股本结构
单位:万股
| 公告日期 | 2025-11-06 | 2025-11-06 | 2025-08-07 | 2025-08-07 | 2025-05-12 | 2025-05-12 |
|---|---|---|---|---|---|---|
| 证券总股本 | 16943.54 | 16506.96 | 16491.29 | 16491.11 | 15754.44 | 8062.13 |
| 普通股本 | 16943.54 | 16506.96 | 16491.29 | 16491.11 | 15754.44 | 8062.13 |
| 优先股 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2025-10-31 | 2025-09-30 | 2025-07-31 | 2025-06-30 | 2025-05-13 | 2025-03-31 |
注释:中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本(万股) | 变动后优先股(万股) | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2025-11-06 | 16943.54 | 未披露 | 定期报告 | 2025-10-31 |
| 2025-11-06 | 16506.96 | 未披露 |
更多>>
From June 30, 2025 to September 30, 2025
Exercise of stock options
|
2025-09-30 |
| 2025-08-07 | 16491.29 | 未披露 | 定期报告 | 2025-07-31 |
| 2025-08-07 | 16491.11 | 未披露 |
更多>>
From March 31, 2025 to June 30, 2025
Exercise of stock options and release of RSUs
Issuance of common stock under the ESPP
Issuance of common stock in follow-on offering, net of issuance cost
Exercise of pre-funded warrants
|
2025-06-30 |
| 2025-05-12 | 15754.44 | 未披露 |
更多>>
Common Stock offered 76,923,076 shares by the company
|
2025-05-13 |
| 2025-05-12 | 8062.13 | 未披露 |
更多>>
From December 31, 2024 to March 31, 2025
Exercise of stock options and release of RSUs
|
2025-03-31 |
| 2025-03-06 | 8009.99 | 未披露 |
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From December 31, 2023 to December 31, 2024
Exercise of stock options and release of RSUs
Issuance of common stock under the Open Market Sale Agreement, net of issuance cost
Exercise of pre-funded warrants
Issuance of common stock under the Employee Stock Purchase Plan
|
2024-12-31 |
| 2024-11-07 | 7825.89 | 未披露 | 定期报告 | 2024-10-31 |
| 2024-11-07 | 7823.26 | 未披露 |
更多>>
From June 30, 2024 to September 30, 2024
Release of RSUs
|
2024-09-30 |
| 2024-08-08 | 7811.76 | 未披露 |
更多>>
From March 31, 2024 to June 30, 2024
Exercise of stock options and release of RSUs
Issuance of common stock under the ESPP
Issuance of common stock under the Open Market Sale Agreement, net of issuance cost
Exercise of pre-funded warrants
|
2024-06-30 |
| 2024-05-08 | 7791.94 | 未披露 | 定期报告 | 2024-05-06 |
| 2024-05-08 | 6813.76 | 未披露 |
更多>>
From December 31, 2023 to March 31, 2024
Exercise of stock options and release of RSUs
|
2024-03-31 |
| 2024-04-04 | 6773.18 | 未披露 | 定期报告 | 2024-03-19 |
| 2024-03-11 | 6772.17 | 未披露 | 定期报告 | 2024-02-29 |
| 2024-03-11 | 6731.08 | 未披露 |
更多>>
From December 31,2022 to December 31,2023
Exercise of stock options and release of RSUs
Issuance of common stock under the Employee Stock Purchase Plan
|
2023-12-31 |
| 2023-11-07 | 6698.89 | 未披露 | 定期报告 | 2023-10-31 |
| 2023-11-07 | 6687.28 | 未披露 |
更多>>
From June 30, 2023 to September 30, 2023
Release of RSUs
|
2023-09-30 |
| 2023-08-08 | 6676.78 | 未披露 |
更多>>
From March 31, 2023 to June 30, 2023
Exercise of stock options
Release of RSUs
Issuance of common stock under the ESPP
|
2023-06-30 |
| 2023-05-09 | 6633.89 | 未披露 |
更多>>
From December 31, 2022 to March 31, 2023
Release of RSUs
|
2023-03-31 |
| 2023-03-27 | 6622.80 | 未披露 |
更多>>
From December 31, 2021 to December 31, 2022
Exercise of stock options and release of RSUs
Issuance of common stock under the Employee Stock Purchase Plan
|
2022-12-31 |
| 2022-11-08 | 6608.44 | 未披露 | 定期报告 | 2022-10-31 |
| 2022-11-08 | 6595.02 | 未披露 |
更多>>
From June 30, 2022 to September 30, 2022
Release of PSUs
|
2022-09-30 |
| 2022-08-04 | 6595.02 | 未披露 | 定期报告 | 2022-07-29 |
| 2022-08-04 | 6575.65 | 未披露 |
更多>>
From March 31, 2022 to June 30, 2022
Exercise of stock options
Issuance of common stock under the ESPP
|
2022-06-30 |
| 2022-04-27 | 6539.84 | 未披露 | 定期报告 | 2022-04-18 |
| 2022-05-05 | 6539.84 | 未披露 |
更多>>
From December 31, 2021 to March 31, 2022
Exercise of stock options
|
2022-03-31 |
| 2022-03-01 | 6539.28 | 未披露 |
更多>>
From December 31, 2020 to December 31, 2021
Exercise of stock options
Issuance of common stock under the Employee Stock Purchase Plan
Issuance of common stock in follow-on offering, net of issuance cost
|
2021-12-31 |
| 2021-11-04 | 6524.91 | 未披露 | 定期报告 | 2021-09-30 |
| 2021-08-05 | 6515.70 | 未披露 |
更多>>
From March 31, 2021 to June 30, 2021
Exercise of stock options
Issuance of common stock under the ESPP
|
2021-06-30 |
| 2021-05-06 | 6501.11 | 未披露 | 定期报告 | 2021-04-30 |
| 2021-04-28 | 6500.42 | 未披露 | 定期报告 | 2021-04-19 |
| 2021-05-06 | 6500.29 | 未披露 |
更多>>
from December 31, 2020 to March 31, 2021
Issuance of common stock in follow-on offering, net of issuance costs
Exercise of stock options
|
2021-03-31 |
| 2021-02-24 | 6478.44 | 未披露 | 定期报告 | 2021-02-02 |
| 2021-01-25 | 6050.91 | 未披露 |
更多>>
1.Common stock offered 14,285,714 shares.
2.The number of shares of common stock to be outstanding after this offering is based on 46,223,402 shares of common stock outstanding as of September 30, 2020.
|
2021-01-25 |
| 2021-02-24 | 4825.18 | 未披露 |
更多>>
From December 31, 2019 to December 31, 2020
Exercise of stock options
Issuance of common stock under the Employee Stock Purchase Plan
Issuance of common stock under the Open Market Sale Agreement, net of issuance cost
|
2020-12-31 |
| 2020-11-05 | 4622.44 | 未披露 | 定期报告 | 2020-10-31 |
| 2020-11-05 | 4622.34 | 未披露 |
更多>>
From June 30, 2020 to September 30, 2020
Exercise of stock options
|
2020-09-30 |
| 2020-08-06 | 4619.22 | 未披露 | 定期报告 | 2020-07-31 |
| 2020-08-06 | 4619.01 | 未披露 |
更多>>
From March 31, 2020 to June 30, 2020
Exercise of stock options
Issuance of common stock under the ESPP
|
2020-06-30 |
| 2020-05-07 | 4592.32 | 未披露 | 定期报告 | 2020-04-30 |
| 2020-04-29 | 4592.26 | 未披露 | 定期报告 | 2020-04-20 |
| 2020-05-07 | 4591.86 | 未披露 |
更多>>
From December 31, 2019 to March 31, 2020
Exercise of stock options
|
2020-03-31 |
| 2020-02-27 | 4556.66 | 未披露 | 定期报告 | 2020-01-31 |
| 2020-02-27 | 4552.31 | 未披露 |
更多>>
from December 31, 2018 to December 31, 2019
Exercise of stock options
Issuance of common stock under the Employee Stock Purchase Plan
Issuance of common stock to UCSB
|
2019-12-31 |
| 2019-11-07 | 4543.42 | 未披露 | 定期报告 | 2019-10-31 |
| 2019-11-07 | 4542.65 | 未披露 |
更多>>
From June 30, 2019 to September 30, 2019
Exercise of stock options
|
2019-09-30 |
| 2019-08-07 | 4540.95 | 未披露 | 定期报告 | 2019-07-31 |
| 2019-08-07 | 4540.38 | 未披露 |
更多>>
from March 31, 2019 to June 30,2019
Exercise of stock options
Issuance of common stock under the ESPP
Issuance of common stock pursuant to license agreement
|
2019-06-30 |
| 2019-04-26 | 4531.15 | 未披露 | 定期报告 | 2019-04-22 |
| 2019-05-09 | 4515.77 | 未披露 |
更多>>
from December 31, 2018 to March 31, 2019
Exercise of stock options
|
2019-03-31 |
| 2019-02-27 | 4511.13 | 未披露 | 定期报告 | 2019-01-31 |
| 2019-02-27 | 4508.32 | 未披露 |
更多>>
from December 31, 2017 to December 31, 2018
Issuance of common stock in follow-on offering, net of issuance costs
Exercise of stock options
Issuance of common stock under the Employee Stock Purchase Plan
|
2018-12-31 |
| 2018-11-06 | 4500.71 | 未披露 | 定期报告 | 2018-11-02 |
| 2018-11-06 | 4499.73 | 未披露 | 定期报告 | 2018-09-30 |
| 2018-08-08 | 4496.37 | 未披露 | 定期报告 | 2018-08-06 |
| 2018-08-08 | 3901.18 | 未披露 | 定期报告 | 2018-06-30 |
| 2018-05-09 | 3895.75 | 未披露 | 定期报告 | 2018-05-07 |
| 2018-04-26 | 3891.61 | 未披露 | 定期报告 | 2018-04-23 |
| 2018-05-09 | 3890.37 | 未披露 | 定期报告 | 2018-03-31 |
| 2018-03-07 | 3861.12 | 未披露 | 定期报告 | 2018-03-05 |
| 2018-03-07 | 3847.86 | 未披露 |
更多>>
from December 31, 2016 to December 31, 2017
Exercise of stock options
Issuance of common stock under the Employee Stock Purchase Plan
Issuance of common stock pursuant to the Amgen Stock Purchase Agreement
|
2017-12-31 |
| 2017-11-07 | 3840.86 | 未披露 | 定期报告 | 2017-11-03 |
| 2017-11-07 | 3709.55 | 未披露 | 定期报告 | 2017-09-30 |
| 2017-08-07 | 3686.74 | 未披露 | 定期报告 | 2017-08-04 |
| 2017-08-07 | 3683.93 | 未披露 | 定期报告 | 2017-06-30 |
| 2017-05-05 | 3674.97 | 未披露 | 定期报告 | 2017-05-03 |
| 2017-05-09 | 3674.37 | 未披露 | 定期报告 | 2017-04-28 |
| 2017-05-05 | 3671.89 | 未披露 | 定期报告 | 2017-03-31 |
| 2017-03-20 | 3656.83 | 未披露 | 定期报告 | 2017-03-17 |
| 2017-03-02 | 3651.82 | 未披露 | 定期报告 | 2017-02-28 |
| 2017-03-02 | 3649.02 | 未披露 |
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From December 31, 2015 to December 31, 2016
Exercise of stock options
Issuance of common stock under the Employee Stock Purchase Plan
Issuance of common stock in connection with services
|
2016-12-31 |
| 2016-11-03 | 3640.23 | 未披露 | 定期报告 | 2016-11-01 |
| 2016-11-03 | 3639.28 | 未披露 | 定期报告 | 2016-09-30 |
| 2016-08-03 | 3628.84 | 未披露 | 定期报告 | 2016-08-01 |
| 2016-08-03 | 3618.73 | 未披露 | 定期报告 | 2016-06-30 |
| 2016-05-06 | 3608.78 | 未披露 | 定期报告 | 2016-05-04 |
| 2016-05-06 | 3608.58 | 未披露 | 定期报告 | 2016-03-31 |
| 2016-03-07 | 3607.79 | 未披露 | 定期报告 | 2016-03-02 |
| 2016-03-07 | 3603.32 | 未披露 |
更多>>
from December 31, 2014 to December 31, 2015
Issuance of Series C preferred stock, net of issuance costs of $30
Issuance of Series B-1 preferred stock upon net exercise of warrants
Issuance of Series D preferred stock, net of issuance costs of $255
Conversion of redeemable convertible preferred stock to common stock in connection with initial public offering
Conversion of convertible preferred stock to common stock in connection with initial public offering
Issuance of common stock in connection with initial public offering, net of underwriting discount of $6,440 and offering costs of $3,796
Exercise of stock options
We effected a one-for-62.997 reverse stock split upon the filing of an amended and restated certificate of incorporation with the Secretary of State of the State of Delaware on October 2, 2015.
|
2015-12-31 |
| 2015-11-23 | 3602.43 | 未披露 | 定期报告 | 2015-11-19 |
| 2015-10-08 | 3492.06 | 未披露 |
更多>>
a one-for-62.997 reverse stock split of our common stock, which we have effected;the conversion of all of our outstanding shares of preferred stock into an aggregate of 27,135,453 shares of common stock immediately prior to the completion of this offering;
|
2015-10-08 |
| 2015-11-23 | 109.46 | 2713.55 |
更多>>
On October 2, 2015, the Company effected a one-for-62.997 reverse stock split of the Company’s issued and outstanding shares of common stock, redeemable convertible preferred stock and convertible preferred stock.
|
2015-10-05 |
| 2015-08-28 | 6326.36 | 170945.39 |
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from December 31, 2014 to June 30, 2015 (unaudited)
Issuance of Series C redeemable convertible preferred stock, net of issuance costs of $30 (unaudited) and for cash and value of convertible preferred stock liability of $1,509 (unaudited)
Issuance of Series D redeemable convertible preferred stock, net of issuance costs of $255 (unaudited)
Exercise of stock options (unaudited)
|
2015-06-30 |
From June 30, 2025 to September 30, 2025
Exercise of stock options
From March 31, 2025 to June 30, 2025
Exercise of stock options and release of RSUs
Issuance of common stock under the ESPP
Issuance of common stock in follow-on offering, net of issuance cost
Exercise of pre-funded warrants
Common Stock offered 76,923,076 shares by the company
From December 31, 2024 to March 31, 2025
Exercise of stock options and release of RSUs
From December 31, 2023 to December 31, 2024
Exercise of stock options and release of RSUs
Issuance of common stock under the Open Market Sale Agreement, net of issuance cost
Exercise of pre-funded warrants
Issuance of common stock under the Employee Stock Purchase Plan
From June 30, 2024 to September 30, 2024
Release of RSUs
From March 31, 2024 to June 30, 2024
Exercise of stock options and release of RSUs
Issuance of common stock under the ESPP
Issuance of common stock under the Open Market Sale Agreement, net of issuance cost
Exercise of pre-funded warrants
From December 31, 2023 to March 31, 2024
Exercise of stock options and release of RSUs
From December 31,2022 to December 31,2023
Exercise of stock options and release of RSUs
Issuance of common stock under the Employee Stock Purchase Plan
From June 30, 2023 to September 30, 2023
Release of RSUs
From March 31, 2023 to June 30, 2023
Exercise of stock options
Release of RSUs
Issuance of common stock under the ESPP
From December 31, 2022 to March 31, 2023
Release of RSUs
From December 31, 2021 to December 31, 2022
Exercise of stock options and release of RSUs
Issuance of common stock under the Employee Stock Purchase Plan
From June 30, 2022 to September 30, 2022
Release of PSUs
From March 31, 2022 to June 30, 2022
Exercise of stock options
Issuance of common stock under the ESPP
From December 31, 2021 to March 31, 2022
Exercise of stock options
From December 31, 2020 to December 31, 2021
Exercise of stock options
Issuance of common stock under the Employee Stock Purchase Plan
Issuance of common stock in follow-on offering, net of issuance cost
From March 31, 2021 to June 30, 2021
Exercise of stock options
Issuance of common stock under the ESPP
from December 31, 2020 to March 31, 2021
Issuance of common stock in follow-on offering, net of issuance costs
Exercise of stock options
1.Common stock offered 14,285,714 shares.
2.The number of shares of common stock to be outstanding after this offering is based on 46,223,402 shares of common stock outstanding as of September 30, 2020.
From December 31, 2019 to December 31, 2020
Exercise of stock options
Issuance of common stock under the Employee Stock Purchase Plan
Issuance of common stock under the Open Market Sale Agreement, net of issuance cost
From June 30, 2020 to September 30, 2020
Exercise of stock options
From March 31, 2020 to June 30, 2020
Exercise of stock options
Issuance of common stock under the ESPP
From December 31, 2019 to March 31, 2020
Exercise of stock options
from December 31, 2018 to December 31, 2019
Exercise of stock options
Issuance of common stock under the Employee Stock Purchase Plan
Issuance of common stock to UCSB
From June 30, 2019 to September 30, 2019
Exercise of stock options
from March 31, 2019 to June 30,2019
Exercise of stock options
Issuance of common stock under the ESPP
Issuance of common stock pursuant to license agreement
from December 31, 2018 to March 31, 2019
Exercise of stock options
from December 31, 2017 to December 31, 2018
Issuance of common stock in follow-on offering, net of issuance costs
Exercise of stock options
Issuance of common stock under the Employee Stock Purchase Plan
from December 31, 2016 to December 31, 2017
Exercise of stock options
Issuance of common stock under the Employee Stock Purchase Plan
Issuance of common stock pursuant to the Amgen Stock Purchase Agreement
From December 31, 2015 to December 31, 2016
Exercise of stock options
Issuance of common stock under the Employee Stock Purchase Plan
Issuance of common stock in connection with services
from December 31, 2014 to December 31, 2015
Issuance of Series C preferred stock, net of issuance costs of $30
Issuance of Series B-1 preferred stock upon net exercise of warrants
Issuance of Series D preferred stock, net of issuance costs of $255
Conversion of redeemable convertible preferred stock to common stock in connection with initial public offering
Conversion of convertible preferred stock to common stock in connection with initial public offering
Issuance of common stock in connection with initial public offering, net of underwriting discount of $6,440 and offering costs of $3,796
Exercise of stock options
We effected a one-for-62.997 reverse stock split upon the filing of an amended and restated certificate of incorporation with the Secretary of State of the State of Delaware on October 2, 2015.
a one-for-62.997 reverse stock split of our common stock, which we have effected;the conversion of all of our outstanding shares of preferred stock into an aggregate of 27,135,453 shares of common stock immediately prior to the completion of this offering;
On October 2, 2015, the Company effected a one-for-62.997 reverse stock split of the Company’s issued and outstanding shares of common stock, redeemable convertible preferred stock and convertible preferred stock.
from December 31, 2014 to June 30, 2015 (unaudited)
Issuance of Series C redeemable convertible preferred stock, net of issuance costs of $30 (unaudited) and for cash and value of convertible preferred stock liability of $1,509 (unaudited)
Issuance of Series D redeemable convertible preferred stock, net of issuance costs of $255 (unaudited)
Exercise of stock options (unaudited)