股本结构
单位：万股
| 公告日期 | 2025-10-28 | 2025-10-28 | 2025-08-05 | 2025-08-05 | 2025-05-02 | 2025-05-02 |
|---|---|---|---|---|---|---|
| 证券总股本 | 19211.43 | 19209.88 | 19201.46 | 19200.17 | 19177.57 | 19175.58 |
| 普通股本 | 19211.43 | 19209.88 | 19201.46 | 19200.17 | 19177.57 | 19175.58 |
| 优先股 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2025-10-23 | 2025-09-30 | 2025-07-28 | 2025-06-30 | 2025-04-25 | 2025-03-31 |
注释：中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本（万股） | 变动后优先股（万股） | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2025-10-28 | 19211.43 | 未披露 | 定期报告 | 2025-10-23 |
| 2025-10-28 | 19209.88 | 未披露 |
更多>>
From June 30, 2025 to September 30, 2025
Issuances under equity incentive plans
|
2025-09-30 |
| 2025-08-05 | 19201.46 | 未披露 | 定期报告 | 2025-07-28 |
| 2025-08-05 | 19200.17 | 未披露 |
更多>>
From March 31, 2025 to June 30, 2025
Issuances under equity incentive plans
|
2025-06-30 |
| 2025-05-02 | 19177.57 | 未披露 | 定期报告 | 2025-04-25 |
| 2025-05-02 | 19175.58 | 未披露 |
更多>>
From December 31,2024 to March 31,2025
Issuances under equity incentive plans
|
2025-03-31 |
| 2025-04-08 | 19175.42 | 未披露 | 定期报告 | 2025-03-24 |
| 2025-04-08 | 19080.36 | 未披露 | 定期报告 | 2025-03-14 |
| 2025-02-24 | 19077.71 | 未披露 | 定期报告 | 2025-02-18 |
| 2025-02-24 | 19076.13 | 未披露 |
更多>>
From December 31, 2023 to December 31, 2024
Issuances under equity incentive plans
|
2024-12-31 |
| 2024-10-31 | 19058.30 | 未披露 | 定期报告 | 2024-10-28 |
| 2024-10-31 | 19055.39 | 未披露 |
更多>>
From June 30, 2024 to September 30, 2024
Issuances under equity incentive plans
|
2024-09-30 |
| 2024-08-05 | 19038.28 | 未披露 | 定期报告 | 2024-07-31 |
| 2024-08-05 | 19035.55 | 未披露 |
更多>>
From March 31, 2024 to June 30, 2024
Issuances under equity incentive plans
|
2024-06-30 |
| 2024-04-26 | 18987.98 | 未披露 | 定期报告 | 2024-04-22 |
| 2024-04-24 | 18977.66 | 未披露 | 定期报告 | 2024-03-31 |
| 2024-04-09 | 18977.50 | 未披露 | 定期报告 | 2024-03-25 |
| 2024-04-09 | 18873.38 | 未披露 | 定期报告 | 2024-03-15 |
| 2024-02-26 | 18867.56 | 未披露 | 定期报告 | 2024-02-16 |
| 2024-02-26 | 18859.82 | 未披露 |
更多>>
From December 31, 2022 to December 31, 2023
Issuances under equity incentive plans
|
2023-12-31 |
| 2023-11-02 | 18836.82 | 未披露 | 定期报告 | 2023-10-30 |
| 2023-11-02 | 18833.95 | 未披露 |
更多>>
From June 30, 2023 to September 30, 2023
Issuances under equity incentive plans
|
2023-09-30 |
| 2023-08-02 | 18817.48 | 未披露 | 定期报告 | 2023-07-28 |
| 2023-08-02 | 18815.17 | 未披露 |
更多>>
From March 31,2023 to June 30,2023
Issuances under equity incentive plans
|
2023-06-30 |
| 2023-04-28 | 18770.09 | 未披露 | 定期报告 | 2023-04-25 |
| 2023-04-28 | 18760.11 | 未披露 |
更多>>
From December 31, 2022 to March 31, 2023
Issuances under equity incentive plans, net of tax
|
2023-03-31 |
| 2023-04-11 | 18760.04 | 未披露 | 定期报告 | 2023-03-27 |
| 2023-04-11 | 18658.93 | 未披露 | 定期报告 | 2023-03-15 |
| 2023-02-27 | 18652.88 | 未披露 | 定期报告 | 2023-02-16 |
| 2023-02-27 | 18625.07 | 未披露 |
更多>>
From December 31, 2021 to December 31, 2022
Issuances under equity incentive plans
Issuances under equity incentive plans, net of tax
|
2022-12-31 |
| 2022-10-28 | 18584.89 | 未披露 | 定期报告 | 2022-10-25 |
| 2022-10-26 | 18582.43 | 未披露 | 定期报告 | 2022-09-30 |
| 2022-08-04 | 18547.39 | 未披露 | 定期报告 | 2022-07-28 |
| 2022-08-04 | 18545.25 | 未披露 |
更多>>
From March 31, 2022 to June 30, 2022
Issuances under equity incentive plans
|
2022-06-30 |
| 2022-04-29 | 18499.53 | 未披露 | 定期报告 | 2022-04-25 |
| 2022-04-29 | 18490.18 | 未披露 |
更多>>
From March 31, 2021 to March 31, 2022
Issuances under equity incentive plans, net of tax
|
2022-03-31 |
| 2022-04-12 | 18489.81 | 未披露 | 定期报告 | 2022-03-28 |
| 2022-04-12 | 18404.92 | 未披露 | 定期报告 | 2022-03-04 |
| 2022-02-25 | 18403.22 | 未披露 | 定期报告 | 2022-02-22 |
| 2022-02-25 | 18391.25 | 未披露 |
更多>>
From December 31, 2020 to December 31, 2021
Issuances under equity incentive plans, net of tax
|
2021-12-31 |
| 2021-10-29 | 18359.34 | 未披露 | 定期报告 | 2021-10-26 |
| 2021-10-29 | 18356.74 | 未披露 |
更多>>
From June 30, 2021 to September 30, 2021
Issuances under equity incentive plans
Repurchase of common stock
|
2021-09-30 |
| 2021-07-30 | 18335.23 | 未披露 | 定期报告 | 2021-07-27 |
| 2021-07-30 | 18332.18 | 未披露 |
更多>>
From March 31, 2021 to June 30, 2021
Issuances under equity incentive plans
|
2021-06-30 |
| 2021-04-30 | 18274.26 | 未披露 | 定期报告 | 2021-04-21 |
| 2021-04-30 | 18267.06 | 未披露 |
更多>>
From December 31,2020 to March 31, 2021
Issuances under equity incentive plans
Common stock held by the NQDC
|
2021-03-31 |
| 2021-04-13 | 18266.05 | 未披露 | 定期报告 | 2021-03-29 |
| 2021-04-13 | 18187.38 | 未披露 | 定期报告 | 2021-03-05 |
| 2021-02-26 | 18182.97 | 未披露 | 定期报告 | 2021-02-12 |
| 2021-02-26 | 18174.10 | 未披露 |
更多>>
From December 31,2019 to December 31,2020
Issuances under equity incentive plans
Repurchase of common stock
Issuances under equity incentive plans, net of tax
Purchase of treasury stock
Retirement of treasury stock
|
2020-12-31 |
| 2020-11-06 | 18152.97 | 未披露 | 定期报告 | 2020-10-23 |
| 2020-11-06 | 18149.23 | 未披露 |
更多>>
from June 30,2020 to September 30,2020
Issuances under equity incentive plans
Common stock held by the NQDC
|
2020-09-30 |
| 2020-08-05 | 18134.96 | 未披露 | 定期报告 | 2020-07-30 |
| 2020-08-05 | 18114.83 | 未披露 |
更多>>
from March 31,2020 to June 30,2020
Issuances under equity incentive plans
Repurchase of common stock
Purchase of treasury stock
Retirement of treasury stock
|
2020-06-30 |
| 2020-05-01 | 18083.69 | 未披露 | 定期报告 | 2020-04-20 |
| 2020-05-01 | 18076.20 | 未披露 |
更多>>
From December 31, 2019 to March 31, 2020
Issuances under equity incentive plans
|
2020-03-31 |
| 2020-04-14 | 18076.08 | 未披露 | 定期报告 | 2020-03-30 |
| 2020-02-27 | 17992.56 | 未披露 | 定期报告 | 2020-02-12 |
| 2020-02-27 | 17983.81 | 未披露 |
更多>>
From December 31, 2018 to December 31, 2019
Issuances under equity incentive plans
|
2019-12-31 |
| 2019-10-29 | 17962.53 | 未披露 | 定期报告 | 2019-10-18 |
| 2019-10-29 | 17960.44 | 未披露 |
更多>>
from June 30, 2019 to September 30, 2019
Issuances under equity incentive plans
|
2019-09-30 |
| 2019-08-02 | 17946.28 | 未披露 | 定期报告 | 2019-07-22 |
| 2019-08-02 | 17943.33 | 未披露 |
更多>>
from December 31, 2018 to June 30, 2019
Issuances under equity incentive plans
|
2019-06-30 |
| 2019-04-29 | 17907.14 | 未披露 | 定期报告 | 2019-04-15 |
| 2019-04-23 | 17905.29 | 未披露 | 定期报告 | 2019-04-08 |
| 2019-04-29 | 17903.31 | 未披露 |
更多>>
from December 31, 2018 to March 31, 2019
Issuances under equity incentive plans
|
2019-03-31 |
| 2019-04-23 | 17846.84 | 未披露 | 定期报告 | 2019-03-15 |
| 2019-02-28 | 17837.22 | 未披露 | 定期报告 | 2019-02-12 |
| 2019-02-28 | 17825.30 | 未披露 |
更多>>
from December 31, 2017 to December 31, 2018
Issuances under equity incentive plans, net of tax
Conversion of convertible notes, net
|
2018-12-31 |
| 2018-10-26 | 17806.21 | 未披露 | 定期报告 | 2018-10-19 |
| 2018-10-26 | 17790.28 | 未披露 |
更多>>
From January 1, 2018 to September 30, 2018
Issuances under equity incentive plans, net of tax
Common stock held by the NQDC
|
2018-09-30 |
| 2018-08-03 | 17759.04 | 未披露 | 定期报告 | 2018-07-23 |
| 2018-08-03 | 17750.81 | 未披露 |
更多>>
From January 1, 2018 to June 30, 2018
Issuances under equity incentive plans, net of tax
Common stock held by the NQDC
|
2018-06-30 |
| 2018-04-27 | 17671.33 | 未披露 | 定期报告 | 2018-04-13 |
| 2018-04-24 | 17668.13 | 未披露 | 定期报告 | 2018-04-09 |
| 2018-04-27 | 17665.35 | 未披露 |
更多>>
from December 31, 2017 to March 31, 2018
Issuances under equity incentive plans, net of tax
Common stock held by the NQDC
|
2018-03-31 |
| 2018-04-24 | 17633.58 | 未披露 | 定期报告 | 2018-03-16 |
| 2018-02-26 | 17607.23 | 未披露 | 定期报告 | 2018-02-13 |
| 2018-02-26 | 17584.37 | 未披露 |
更多>>
From December 31, 2016 to December 31, 2017
Issuances under equity incentive plans, net of tax
Conversion of convertible notes, net
|
2017-12-31 |
| 2017-10-31 | 17562.13 | 未披露 | 定期报告 | 2017-10-25 |
| 2017-10-31 | 17549.54 | 未披露 |
更多>>
From December 31, 2016 to September 30, 2017
Issuances under equity incentive plans, net of tax
Issuances of common stock under the Employee Stock Purchase Plan (the ESPP)
Conversion of convertible notes, net
|
2017-09-30 |
| 2017-08-02 | 17526.83 | 未披露 | 定期报告 | 2017-07-20 |
| 2017-08-02 | 17524.88 | 未披露 |
更多>>
from December 31, 2016 to June 30, 2017
Issuances under equity incentive plans,net of tax
Issuances of common stock under the Employee Stock Purchase Plan (the ESPP)
Conversion of convertible notes, net
|
2017-06-30 |
| 2017-05-04 | 17449.00 | 未披露 | 定期报告 | 2017-04-20 |
| 2017-04-25 | 17335.21 | 未披露 | 定期报告 | 2017-04-10 |
| 2017-05-04 | 17330.42 | 未披露 |
更多>>
from December 31, 2016 to March 31, 2017
Issuances under equity incentive plans,net of tax
|
2017-03-31 |
| 2017-04-25 | 17328.70 | 未披露 | 定期报告 | 2017-03-17 |
| 2017-02-27 | 17286.65 | 未披露 | 定期报告 | 2017-02-13 |
| 2017-02-27 | 17264.76 | 未披露 |
更多>>
from December 31, 2015 to December 31, 2016
Issuance of common stock, net of offering costs
Issuance of common stock under ESPP
Issuances under equity incentive plans, net of tax
Conversion of convertible notes, net
|
2016-12-31 |
| 2016-11-03 | 17198.74 | 未披露 | 定期报告 | 2016-10-28 |
| 2016-11-03 | 17169.76 | 未披露 |
更多>>
From December 31, 2015 to September 30, 2016
Issuance of common stock, net of offering costs
Issuance of common stock under the 2006 Employee Stock Purchase Plan (the ESPP)
Exercise of common stock options
Restricted stock units vested during the period, net
Conversion of convertible notes, net
|
2016-09-30 |
| 2016-08-08 | 16346.58 | 未披露 | 定期报告 | 2016-07-29 |
| 2016-08-08 | 16328.21 | 0.01 |
更多>>
from December 31, 2015 to June 30, 2016
Issuance of common stock under the 2006 Employee Stock Purchase Plan (the ESPP)
Exercise of common stock options
Restricted stock units vested during the period, net
Conversion of convertible notes, netCommon stock held by Nonqualified Deferred Compensation Plan (the NQDC)
|
2016-06-30 |
| 2016-05-02 | 16232.24 | 未披露 | 定期报告 | 2016-04-22 |
| 2016-04-25 | 16229.28 | 未披露 | 定期报告 | 2016-04-11 |
| 2016-05-02 | 16224.30 | 未披露 |
更多>>
from December 31, 2015 to March 31, 2016
Exercise of common stock options
Restricted stock vested during the period, net
Conversion of convertible notes, net
|
2016-03-31 |
| 2016-02-29 | 16159.07 | 未披露 | 定期报告 | 2016-02-12 |
| 2016-02-29 | 16152.60 | 未披露 |
更多>>
from December 31, 2014 to December 31, 2015
Issuance of common stock, net of offering costs
Issuance of common stock under ESPP
Exercise of common stock options
Conversion of convertible notes, net
Restricted stock vested during the period, net
|
2015-12-31 |
| 2015-11-02 | 16125.17 | 未披露 | 定期报告 | 2015-10-23 |
| 2015-11-02 | 16122.64 | 未披露 | 定期报告 | 2015-09-30 |
| 2015-08-05 | 16109.41 | 未披露 | 定期报告 | 2015-07-27 |
| 2015-08-03 | 16100.85 | 未披露 | 定期报告 | 2015-06-30 |
| 2015-05-05 | 16033.68 | 未披露 | 定期报告 | 2015-04-24 |
| 2015-04-23 | 16030.88 | 未披露 | 定期报告 | 2015-04-10 |
| 2015-05-05 | 16028.23 | 未披露 | 定期报告 | 2015-03-31 |
| 2015-03-02 | 14909.36 | 未披露 |
更多>>
From December 31,2013 to December 31,2014
Issuance of common stock under ESPP
Issuance of common stock, net of offering costs
Exercise of common stock options
Conversion of convertible notes
Restricted stock vested during the period, net
|
2014-12-31 |
| 2014-10-28 | 14746.55 | 未披露 | 定期报告 | 2014-10-18 |
| 2014-10-23 | 14793.40 | 未披露 | 定期报告 | 2014-09-30 |
| 2014-07-31 | 14711.69 | 未披露 | 定期报告 | 2014-07-18 |
| 2014-07-31 | 14706.80 | 未披露 | 定期报告 | 2014-06-30 |
| 2014-05-02 | 14592.68 | 未披露 | 定期报告 | 2014-04-18 |
| 2014-04-22 | 14573.64 | 未披露 | 定期报告 | 2014-04-07 |
| 2014-05-01 | 14573.84 | 未披露 | 定期报告 | 2014-03-31 |
| 2014-02-26 | 14362.32 | 未披露 | 定期报告 | 2014-02-14 |
| 2015-03-02 | 15913.57 | 未披露 | 定期报告 | 2014-02-13 |
| 2014-02-26 | 14346.37 | 未披露 |
更多>>
From December 31,2012 to December 31,2013
Issuance of common stock under ESPP
Exercise of common stock options
Conversion of convertible notes
Restricted stock vested during the period, net
|
2013-12-31 |
| 2013-10-28 | 14221.27 | 未披露 | 定期报告 | 2013-10-18 |
| 2013-10-07 | 14220.70 | 未披露 | 定期报告 | 2013-10-04 |
| 2013-10-24 | 14220.10 | 未披露 | 定期报告 | 2013-09-30 |
| 2013-07-29 | 14010.56 | 未披露 | 定期报告 | 2013-07-19 |
| 2013-07-25 | 14005.00 | 未披露 | 定期报告 | 2013-06-30 |
| 2013-04-29 | 13901.02 | 未披露 | 定期报告 | 2013-04-19 |
| 2013-04-29 | 13887.32 | 未披露 | 定期报告 | 2013-03-31 |
| 2013-04-05 | 13432.79 | 未披露 | 定期报告 | 2013-03-18 |
| 2013-02-26 | 12610.16 | 未披露 | 定期报告 | 2013-02-15 |
| 2013-02-26 | 12580.92 | 未披露 |
更多>>
from December 31, 2011 to December 31, 2012
Issuance of common stock, net of offering costs
Issuance of common stock under ESPP
Exercise of common stock options
Conversion of convertible notes
Restricted stock vested during the period, net
|
2012-12-31 |
| 2012-10-29 | 12382.61 | 未披露 | 定期报告 | 2012-10-12 |
| 2012-10-25 | 12379.02 | 未披露 | 定期报告 | 2012-09-30 |
| 2012-08-02 | 12355.52 | 未披露 | 定期报告 | 2012-07-13 |
| 2012-08-01 | 12323.59 | 未披露 | 定期报告 | 2012-06-30 |
| 2012-04-30 | 11570.10 | 未披露 | 定期报告 | 2012-04-13 |
| 2012-04-26 | 11568.18 | 未披露 | 定期报告 | 2012-03-31 |
| 2012-02-22 | 11505.70 | 未披露 | 定期报告 | 2012-02-13 |
| 2012-02-16 | 11478.97 | 未披露 | 定期报告 | 2011-12-31 |
| 2011-10-31 | 11421.44 | 未披露 | 定期报告 | 2011-10-15 |
| 2011-10-27 | 11414.98 | 未披露 | 定期报告 | 2011-09-30 |
| 2011-08-01 | 11182.73 | 未披露 | 定期报告 | 2011-07-15 |
| 2011-07-28 | 11156.48 | 未披露 | 定期报告 | 2011-06-30 |
| 2011-04-29 | 11090.96 | 未披露 | 定期报告 | 2011-04-15 |
| 2011-04-29 | 11087.35 | 未披露 | 定期报告 | 2011-03-31 |
| 2011-02-24 | 11072.31 | 未披露 | 定期报告 | 2011-02-15 |
| 2011-02-24 | 11063.45 | 未披露 |
更多>>
Issuance of common stock under ESPP
Exercise of common stock options
Conversion of convertible notes
Restricted stock vested during the period
|
2010-12-31 |
| 2010-10-29 | 10249.71 | 未披露 | 定期报告 | 2010-10-22 |
| 2010-10-29 | 10246.45 | 未披露 | 定期报告 | 2010-09-30 |
| 2010-08-04 | 10205.87 | 未披露 | 定期报告 | 2010-07-23 |
| 2010-08-04 | 10201.68 | 未披露 | 定期报告 | 2010-06-30 |
| 2010-05-03 | 10162.67 | 未披露 | 定期报告 | 2010-04-23 |
| 2010-05-03 | 10155.12 | 未披露 | 定期报告 | 2010-03-31 |
| 2010-02-26 | 10113.14 | 未披露 | 定期报告 | 2010-02-17 |
| 2010-02-26 | 10096.19 | 未披露 |
更多>>
from December 31, 2008 to December 31, 2009
Issuance of common stock under ESPP
Exercise of common stock options
Restricted stock vested during the period
|
2009-12-31 |
| 2009-02-27 | 9994.58 | 未披露 | 定期报告 | 2009-02-17 |
| 2009-02-27 | 9986.81 | 未披露 |
更多>>
from December 31, 2007 to December 31, 2008
Issuance of common stock under ESPP
Exercise of common stock options
Restricted stock vested during the period
Conversion of convertible notes
|
2008-12-31 |
| 2008-02-28 | 9738.13 | 未披露 | 定期报告 | 2008-02-19 |
| 2008-02-28 | 9711.42 | 未披露 |
更多>>
from December 31, 2006 to December 31, 2007
Issuance of common stock under ESPP
Exercise of common stock options
Conversion of convertible notes
|
2007-12-31 |
| 2007-02-28 | 9554.30 | 未披露 | 定期报告 | 2007-02-20 |
| 2007-02-28 | 9172.55 | 未披露 |
更多>>
from January 1, 2006 to December 31, 2006
Issuance of common stock in a public offering, net of issuance costs
Issuance of common stock under ESPP
Exercise of common stock options
Conversion of convertible notes
|
2006-12-31 |
| 2006-03-07 | 7464.20 | 未披露 | 定期报告 | 2006-02-21 |
| 2006-03-07 | 7430.16 | 未披露 |
更多>>
from January 1, 2005 to December 31, 2005
Issuance of common stock in a public offering, net of issuance costs
Issuance of common stock under ESPP
Exercise of common stock options
|
2005-12-31 |
| 2005-03-16 | 6451.12 | 未披露 | 定期报告 | 2005-02-22 |
| 2005-03-16 | 6450.12 | 未披露 |
更多>>
from January 1, 2004 to December 31, 2004
Issuance of common stock under ESPP
Exercise of common stock options
|
2004-12-31 |
| 2004-02-27 | 6422.82 | 未披露 | 定期报告 | 2004-02-20 |
| 2004-02-27 | 6415.63 | 未披露 |
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from January 1, 2003 to December 31, 2003
Issuance of common stock under ESPP
Issuance of common stock to Acqua Wellington, net of issuance costs
Issuance of common stock in a public offering, net of issuance costs
Deferred compensation related to restricted common stock issuance
Exercise of common stock options
Issuance of restricted stock to non-employees
|
2003-12-31 |
| 2003-03-03 | 5386.44 | 未披露 | 定期报告 | 2003-02-20 |
| 2003-03-03 | 5378.24 | 未披露 |
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from January 1, 2002 to December 31, 2002
Issuance of common stock under ESPP on April 30 and October 31, 2002, $5.13 and $5.10 per share, respectively
Issuance of 885 shares of common stock to purchase Synapse on March 21, 2002, $11.50 per share, net of issuance costs
Issuance of 11,368 shares of common stock and stock options in GBL acquisition in August 2002
Retirement of 11,368 shares of common stock acquired from GBL in August 2002
Exercise of common stock options
|
2002-12-31 |
| 2002-04-01 | 5244.74 | 未披露 | 定期报告 | 2002-03-15 |
| 2002-04-01 | 5240.24 | 未披露 |
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from January 1, 2001 to December 31, 2001
Issuance of common stock under ESPP on April 30 and October 31, 2001 at $9.22 and $9.51 per share,respectively
Issuance of 1,345 shares of common stock to Acqua Wellington for cash in five transactions priced from $9.60 to $10.16 per share net of issuance costs
Issuance of 4,870 shares of common stock and warrants to purchase 753 shares of common stock on May 16 and 17, 2001 at $9.45 per share, net of issuance costs
Issuance of 814 shares of common stock on October 31, 2001 at $10.218 per shareto purchase certain therapeutic assets of IBEX
Issuance of 8,050 shares of common stock on December 13, 2001 in a public offering at $12 per share net of issuance costs
Exercise of common stock options
|
2001-12-31 |
| 2001-03-20 | 3711.56 | 未披露 | 定期报告 | 2001-03-09 |
| 2001-03-20 | 3692.20 | 未披露 |
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from December 31, 1999 to December 31, 2000
Issuance of common stock on April 30, 2000 pursuant to the Employee Stock Purchase Plan at $11.05 per share
Issuance of common stock on October 31, 2000 pursuant to the Employee Stock Purchase Plan at $11.05 per share
Exercise of common stock options
Exercise of common stock warrants
Common stock surrendered by stockholders for payment of principal and interest
|
2000-12-31 |
| 2000-03-30 | 3495.11 | 未披露 | 定期报告 | 2000-02-16 |
| 2000-03-30 | 3483.26 | 未披露 |
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from January 1, 1999 to December 31, 1999
Issuance of common stock on July 23, 1999, in an initial public offering (IPO) for cash at $13.00 per share (net of issuance costs of $6,690)
Issuance of common stock on July 23, 1999 to Genzyme Corporation in a private placement concurrent with the IPO for cash at $13.00 per share
Issuance of common stock on July 23, 1999 concurrent with the IPO upon conversion of promissory notes plus accrued interest of $720,200 at $10.00 per share (net of issuance costs of $1,150)
Issuance of common stock on August 3, 1999 and August 25, 1999 from the over-allotment exercise by underwriters at $13.00 per share (net of issuance costs of $633)
Exercise of common stock options
|
1999-12-31 |
From June 30, 2025 to September 30, 2025
Issuances under equity incentive plans
From March 31, 2025 to June 30, 2025
Issuances under equity incentive plans
From December 31,2024 to March 31,2025
Issuances under equity incentive plans
From December 31, 2023 to December 31, 2024
Issuances under equity incentive plans
From June 30, 2024 to September 30, 2024
Issuances under equity incentive plans
From March 31, 2024 to June 30, 2024
Issuances under equity incentive plans
From December 31, 2022 to December 31, 2023
Issuances under equity incentive plans
From June 30, 2023 to September 30, 2023
Issuances under equity incentive plans
From March 31,2023 to June 30,2023
Issuances under equity incentive plans
From December 31, 2022 to March 31, 2023
Issuances under equity incentive plans, net of tax
From December 31, 2021 to December 31, 2022
Issuances under equity incentive plans
Issuances under equity incentive plans, net of tax
From March 31, 2022 to June 30, 2022
Issuances under equity incentive plans
From March 31, 2021 to March 31, 2022
Issuances under equity incentive plans, net of tax
From December 31, 2020 to December 31, 2021
Issuances under equity incentive plans, net of tax
From June 30, 2021 to September 30, 2021
Issuances under equity incentive plans
Repurchase of common stock
From March 31, 2021 to June 30, 2021
Issuances under equity incentive plans
From December 31,2020 to March 31, 2021
Issuances under equity incentive plans
Common stock held by the NQDC
From December 31,2019 to December 31,2020
Issuances under equity incentive plans
Repurchase of common stock
Issuances under equity incentive plans, net of tax
Purchase of treasury stock
Retirement of treasury stock
from June 30,2020 to September 30,2020
Issuances under equity incentive plans
Common stock held by the NQDC
from March 31,2020 to June 30,2020
Issuances under equity incentive plans
Repurchase of common stock
Purchase of treasury stock
Retirement of treasury stock
From December 31, 2019 to March 31, 2020
Issuances under equity incentive plans
From December 31, 2018 to December 31, 2019
Issuances under equity incentive plans
from June 30, 2019 to September 30, 2019
Issuances under equity incentive plans
from December 31, 2018 to June 30, 2019
Issuances under equity incentive plans
from December 31, 2018 to March 31, 2019
Issuances under equity incentive plans
from December 31, 2017 to December 31, 2018
Issuances under equity incentive plans, net of tax
Conversion of convertible notes, net
From January 1, 2018 to September 30, 2018
Issuances under equity incentive plans, net of tax
Common stock held by the NQDC
From January 1, 2018 to June 30, 2018
Issuances under equity incentive plans, net of tax
Common stock held by the NQDC
from December 31, 2017 to March 31, 2018
Issuances under equity incentive plans, net of tax
Common stock held by the NQDC
From December 31, 2016 to December 31, 2017
Issuances under equity incentive plans, net of tax
Conversion of convertible notes, net
From December 31, 2016 to September 30, 2017
Issuances under equity incentive plans, net of tax
Issuances of common stock under the Employee Stock Purchase Plan (the ESPP)
Conversion of convertible notes, net
from December 31, 2016 to June 30, 2017
Issuances under equity incentive plans,net of tax
Issuances of common stock under the Employee Stock Purchase Plan (the ESPP)
Conversion of convertible notes, net
from December 31, 2016 to March 31, 2017
Issuances under equity incentive plans,net of tax
from December 31, 2015 to December 31, 2016
Issuance of common stock, net of offering costs
Issuance of common stock under ESPP
Issuances under equity incentive plans, net of tax
Conversion of convertible notes, net
From December 31, 2015 to September 30, 2016
Issuance of common stock, net of offering costs
Issuance of common stock under the 2006 Employee Stock Purchase Plan (the ESPP)
Exercise of common stock options
Restricted stock units vested during the period, net
Conversion of convertible notes, net
from December 31, 2015 to June 30, 2016
Issuance of common stock under the 2006 Employee Stock Purchase Plan (the ESPP)
Exercise of common stock options
Restricted stock units vested during the period, net
Conversion of convertible notes, netCommon stock held by Nonqualified Deferred Compensation Plan (the NQDC)
from December 31, 2015 to March 31, 2016
Exercise of common stock options
Restricted stock vested during the period, net
Conversion of convertible notes, net
from December 31, 2014 to December 31, 2015
Issuance of common stock, net of offering costs
Issuance of common stock under ESPP
Exercise of common stock options
Conversion of convertible notes, net
Restricted stock vested during the period, net
From December 31,2013 to December 31,2014
Issuance of common stock under ESPP
Issuance of common stock, net of offering costs
Exercise of common stock options
Conversion of convertible notes
Restricted stock vested during the period, net
From December 31,2012 to December 31,2013
Issuance of common stock under ESPP
Exercise of common stock options
Conversion of convertible notes
Restricted stock vested during the period, net
from December 31, 2011 to December 31, 2012
Issuance of common stock, net of offering costs
Issuance of common stock under ESPP
Exercise of common stock options
Conversion of convertible notes
Restricted stock vested during the period, net
Issuance of common stock under ESPP
Exercise of common stock options
Conversion of convertible notes
Restricted stock vested during the period
from December 31, 2008 to December 31, 2009
Issuance of common stock under ESPP
Exercise of common stock options
Restricted stock vested during the period
from December 31, 2007 to December 31, 2008
Issuance of common stock under ESPP
Exercise of common stock options
Restricted stock vested during the period
Conversion of convertible notes
from December 31, 2006 to December 31, 2007
Issuance of common stock under ESPP
Exercise of common stock options
Conversion of convertible notes
from January 1, 2006 to December 31, 2006
Issuance of common stock in a public offering, net of issuance costs
Issuance of common stock under ESPP
Exercise of common stock options
Conversion of convertible notes
from January 1, 2005 to December 31, 2005
Issuance of common stock in a public offering, net of issuance costs
Issuance of common stock under ESPP
Exercise of common stock options
from January 1, 2004 to December 31, 2004
Issuance of common stock under ESPP
Exercise of common stock options
from January 1, 2003 to December 31, 2003
Issuance of common stock under ESPP
Issuance of common stock to Acqua Wellington, net of issuance costs
Issuance of common stock in a public offering, net of issuance costs
Deferred compensation related to restricted common stock issuance
Exercise of common stock options
Issuance of restricted stock to non-employees
from January 1, 2002 to December 31, 2002
Issuance of common stock under ESPP on April 30 and October 31, 2002, $5.13 and $5.10 per share, respectively
Issuance of 885 shares of common stock to purchase Synapse on March 21, 2002, $11.50 per share, net of issuance costs
Issuance of 11,368 shares of common stock and stock options in GBL acquisition in August 2002
Retirement of 11,368 shares of common stock acquired from GBL in August 2002
Exercise of common stock options
from January 1, 2001 to December 31, 2001
Issuance of common stock under ESPP on April 30 and October 31, 2001 at $9.22 and $9.51 per share,respectively
Issuance of 1,345 shares of common stock to Acqua Wellington for cash in five transactions priced from $9.60 to $10.16 per share net of issuance costs
Issuance of 4,870 shares of common stock and warrants to purchase 753 shares of common stock on May 16 and 17, 2001 at $9.45 per share, net of issuance costs
Issuance of 814 shares of common stock on October 31, 2001 at $10.218 per shareto purchase certain therapeutic assets of IBEX
Issuance of 8,050 shares of common stock on December 13, 2001 in a public offering at $12 per share net of issuance costs
Exercise of common stock options
from December 31, 1999 to December 31, 2000
Issuance of common stock on April 30, 2000 pursuant to the Employee Stock Purchase Plan at $11.05 per share
Issuance of common stock on October 31, 2000 pursuant to the Employee Stock Purchase Plan at $11.05 per share
Exercise of common stock options
Exercise of common stock warrants
Common stock surrendered by stockholders for payment of principal and interest
from January 1, 1999 to December 31, 1999
Issuance of common stock on July 23, 1999, in an initial public offering (IPO) for cash at $13.00 per share (net of issuance costs of $6,690)
Issuance of common stock on July 23, 1999 to Genzyme Corporation in a private placement concurrent with the IPO for cash at $13.00 per share
Issuance of common stock on July 23, 1999 concurrent with the IPO upon conversion of promissory notes plus accrued interest of $720,200 at $10.00 per share (net of issuance costs of $1,150)
Issuance of common stock on August 3, 1999 and August 25, 1999 from the over-allotment exercise by underwriters at $13.00 per share (net of issuance costs of $633)
Exercise of common stock options