主要股东
注：以下部分股东代表特定权益共同体，直接或间接持有上市公司股份
| 序号 | 股东名称 | 是否机构 | 持股数(股) | 持股比例 | 持股变动数(股) | 持股数变动比例 | 投票权比例 |
|---|---|---|---|---|---|---|---|
| 1 | Janus Henderson Group plc | 是 | 329.21万 | 9.97% | 新增 | 新增 | -- |
| 2 | EVENTIDE ASSET MANAGEMENT, LLC | 是 | 220.76万 | 6.68% | 新增 | 新增 | -- |
| 3 | 贝莱德集团公司 | 是 | 196.56万 | 5.95% | 新增 | 新增 | -- |
| 4 | Rock Springs Capital Management LP | 是 | 191.57万 | 5.80% | 新增 | 新增 | -- |
| 5 | Frazier Healthcare VI,L.P. | 是 | 188.73万 | 5.71% | 新增 | 新增 | -- |
内部人交易
| 日期 | 股东名称 | 变动股数(万股) | 交易后持股数量(万股) | 交易价格 | 是否直接持有 | 内部人类型 |
|---|---|---|---|---|---|---|
| 2025-12-08 | Dreyer Scott |
|
12.12 | 15.90 | 是 | EVP & Chief Commercial Officer |
| 2025-12-08 | Dreyer Scott |
|
11.01 | 47.89 | 是 | EVP & Chief Commercial Officer |
| 2025-12-08 | Dreyer Scott |
|
10.36 | 48.66 | 是 | EVP & Chief Commercial Officer |
| 2025-12-05 | Balice-Gordon Rita J. |
|
5.26 | 47.03 | 是 | -- |
| 2025-11-12 | Fallon John A. |
|
9.95 | 9.33 | 是 | -- |
| 2025-11-12 | Fallon John A. |
|
7.96 | 16.49 | 是 | -- |
| 2025-11-12 | Fallon John A. |
|
6.46 | 47.21 | 是 | -- |
| 2025-11-12 | Karnani Vikram |
|
9.70 | 47.35 | 是 | President and CEO |
| 2025-11-06 | Tupper Colleen |
|
13.15 | 40.38 | 是 | EVP & Chief Financial Officer |
| 2025-11-06 | Tupper Colleen |
|
12.67 | 41.28 | 是 | EVP & Chief Financial Officer |
| 2025-08-29 | Smith Thomas B |
|
7.03 | 38.42 | 是 | EVP and Chief Medical Officer |
| 2025-08-18 | Dreyer Scott |
|
12.00 | 21.34 | 是 | EVP & Chief Commercial Officer |
| 2025-08-18 | Dreyer Scott |
|
10.36 | 38.21 | 是 | EVP & Chief Commercial Officer |
| 2025-08-15 | SANTINI GINO |
|
10.04 | 13.45 | 是 | -- |
| 2025-08-15 | SANTINI GINO |
|
9.50 | 37.19 | 是 | -- |
| 2025-08-13 | Dreyer Scott |
|
10.85 | 21.34 | 是 | EVP & Chief Commercial Officer |
| 2025-08-13 | Dreyer Scott |
|
10.36 | 38.03 | 是 | EVP & Chief Commercial Officer |
| 2025-06-09 | Freund John Gordon |
|
7.73 | 13.45 | 是 | -- |
| 2025-06-09 | Freund John Gordon |
|
7.07 | 30.62 | 是 | -- |
| 2025-05-15 | Paya Carlos V |
|
1.96 | 0.00 | 是 | -- |
| 2025-05-15 | SANTINI GINO |
|
8.54 | 0.00 | 是 | -- |
| 2025-05-15 | Freund John Gordon |
|
6.23 | 0.00 | 是 | -- |
| 2025-05-15 | BOHLIN GAREN G |
|
6.23 | 0.00 | 是 | -- |
| 2025-05-15 | Lurker Nancy |
|
2.25 | 0.00 | 是 | -- |
| 2025-05-15 | Balice-Gordon Rita J. |
|
5.63 | 0.00 | 是 | -- |
| 2025-05-15 | Fallon John A. |
|
6.46 | 0.00 | 是 | -- |
| 2025-03-20 | Dreyer Scott |
|
12.25 | 30.00 | 是 | EVP & Chief Commercial Officer |
| 2025-03-20 | Dreyer Scott |
|
10.36 | 30.03 | 是 | EVP & Chief Commercial Officer |
| 2025-03-20 | Tupper Colleen |
|
15.67 | 30.03 | 是 | EVP & Chief Financial Officer |
| 2025-03-20 | Tupper Colleen |
|
16.31 | 30.00 | 是 | EVP & Chief Financial Officer |
| 2025-03-17 | Dieter David |
|
6.84 | 0.00 | 是 | EVP & General Counsel |
| 2025-03-14 | Dreyer Scott |
|
12.44 | 30.00 | 是 | EVP & Chief Commercial Officer |
| 2025-03-14 | Tupper Colleen |
|
16.43 | 30.00 | 是 | EVP & Chief Financial Officer |
| 2025-03-11 | Tupper Colleen |
|
16.52 | 30.01 | 是 | EVP & Chief Financial Officer |
| 2025-03-11 | Dreyer Scott |
|
12.67 | 30.00 | 是 | EVP & Chief Commercial Officer |
| 2025-03-06 | Dreyer Scott |
|
14.44 | 30.00 | 是 | EVP & Chief Commercial Officer |
| 2025-03-06 | Dreyer Scott |
|
14.21 | 30.00 | 是 | EVP & Chief Commercial Officer |
| 2025-03-06 | Tupper Colleen |
|
17.72 | 30.00 | 是 | EVP & Chief Financial Officer |
| 2025-03-06 | Tupper Colleen |
|
17.57 | 30.00 | 是 | EVP & Chief Financial Officer |
| 2025-03-04 | Kuhlmann Shirley R. |
|
19.42 | 24.03 | 是 | EVP and General Counsel |
| 2025-03-04 | Kuhlmann Shirley R. |
|
15.42 | 28.08 | 是 | EVP and General Counsel |
| 2025-03-04 | Kuhlmann Shirley R. |
|
13.42 | 28.03 | 是 | EVP and General Counsel |
| 2025-03-04 | Kuhlmann Shirley R. |
|
10.81 | 28.50 | 是 | EVP and General Counsel |
| 2025-02-10 | Heffernan Michael Thomas |
|
5.03 | 0.00 | 是 | -- |
| 2025-02-10 | Smith Thomas B |
|
8.83 | 0.00 | 是 | EVP and Chief Medical Officer |
| 2025-02-10 | Smith Thomas B |
|
9.36 | 0.00 | 是 | EVP and Chief Medical Officer |
| 2025-02-10 | Smith Thomas B |
|
9.21 | 30.52 | 是 | EVP and Chief Medical Officer |
| 2025-02-10 | Smith Thomas B |
|
8.77 | 30.52 | 是 | EVP and Chief Medical Officer |
| 2025-02-10 | Kuhlmann Shirley R. |
|
16.01 | 0.00 | 是 | EVP and General Counsel |
| 2025-02-10 | Kuhlmann Shirley R. |
|
18.92 | 0.00 | 是 | EVP and General Counsel |
| 2025-02-10 | Kuhlmann Shirley R. |
|
17.94 | 30.52 | 是 | EVP and General Counsel |
| 2025-02-10 | Kuhlmann Shirley R. |
|
15.42 | 30.52 | 是 | EVP and General Counsel |
| 2025-02-10 | Tupper Colleen |
|
18.26 | 0.00 | 是 | EVP & Chief Financial Officer |
| 2025-02-10 | Tupper Colleen |
|
20.96 | 0.00 | 是 | EVP & Chief Financial Officer |
| 2025-02-10 | Tupper Colleen |
|
20.15 | 30.52 | 是 | EVP & Chief Financial Officer |
| 2025-02-10 | Tupper Colleen |
|
17.91 | 30.52 | 是 | EVP & Chief Financial Officer |
| 2025-02-04 | Lurker Nancy |
|
1.27 | 0.00 | 是 | -- |
| 2025-01-10 | Kuhlmann Shirley R. |
|
14.67 | 21.34 | 是 | EVP and General Counsel |
| 2025-01-10 | Kuhlmann Shirley R. |
|
12.53 | 32.87 | 是 | EVP and General Counsel |
| 2025-01-10 | Kuhlmann Shirley R. |
|
11.92 | 33.64 | 是 | EVP and General Counsel |
| 2024-11-12 | Karnani Vikram |
|
10.60 | 0.00 | 是 | President and CEO |
| 2024-09-13 | Smith Thomas B |
|
5.38 | 36.62 | 是 | EVP and Chief Medical Officer |
| 2024-09-05 | Kuhlmann Shirley R. |
|
12.26 | 38.18 | 是 | EVP and General Counsel |
| 2024-09-05 | Kuhlmann Shirley R. |
|
12.02 | 39.14 | 是 | EVP and General Counsel |
| 2024-09-05 | Kuhlmann Shirley R. |
|
11.92 | 37.46 | 是 | EVP and General Counsel |
| 2024-06-03 | Kuhlmann Shirley R. |
|
14.01 | 32.55 | 是 | EVP and General Counsel |
| 2024-06-03 | Kuhlmann Shirley R. |
|
13.94 | 33.22 | 是 | EVP and General Counsel |
| 2024-05-28 | Tupper Colleen |
|
13.08 | 34.21 | 是 | EVP & Chief Financial Officer |
| 2024-05-23 | Dreyer Scott |
|
19.01 | 24.03 | 是 | EVP & Chief Commercial Officer |
| 2024-05-23 | Dreyer Scott |
|
13.89 | 33.82 | 是 | EVP & Chief Commercial Officer |
| 2024-05-23 | Dreyer Scott |
|
16.27 | 24.03 | 是 | EVP & Chief Commercial Officer |
| 2024-05-23 | Dreyer Scott |
|
10.59 | 33.98 | 是 | EVP & Chief Commercial Officer |
| 2024-05-16 | Heffernan Michael Thomas |
|
4.55 | 0.00 | 是 | -- |
| 2024-05-16 | Freund John Gordon |
|
5.25 | 0.00 | 是 | -- |
| 2024-05-16 | Fallon John A. |
|
5.48 | 0.00 | 是 | -- |
| 2024-05-16 | McFarlane Neil F. |
|
4.94 | 0.00 | 是 | -- |
| 2024-05-16 | Balice-Gordon Rita J. |
|
4.65 | 0.00 | 是 | -- |
| 2024-05-16 | SANTINI GINO |
|
7.57 | 0.00 | 是 | -- |
| 2024-05-16 | Melincoff Gwen A |
|
5.25 | 0.00 | 是 | -- |
| 2024-05-14 | BOHLIN GAREN G |
|
7.38 | 5.73 | 是 | -- |
| 2024-05-14 | BOHLIN GAREN G |
|
4.48 | 32.30 | 是 | -- |
| 2024-05-14 | BOHLIN GAREN G |
|
5.25 | 0.00 | 是 | -- |
| 2024-02-29 | Smith Thomas B |
|
6.34 | 36.76 | 是 | EVP and Chief Medical Officer |
| 2024-02-26 | Dreyer Scott |
|
13.89 | 37.15 | 是 | EVP & Chief Commercial Officer |
| 2024-02-26 | Dreyer Scott |
|
13.96 | 36.38 | 是 | EVP & Chief Commercial Officer |
| 2024-02-12 | Smith Thomas B |
|
6.57 | 33.70 | 是 | EVP and Chief Medical Officer |
| 2024-02-12 | Smith Thomas B |
|
6.44 | 33.70 | 是 | EVP and Chief Medical Officer |
| 2024-02-12 | Dreyer Scott |
|
14.63 | 0.00 | 是 | EVP & Chief Commercial Officer |
| 2024-02-12 | Ciaffoni Joseph |
|
39.40 | 0.00 | 是 | President and CEO |
| 2024-02-12 | Ciaffoni Joseph |
|
57.37 | 0.00 | 是 | President and CEO |
| 2024-02-12 | Ciaffoni Joseph |
|
52.63 | 33.70 | 是 | President and CEO |
| 2024-02-12 | Dreyer Scott |
|
17.86 | 0.00 | 是 | EVP & Chief Commercial Officer |
| 2024-02-12 | Dreyer Scott |
|
15.91 | 33.70 | 是 | EVP & Chief Commercial Officer |
| 2024-02-12 | Dreyer Scott |
|
14.89 | 33.70 | 是 | EVP & Chief Commercial Officer |
| 2024-02-12 | Ciaffoni Joseph |
|
44.49 | 33.70 | 是 | President and CEO |
| 2024-02-12 | Kuhlmann Shirley R. |
|
16.29 | 0.00 | 是 | EVP and General Counsel |
| 2024-02-12 | Kuhlmann Shirley R. |
|
19.62 | 0.00 | 是 | EVP and General Counsel |
| 2024-02-12 | Kuhlmann Shirley R. |
|
17.50 | 33.70 | 是 | EVP and General Counsel |
| 2024-02-12 | Kuhlmann Shirley R. |
|
16.44 | 33.70 | 是 | EVP and General Counsel |
| 2024-02-12 | Smith Thomas B |
|
6.30 | 0.00 | 是 | EVP and Chief Medical Officer |
| 2024-02-12 | Smith Thomas B |
|
6.76 | 0.00 | 是 | EVP and Chief Medical Officer |
| 2024-02-12 | Tupper Colleen |
|
14.60 | 0.00 | 是 | EVP & Chief Financial Officer |
| 2024-02-12 | Tupper Colleen |
|
17.69 | 0.00 | 是 | EVP & Chief Financial Officer |
| 2024-02-12 | Tupper Colleen |
|
16.00 | 33.70 | 是 | EVP & Chief Financial Officer |
| 2024-02-12 | Tupper Colleen |
|
15.06 | 33.70 | 是 | EVP & Chief Financial Officer |
| 2024-01-16 | Dreyer Scott |
|
11.13 | 32.28 | 是 | EVP & Chief Commercial Officer |