主要股东
注：以下部分股东代表特定权益共同体，直接或间接持有上市公司股份
| 序号 | 股东名称 | 是否机构 | 持股数(股) | 持股比例 | 持股变动数(股) | 持股数变动比例 | 投票权比例 |
|---|---|---|---|---|---|---|---|
| 1 | Entities affiliated with OrbiMed Private Investments V, L.P. | 是 | 441.33万 | 10.50% | 新增 | 新增 | -- |
| 2 | Entities affiliated with FMR LLC | 是 | 420.32万 | 9.90% |
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| 3 | Entities affiliated with RA Capital Management, LLC | 是 | 413.24万 | 9.80% | 新增 | 新增 | -- |
| 4 | 普信投资公司 | 是 | 411.09万 | 9.80% | 新增 | 新增 | -- |
| 5 | Baker Bros. Advisors LP | 是 | 283.74万 | 6.70% |
|
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-- |
| 6 | James I. Healy | 否 | 222.32万 | 5.30% |
|
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-- |
| 7 | Entities affiliated with Vivo Capital | 是 | 216.68万 | 5.10% |
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| 序号 | 股东名称 | 是否机构 | 持股数(股) | 持股比例 | 持股变动数(股) | 持股数变动比例 | 投票权比例 |
|---|---|---|---|---|---|---|---|
| 1 | Entities affiliated with RA Capital Management,LLC | 是 | 558.07万 | 13.40% | 新增 | 新增 | -- |
| 2 | OrbiMed Private Investments V, LP | 是 | 437.44万 | 10.50% | 新增 | 新增 | -- |
| 3 | Entities affiliated with FMR LLC | 是 | 363.02万 | 8.70% | 新增 | 新增 | -- |
| 4 | Baker Bros. Advisors LP | 是 | 261.88万 | 6.30% | 新增 | 新增 | -- |
| 5 | James I. Healy | 否 | 247.95万 | 6.00% | 新增 | 新增 | -- |
| 6 | Entities affiliated with Vivo Capital | 是 | 216.68万 | 5.20% | 新增 | 新增 | -- |
| 7 | Entities affiliated with EcoR1 Capital, LLC | 是 | 210.76万 | 5.10% | 新增 | 新增 | -- |
机构持股汇总
非主要股东机构持股变动
| 机构或基金名称 | 持有数量 | 持股市值(亿美元) | 持股变动(万股) | 变动比例(%) |
|---|---|---|---|---|
|
American Century Companies Inc
|
54.46万股 | 0.75 | 1.38 | 2.60 |
|
Ameriprise Financial Inc
|
56.29万股 | 0.78 | -2.51 | -4.27 |
|
Artisan Partners Limited Partnership
|
372.09万股 | 5.14 | -26.95 | -6.76 |
|
Avoro Capital Advisors Llc
|
511.00万股 | 7.07 | 13.00 | 2.61 |
|
Capital International Investors
|
306.06万股 | 4.23 | 1.37 | 0.45 |
|
Fmr Llc
|
447.17万股 | 6.18 | -6.00 | -1.32 |
|
Franklin Resources Inc
|
159.00万股 | 2.20 | -16.35 | -9.33 |
|
Goldman Sachs Group Inc
|
65.30万股 | 0.90 | 11.47 | 21.31 |
|
Invesco Ltd.
|
91.79万股 | 1.27 | -2.93 | -3.10 |
|
Janus Henderson Group Plc
|
432.31万股 | 5.98 | -10.47 | -2.37 |
|
Massachusetts Financial Services Co
|
188.28万股 | 2.60 | -1.91 | -1.00 |
|
Perceptive Advisors Llc
|
108.85万股 | 1.51 | 12.46 | 12.93 |
|
Polar Capital Holdings Plc
|
85.79万股 | 1.19 | 2.01 | 2.40 |
|
Price T Rowe Associates Inc
|
172.62万股 | 2.39 | -14.93 | -7.96 |
|
Principal Financial Group Inc
|
79.37万股 | 1.10 | 76.56 | 2722.87 |
|
Ra Capital Management, L.P.
|
1028.15万股 | 14.22 | - | 不足0.01 |
|
T. ROWE PRICE INVESTMENT MANAGEMENT, INC.
|
266.66万股 | 3.69 | -91.69 | -25.59 |
|
Vestal Point Capital, Lp
|
60.00万股 | 0.83 | 40.00 | 200.00 |
|
Wellington Management Group Llp
|
179.89万股 | 2.49 | 88.08 | 95.94 |
|
Westfield Capital Management Co Lp
|
525.99万股 | 7.27 | -19.15 | -3.51 |
| 机构或基金名称 | 持有数量 | 持股市值(亿美元) | 持股变动(万股) | 变动比例(%) |
|---|---|---|---|---|
|
American Century Companies Inc
|
54.46万股 | 0.75 | 1.38 | 2.60 |
|
Ameriprise Financial Inc
|
56.29万股 | 0.78 | -2.51 | -4.27 |
|
Artisan Partners Limited Partnership
|
372.09万股 | 5.14 | -26.95 | -6.76 |
|
Avoro Capital Advisors Llc
|
511.00万股 | 7.07 | 13.00 | 2.61 |
|
Capital International Investors
|
306.06万股 | 4.23 | 1.37 | 0.45 |
|
Fmr Llc
|
447.17万股 | 6.18 | -6.00 | -1.32 |
|
Franklin Resources Inc
|
159.00万股 | 2.20 | -16.35 | -9.33 |
|
Goldman Sachs Group Inc
|
65.30万股 | 0.90 | 11.47 | 21.31 |
|
Invesco Ltd.
|
91.79万股 | 1.27 | -2.93 | -3.10 |
|
Janus Henderson Group Plc
|
432.31万股 | 5.98 | -10.47 | -2.37 |
|
Massachusetts Financial Services Co
|
188.28万股 | 2.60 | -1.91 | -1.00 |
|
Perceptive Advisors Llc
|
108.85万股 | 1.51 | 12.46 | 12.93 |
|
Polar Capital Holdings Plc
|
85.79万股 | 1.19 | 2.01 | 2.40 |
|
Price T Rowe Associates Inc
|
172.62万股 | 2.39 | -14.93 | -7.96 |
|
Principal Financial Group Inc
|
79.37万股 | 1.10 | 76.56 | 2722.87 |
|
Ra Capital Management, L.P.
|
1028.15万股 | 14.22 | - | 不足0.01 |
|
T. ROWE PRICE INVESTMENT MANAGEMENT, INC.
|
266.66万股 | 3.69 | -91.69 | -25.59 |
|
Vestal Point Capital, Lp
|
60.00万股 | 0.83 | 40.00 | 200.00 |
|
Wellington Management Group Llp
|
179.89万股 | 2.49 | 88.08 | 95.94 |
|
Westfield Capital Management Co Lp
|
525.99万股 | 7.27 | -19.15 | -3.51 |
| 机构或基金名称 | 持有数量 | 持股市值(亿美元) | 持股变动(万股) | 变动比例(%) |
|---|---|---|---|---|
|
American Century Companies Inc
|
54.46万股 | 0.75 | 1.38 | 2.60 |
|
Ameriprise Financial Inc
|
56.29万股 | 0.78 | -2.51 | -4.27 |
|
Artisan Partners Limited Partnership
|
372.09万股 | 5.14 | -26.95 | -6.76 |
|
Avoro Capital Advisors Llc
|
511.00万股 | 7.07 | 13.00 | 2.61 |
|
Capital International Investors
|
306.06万股 | 4.23 | 1.37 | 0.45 |
|
Fmr Llc
|
447.17万股 | 6.18 | -6.00 | -1.32 |
|
Franklin Resources Inc
|
159.00万股 | 2.20 | -16.35 | -9.33 |
|
Goldman Sachs Group Inc
|
65.30万股 | 0.90 | 11.47 | 21.31 |
|
Invesco Ltd.
|
91.79万股 | 1.27 | -2.93 | -3.10 |
|
Janus Henderson Group Plc
|
432.31万股 | 5.98 | -10.47 | -2.37 |
|
Massachusetts Financial Services Co
|
188.28万股 | 2.60 | -1.91 | -1.00 |
|
Perceptive Advisors Llc
|
108.85万股 | 1.51 | 12.46 | 12.93 |
|
Polar Capital Holdings Plc
|
85.79万股 | 1.19 | 2.01 | 2.40 |
|
Price T Rowe Associates Inc
|
172.62万股 | 2.39 | -14.93 | -7.96 |
|
Principal Financial Group Inc
|
79.37万股 | 1.10 | 76.56 | 2722.87 |
|
Ra Capital Management, L.P.
|
1028.15万股 | 14.22 | - | 不足0.01 |
|
T. ROWE PRICE INVESTMENT MANAGEMENT, INC.
|
266.66万股 | 3.69 | -91.69 | -25.59 |
|
Vestal Point Capital, Lp
|
60.00万股 | 0.83 | 40.00 | 200.00 |
|
Wellington Management Group Llp
|
179.89万股 | 2.49 | 88.08 | 95.94 |
|
Westfield Capital Management Co Lp
|
525.99万股 | 7.27 | -19.15 | -3.51 |
| 机构或基金名称 | 持有数量 | 持股市值(亿美元) | 持股变动(万股) | 变动比例(%) |
|---|---|---|---|---|
|
American Century Companies Inc
|
54.46万股 | 0.75 | 1.38 | 2.60 |
|
Ameriprise Financial Inc
|
56.29万股 | 0.78 | -2.51 | -4.27 |
|
Artisan Partners Limited Partnership
|
372.09万股 | 5.14 | -26.95 | -6.76 |
|
Avoro Capital Advisors Llc
|
511.00万股 | 7.07 | 13.00 | 2.61 |
|
Capital International Investors
|
306.06万股 | 4.23 | 1.37 | 0.45 |
|
Fmr Llc
|
447.17万股 | 6.18 | -6.00 | -1.32 |
|
Franklin Resources Inc
|
159.00万股 | 2.20 | -16.35 | -9.33 |
|
Goldman Sachs Group Inc
|
65.30万股 | 0.90 | 11.47 | 21.31 |
|
Invesco Ltd.
|
91.79万股 | 1.27 | -2.93 | -3.10 |
|
Janus Henderson Group Plc
|
432.31万股 | 5.98 | -10.47 | -2.37 |
|
Massachusetts Financial Services Co
|
188.28万股 | 2.60 | -1.91 | -1.00 |
|
Perceptive Advisors Llc
|
108.85万股 | 1.51 | 12.46 | 12.93 |
|
Polar Capital Holdings Plc
|
85.79万股 | 1.19 | 2.01 | 2.40 |
|
Price T Rowe Associates Inc
|
172.62万股 | 2.39 | -14.93 | -7.96 |
|
Principal Financial Group Inc
|
79.37万股 | 1.10 | 76.56 | 2722.87 |
|
Ra Capital Management, L.P.
|
1028.15万股 | 14.22 | - | 不足0.01 |
|
T. ROWE PRICE INVESTMENT MANAGEMENT, INC.
|
266.66万股 | 3.69 | -91.69 | -25.59 |
|
Vestal Point Capital, Lp
|
60.00万股 | 0.83 | 40.00 | 200.00 |
|
Wellington Management Group Llp
|
179.89万股 | 2.49 | 88.08 | 95.94 |
|
Westfield Capital Management Co Lp
|
525.99万股 | 7.27 | -19.15 | -3.51 |
| 机构或基金名称 | 持有数量 | 持股市值(亿美元) | 持股变动(万股) | 变动比例(%) |
|---|---|---|---|---|
|
American Century Companies Inc
|
54.46万股 | 0.75 | 1.38 | 2.60 |
|
Artisan Partners Limited Partnership
|
372.09万股 | 5.14 | -26.95 | -6.76 |
|
Blackrock, Inc.
|
45.15万股 | 0.62 | -2.02 | -4.29 |
|
Capital International Investors
|
306.06万股 | 4.23 | 1.37 | 0.45 |
|
Fil Ltd
|
45.93万股 | 0.64 | -0.48 | -1.03 |
|
Fmr Llc
|
447.17万股 | 6.18 | -6.00 | -1.32 |
|
Franklin Resources Inc
|
159.00万股 | 2.20 | -16.35 | -9.33 |
|
Jpmorgan Chase & Co
|
29.24万股 | 0.40 | 8.43 | 40.48 |
|
Macquarie Group Ltd
|
30.95万股 | 0.43 | 19.28 | 165.16 |
|
Massachusetts Financial Services Co
|
188.28万股 | 2.60 | -1.91 | -1.00 |
|
Principal Financial Group Inc
|
79.37万股 | 1.10 | 76.56 | 2722.87 |
|
Td Asset Management Inc
|
29.63万股 | 0.41 | 0.43 | 1.46 |
|
Westfield Capital Management Co Lp
|
525.99万股 | 7.27 | -19.15 | -3.51 |
|
Invesco Ltd.
|
91.79万股 | 1.27 | -2.93 | -3.10 |