股本结构
单位：万股
| 公告日期 | 2025-08-13 | 2025-08-13 | 2025-05-14 | 2025-05-14 | 2025-03-27 | 2025-03-27 |
|---|---|---|---|---|---|---|
| 证券总股本 | 3105.42 | 3104.20 | 3104.26 | 3104.20 | 3104.20 | 3104.20 |
| 普通股本 | 3105.42 | 3104.20 | 3104.26 | 3104.20 | 3104.20 | 3104.20 |
| 优先股 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2025-08-08 | 2025-06-30 | 2025-05-09 | 2025-03-31 | 2025-03-25 | 2024-12-31 |
注释：中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本（万股） | 变动后优先股（万股） | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2025-08-13 | 3105.42 | 未披露 | 定期报告 | 2025-08-08 |
| 2025-08-13 | 3104.20 | 未披露 | 定期报告 | 2025-06-30 |
| 2025-05-14 | 3104.26 | 未披露 | 定期报告 | 2025-05-09 |
| 2025-05-14 | 3104.20 | 未披露 | 定期报告 | 2025-03-31 |
| 2025-03-27 | 3104.20 | 未披露 | 定期报告 | 2025-03-25 |
| 2025-03-27 | 3104.20 | 未披露 |
更多>>
From December 31, 2023 to December 31, 2024
Issuance of common stock pursuant to the 2021 Sales Agreement, net of issuance costs of $13
Issuance of common stock upon exercise of stock options and from the ESPP
|
2024-12-31 |
| 2024-11-14 | 3104.20 | 未披露 | 定期报告 | 2024-11-11 |
| 2024-11-14 | 3103.90 | 未披露 | 定期报告 | 2024-09-30 |
| 2024-05-14 | 3103.94 | 未披露 | 定期报告 | 2024-05-09 |
| 2024-05-14 | 3103.60 | 未披露 |
更多>>
From December 31, 2023 to March 31, 2024
Issuance of common stock pursuant to the 2021 Sales Agreement, net of issuance costs of $13,000
|
2024-03-31 |
| 2024-03-28 | 3103.60 | 未披露 | 定期报告 | 2024-03-26 |
| 2024-03-28 | 3033.40 | 未披露 |
更多>>
From December 31, 2022 to December 31, 2023
Issuance of common stock upon warrant exercises
Issuance of common stock in the February 2023 registered direct offering
Issuance of common stock pursuant to the 2021 Sales Agreement, net of issuance costs of $32
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
Issuance of common stock in the July 2023 registered direct offering, net of issuance costs of $673
|
2023-12-31 |
| 2023-11-14 | 2982.89 | 未披露 | 定期报告 | 2023-11-13 |
| 2023-11-14 | 2852.40 | 未披露 |
更多>>
From June 30, 2023 to September 30, 2023
Issuance of common stock in the July 2023 registered direct offering, net of issuance costs of $673
Issuance of common stock upon warrant exercises
|
2023-09-30 |
| 2023-08-10 | 2760.01 | 未披露 | 定期报告 | 2023-08-07 |
| 2023-07-21 | 2748.09 | 未披露 |
更多>>
Common stock offered 2,991,027 shares by the company
|
2023-07-21 |
| 2023-05-09 | 2448.98 | 未披露 | 定期报告 | 2023-05-03 |
| 2023-05-09 | 2448.50 | 未披露 |
更多>>
From December 31, 2022 to March 31, 2023
Issuance of common stock upon equity financing
|
2023-03-31 |
| 2023-03-08 | 2448.49 | 未披露 | 定期报告 | 2023-03-03 |
| 2023-02-07 | 2450.00 | 未披露 |
更多>>
Common stock offered 1,700,000 shares by the company
|
2023-02-08 |
| 2023-03-08 | 2278.50 | 未披露 |
更多>>
From December 31, 2021 to December 31, 2022
Issuance of common stock upon equity financings, net of issuance costs of $0
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
|
2022-12-31 |
| 2022-11-29 | 2280.00 | 未披露 |
更多>>
DURECT Corporation Announces 1-for-10 Reverse Stock Split.
|
2022-12-06 |
| 2022-11-03 | 22785.98 | 未披露 | 定期报告 | 2022-11-01 |
| 2022-10-07 | 22779.40 | 未披露 | 定期报告 | 2022-10-03 |
| 2022-11-03 | 22779.40 | 未披露 |
更多>>
From June 30, 2022 to September 30, 2022
Issuance of common stock upon equity financings, net of issuance costs of $506
|
2022-09-30 |
| 2022-08-05 | 22776.40 | 未披露 | 定期报告 | 2022-08-03 |
| 2022-08-05 | 22776.40 | 未披露 |
更多>>
From March 31, 2022 to June 30, 2022
Issuance of common stock upon exercise of stock options
|
2022-06-30 |
| 2022-05-05 | 22776.40 | 未披露 | 定期报告 | 2022-05-03 |
| 2022-05-05 | 22769.40 | 未披露 |
更多>>
From December 31, 2021 to March 31, 2022
Issuance of common stock upon exercise of stock options
|
2022-03-31 |
| 2022-03-08 | 22769.40 | 未披露 | 定期报告 | 2022-03-03 |
| 2022-03-08 | 22768.00 | 未披露 |
更多>>
From December 31, 2020 to December 31, 2021
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
Issuance of common stock upon equity financings, net of issuance costs of $395,000
|
2021-12-31 |
| 2021-11-03 | 22750.58 | 未披露 | 定期报告 | 2021-10-28 |
| 2021-11-03 | 22750.60 | 未披露 |
更多>>
From June 30, 2021 to September 30, 2021
Issuance of common stock upon exercise of stock options
|
2021-09-30 |
| 2021-07-30 | 22749.62 | 未披露 | 定期报告 | 2021-07-28 |
| 2021-07-30 | 22749.60 | 未披露 |
更多>>
From March 31, 2021 to June 30, 2021
Issuance of common stock upon exercise of stock options, ESPP purchases and other
|
2021-06-30 |
| 2021-05-05 | 22740.62 | 未披露 | 定期报告 | 2021-05-03 |
| 2021-04-23 | 22734.98 | 未披露 | 定期报告 | 2021-04-20 |
| 2021-05-05 | 22735.00 | 未披露 |
更多>>
From December 31, 2020 to March 31, 2021
Issuance of common stock upon exercise of stock options
Issuance of common stock upon equity financings, net of issuance costs of $269
|
2021-03-31 |
| 2021-03-05 | 22720.19 | 未披露 | 定期报告 | 2021-03-01 |
| 2021-02-08 | 22088.35 | 未披露 |
更多>>
1.Common stock offered by the company pursuant to this prospectus supplement 17,708,333 shares.
2.The number of shares of common stock to be outstanding after this offering is based on 203,175,181 shares outstanding as of September 30, 2020.
|
2021-02-08 |
| 2021-03-05 | 20353.30 | 未披露 |
更多>>
From December 31, 2019 to December 31, 2020
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
Issuance of common stock upon equity financings, net of issuance costs of $380
|
2020-12-31 |
| 2020-11-03 | 20317.93 | 未披露 | 定期报告 | 2020-10-29 |
| 2021-02-04 | 20317.52 | 未披露 |
更多>>
from June 30, 2020 to September 30, 2020
Issuance of common stock upon equity financings, net of issuance costs of $188
Issuance of common stock upon exercise of stock options
|
2020-09-30 |
| 2020-08-04 | 20057.67 | 未披露 | 定期报告 | 2020-07-31 |
| 2020-08-04 | 19956.30 | 未披露 |
更多>>
from March 31, 2020 to June 30, 2020
Issuance of common stock upon equity financings, net of issuance costs of $192
Issuance of common stock upon exercise of stock options, ESPP purchases and other
|
2020-06-30 |
| 2020-05-11 | 19602.46 | 未披露 | 定期报告 | 2020-05-06 |
| 2020-04-27 | 19590.00 | 未披露 | 定期报告 | 2020-04-22 |
| 2020-03-05 | 19581.88 | 未披露 | 定期报告 | 2020-02-28 |
| 2020-03-05 | 19525.70 | 未披露 |
更多>>
from December 31, 2018 to December 31, 2019
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
Issuance of common stock upon equity financings, net of issuance costs of $356
|
2019-12-31 |
| 2019-11-05 | 19236.22 | 未披露 | 定期报告 | 2019-10-30 |
| 2019-11-05 | 19224.30 | 未披露 |
更多>>
from June 30, 2019 to September 30, 2019
Issuance of common stock upon ESPP purchases
|
2019-09-30 |
| 2019-08-02 | 19194.22 | 未披露 | 定期报告 | 2019-07-30 |
| 2019-08-02 | 19193.10 | 未披露 |
更多>>
From March 31, 2019 to June 30, 2019
Issuance of common stock upon equity financings, net of issuance costs of $127
Issuance of common stock upon ESPP purchases
|
2019-06-30 |
| 2019-06-24 | 19130.25 | 未披露 | 定期报告 | 2019-06-24 |
| 2019-05-07 | 16235.99 | 未披露 | 定期报告 | 2019-05-03 |
| 2019-04-26 | 16230.25 | 未披露 | 定期报告 | 2019-04-23 |
| 2019-05-07 | 16230.30 | 未披露 |
更多>>
From December 31, 2018 to March 31, 2019
Issuance of common stock upon equity financings, net of issuance costs of $129
|
2019-03-31 |
| 2019-03-08 | 16205.97 | 未披露 | 定期报告 | 2019-03-04 |
| 2019-03-08 | 16206.00 | 未披露 |
更多>>
From December 31, 2017 to December 31, 2018
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
Issuance of common stock upon equity financings, net of issuance costs of $566
|
2018-12-31 |
| 2018-11-08 | 16205.97 | 未披露 | 定期报告 | 2018-11-02 |
| 2018-08-02 | 16200.17 | 未披露 | 定期报告 | 2018-07-30 |
| 2018-08-02 | 16200.17 | 未披露 | 定期报告 | 2018-06-30 |
| 2018-05-09 | 16170.93 | 未披露 | 定期报告 | 2018-05-03 |
| 2018-04-27 | 16163.24 | 未披露 | 定期报告 | 2018-04-24 |
| 2018-03-08 | 15333.70 | 未披露 | 定期报告 | 2018-03-02 |
| 2018-03-08 | 15083.70 | 未披露 |
更多>>
From December 31, 2016 to December 31, 2017
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
Issuance of common stock upon equity financings, net of issuance costs of $374
|
2017-12-31 |
| 2017-11-02 | 14854.61 | 未披露 | 定期报告 | 2017-10-27 |
| 2017-08-09 | 14699.86 | 未披露 | 定期报告 | 2017-08-04 |
| 2017-05-10 | 14196.65 | 未披露 | 定期报告 | 2017-05-05 |
| 2017-04-27 | 14190.65 | 未披露 | 定期报告 | 2017-04-24 |
| 2017-03-15 | 14189.28 | 未披露 | 定期报告 | 2017-03-09 |
| 2017-03-15 | 14129.70 | 未披露 |
更多>>
From December 31, 2015 to December 31, 2016
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
Issuance of common stock upon equity financings, net of issuance costs of $1,364
|
2016-12-31 |
| 2016-11-01 | 13858.16 | 未披露 | 定期报告 | 2016-09-30 |
| 2016-08-02 | 13741.04 | 未披露 | 定期报告 | 2016-07-25 |
| 2016-05-06 | 13736.24 | 未披露 | 定期报告 | 2016-05-02 |
| 2016-04-28 | 12346.53 | 未披露 | 定期报告 | 2016-04-25 |
| 2016-03-01 | 12206.59 | 未披露 | 定期报告 | 2016-02-18 |
| 2016-03-01 | 12183.90 | 未披露 |
更多>>
From December 31, 2014 to December 31, 2015
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
Issuance of common stock upon equity financings, net of issuance costs of $491
|
2015-12-31 |
| 2015-11-03 | 12052.52 | 未披露 | 定期报告 | 2015-10-26 |
| 2015-08-04 | 12048.17 | 未披露 | 定期报告 | 2015-07-24 |
| 2015-05-01 | 11956.86 | 未披露 | 定期报告 | 2015-04-24 |
| 2015-04-22 | 11646.46 | 未披露 | 定期报告 | 2015-04-20 |
| 2015-03-03 | 11373.34 | 未披露 | 定期报告 | 2015-02-18 |
| 2015-03-03 | 11373.30 | 未披露 |
更多>>
from December 31,2013 to December 31,2014
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
Issuance of common stock upon equity financing, net of issuance cost of $192
|
2014-12-31 |
| 2014-11-04 | 11367.55 | 未披露 | 定期报告 | 2014-10-28 |
| 2014-08-08 | 11159.66 | 未披露 | 定期报告 | 2014-07-31 |
| 2014-04-23 | 11052.29 | 未披露 | 定期报告 | 2014-04-21 |
| 2014-02-28 | 11048.36 | 未披露 | 定期报告 | 2014-02-14 |
| 2014-02-28 | 11040.90 | 未披露 |
更多>>
from December 31,2012 to December 31,2013
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
Issuance of common stock upon equity financing, net of issuance cost of $825
|
2013-12-31 |
| 2013-12-20 | 11039.05 | 未披露 | 定期报告 | 2013-12-17 |
| 2013-11-05 | 10207.34 | 未披露 | 定期报告 | 2013-10-31 |
| 2013-08-06 | 10202.62 | 未披露 | 定期报告 | 2013-07-31 |
| 2013-04-29 | 10189.45 | 未披露 | 定期报告 | 2013-04-26 |
| 2013-03-01 | 10188.18 | 未披露 | 定期报告 | 2013-02-15 |
| 2013-03-01 | 10188.00 | 未披露 |
更多>>
from December 31, 2011 to December 31, 2012
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
Issuance of common stock upon equity financing, net of issuance cost of $983
|
2012-12-31 |
| 2012-11-06 | 8780.87 | 未披露 | 定期报告 | 2012-10-31 |
| 2012-08-07 | 8765.91 | 未披露 | 定期报告 | 2012-07-31 |
| 2012-05-04 | 8762.97 | 未披露 | 定期报告 | 2012-05-01 |
| 2012-03-02 | 8754.71 | 未披露 | 定期报告 | 2012-02-29 |
| 2012-03-02 | 8754.70 | 未披露 |
更多>>
from December 31, 2010 to December 31, 2011
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
|
2011-12-31 |
| 2011-08-05 | 8745.01 | 未披露 | 定期报告 | 2011-07-29 |
| 2011-05-06 | 8733.43 | 未披露 | 定期报告 | 2011-04-29 |
| 2011-03-03 | 8728.90 | 未披露 | 定期报告 | 2011-02-28 |
| 2011-03-03 | 8705.30 | 未披露 |
更多>>
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
|
2010-12-31 |
| 2010-11-04 | 8689.47 | 未披露 | 定期报告 | 2010-10-29 |
| 2010-08-05 | 8688.94 | 未披露 | 定期报告 | 2010-07-31 |
| 2010-05-10 | 8678.28 | 未披露 | 定期报告 | 2010-04-30 |
| 2010-03-04 | 8675.48 | 未披露 | 定期报告 | 2010-02-26 |
| 2010-03-04 | 8675.50 | 未披露 |
更多>>
from December 31, 2008 to December 31, 2009
Issuance of common stock upon equity financing
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
|
2009-12-31 |
| 2009-03-10 | 8202.59 | 未披露 | 定期报告 | 2009-02-27 |
| 2009-03-10 | 8201.80 | 未披露 |
更多>>
from December 31, 2007 to December 31, 2008
Conversion of subordinated convertible notes
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
|
2008-12-31 |
| 2008-03-13 | 7411.22 | 未披露 | 定期报告 | 2008-02-29 |
| 2008-03-13 | 7410.70 | 未披露 |
更多>>
from December 31, 2006 to December 31, 2007
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
Conversion of subordinated convertible notes
|
2007-12-31 |
| 2007-03-15 | 6923.21 | 未披露 | 定期报告 | 2007-02-28 |
| 2007-03-15 | 6921.20 | 未披露 |
更多>>
from December 31, 2005 to December 31, 2006
Conversion of subordinated convertible notes
Issuance of common stock in connection with acquisition of Absorbable Polymer Technologies, Inc.
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
|
2006-12-31 |
| 2006-03-16 | 6195.49 | 未披露 | 定期报告 | 2006-02-28 |
| 2006-03-16 | 6160.90 | 未披露 |
更多>>
from December 31, 2004 to December 31, 2005
Secondary equity offering
Early conversion of convertible notes
Issuance of common stock in connection with acquisition of Absorbable Polymer Technologies, Inc.
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
|
2005-12-31 |
| 2005-03-14 | 5187.51 | 未披露 | 定期报告 | 2005-02-28 |
| 2005-03-14 | 5187.00 | 未披露 |
更多>>
from December 31, 2003 to December 31, 2004
Issuance of common stock to an employee for notes receivable.
Issuance of common stock in connection with acquisition of Absorbable Polymer Technologies, Inc.
Repurchase of unvested stock for cash and cancellation of certain notes receivable from stockholders
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
|
2004-12-31 |
| 2004-03-11 | 5117.53 | 未披露 | 定期报告 | 2004-02-27 |
| 2004-03-11 | 5116.30 | 未披露 |
更多>>
from December 31, 2002 to December 31, 2003
Issuance of common stock upon exercise of stock options, warrants and purchases of ESPP shares
Repurchase of unvested stock for cash and cancellation of certain notes receivable from stockholders
Issuance of common stock in connection with acquisition of Absorbable Polymer Technologies, Inc.
|
2003-12-31 |
| 2003-03-14 | 5041.54 | 未披露 | 定期报告 | 2003-02-28 |
| 2003-03-14 | 5044.30 | 未披露 |
更多>>
from December 31, 2001 to December 31, 2002
Issuance of common stock to corporate partner for cash.
Repurchase of unvested stock for cash and cancellation of certain notes receivable from stockholders
Issuance of common stock upon exercise of stock options, warrants and purchases of ESPP shares
|
2002-12-31 |
| 2002-03-28 | 4876.71 | 未披露 | 定期报告 | 2002-03-15 |
| 2002-03-28 | 4875.80 | 未披露 |
更多>>
from December 31, 2000 to December 31, 2001
Issuance of common stock and assumption of options and warrants in connection with acquisition of Southern BioSystems, Inc.
Issuance of common stock upon exercise of stock options, warrants and purchases of ESPP shares
|
2001-12-31 |
| 2001-03-30 | 4656.55 | 未披露 | 定期报告 | 2001-03-16 |
| 2001-03-30 | 4656.50 | 未披露 |
更多>>
from December 31,1999 to December 31,2000
Exercise of a warrant for common stock by an equipment lessor
Issuance of common stock upon exercise of stock options for notes receivable and cash
Issuance of common stock net of issuance cost of $7 and a warrant to purchase 1,000 shares of common stock to ALZA corporation for commercial rights and reduced royalties
Issuance common stock in initial public offering at $12.00 per share net of issuance costs of $8,361
Conversion of convertible preferred stock to common stock upon initial public offering
Issuance of Series C convertible preferred stock for cash net of issuance costs of $45
|
2000-12-31 |
From December 31, 2023 to December 31, 2024
Issuance of common stock pursuant to the 2021 Sales Agreement, net of issuance costs of $13
Issuance of common stock upon exercise of stock options and from the ESPP
From December 31, 2023 to March 31, 2024
Issuance of common stock pursuant to the 2021 Sales Agreement, net of issuance costs of $13,000
From December 31, 2022 to December 31, 2023
Issuance of common stock upon warrant exercises
Issuance of common stock in the February 2023 registered direct offering
Issuance of common stock pursuant to the 2021 Sales Agreement, net of issuance costs of $32
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
Issuance of common stock in the July 2023 registered direct offering, net of issuance costs of $673
From June 30, 2023 to September 30, 2023
Issuance of common stock in the July 2023 registered direct offering, net of issuance costs of $673
Issuance of common stock upon warrant exercises
Common stock offered 2,991,027 shares by the company
From December 31, 2022 to March 31, 2023
Issuance of common stock upon equity financing
Common stock offered 1,700,000 shares by the company
From December 31, 2021 to December 31, 2022
Issuance of common stock upon equity financings, net of issuance costs of $0
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
DURECT Corporation Announces 1-for-10 Reverse Stock Split.
From June 30, 2022 to September 30, 2022
Issuance of common stock upon equity financings, net of issuance costs of $506
From March 31, 2022 to June 30, 2022
Issuance of common stock upon exercise of stock options
From December 31, 2021 to March 31, 2022
Issuance of common stock upon exercise of stock options
From December 31, 2020 to December 31, 2021
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
Issuance of common stock upon equity financings, net of issuance costs of $395,000
From June 30, 2021 to September 30, 2021
Issuance of common stock upon exercise of stock options
From March 31, 2021 to June 30, 2021
Issuance of common stock upon exercise of stock options, ESPP purchases and other
From December 31, 2020 to March 31, 2021
Issuance of common stock upon exercise of stock options
Issuance of common stock upon equity financings, net of issuance costs of $269
1.Common stock offered by the company pursuant to this prospectus supplement 17,708,333 shares.
2.The number of shares of common stock to be outstanding after this offering is based on 203,175,181 shares outstanding as of September 30, 2020.
From December 31, 2019 to December 31, 2020
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
Issuance of common stock upon equity financings, net of issuance costs of $380
from June 30, 2020 to September 30, 2020
Issuance of common stock upon equity financings, net of issuance costs of $188
Issuance of common stock upon exercise of stock options
from March 31, 2020 to June 30, 2020
Issuance of common stock upon equity financings, net of issuance costs of $192
Issuance of common stock upon exercise of stock options, ESPP purchases and other
from December 31, 2018 to December 31, 2019
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
Issuance of common stock upon equity financings, net of issuance costs of $356
from June 30, 2019 to September 30, 2019
Issuance of common stock upon ESPP purchases
From March 31, 2019 to June 30, 2019
Issuance of common stock upon equity financings, net of issuance costs of $127
Issuance of common stock upon ESPP purchases
From December 31, 2018 to March 31, 2019
Issuance of common stock upon equity financings, net of issuance costs of $129
From December 31, 2017 to December 31, 2018
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
Issuance of common stock upon equity financings, net of issuance costs of $566
From December 31, 2016 to December 31, 2017
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
Issuance of common stock upon equity financings, net of issuance costs of $374
From December 31, 2015 to December 31, 2016
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
Issuance of common stock upon equity financings, net of issuance costs of $1,364
From December 31, 2014 to December 31, 2015
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
Issuance of common stock upon equity financings, net of issuance costs of $491
from December 31,2013 to December 31,2014
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
Issuance of common stock upon equity financing, net of issuance cost of $192
from December 31,2012 to December 31,2013
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
Issuance of common stock upon equity financing, net of issuance cost of $825
from December 31, 2011 to December 31, 2012
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
Issuance of common stock upon equity financing, net of issuance cost of $983
from December 31, 2010 to December 31, 2011
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
from December 31, 2008 to December 31, 2009
Issuance of common stock upon equity financing
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
from December 31, 2007 to December 31, 2008
Conversion of subordinated convertible notes
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
from December 31, 2006 to December 31, 2007
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
Conversion of subordinated convertible notes
from December 31, 2005 to December 31, 2006
Conversion of subordinated convertible notes
Issuance of common stock in connection with acquisition of Absorbable Polymer Technologies, Inc.
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
from December 31, 2004 to December 31, 2005
Secondary equity offering
Early conversion of convertible notes
Issuance of common stock in connection with acquisition of Absorbable Polymer Technologies, Inc.
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
from December 31, 2003 to December 31, 2004
Issuance of common stock to an employee for notes receivable.
Issuance of common stock in connection with acquisition of Absorbable Polymer Technologies, Inc.
Repurchase of unvested stock for cash and cancellation of certain notes receivable from stockholders
Issuance of common stock upon exercise of stock options and purchases of ESPP shares
from December 31, 2002 to December 31, 2003
Issuance of common stock upon exercise of stock options, warrants and purchases of ESPP shares
Repurchase of unvested stock for cash and cancellation of certain notes receivable from stockholders
Issuance of common stock in connection with acquisition of Absorbable Polymer Technologies, Inc.
from December 31, 2001 to December 31, 2002
Issuance of common stock to corporate partner for cash.
Repurchase of unvested stock for cash and cancellation of certain notes receivable from stockholders
Issuance of common stock upon exercise of stock options, warrants and purchases of ESPP shares
from December 31, 2000 to December 31, 2001
Issuance of common stock and assumption of options and warrants in connection with acquisition of Southern BioSystems, Inc.
Issuance of common stock upon exercise of stock options, warrants and purchases of ESPP shares
from December 31,1999 to December 31,2000
Exercise of a warrant for common stock by an equipment lessor
Issuance of common stock upon exercise of stock options for notes receivable and cash
Issuance of common stock net of issuance cost of $7 and a warrant to purchase 1,000 shares of common stock to ALZA corporation for commercial rights and reduced royalties
Issuance common stock in initial public offering at $12.00 per share net of issuance costs of $8,361
Conversion of convertible preferred stock to common stock upon initial public offering
Issuance of Series C convertible preferred stock for cash net of issuance costs of $45