股本结构

单位:万股
公告日期 2025-11-06 2025-11-06 2025-08-07 2025-08-07 2025-05-12 2025-05-12
证券总股本 16943.54 16506.96 16491.29 16491.11 15754.44 8062.13
普通股本 16943.54 16506.96 16491.29 16491.11 15754.44 8062.13
优先股 未披露 未披露 未披露 未披露 未披露 未披露
其他 未披露 未披露 未披露 未披露 未披露 未披露
变动日期 2025-10-31 2025-09-30 2025-07-31 2025-06-30 2025-05-13 2025-03-31
注释:中概股证券总股本=普通股股本/ 存托凭证比例

历史变动

公告日期 变动后普通股本(万股) 变动后优先股(万股) 变动原因 变动日期
2025-11-06 16943.54 未披露 定期报告 2025-10-31
2025-11-06 16506.96 未披露
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From June 30, 2025 to September 30, 2025 Exercise of stock options
2025-09-30
2025-08-07 16491.29 未披露 定期报告 2025-07-31
2025-08-07 16491.11 未披露
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From March 31, 2025 to June 30, 2025 Exercise of stock options and release of RSUs Issuance of common stock under the ESPP Issuance of common stock in follow-on offering, net of issuance cost Exercise of pre-funded warrants
2025-06-30
2025-05-12 15754.44 未披露
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Common Stock offered 76,923,076 shares by the company
2025-05-13
2025-05-12 8062.13 未披露
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From December 31, 2024 to March 31, 2025 Exercise of stock options and release of RSUs
2025-03-31
2025-03-06 8009.99 未披露
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From December 31, 2023 to December 31, 2024 Exercise of stock options and release of RSUs Issuance of common stock under the Open Market Sale Agreement, net of issuance cost Exercise of pre-funded warrants Issuance of common stock under the Employee Stock Purchase Plan
2024-12-31
2024-11-07 7825.89 未披露 定期报告 2024-10-31
2024-11-07 7823.26 未披露
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From June 30, 2024 to September 30, 2024 Release of RSUs
2024-09-30
2024-08-08 7811.76 未披露
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From March 31, 2024 to June 30, 2024 Exercise of stock options and release of RSUs Issuance of common stock under the ESPP Issuance of common stock under the Open Market Sale Agreement, net of issuance cost Exercise of pre-funded warrants
2024-06-30
2024-05-08 7791.94 未披露 定期报告 2024-05-06
2024-05-08 6813.76 未披露
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From December 31, 2023 to March 31, 2024 Exercise of stock options and release of RSUs
2024-03-31
2024-04-04 6773.18 未披露 定期报告 2024-03-19
2024-03-11 6772.17 未披露 定期报告 2024-02-29
2024-03-11 6731.08 未披露
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From December 31,2022 to December 31,2023 Exercise of stock options and release of RSUs Issuance of common stock under the Employee Stock Purchase Plan
2023-12-31
2023-11-07 6698.89 未披露 定期报告 2023-10-31
2023-11-07 6687.28 未披露
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From June 30, 2023 to September 30, 2023 Release of RSUs
2023-09-30
2023-08-08 6676.78 未披露
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From March 31, 2023 to June 30, 2023 Exercise of stock options Release of RSUs Issuance of common stock under the ESPP
2023-06-30
2023-05-09 6633.89 未披露
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From December 31, 2022 to March 31, 2023 Release of RSUs
2023-03-31
2023-03-27 6622.80 未披露
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From December 31, 2021 to December 31, 2022 Exercise of stock options and release of RSUs Issuance of common stock under the Employee Stock Purchase Plan
2022-12-31
2022-11-08 6608.44 未披露 定期报告 2022-10-31
2022-11-08 6595.02 未披露
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From June 30, 2022 to September 30, 2022 Release of PSUs
2022-09-30
2022-08-04 6595.02 未披露 定期报告 2022-07-29
2022-08-04 6575.65 未披露
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From March 31, 2022 to June 30, 2022 Exercise of stock options Issuance of common stock under the ESPP
2022-06-30
2022-04-27 6539.84 未披露 定期报告 2022-04-18
2022-05-05 6539.84 未披露
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From December 31, 2021 to March 31, 2022 Exercise of stock options
2022-03-31
2022-03-01 6539.28 未披露
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From December 31, 2020 to December 31, 2021 Exercise of stock options Issuance of common stock under the Employee Stock Purchase Plan Issuance of common stock in follow-on offering, net of issuance cost
2021-12-31
2021-11-04 6524.91 未披露 定期报告 2021-09-30
2021-08-05 6515.70 未披露
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From March 31, 2021 to June 30, 2021 Exercise of stock options Issuance of common stock under the ESPP
2021-06-30
2021-05-06 6501.11 未披露 定期报告 2021-04-30
2021-04-28 6500.42 未披露 定期报告 2021-04-19
2021-05-06 6500.29 未披露
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from December 31, 2020 to March 31, 2021 Issuance of common stock in follow-on offering, net of issuance costs Exercise of stock options
2021-03-31
2021-02-24 6478.44 未披露 定期报告 2021-02-02
2021-01-25 6050.91 未披露
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1.Common stock offered 14,285,714 shares. 2.The number of shares of common stock to be outstanding after this offering is based on 46,223,402 shares of common stock outstanding as of September 30, 2020.
2021-01-25
2021-02-24 4825.18 未披露
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From December 31, 2019 to December 31, 2020 Exercise of stock options Issuance of common stock under the Employee Stock Purchase Plan Issuance of common stock under the Open Market Sale Agreement, net of issuance cost
2020-12-31
2020-11-05 4622.44 未披露 定期报告 2020-10-31
2020-11-05 4622.34 未披露
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From June 30, 2020 to September 30, 2020 Exercise of stock options
2020-09-30
2020-08-06 4619.22 未披露 定期报告 2020-07-31
2020-08-06 4619.01 未披露
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From March 31, 2020 to June 30, 2020 Exercise of stock options Issuance of common stock under the ESPP
2020-06-30
2020-05-07 4592.32 未披露 定期报告 2020-04-30
2020-04-29 4592.26 未披露 定期报告 2020-04-20
2020-05-07 4591.86 未披露
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From December 31, 2019 to March 31, 2020 Exercise of stock options
2020-03-31
2020-02-27 4556.66 未披露 定期报告 2020-01-31
2020-02-27 4552.31 未披露
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from December 31, 2018 to December 31, 2019 Exercise of stock options Issuance of common stock under the Employee Stock Purchase Plan Issuance of common stock to UCSB
2019-12-31
2019-11-07 4543.42 未披露 定期报告 2019-10-31
2019-11-07 4542.65 未披露
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From June 30, 2019 to September 30, 2019 Exercise of stock options
2019-09-30
2019-08-07 4540.95 未披露 定期报告 2019-07-31
2019-08-07 4540.38 未披露
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from March 31, 2019 to June 30,2019 Exercise of stock options Issuance of common stock under the ESPP Issuance of common stock pursuant to license agreement
2019-06-30
2019-04-26 4531.15 未披露 定期报告 2019-04-22
2019-05-09 4515.77 未披露
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from December 31, 2018 to March 31, 2019 Exercise of stock options
2019-03-31
2019-02-27 4511.13 未披露 定期报告 2019-01-31
2019-02-27 4508.32 未披露
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from December 31, 2017 to December 31, 2018 Issuance of common stock in follow-on offering, net of issuance costs Exercise of stock options Issuance of common stock under the Employee Stock Purchase Plan
2018-12-31
2018-11-06 4500.71 未披露 定期报告 2018-11-02
2018-11-06 4499.73 未披露 定期报告 2018-09-30
2018-08-08 4496.37 未披露 定期报告 2018-08-06
2018-08-08 3901.18 未披露 定期报告 2018-06-30
2018-05-09 3895.75 未披露 定期报告 2018-05-07
2018-04-26 3891.61 未披露 定期报告 2018-04-23
2018-05-09 3890.37 未披露 定期报告 2018-03-31
2018-03-07 3861.12 未披露 定期报告 2018-03-05
2018-03-07 3847.86 未披露
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from December 31, 2016 to December 31, 2017 Exercise of stock options Issuance of common stock under the Employee Stock Purchase Plan Issuance of common stock pursuant to the Amgen Stock Purchase Agreement
2017-12-31
2017-11-07 3840.86 未披露 定期报告 2017-11-03
2017-11-07 3709.55 未披露 定期报告 2017-09-30
2017-08-07 3686.74 未披露 定期报告 2017-08-04
2017-08-07 3683.93 未披露 定期报告 2017-06-30
2017-05-05 3674.97 未披露 定期报告 2017-05-03
2017-05-09 3674.37 未披露 定期报告 2017-04-28
2017-05-05 3671.89 未披露 定期报告 2017-03-31
2017-03-20 3656.83 未披露 定期报告 2017-03-17
2017-03-02 3651.82 未披露 定期报告 2017-02-28
2017-03-02 3649.02 未披露
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From December 31, 2015 to December 31, 2016 Exercise of stock options Issuance of common stock under the Employee Stock Purchase Plan Issuance of common stock in connection with services
2016-12-31
2016-11-03 3640.23 未披露 定期报告 2016-11-01
2016-11-03 3639.28 未披露 定期报告 2016-09-30
2016-08-03 3628.84 未披露 定期报告 2016-08-01
2016-08-03 3618.73 未披露 定期报告 2016-06-30
2016-05-06 3608.78 未披露 定期报告 2016-05-04
2016-05-06 3608.58 未披露 定期报告 2016-03-31
2016-03-07 3607.79 未披露 定期报告 2016-03-02
2016-03-07 3603.32 未披露
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from December 31, 2014 to December 31, 2015 Issuance of Series C preferred stock, net of issuance costs of $30 Issuance of Series B-1 preferred stock upon net exercise of warrants Issuance of Series D preferred stock, net of issuance costs of $255 Conversion of redeemable convertible preferred stock to common stock in connection with initial public offering Conversion of convertible preferred stock to common stock in connection with initial public offering Issuance of common stock in connection with initial public offering, net of underwriting discount of $6,440 and offering costs of $3,796 Exercise of stock options We effected a one-for-62.997 reverse stock split upon the filing of an amended and restated certificate of incorporation with the Secretary of State of the State of Delaware on October 2, 2015.
2015-12-31
2015-11-23 3602.43 未披露 定期报告 2015-11-19
2015-10-08 3492.06 未披露
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a one-for-62.997 reverse stock split of our common stock, which we have effected;the conversion of all of our outstanding shares of preferred stock into an aggregate of 27,135,453 shares of common stock immediately prior to the completion of this offering;
2015-10-08
2015-11-23 109.46 2713.55
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On October 2, 2015, the Company effected a one-for-62.997 reverse stock split of the Company’s issued and outstanding shares of common stock, redeemable convertible preferred stock and convertible preferred stock.
2015-10-05
2015-08-28 6326.36 170945.39
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from December 31, 2014 to June 30, 2015 (unaudited) Issuance of Series C redeemable convertible preferred stock, net of issuance costs of $30 (unaudited) and for cash and value of convertible preferred stock liability of $1,509 (unaudited) Issuance of Series D redeemable convertible preferred stock, net of issuance costs of $255 (unaudited) Exercise of stock options (unaudited)
2015-06-30
From June 30, 2025 to September 30, 2025 Exercise of stock options
From March 31, 2025 to June 30, 2025 Exercise of stock options and release of RSUs Issuance of common stock under the ESPP Issuance of common stock in follow-on offering, net of issuance cost Exercise of pre-funded warrants
Common Stock offered 76,923,076 shares by the company
From December 31, 2024 to March 31, 2025 Exercise of stock options and release of RSUs
From December 31, 2023 to December 31, 2024 Exercise of stock options and release of RSUs Issuance of common stock under the Open Market Sale Agreement, net of issuance cost Exercise of pre-funded warrants Issuance of common stock under the Employee Stock Purchase Plan
From June 30, 2024 to September 30, 2024 Release of RSUs
From March 31, 2024 to June 30, 2024 Exercise of stock options and release of RSUs Issuance of common stock under the ESPP Issuance of common stock under the Open Market Sale Agreement, net of issuance cost Exercise of pre-funded warrants
From December 31, 2023 to March 31, 2024 Exercise of stock options and release of RSUs
From December 31,2022 to December 31,2023 Exercise of stock options and release of RSUs Issuance of common stock under the Employee Stock Purchase Plan
From June 30, 2023 to September 30, 2023 Release of RSUs
From March 31, 2023 to June 30, 2023 Exercise of stock options Release of RSUs Issuance of common stock under the ESPP
From December 31, 2022 to March 31, 2023 Release of RSUs
From December 31, 2021 to December 31, 2022 Exercise of stock options and release of RSUs Issuance of common stock under the Employee Stock Purchase Plan
From June 30, 2022 to September 30, 2022 Release of PSUs
From March 31, 2022 to June 30, 2022 Exercise of stock options Issuance of common stock under the ESPP
From December 31, 2021 to March 31, 2022 Exercise of stock options
From December 31, 2020 to December 31, 2021 Exercise of stock options Issuance of common stock under the Employee Stock Purchase Plan Issuance of common stock in follow-on offering, net of issuance cost
From March 31, 2021 to June 30, 2021 Exercise of stock options Issuance of common stock under the ESPP
from December 31, 2020 to March 31, 2021 Issuance of common stock in follow-on offering, net of issuance costs Exercise of stock options
1.Common stock offered 14,285,714 shares. 2.The number of shares of common stock to be outstanding after this offering is based on 46,223,402 shares of common stock outstanding as of September 30, 2020.
From December 31, 2019 to December 31, 2020 Exercise of stock options Issuance of common stock under the Employee Stock Purchase Plan Issuance of common stock under the Open Market Sale Agreement, net of issuance cost
From June 30, 2020 to September 30, 2020 Exercise of stock options
From March 31, 2020 to June 30, 2020 Exercise of stock options Issuance of common stock under the ESPP
From December 31, 2019 to March 31, 2020 Exercise of stock options
from December 31, 2018 to December 31, 2019 Exercise of stock options Issuance of common stock under the Employee Stock Purchase Plan Issuance of common stock to UCSB
From June 30, 2019 to September 30, 2019 Exercise of stock options
from March 31, 2019 to June 30,2019 Exercise of stock options Issuance of common stock under the ESPP Issuance of common stock pursuant to license agreement
from December 31, 2018 to March 31, 2019 Exercise of stock options
from December 31, 2017 to December 31, 2018 Issuance of common stock in follow-on offering, net of issuance costs Exercise of stock options Issuance of common stock under the Employee Stock Purchase Plan
from December 31, 2016 to December 31, 2017 Exercise of stock options Issuance of common stock under the Employee Stock Purchase Plan Issuance of common stock pursuant to the Amgen Stock Purchase Agreement
From December 31, 2015 to December 31, 2016 Exercise of stock options Issuance of common stock under the Employee Stock Purchase Plan Issuance of common stock in connection with services
from December 31, 2014 to December 31, 2015 Issuance of Series C preferred stock, net of issuance costs of $30 Issuance of Series B-1 preferred stock upon net exercise of warrants Issuance of Series D preferred stock, net of issuance costs of $255 Conversion of redeemable convertible preferred stock to common stock in connection with initial public offering Conversion of convertible preferred stock to common stock in connection with initial public offering Issuance of common stock in connection with initial public offering, net of underwriting discount of $6,440 and offering costs of $3,796 Exercise of stock options We effected a one-for-62.997 reverse stock split upon the filing of an amended and restated certificate of incorporation with the Secretary of State of the State of Delaware on October 2, 2015.
a one-for-62.997 reverse stock split of our common stock, which we have effected;the conversion of all of our outstanding shares of preferred stock into an aggregate of 27,135,453 shares of common stock immediately prior to the completion of this offering;
On October 2, 2015, the Company effected a one-for-62.997 reverse stock split of the Company’s issued and outstanding shares of common stock, redeemable convertible preferred stock and convertible preferred stock.
from December 31, 2014 to June 30, 2015 (unaudited) Issuance of Series C redeemable convertible preferred stock, net of issuance costs of $30 (unaudited) and for cash and value of convertible preferred stock liability of $1,509 (unaudited) Issuance of Series D redeemable convertible preferred stock, net of issuance costs of $255 (unaudited) Exercise of stock options (unaudited)