
| 2024-11-07 | 2708.74 | 未披露 | 定期报告 | 2024-11-05 |
| 2024-11-07 | 2708.40 | 未披露 |
更多>>
From June 30, 2024 to September 30, 2024
Issuance of common stock under equity plans
Issuance of common stock upon exercise of stock options
|
2024-09-30 |
| 2024-08-05 | 2704.22 | 未披露 | 定期报告 | 2024-08-02 |
| 2024-08-05 | 2704.20 | 未披露 |
更多>>
From March 31, 2024 to June 30, 2024
Issuance of common stock upon exercise of stock options
|
2024-06-30 |
| 2024-05-08 | 2693.18 | 未披露 | 定期报告 | 2024-05-03 |
| 2024-04-29 | 2692.80 | 未披露 | 定期报告 | 2024-04-22 |
| 2024-04-29 | 2692.07 | 未披露 | 定期报告 | 2024-04-15 |
| 2024-05-08 | 2691.70 | 未披露 |
更多>>
From December 31, 2023 to March 31, 2024
Issuance of common stock upon exercise of stock options
|
2024-03-31 |
| 2024-03-14 | 2691.52 | 未披露 | 定期报告 | 2024-03-04 |
| 2024-03-14 | 2682.80 | 未披露 |
更多>>
From December 31, 2022 to December 31, 2023
Issuance of common stock under equity plans
Issuance of common stock upon exercise of stock options
|
2023-12-31 |
| 2023-11-14 | 2672.33 | 未披露 | 定期报告 | 2023-11-10 |
| 2023-11-14 | 2672.30 | 未披露 |
更多>>
From June 30, 2023 to September 30, 2023
Issuance of common stock under equity plans
Issuance of common stock upon exercise of stock options
|
2023-09-30 |
| 2023-08-07 | 2659.85 | 未披露 | 定期报告 | 2023-08-02 |
| 2023-08-07 | 2657.40 | 未披露 |
更多>>
From March 31, 2023 to June 30, 2023
Issuance of common stock upon exercise of stock options
|
2023-06-30 |
| 2023-05-01 | 2656.30 | 未披露 | 定期报告 | 2023-04-28 |
| 2023-05-09 | 2655.50 | 未披露 | 定期报告 | 2023-03-31 |
| 2023-03-29 | 2655.55 | 未披露 | 定期报告 | 2023-03-21 |
| 2023-03-29 | 2655.50 | 未披露 |
更多>>
From December 31, 2021 to December 31, 2022
Issuance of common stock under equity plans
Issuance of common stock upon exercise of stock options
|
2022-12-31 |
| 2022-12-23 | 2655.55 | 未披露 | 定期报告 | 2022-12-23 |
| 2022-12-23 | 2655.55 | 未披露 | 定期报告 | 2022-12-19 |
| 2022-11-09 | 2649.29 | 未披露 | 定期报告 | 2022-11-02 |
| 2022-11-09 | 2649.20 | 未披露 |
更多>>
From June 30, 2022 to September 30, 2022
Issuance of common stock under equity plans
Issuance of common stock upon exercise of stock options
|
2022-09-30 |
| 2022-08-09 | 2657.64 | 未披露 | 定期报告 | 2022-08-05 |
| 2022-08-09 | 2643.40 | 未披露 |
更多>>
From March 31, 2022 to June 30, 2022
Issuance of common stock upon exercise of stock options
|
2022-06-30 |
| 2022-05-02 | 2641.90 | 未披露 | 定期报告 | 2022-04-15 |
| 2022-05-09 | 2640.70 | 未披露 |
更多>>
From December 31, 2021 to March 31, 2022
Issuance of common stock upon exercise of stock options
|
2022-03-31 |
| 2022-03-01 | 2637.50 | 未披露 | 定期报告 | 2022-02-23 |
| 2022-03-01 | 2637.20 | 未披露 |
更多>>
From December 31, 2020 to December 31, 2021
Issuance of common stock related to acquired in-process research and development
Issuance of common stock upon exercise of stock options
Issuance of common stock under equity plans
|
2021-12-31 |
| 2021-11-09 | 2636.05 | 未披露 | 定期报告 | 2021-11-03 |
| 2021-11-09 | 2634.90 | 未披露 |
更多>>
From June 30, 2021 to September 30, 2021
Issuance of common stock under equity plans
Issuance of common stock upon exercise of stock options
|
2021-09-30 |
| 2021-08-10 | 2632.71 | 未披露 | 定期报告 | 2021-08-05 |
| 2021-08-10 | 2632.70 | 未披露 |
更多>>
From March 31, 2021 to June 30, 2021
Issuance of common stock upon exercise of stock options
|
2021-06-30 |
| 2021-04-30 | 2632.03 | 未披露 | 定期报告 | 2021-04-22 |
| 2021-04-30 | 2631.90 | 未披露 | 定期报告 | 2021-04-01 |
| 2021-05-10 | 2631.90 | 未披露 |
更多>>
From December 31, 2020 To March 31, 2021
Issuance of common stock related to acquired in-process research and development
Issuance of common stock upon exercise of stock options
|
2021-03-31 |
| 2021-03-01 | 2628.03 | 未披露 | 定期报告 | 2021-02-24 |
| 2021-03-01 | 2619.20 | 未披露 |
更多>>
From December 31, 2019 to December 31, 2020
Issuance of common stock to Ultragenyx on option exercise
Issuance of common stock, net of issuance costs
Issuance of common stock upon exercise of stock options
|
2020-12-31 |
| 2020-11-09 | 2449.31 | 未披露 | 定期报告 | 2020-11-02 |
| 2020-12-07 | 2447.30 | 未披露 |
更多>>
From June 30, 2020 to September 18, 2020
Issuance of common stock, net of issuance costs
Issuance of common stock upon exercise of stock options
|
2020-09-18 |
| 2020-08-10 | 2438.82 | 未披露 | 定期报告 | 2020-08-05 |
| 2020-07-31 | 2387.42 | 未披露 |
更多>>
1.Common stock offered by the company 3,264,151 shares of common stock.
2.The number of shares of common stock to be outstanding immediately following this offering as shown above is based on 20,610,056 shares of common stock outstanding on June 30, 2020.
|
2020-07-31 |
| 2020-08-10 | 2061.00 | 未披露 |
更多>>
From March 31, 2020 to June 30, 2020
Issuance of common stock, net of issuance costs
Issuance of common stock to Ultragenyx on option exercise
Issuance of common stock upon exercise of stock options
|
2020-06-30 |
| 2020-05-22 | 2049.23 | 未披露 | 定期报告 | 2020-05-22 |
| 2020-05-08 | 1989.23 | 未披露 | 定期报告 | 2020-05-08 |
| 2020-05-08 | 1989.23 | 未披露 | 定期报告 | 2020-05-06 |
| 2020-04-20 | 1925.56 | 未披露 |
更多>>
1.Common stock offered by us: 4,117,650 shares
2.The number of shares our common stock to be outstanding after the offering is based on 15,137,964 shares of our common stock outstanding as of December 31, 2019
|
2020-04-20 |
| 2020-05-08 | 1515.70 | 未披露 |
更多>>
From December 31, 2019 to March 31, 2020
Issuance of common stock upon exercise of stock options
|
2020-03-31 |
| 2020-03-16 | 1513.80 | 未披露 | 定期报告 | 2020-03-01 |
| 2020-03-16 | 1513.80 | 未披露 |
更多>>
from December 31, 2018 to December 31, 2019
Redomiciliation share exchange
Issuance of restricted common stock and option, net of issuance costs
Issuance of common stock, net of issuance costs
Issuance of common stock upon exercise of stock options
|
2019-12-31 |
| 2019-12-12 | 1513.80 | 未披露 | 定期报告 | 2019-12-11 |
| 2019-11-08 | 1512.53 | 未披露 |
更多>>
from June 30, 2019 to September 30, 2019
Issuance of common stock upon exercise of stock options
|
2019-09-30 |
| 2019-10-01 | 1427.53 | 未披露 | 定期报告 | 2019-09-18 |
| 2019-08-05 | 1427.44 | 未披露 | 定期报告 | 2019-08-05 |
| 2019-08-02 | 1312.87 | 未披露 | 定期报告 | 2019-08-01 |
| 2019-08-14 | 1312.00 | 未披露 |
更多>>
from December 31, 2018 to June 30, 2019
Treasury stock
Issuance of common stock upon exercise of stock options
Issuance of restricted common stock and option, net of issuance costs
|
2019-06-30 |
| 2019-06-21 | 1311.88 | 未披露 | 定期报告 | 2019-06-21 |
| 2019-04-11 | 1076.15 | 未披露 | 定期报告 | 2019-04-08 |
| 2019-05-13 | 1071.90 | 未披露 | 定期报告 | 2019-03-31 |
| 2019-03-18 | 1076.15 | 未披露 | 定期报告 | 2019-03-01 |
| 2019-03-18 | 1071.90 | 未披露 |
更多>>
from December 31, 2017 to December 31, 2018
Issuance of common shares upon exercise of share options
|
2018-12-31 |
| 2018-11-07 | 1071.80 | 未披露 |
更多>>
From December 31, 2017 to September 30, 2018
Shares issued in conjunction with share option exercise
|
2018-09-30 |
| 2018-07-27 | 1074.39 | 未披露 | 定期报告 | 2018-07-20 |
| 2018-09-28 | 1074.00 | 未披露 |
更多>>
From December 31, 2017 to June 30, 2018
Shares issued in conjunction with share option exercise
|
2018-06-30 |
| 2018-06-15 | 1073.82 | 未披露 | 定期报告 | 2018-06-06 |
| 2018-05-14 | 1032.44 | 未披露 | 定期报告 | 2018-03-01 |
| 2018-02-05 | 1069.19 | 未披露 | 定期报告 | 2018-01-31 |
| 2018-05-14 | 1065.60 | 未披露 |
更多>>
from December 31, 2016 to December 31, 2017
Conversion of Preferred Shares to Ordinary Shares
Shares issued in conjunction with share option exercise
Issuance of shares upon exercise of warrants
Issuance of shares upon conversion of notes
Issuance of shares in connection with merger, net
|
2017-12-31 |
| 2017-11-16 | 1056.89 | 未披露 |
更多>>
The Company announced today that its Board of Directors (the "Board") has determined to effect a reverse stock split at a ratio of one-for-seven as of the opening of trading on or around November 16, 2017.Immediately after the Merger, there were approximately 10,568,901 Ordinary Shares.The Ordinary Shares have a new CUSIP number, M1492T 105.
|
2017-11-16 |
| 2017-04-28 | 2756.28 | 未披露 |
更多>>
from December 31, 2015 to December 31, 2016
Issuance of shares upon exercise of options
|
2016-12-31 |
| 2016-03-04 | 2756.09 | 未披露 |
更多>>
from December 31, 2014 to December 31, 2015
Issuance of shares upon exercise of options
Issuance of shares upon public offering ($4.00 per share), net of $203 issuance expenses
Issuance of shares upon public offering ($6.50 per share), net of $421 issuance expenses
|
2015-12-31 |
| 2015-11-12 | 2118.17 | 未披露 |
更多>>
from December 31, 2014 to June 30, 2015
Exercise of options
Issuance of shares upon public offering ($4 per share), net of $203 issuance expenses
|
2015-06-30 |
| 2015-02-27 | 1370.27 | 未披露 |
更多>>
from December 31, 2013 to December 31, 2014
Issuance of shares upon exercise of options
Issuance of shares upon cashless exercise of warrants
|
2014-12-31 |
| 2015-01-08 | 1369.54 | 未披露 |
更多>>
from December 31, 2013 to June 30, 2014
Issuance of shares upon cashless exercise of warrants
|
2014-06-30 |
| 2014-03-28 | 1363.67 | 未披露 |
更多>>
From December 31,2012 to December 31,2013
Exercise of options
Issuance of shares upon cashless exercise of warrants
Issuance of shares upon conversion of convertible notes
Issuance of shares upon initial public offering ($8 per share), net of $3,080 issuance expenses
Issuance of shares upon secondary public offering ($16.5 per share), net of $2,616 issuance expenses
|
2013-12-31 |
| 2013-10-15 | 1112.80 | 未披露 | 定期报告 | 2013-10-01 |
| 2013-05-22 | 1112.69 | 未披露 | 定期报告 | 2013-05-22 |
| 2013-04-05 | 779.43 | 未披露 |
更多>>
from December 31, 2011 to April 2, 2013
Treasury shares
Exercise of options
The number of our ordinary shares to be outstanding immediately after this offering is based on 7,794,256 ordinary shares outstanding as of April 1, 2013 (giving prospective effect to the issuance of bonus shares equivalent to a 5.87-for-1 stock split).
|
2013-04-02 |
| 2013-01-14 | 132.78 | 未披露 |
更多>>
from December 31, 2011 to December 31, 2012
Treasury shares
Exercise of options
|
2012-12-31 |
From June 30, 2025 to September 30, 2025
Issuance of common stock under equity plans
Issuance of common stock upon exercise of stock options
From March 31, 2025 to June 30, 2025
Issuance of common stock upon exercise of stock options
From December 31, 2024 to March 31, 2025
Issuance of common stock upon exercise of stock options
From December 31, 2023 to December 31, 2024
Issuance of common stock under equity plans
Issuance of common stock upon exercise of stock options
From June 30, 2024 to September 30, 2024
Issuance of common stock under equity plans
Issuance of common stock upon exercise of stock options
From March 31, 2024 to June 30, 2024
Issuance of common stock upon exercise of stock options
From December 31, 2023 to March 31, 2024
Issuance of common stock upon exercise of stock options
From December 31, 2022 to December 31, 2023
Issuance of common stock under equity plans
Issuance of common stock upon exercise of stock options
From June 30, 2023 to September 30, 2023
Issuance of common stock under equity plans
Issuance of common stock upon exercise of stock options
From March 31, 2023 to June 30, 2023
Issuance of common stock upon exercise of stock options
From December 31, 2021 to December 31, 2022
Issuance of common stock under equity plans
Issuance of common stock upon exercise of stock options
From June 30, 2022 to September 30, 2022
Issuance of common stock under equity plans
Issuance of common stock upon exercise of stock options
From March 31, 2022 to June 30, 2022
Issuance of common stock upon exercise of stock options
From December 31, 2021 to March 31, 2022
Issuance of common stock upon exercise of stock options
From December 31, 2020 to December 31, 2021
Issuance of common stock related to acquired in-process research and development
Issuance of common stock upon exercise of stock options
Issuance of common stock under equity plans
From June 30, 2021 to September 30, 2021
Issuance of common stock under equity plans
Issuance of common stock upon exercise of stock options
From March 31, 2021 to June 30, 2021
Issuance of common stock upon exercise of stock options
From December 31, 2020 To March 31, 2021
Issuance of common stock related to acquired in-process research and development
Issuance of common stock upon exercise of stock options
From December 31, 2019 to December 31, 2020
Issuance of common stock to Ultragenyx on option exercise
Issuance of common stock, net of issuance costs
Issuance of common stock upon exercise of stock options
From June 30, 2020 to September 18, 2020
Issuance of common stock, net of issuance costs
Issuance of common stock upon exercise of stock options
1.Common stock offered by the company 3,264,151 shares of common stock.
2.The number of shares of common stock to be outstanding immediately following this offering as shown above is based on 20,610,056 shares of common stock outstanding on June 30, 2020.
From March 31, 2020 to June 30, 2020
Issuance of common stock, net of issuance costs
Issuance of common stock to Ultragenyx on option exercise
Issuance of common stock upon exercise of stock options
1.Common stock offered by us: 4,117,650 shares
2.The number of shares our common stock to be outstanding after the offering is based on 15,137,964 shares of our common stock outstanding as of December 31, 2019
From December 31, 2019 to March 31, 2020
Issuance of common stock upon exercise of stock options
from December 31, 2018 to December 31, 2019
Redomiciliation share exchange
Issuance of restricted common stock and option, net of issuance costs
Issuance of common stock, net of issuance costs
Issuance of common stock upon exercise of stock options
from June 30, 2019 to September 30, 2019
Issuance of common stock upon exercise of stock options
from December 31, 2018 to June 30, 2019
Treasury stock
Issuance of common stock upon exercise of stock options
Issuance of restricted common stock and option, net of issuance costs
from December 31, 2017 to December 31, 2018
Issuance of common shares upon exercise of share options
From December 31, 2017 to September 30, 2018
Shares issued in conjunction with share option exercise
From December 31, 2017 to June 30, 2018
Shares issued in conjunction with share option exercise
from December 31, 2016 to December 31, 2017
Conversion of Preferred Shares to Ordinary Shares
Shares issued in conjunction with share option exercise
Issuance of shares upon exercise of warrants
Issuance of shares upon conversion of notes
Issuance of shares in connection with merger, net
The Company announced today that its Board of Directors (the "Board") has determined to effect a reverse stock split at a ratio of one-for-seven as of the opening of trading on or around November 16, 2017.Immediately after the Merger, there were approximately 10,568,901 Ordinary Shares.The Ordinary Shares have a new CUSIP number, M1492T 105.
from December 31, 2015 to December 31, 2016
Issuance of shares upon exercise of options
from December 31, 2014 to December 31, 2015
Issuance of shares upon exercise of options
Issuance of shares upon public offering ($4.00 per share), net of $203 issuance expenses
Issuance of shares upon public offering ($6.50 per share), net of $421 issuance expenses
from December 31, 2014 to June 30, 2015
Exercise of options
Issuance of shares upon public offering ($4 per share), net of $203 issuance expenses
from December 31, 2013 to December 31, 2014
Issuance of shares upon exercise of options
Issuance of shares upon cashless exercise of warrants
from December 31, 2013 to June 30, 2014
Issuance of shares upon cashless exercise of warrants
From December 31,2012 to December 31,2013
Exercise of options
Issuance of shares upon cashless exercise of warrants
Issuance of shares upon conversion of convertible notes
Issuance of shares upon initial public offering ($8 per share), net of $3,080 issuance expenses
Issuance of shares upon secondary public offering ($16.5 per share), net of $2,616 issuance expenses
from December 31, 2011 to April 2, 2013
Treasury shares
Exercise of options
The number of our ordinary shares to be outstanding immediately after this offering is based on 7,794,256 ordinary shares outstanding as of April 1, 2013 (giving prospective effect to the issuance of bonus shares equivalent to a 5.87-for-1 stock split).
from December 31, 2011 to December 31, 2012
Treasury shares
Exercise of options