主要股东
注：以下部分股东代表特定权益共同体，直接或间接持有上市公司股份
| 序号 | 股东名称 | 是否机构 | 持股数(股) | 持股比例 | 持股变动数(股) | 持股数变动比例 | 投票权比例 |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management, L.P. | 是 | 586.46万 | 8.50% | 新增 | 新增 | -- |
| 2 | PFM Health Sciences, LP | 是 | 519.16万 | 7.53% | 新增 | 新增 | -- |
| 3 | Fred A. Middleton | 否 | 434.99万 | 6.30% | 新增 | 新增 | -- |
| 4 | Venrock Healthcare Capital Partners II, L.P. | 是 | 430.00万 | 6.23% | 新增 | 新增 | -- |
| 5 | Entities related to Sanderling Ventures | 是 | 404.56万 | 5.87% | 新增 | 新增 | -- |
机构持股汇总
| 主力进出\报告期 | 2018-12-20 | 2018-11-19 | 2018-11-15 | 2018-11-14 | 2018-11-13 | 2018-11-09 |
|---|---|---|---|---|---|---|
| 机构数量(家) | 153 | 153 | 154 | 152 | 153 | 151 |
| 累计持有数量(万股) | 6271.38 | 6271.46 | 6222.39 | 5163.21 | 5522.44 | 5322.56 |
| 累计市值(亿) | 15.05 | 14.84 | 14.64 | 12.17 | 13.01 | 12.59 |
| 持仓比例(%) | 76.39% | 76.39% | 75.79% | 62.89% | 67.27% | 64.84% |
| 净交易量(万股) |
注：若当期数据无主力机构持仓或公司定期报告未披露完毕，则不显示。
非主要股东机构持股变动
| 机构或基金名称 | 持有数量 | 持股市值(亿美元) | 持股变动(万股) | 变动比例(%) |
|---|---|---|---|---|
|
Vanguard Group Inc
|
352.44万股 | 0.84 | 39.43 | 12.60 |
|
Point72 Asset Management, L.P.
|
210.68万股 | 0.50 | 210.68 | 不足0.01 |
|
Ghost Tree Capital, Llc
|
110.00万股 | 0.26 | 60.00 | 120.00 |
|
Fmr Llc
|
90.71万股 | 0.22 | 1.48 | 1.66 |
|
Ra Capital Management, Llc
|
619.61万股 | 1.48 | 54.63 | 9.67 |
|
Blackrock Inc.
|
527.41万股 | 1.26 | 6.54 | 1.26 |
|
Deerfield Management Company, L.P.
|
351.41万股 | 0.84 | 118.98 | 51.19 |
|
Price T Rowe Associates Inc
|
326.19万股 | 0.78 | 64.21 | 24.51 |
|
Baker Bros. ADVISORS LP
|
254.81万股 | 0.61 | 27.03 | 11.87 |
|
Perceptive Advisors Llc
|
244.17万股 | 0.58 | 52.00 | 27.06 |
|
State Street Corp
|
161.61万股 | 0.39 | 4.84 | 3.09 |
|
Great Point Partners I Lp
|
160.61万股 | 0.38 | 160.61 | 不足0.01 |
|
Citadel Advisors Llc
|
136.19万股 | 0.32 | -63.94 | -31.95 |
|
Invesco Ltd.
|
135.05万股 | 0.32 | 36.18 | 36.59 |
|
Adage Capital Partners Gp, L.L.C.
|
120.00万股 | 0.29 | 45.00 | 60.00 |
|
Teachers Advisors, Llc
|
99.95万股 | 0.24 | 87.52 | 703.65 |
|
Venbio Select Advisor Llc
|
530.17万股 | 1.26 | -39.35 | -6.91 |
|
Vhcp Management Ii, Llc
|
421.13万股 | 1.00 | -8.87 | -2.06 |
|
Janus Henderson Group Plc
|
175.84万股 | 0.42 | 175.84 | 不足0.01 |
|
Eventide Asset Management, Llc
|
131.40万股 | 0.31 | 96.40 | 275.43 |
| 机构或基金名称 | 持有数量 | 持股市值(亿美元) | 持股变动(万股) | 变动比例(%) |
|---|---|---|---|---|
|
Venbio Select Advisor Llc
|
530.17万股 | 1.26 | -39.35 | -6.91 |
|
Vhcp Management Ii, Llc
|
421.13万股 | 1.00 | -8.87 | -2.06 |
|
Deerfield Management Company, L.P.
|
351.41万股 | 0.84 | 118.98 | 51.19 |
|
Price T Rowe Associates Inc
|
326.19万股 | 0.78 | 64.21 | 24.51 |
|
Baker Bros. ADVISORS LP
|
254.81万股 | 0.61 | 27.03 | 11.87 |
|
Perceptive Advisors Llc
|
244.17万股 | 0.58 | 52.00 | 27.06 |
|
Janus Henderson Group Plc
|
175.84万股 | 0.42 | 175.84 | 不足0.01 |
|
Adage Capital Partners Gp, L.L.C.
|
120.00万股 | 0.29 | 45.00 | 60.00 |
|
Ghost Tree Capital, Llc
|
110.00万股 | 0.26 | 60.00 | 120.00 |
|
Ra Capital Management, Llc
|
619.61万股 | 1.48 | 54.63 | 9.67 |
|
Blackrock Inc.
|
527.41万股 | 1.26 | 6.54 | 1.26 |
|
Vanguard Group Inc
|
352.44万股 | 0.84 | 39.43 | 12.60 |
|
Point72 Asset Management, L.P.
|
210.68万股 | 0.50 | 210.68 | 不足0.01 |
|
State Street Corp
|
161.61万股 | 0.39 | 4.84 | 3.09 |
|
Great Point Partners I Lp
|
160.61万股 | 0.38 | 160.61 | 不足0.01 |
|
Citadel Advisors Llc
|
136.19万股 | 0.32 | -63.94 | -31.95 |
|
Invesco Ltd.
|
135.05万股 | 0.32 | 36.18 | 36.59 |
|
Eventide Asset Management, Llc
|
131.40万股 | 0.31 | 96.40 | 275.43 |
|
Teachers Advisors, Llc
|
99.95万股 | 0.24 | 87.52 | 703.65 |
|
Fmr Llc
|
90.71万股 | 0.22 | 1.48 | 1.66 |
| 机构或基金名称 | 持有数量 | 持股市值(亿美元) | 持股变动(万股) | 变动比例(%) |
|---|---|---|---|---|
|
Ra Capital Management, Llc
|
619.61万股 | 1.45 | 54.63 | 9.67 |
|
Blackrock Inc.
|
527.41万股 | 1.24 | 6.54 | 1.26 |
|
Vhcp Management Ii, Llc
|
421.13万股 | 0.99 | -8.87 | -2.06 |
|
Vanguard Group Inc
|
352.44万股 | 0.83 | 39.43 | 12.60 |
|
Baker Bros. ADVISORS LP
|
254.81万股 | 0.60 | 27.03 | 11.87 |
|
Perceptive Advisors Llc
|
244.17万股 | 0.57 | 52.00 | 27.06 |
|
Point72 Asset Management, L.P.
|
210.68万股 | 0.49 | 210.68 | 不足0.01 |
|
Citadel Advisors Llc
|
136.19万股 | 0.32 | -63.94 | -31.95 |
|
Eventide Asset Management, Llc
|
131.40万股 | 0.31 | 96.40 | 275.43 |
|
Venbio Select Advisor Llc
|
530.17万股 | 1.24 | -39.35 | -6.91 |
|
Price T Rowe Associates Inc
|
326.19万股 | 0.76 | 64.21 | 24.51 |
|
Janus Henderson Group Plc
|
175.84万股 | 0.41 | 175.84 | 不足0.01 |
|
State Street Corp
|
161.61万股 | 0.38 | 4.84 | 3.09 |
|
Great Point Partners I Lp
|
160.61万股 | 0.38 | 160.61 | 不足0.01 |
|
Adage Capital Partners Gp, L.L.C.
|
120.00万股 | 0.28 | 45.00 | 60.00 |
|
Teachers Advisors, Llc
|
99.95万股 | 0.23 | 87.52 | 703.65 |
|
Fmr Llc
|
90.71万股 | 0.21 | 1.48 | 1.66 |
|
Deerfield Management Company, L.P.
|
351.41万股 | 0.82 | 118.98 | 51.19 |
|
Invesco Ltd.
|
135.05万股 | 0.32 | 36.18 | 36.59 |
|
Ghost Tree Capital, Llc
|
110.00万股 | 0.26 | 60.00 | 120.00 |
| 机构或基金名称 | 持有数量 | 持股市值(亿美元) | 持股变动(万股) | 变动比例(%) |
|---|---|---|---|---|
|
Ra Capital Management, Llc
|
619.61万股 | 1.46 | 54.63 | 9.67 |
|
Blackrock Inc.
|
527.41万股 | 1.24 | 6.54 | 1.26 |
|
Deerfield Management Company, L.P.
|
351.41万股 | 0.83 | 118.98 | 51.19 |
|
Baker Bros. ADVISORS LP
|
254.81万股 | 0.60 | 27.03 | 11.87 |
|
Point72 Asset Management, L.P.
|
210.68万股 | 0.50 | 210.68 | 不足0.01 |
|
Janus Henderson Group Plc
|
175.84万股 | 0.41 | 175.84 | 不足0.01 |
|
State Street Corp
|
161.61万股 | 0.38 | 4.84 | 3.09 |
|
Great Point Partners I Lp
|
160.61万股 | 0.38 | 160.61 | 不足0.01 |
|
Citadel Advisors Llc
|
136.19万股 | 0.32 | -63.94 | -31.95 |
|
Invesco Ltd.
|
135.05万股 | 0.32 | 36.18 | 36.59 |
|
Eventide Asset Management, Llc
|
131.40万股 | 0.31 | 96.40 | 275.43 |
|
Adage Capital Partners Gp, L.L.C.
|
120.00万股 | 0.28 | 45.00 | 60.00 |
|
Teachers Advisors, Llc
|
99.95万股 | 0.24 | 87.52 | 703.65 |
|
Venbio Select Advisor Llc
|
530.17万股 | 1.25 | -39.35 | -6.91 |
|
Vhcp Management Ii, Llc
|
421.13万股 | 0.99 | -8.87 | -2.06 |
|
Vanguard Group Inc
|
352.44万股 | 0.83 | 39.43 | 12.60 |
|
Price T Rowe Associates Inc
|
326.19万股 | 0.77 | 64.21 | 24.51 |
|
Ghost Tree Capital, Llc
|
110.00万股 | 0.26 | 60.00 | 120.00 |
|
Fmr Llc
|
90.71万股 | 0.21 | 1.48 | 1.66 |
|
Perceptive Advisors Llc
|
244.17万股 | 0.58 | 52.00 | 27.06 |
| 机构或基金名称 | 持有数量 | 持股市值(亿美元) | 持股变动(万股) | 变动比例(%) |
|---|---|---|---|---|
|
Ra Capital Management, Llc
|
619.61万股 | 1.46 | 54.63 | 9.67 |
|
Blackrock Inc.
|
527.41万股 | 1.25 | 6.54 | 1.26 |
|
Vhcp Management Ii, Llc
|
421.13万股 | 0.99 | -8.87 | -2.06 |
|
Deerfield Management Company, L.P.
|
351.41万股 | 0.83 | 118.98 | 51.19 |
|
Invesco Ltd.
|
135.05万股 | 0.32 | 36.18 | 36.59 |
|
Adage Capital Partners Gp, L.L.C.
|
120.00万股 | 0.28 | 45.00 | 60.00 |
|
Perceptive Advisors Llc
|
244.17万股 | 0.58 | 52.00 | 27.06 |
|
Point72 Asset Management, L.P.
|
210.68万股 | 0.50 | 210.68 | 不足0.01 |
|
Janus Henderson Group Plc
|
175.84万股 | 0.42 | 175.84 | 不足0.01 |
|
Great Point Partners I Lp
|
160.61万股 | 0.38 | 160.61 | 不足0.01 |
|
Fmr Llc
|
90.71万股 | 0.21 | 1.48 | 1.66 |
|
Venbio Select Advisor Llc
|
530.17万股 | 1.25 | -39.35 | -6.91 |
|
Vanguard Group Inc
|
352.44万股 | 0.83 | 39.43 | 12.60 |
|
Price T Rowe Associates Inc
|
326.19万股 | 0.77 | 64.21 | 24.51 |
|
Baker Bros. ADVISORS LP
|
254.81万股 | 0.60 | 27.03 | 11.87 |
|
State Street Corp
|
161.61万股 | 0.38 | 4.84 | 3.09 |
|
Citadel Advisors Llc
|
136.19万股 | 0.32 | -63.94 | -31.95 |
|
Eventide Asset Management, Llc
|
131.40万股 | 0.31 | 96.40 | 275.43 |
|
Rock Springs Capital Management Lp
|
85.00万股 | 0.20 | 17.50 | 25.93 |
|
Ghost Tree Capital, Llc
|
110.00万股 | 0.26 | 60.00 | 120.00 |