股本结构

单位:万股
公告日期 2025-11-06 2025-11-06 2025-08-11 2025-07-02 2025-08-05 2025-05-06
证券总股本 1292.89 1273.39 1249.89 1200.07 1070.84 1046.23
普通股本 1292.89 1273.39 1249.89 1200.07 1070.84 1046.23
优先股 未披露 未披露 未披露 未披露 未披露 未披露
其他 未披露 未披露 未披露 未披露 未披露 未披露
变动日期 2025-11-04 2025-09-30 2025-07-25 2025-07-03 2025-06-30 2025-03-31
注释:中概股证券总股本=普通股股本/ 存托凭证比例

历史变动

公告日期 变动后普通股本(万股) 变动后优先股(万股) 变动原因 变动日期
2025-11-06 1292.89 未披露 定期报告 2025-11-04
2025-11-06 1273.39 未披露
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From June 30, 2025 to September 30, 2025 Issuance of common stock in connection with July 2025 Offerings, net of issuance costs Exercise of prefunded warrants
2025-09-30
2025-08-11 1249.89 未披露 定期报告 2025-07-25
2025-07-02 1200.07 未披露
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Common stock offered by the company 1,538,460 shares of common stock.
2025-07-03
2025-08-05 1070.84 未披露
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From March 31, 2025 to June 30, 2025 Issuance of common stock under employee benefit plans, net of shares received to settle minimum tax obligation for vesting of restricted stock awards Cancellation of restricted stock awards Exercise of pre-funded warrants
2025-06-30
2025-05-06 1046.23 未披露
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From December 31, 2024 to March 31, 2025 Issuance of common stock in connection with March 2025 Offerings, net of issuance costs
2025-03-31
2025-03-31 848.78 未披露
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From December 31, 2023 to December 31, 2024 Issuance of common stock in connection with October 2024 Financings, net of issuance costs Issuance of shares in connection with 2024 Sales Agreement, net of issuance costs Issuance of common stock under employee benefit plans, net of shares received to settle minimum tax obligation for vesting of restricted stock awards Cancellation of restricted stock awards
2024-12-31
2024-11-14 846.70 未披露 定期报告 2024-11-11
2024-10-30 837.74 未披露
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Common stock offered 2,398,414 shares by the company
2024-10-30
2024-11-14 602.03 未披露
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From June 30, 2024 to September 30, 2024 Cancellation of restricted stock awards Issuance of shares in connection with 2024 Sales Agreement, net of issuance costs
2024-09-30
2024-08-01 597.89 未披露 定期报告 2024-07-25
2024-08-01 590.43 未披露
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From March 31, 2024 to June 30, 2024 Issuance of common stock under employee benefit plans, net of shares received to settle minimum tax obligation for vesting of restricted stock awards Issuance of shares in connection with 2024 Sales Agreement, net of fees of $0.1 million for issuance of shares
2024-06-30
2024-02-08 589.41 未披露
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From December 31, 2022 to December 31,2023 Issuance of common stock in connection with July Registered Direct, net of fees of $1.3 million Issuance of common stock under employee benefit plans, including restricted stock awards Cancellation of restricted stock awards
2023-12-31
2023-12-21 589.41 未披露 定期报告 2023-12-18
2023-11-02 588.31 未披露 定期报告 2023-10-26
2023-11-02 588.53 未披露
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From June 30, 2023 to September 30, 2023 Issuance of shares in connection with July Registered Direct, net of fees of $1.3 million for issuance of shares Cancellation of restricted stock awards
2023-09-30
2023-09-28 588.52 未披露
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On September 26, 2023, Curis, Inc. approved a 1-for-20 reverse stock split of the issued and outstanding shares of Common Stock.
2023-09-29
2023-08-03 11770.46 未披露 定期报告 2023-07-27
2023-07-06 11775.46 未披露
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Common Stock offered by the company 18,409,756 shares
2023-07-10
2023-08-03 9934.48 未披露
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From March 31, 2023 to June 30, 2023 Issuance of common stock under employee benefit plans, including restricted stock awards
2023-06-30
2023-03-13 9661.79 未披露
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From December 31, 2022 to March 2, 2023 Issuance of common stock under employee benefit plans
2023-03-02
2023-03-13 9660.76 未披露
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From December 31, 2021 to December 31, 2022 Issuances of common stock under stock-based compensation plans Issuance of shares in connection with 2021 Sales Agreement, net of fees of $0.7 million for issuance of shares
2022-12-31
2022-11-09 9639.84 未披露
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From June 30, 2022 to September 30, 2022 Issuance of shares in connection with 2021 Sales Agreement, net of fees of $0.7 million for issuance of shares
2022-09-30
2022-08-04 9181.47 未披露
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From March 31, 2022 to June 30, 2022 Issuance of stock under Employee Stock Purchase Plan
2022-06-30
2022-02-24 9164.54 未披露
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From December 31, 2020 to December 31, 2021 Issuances of common stock for purchases under the ESPP Exercise of stock options
2021-12-31
2021-11-09 9160.92 未披露
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From June 30, 2021 to September 30, 2021 Exercise of stock options
2021-09-30
2021-08-03 9159.64 未披露
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From March 31, 2021 to June 30, 2021 Issuance of stock under Employee Stock Purchase Plan Exercise of stock options
2021-06-30
2021-05-12 9153.53 未披露 定期报告 2021-05-10
2021-05-12 9153.43 未披露
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From December 31, 2020 to March 31, 2021 Exercise of stock options
2021-03-31
2021-04-14 9151.91 未披露 定期报告 2021-03-29
2021-03-16 9150.75 未披露 定期报告 2021-03-12
2021-03-16 9150.25 未披露
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From December 31, 2019 to December 31, 2020 Issuances of common stock upon the exercise of stock options and for purchases under the ESPP Issuance of stock in connection with Aspire Capital Agreement, net of issuance costs Issuance of shares in connection with Capital on Demand Sales Agreement, net of issuance costs Issuance of stock under registered direct offering, net of issuance costs Issuance of common stock under registration statement, net of issuance costs Exercise of stock options
2020-12-31
2020-12-11 8230.51 未披露
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1.Common stock offered by the company 25,652,174 shares. 2.The number of shares of common stock that will be outstanding immediately after this offering as shown above is based on 56,652,885 shares outstanding as of September 30, 2020.
2020-12-11
2020-11-10 5881.74 未披露 定期报告 2020-11-03
2020-11-10 5665.29 未披露
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From June 30, 2020 to September 30, 2020 Issuance of shares in connection with Aspire Capital Agreement Issuance of shares in connection with Capital on Demand Sales Agreement
2020-09-30
2020-08-04 5386.79 未披露 定期报告 2020-07-28
2020-08-04 5063.90 未披露
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From March 31, 2020 to June 30, 2020 Issuance of stock under Employee Stock Purchase Plan Exercise of stock options
2020-06-30
2020-06-15 5058.23 未披露
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1.Common stock offered by us 14,000,000 shares of common stock. 2.The number of shares of our common stock that will be outstanding immediately after this offering as shown above is based on 36,582,309 shares outstanding as of March 31, 2020
2020-06-15
2020-04-22 3658.23 未披露 定期报告 2020-04-06
2020-05-12 3658.23 未披露
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From December 31, 2019 to March 12, 2020 Issuance of shares in connection with Aspire Capital agreement
2020-03-12
2020-03-19 3324.18 未披露
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from December 31, 2018 to December 31, 2019 Issuances of common stock upon the exercise of stock options and for purchases under the ESPP Cancellation of restricted stock awards
2019-12-31
2019-08-09 3320.29 未披露
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From March 31, 2019 to June 30, 2019 Issuance of stock under the Employee Stock Purchase Plan
2019-06-30
2019-05-14 3315.08 未披露
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from December 31, 2018 to March 25, 2019 Issuance of common stock, net
2019-03-25
2019-04-11 3315.08 未披露 定期报告 2019-01-31
2019-03-26 3315.93 未披露
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from December 31, 2017 to December 31, 2018 Issuance of stock under grant of restricted stock awards Issuances of common stock upon the exercise of stock options and for purchases under the ESPP Cancellation of restricted stock awards Retirement of Treasury Stock
2018-12-31
2018-11-01 3311.31 未披露 定期报告 2018-09-30
2018-08-02 3318.11 未披露 定期报告 2018-06-30
2018-05-22 3312.57 未披露
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Curis, Inc. (NASDAQ:CRIS) announced that its Board of Directors approved a 1-for-5 reverse split of Curis's common stock that is expected to take effect on Tuesday, May 29, 2018 after the close of trading.
2018-05-30
2018-03-08 16562.84 未披露 定期报告 2018-03-02
2018-03-08 16415.71 未披露
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From December 31, 2016 to December 31, 2017 Issuances of common pursuant to sales of shares in the Company’s public offering, net of $0.3 million of issuance costs Issuances of common pursuant to sales of shares from the Company’s ATM, net of $0.2 million of commissions Issuances of common stock upon the exercise of stock options and for purchases under the ESPP Exercise of stock options settled in shares
2017-12-31
2017-11-07 16398.38 未披露 定期报告 2017-09-30
2017-08-03 14387.90 未披露 定期报告 2017-06-30
2017-05-04 14377.27 未披露 定期报告 2017-04-26
2017-05-04 14367.72 未披露 定期报告 2017-03-31
2017-04-04 14319.56 未披露 定期报告 2017-03-20
2017-03-09 14188.87 未披露 定期报告 2017-03-02
2017-03-09 14112.40 未披露
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From December 31, 2015 to December 31, 2016 Issuance of common stock in consideration for rights granted under the Aurigene collaboration agreement Issuances of common stock upon the exercise of stock options, and for purchases under the ESPP
2016-12-31
2016-11-03 14054.90 未披露 定期报告 2016-10-31
2016-11-03 13999.44 未披露 定期报告 2016-09-30
2016-08-04 12947.20 未披露 定期报告 2016-07-29
2016-08-04 12946.22 未披露 定期报告 2016-06-30
2016-05-09 12918.14 未披露 定期报告 2016-05-02
2016-04-05 12903.85 未披露 定期报告 2016-03-21
2016-02-29 12902.20 未披露 定期报告 2016-02-25
2016-04-05 12900.33 未披露 定期报告 2016-01-31
2016-02-29 12899.04 未披露
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From December 31, 2014 to December 31, 2015 Issuances of common pursuant to sales of shares in the Company’s public offering , net of $4,380,590 in issuance costs Issuance of common stock in consideration for rights granted under the Aurigene collaboration agreement Issuances of common stock upon the exercise of stock options, for purchases under the ESPP
2015-12-31
2015-11-09 12839.47 未披露 定期报告 2015-09-30
2015-08-06 12961.38 未披露 定期报告 2015-08-02
2015-08-06 12839.09 未披露 定期报告 2015-06-30
2015-05-07 12833.97 未披露 定期报告 2015-05-03
2015-05-07 12833.77 未披露 定期报告 2015-03-31
2015-04-15 12833.57 未披露 定期报告 2015-03-30
2015-02-24 10317.85 未披露 定期报告 2015-02-18
2015-02-24 8603.08 未披露
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From December 31, 2013 to December 31, 2014 Issuances of common stock upon the exercise of stock options and for purchases under the ESPP
2014-12-31
2014-08-07 8600.49 未披露 定期报告 2014-06-30
2014-03-13 8594.81 未披露 定期报告 2014-03-06
2014-03-13 8585.90 未披露
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From December 31,2012 to December 31,2013 Issuances of common stock upon the exercise of stock options, for purchases under the ESPP, and pursuant to sales of shares under the Company’s ATM agreement, net of $641,052 in ATM issuance costs Repurchase of Company common stock
2013-12-31
2013-11-12 8579.80 未披露 定期报告 2013-11-04
2013-11-12 8413.02 未披露 定期报告 2013-09-30
2013-08-08 8169.49 未披露 定期报告 2013-08-01
2013-07-03 8168.39 未披露 定期报告 2013-06-27
2013-05-09 8053.83 未披露 定期报告 2013-05-01
2013-05-09 8015.41 未披露 定期报告 2013-03-31
2013-03-13 8012.20 未披露 定期报告 2013-03-06
2013-03-13 8001.78 未披露
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from December 31, 2011 to December 31, 2012 Issuances of common stock upon the exercise of warrants and stock options, for purchases under the ESPP, and pursuant to sales of shares under the Company’s ATM agreement , net of $27,356 in ATM issuance costs and including fair value of warrants exercised of $615,859 Issuance of common stock to licensors
2012-12-31
2012-11-06 7996.09 未披露 定期报告 2012-10-30
2012-11-06 7995.07 未披露 定期报告 2012-09-30
2012-08-09 7962.26 未披露 定期报告 2012-08-02
2012-08-09 7953.39 未披露 定期报告 2012-06-30
2012-05-10 7901.33 未披露 定期报告 2012-05-02
2012-05-10 7868.07 未披露 定期报告 2012-03-31
2012-02-29 7751.24 未披露 定期报告 2012-02-24
2012-02-29 7711.77 未披露
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from December 31, 2010 to December 31, 2011 Issuances of common stock upon the exercise of warrants and stock options, for purchases under the ESPP, and pursuant to sales of shares under the Company’s ATM agreement , net of $128,155 in ATM issuance costs
2011-12-31
2011-10-31 7658.04 未披露 定期报告 2011-10-27
2011-10-31 7657.57 未披露 定期报告 2011-09-30
2011-08-04 7654.56 未披露 定期报告 2011-07-27
2011-08-04 7648.01 未披露 定期报告 2011-06-30
2011-04-28 7635.00 未披露 定期报告 2011-03-31
2011-03-08 7576.62 未披露 定期报告 2011-03-03
2011-03-08 7575.62 未披露
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Issuance of common stock in conjunction with the registered direct offering, net of issuance costs of $1,310,000 and net of fair value of warrants of $2,180,555 Issuances of common stock upon the exercise of warrants Other issuances of common stock
2010-12-31
2010-10-28 7563.87 未披露 定期报告 2010-09-30
2010-08-03 7562.18 未披露 定期报告 2010-06-30
2010-05-06 7561.77 未披露 定期报告 2010-05-03
2010-05-06 7560.02 未披露 定期报告 2010-03-31
2010-03-03 7555.93 未披露 定期报告 2010-02-26
2010-03-03 6731.24 未披露
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from December 31, 2008 to December 31, 2009 Issuances of common stock upon the exercise of warrants Other issuances of common stock
2009-12-31
2009-02-26 6365.37 未披露
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from December 31, 2007 to December 31, 2008 Issuances of common stock
2008-12-31
2008-03-14 6324.11 未披露
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from December 31, 2006 to December 31, 2007 Issuance of common stock and warrants, net of issuance costs of $78,000 Other issuances of common stock Issuance of stock to non-employees for services
2007-12-31
2007-03-02 4937.35 未披露 定期报告 2007-02-28
2007-03-02 4933.39 未披露
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from December 31, 2005 to December 31, 2006 Issuance of common stock in connection with conversion of note payable to Becton Dickinson Other issuances of common stock
2006-12-31
2006-03-31 4899.63 未披露 定期报告 2006-03-22
2006-03-31 4832.66 未披露
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from December 31, 2004 to December 31, 2005 Issuance of common stock in connection with conversion of note payable to Elan Pharma International, Limited Other issuances of common stock
2005-12-31
2005-03-15 4788.01 未披露 定期报告 2005-03-08
2005-03-15 4751.74 未披露
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from December 31, 2003 to December 31, 2004 Issuance of common stock and warrants, net of issuance costs of $1,262,000 Issuance of common stock to collaborator Other issuances of common stock
2004-12-31
2004-03-01 4135.91 未披露 定期报告 2004-02-23
2004-03-01 4056.10 未披露
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from December 31, 2002 to December 31, 2003 Issuance of common stock in connection with the cancellation of Series A preferred stock and forgiveness of debt Issuance of common stock and warrants, net of issuance costs of $1,107,000 Issuance of common stock under technology license agreement Issuance of common stock to collaborator Other issuances of common stock Purchase of treasury stock
2003-12-31
2003-03-14 3172.08 未披露 定期报告 2003-02-28
2003-03-14 3174.63 0.10
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from December 31, 2001 to December 31, 2002 Issuance of restricted common stock for services Other issuances of common stock Purchase of treasury stock
2002-12-31
2002-03-29 3232.92 0.20
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from December 31, 2000 to December 31, 2001 Issuance of common stock, net of issuance costs of approximately $147,000 Other issuances of common stock Issuance of common stock for license fee Issuance of common stock as repayment of note payable
2001-12-31
2001-03-30 3142.02 未披露 定期报告 2001-03-19
2001-03-30 3138.36 未披露
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from December 31, 1999 to December 31, 2000 Issuance of 5.2 million shares of common stock, net of issuance costs of approximately $3.5 million Issuance of common stock related to the acquisitions of Ontogeny and Reprogenesis Warrant exercises into common stock Other issuances of common stock Exercise of common stock options through issuance of notes receivable
2000-12-31
From June 30, 2025 to September 30, 2025 Issuance of common stock in connection with July 2025 Offerings, net of issuance costs Exercise of prefunded warrants
Common stock offered by the company 1,538,460 shares of common stock.
From March 31, 2025 to June 30, 2025 Issuance of common stock under employee benefit plans, net of shares received to settle minimum tax obligation for vesting of restricted stock awards Cancellation of restricted stock awards Exercise of pre-funded warrants
From December 31, 2024 to March 31, 2025 Issuance of common stock in connection with March 2025 Offerings, net of issuance costs
From December 31, 2023 to December 31, 2024 Issuance of common stock in connection with October 2024 Financings, net of issuance costs Issuance of shares in connection with 2024 Sales Agreement, net of issuance costs Issuance of common stock under employee benefit plans, net of shares received to settle minimum tax obligation for vesting of restricted stock awards Cancellation of restricted stock awards
Common stock offered 2,398,414 shares by the company
From June 30, 2024 to September 30, 2024 Cancellation of restricted stock awards Issuance of shares in connection with 2024 Sales Agreement, net of issuance costs
From March 31, 2024 to June 30, 2024 Issuance of common stock under employee benefit plans, net of shares received to settle minimum tax obligation for vesting of restricted stock awards Issuance of shares in connection with 2024 Sales Agreement, net of fees of $0.1 million for issuance of shares
From December 31, 2022 to December 31,2023 Issuance of common stock in connection with July Registered Direct, net of fees of $1.3 million Issuance of common stock under employee benefit plans, including restricted stock awards Cancellation of restricted stock awards
From June 30, 2023 to September 30, 2023 Issuance of shares in connection with July Registered Direct, net of fees of $1.3 million for issuance of shares Cancellation of restricted stock awards
On September 26, 2023, Curis, Inc. approved a 1-for-20 reverse stock split of the issued and outstanding shares of Common Stock.
Common Stock offered by the company 18,409,756 shares
From March 31, 2023 to June 30, 2023 Issuance of common stock under employee benefit plans, including restricted stock awards
From December 31, 2022 to March 2, 2023 Issuance of common stock under employee benefit plans
From December 31, 2021 to December 31, 2022 Issuances of common stock under stock-based compensation plans Issuance of shares in connection with 2021 Sales Agreement, net of fees of $0.7 million for issuance of shares
From June 30, 2022 to September 30, 2022 Issuance of shares in connection with 2021 Sales Agreement, net of fees of $0.7 million for issuance of shares
From March 31, 2022 to June 30, 2022 Issuance of stock under Employee Stock Purchase Plan
From December 31, 2020 to December 31, 2021 Issuances of common stock for purchases under the ESPP Exercise of stock options
From June 30, 2021 to September 30, 2021 Exercise of stock options
From March 31, 2021 to June 30, 2021 Issuance of stock under Employee Stock Purchase Plan Exercise of stock options
From December 31, 2020 to March 31, 2021 Exercise of stock options
From December 31, 2019 to December 31, 2020 Issuances of common stock upon the exercise of stock options and for purchases under the ESPP Issuance of stock in connection with Aspire Capital Agreement, net of issuance costs Issuance of shares in connection with Capital on Demand Sales Agreement, net of issuance costs Issuance of stock under registered direct offering, net of issuance costs Issuance of common stock under registration statement, net of issuance costs Exercise of stock options
1.Common stock offered by the company 25,652,174 shares. 2.The number of shares of common stock that will be outstanding immediately after this offering as shown above is based on 56,652,885 shares outstanding as of September 30, 2020.
From June 30, 2020 to September 30, 2020 Issuance of shares in connection with Aspire Capital Agreement Issuance of shares in connection with Capital on Demand Sales Agreement
From March 31, 2020 to June 30, 2020 Issuance of stock under Employee Stock Purchase Plan Exercise of stock options
1.Common stock offered by us 14,000,000 shares of common stock. 2.The number of shares of our common stock that will be outstanding immediately after this offering as shown above is based on 36,582,309 shares outstanding as of March 31, 2020
From December 31, 2019 to March 12, 2020 Issuance of shares in connection with Aspire Capital agreement
from December 31, 2018 to December 31, 2019 Issuances of common stock upon the exercise of stock options and for purchases under the ESPP Cancellation of restricted stock awards
From March 31, 2019 to June 30, 2019 Issuance of stock under the Employee Stock Purchase Plan
from December 31, 2018 to March 25, 2019 Issuance of common stock, net
from December 31, 2017 to December 31, 2018 Issuance of stock under grant of restricted stock awards Issuances of common stock upon the exercise of stock options and for purchases under the ESPP Cancellation of restricted stock awards Retirement of Treasury Stock
Curis, Inc. (NASDAQ:CRIS) announced that its Board of Directors approved a 1-for-5 reverse split of Curis's common stock that is expected to take effect on Tuesday, May 29, 2018 after the close of trading.
From December 31, 2016 to December 31, 2017 Issuances of common pursuant to sales of shares in the Company’s public offering, net of $0.3 million of issuance costs Issuances of common pursuant to sales of shares from the Company’s ATM, net of $0.2 million of commissions Issuances of common stock upon the exercise of stock options and for purchases under the ESPP Exercise of stock options settled in shares
From December 31, 2015 to December 31, 2016 Issuance of common stock in consideration for rights granted under the Aurigene collaboration agreement Issuances of common stock upon the exercise of stock options, and for purchases under the ESPP
From December 31, 2014 to December 31, 2015 Issuances of common pursuant to sales of shares in the Company’s public offering , net of $4,380,590 in issuance costs Issuance of common stock in consideration for rights granted under the Aurigene collaboration agreement Issuances of common stock upon the exercise of stock options, for purchases under the ESPP
From December 31, 2013 to December 31, 2014 Issuances of common stock upon the exercise of stock options and for purchases under the ESPP
From December 31,2012 to December 31,2013 Issuances of common stock upon the exercise of stock options, for purchases under the ESPP, and pursuant to sales of shares under the Company’s ATM agreement, net of $641,052 in ATM issuance costs Repurchase of Company common stock
from December 31, 2011 to December 31, 2012 Issuances of common stock upon the exercise of warrants and stock options, for purchases under the ESPP, and pursuant to sales of shares under the Company’s ATM agreement , net of $27,356 in ATM issuance costs and including fair value of warrants exercised of $615,859 Issuance of common stock to licensors
from December 31, 2010 to December 31, 2011 Issuances of common stock upon the exercise of warrants and stock options, for purchases under the ESPP, and pursuant to sales of shares under the Company’s ATM agreement , net of $128,155 in ATM issuance costs
Issuance of common stock in conjunction with the registered direct offering, net of issuance costs of $1,310,000 and net of fair value of warrants of $2,180,555 Issuances of common stock upon the exercise of warrants Other issuances of common stock
from December 31, 2008 to December 31, 2009 Issuances of common stock upon the exercise of warrants Other issuances of common stock
from December 31, 2007 to December 31, 2008 Issuances of common stock
from December 31, 2006 to December 31, 2007 Issuance of common stock and warrants, net of issuance costs of $78,000 Other issuances of common stock Issuance of stock to non-employees for services
from December 31, 2005 to December 31, 2006 Issuance of common stock in connection with conversion of note payable to Becton Dickinson Other issuances of common stock
from December 31, 2004 to December 31, 2005 Issuance of common stock in connection with conversion of note payable to Elan Pharma International, Limited Other issuances of common stock
from December 31, 2003 to December 31, 2004 Issuance of common stock and warrants, net of issuance costs of $1,262,000 Issuance of common stock to collaborator Other issuances of common stock
from December 31, 2002 to December 31, 2003 Issuance of common stock in connection with the cancellation of Series A preferred stock and forgiveness of debt Issuance of common stock and warrants, net of issuance costs of $1,107,000 Issuance of common stock under technology license agreement Issuance of common stock to collaborator Other issuances of common stock Purchase of treasury stock
from December 31, 2001 to December 31, 2002 Issuance of restricted common stock for services Other issuances of common stock Purchase of treasury stock
from December 31, 2000 to December 31, 2001 Issuance of common stock, net of issuance costs of approximately $147,000 Other issuances of common stock Issuance of common stock for license fee Issuance of common stock as repayment of note payable
from December 31, 1999 to December 31, 2000 Issuance of 5.2 million shares of common stock, net of issuance costs of approximately $3.5 million Issuance of common stock related to the acquisitions of Ontogeny and Reprogenesis Warrant exercises into common stock Other issuances of common stock Exercise of common stock options through issuance of notes receivable