股本结构
单位：万股
| 公告日期 | 2026-02-10 | 2026-02-10 | 2025-11-04 | 2025-11-04 | 2025-07-28 | 2025-07-28 |
|---|---|---|---|---|---|---|
| 证券总股本 | 25970.87 | 26248.30 | 26811.22 | 26809.80 | 26920.25 | 27013.20 |
| 普通股本 | 25970.87 | 26248.30 | 26811.22 | 26809.80 | 26920.25 | 27013.20 |
| 优先股 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2026-02-02 | 2025-12-31 | 2025-10-27 | 2025-09-30 | 2025-07-21 | 2025-06-30 |
注释：中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本（万股） | 变动后优先股（万股） | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2026-02-10 | 25970.87 | 未披露 | 定期报告 | 2026-02-02 |
| 2026-02-10 | 26248.30 | 未披露 |
更多>>
From December 31, 2024 to December 31, 2025
Issuance of common stock under the equity incentive plan and stock purchase plan
Repurchases of common stock
|
2025-12-31 |
| 2025-11-04 | 26811.22 | 未披露 | 定期报告 | 2025-10-27 |
| 2025-11-04 | 26809.80 | 未披露 |
更多>>
From June 30, 2025 to September 30, 2025
Issuance of common stock under the equity incentive plan
Repurchases of common stock
|
2025-09-30 |
| 2025-07-28 | 26920.25 | 未披露 | 定期报告 | 2025-07-21 |
| 2025-07-28 | 27013.20 | 未披露 |
更多>>
From March 31, 2025 to June 30, 2025
Issuance of common stock under the equity incentive plans and stock purchase plan
Repurchases of common stock
|
2025-06-30 |
| 2025-05-13 | 27270.83 | 未披露 | 定期报告 | 2025-05-05 |
| 2025-05-13 | 27503.30 | 未披露 |
更多>>
From December 31, 2024 to March 31, 2025
Issuance of common stock under the equity incentive plans
Repurchases of common stock
|
2025-03-31 |
| 2025-04-16 | 27834.57 | 未披露 | 定期报告 | 2025-02-28 |
| 2025-02-11 | 27988.15 | 未披露 | 定期报告 | 2025-02-03 |
| 2025-02-11 | 28173.20 | 未披露 |
更多>>
From December 31, 2023 to December 31, 2024
Issuance of common stock under the equity incentive plan and stock purchase plan
Repurchases of common stock
|
2024-12-31 |
| 2024-10-29 | 28557.90 | 未披露 | 定期报告 | 2024-10-21 |
| 2024-10-29 | 28578.00 | 未披露 |
更多>>
From June 30, 2024 to September 30, 2024
Issuance of common stock under the equity incentive plan
Repurchases of common stock
|
2024-09-30 |
| 2024-08-06 | 28525.17 | 未披露 | 定期报告 | 2024-07-29 |
| 2024-08-06 | 28522.20 | 未披露 |
更多>>
From March 31, 2024 to June 30, 2024
Issuance of common stock under the equity incentive plan and stock purchase plan
Repurchases of common stock
|
2024-06-30 |
| 2024-04-30 | 29129.27 | 未披露 | 定期报告 | 2024-04-22 |
| 2024-04-18 | 29480.00 | 未披露 | 定期报告 | 2024-04-01 |
| 2024-04-30 | 29503.20 | 未披露 |
更多>>
From December 31, 2023 to March 31, 2024
Issuance of common stock under equity incentive plans
Repurchases of common stock
|
2024-03-31 |
| 2024-04-18 | 29974.99 | 未披露 | 定期报告 | 2024-02-28 |
| 2024-02-06 | 30319.43 | 未披露 | 定期报告 | 2024-01-29 |
| 2024-02-06 | 30279.30 | 未披露 |
更多>>
From December 31, 2022 to December 31,2023
Issuance of common stock under equity incentive and stock purchase plans
Repurchases of common stock
|
2023-12-31 |
| 2023-11-01 | 31097.41 | 未披露 | 定期报告 | 2023-10-23 |
| 2023-11-01 | 31097.00 | 未披露 |
更多>>
From June 30, 2023 to September 30, 2023
Issuance of common stock under equity incentive plans
Repurchases of common stock
|
2023-09-30 |
| 2023-08-01 | 31838.08 | 未披露 | 定期报告 | 2023-07-24 |
| 2023-08-01 | 32025.30 | 未披露 |
更多>>
From March 31, 2023 to June 30, 2023
Issuance of common stock under equity incentive and stock purchase plans
Repurchases of common stock
|
2023-06-30 |
| 2023-05-09 | 32563.67 | 未披露 | 定期报告 | 2023-05-01 |
| 2023-05-09 | 32498.50 | 未披露 |
更多>>
From December 31, 2022 to March 31, 2023
Issuance of common stock under equity incentive and stock purchase plans
|
2023-03-31 |
| 2023-02-07 | 32408.73 | 未披露 | 定期报告 | 2023-01-30 |
| 2023-02-07 | 32395.10 | 未披露 |
更多>>
From December 31, 2021 to December 31, 2022
Issuance of common stock under equity incentive and stock purchase plans
|
2022-12-31 |
| 2022-11-01 | 32256.14 | 未披露 | 定期报告 | 2022-10-24 |
| 2022-08-09 | 32183.18 | 未披露 | 定期报告 | 2022-08-01 |
| 2022-08-09 | 32180.00 | 未披露 |
更多>>
From March 31, 2022 to June 30, 2022
Issuance of common stock under equity incentive plans and stock purchase plan
|
2022-06-30 |
| 2022-05-10 | 32074.07 | 未披露 | 定期报告 | 2022-05-02 |
| 2022-05-10 | 32026.80 | 未披露 |
更多>>
From December 31, 2021 to March 31, 2022
Issuance of common stock under equity incentive plans
|
2022-03-31 |
| 2022-04-14 | 32018.23 | 未披露 | 定期报告 | 2022-03-28 |
| 2022-04-14 | 31993.10 | 未披露 | 定期报告 | 2022-02-28 |
| 2022-02-18 | 31944.82 | 未披露 | 定期报告 | 2022-02-07 |
| 2022-02-18 | 31884.20 | 未披露 |
更多>>
From December 31, 2020 to December 31, 2021
Issuance of common stock under equity incentive and stock purchase plans
|
2021-12-31 |
| 2021-11-02 | 31639.74 | 未披露 | 定期报告 | 2021-10-25 |
| 2021-11-02 | 31630.50 | 未披露 |
更多>>
From June 30, 2021 to September 30, 2021
Issuance of common stock under equity incentive plans
|
2021-09-30 |
| 2021-08-05 | 31504.88 | 未披露 | 定期报告 | 2021-07-26 |
| 2021-08-05 | 31482.20 | 未披露 |
更多>>
From March 31, 2021 to June 30, 2021
Issuance of common stock under equity incentive and stock purchase plans
|
2021-06-30 |
| 2021-05-06 | 31338.72 | 未披露 | 定期报告 | 2021-04-26 |
| 2021-05-06 | 31326.20 | 未披露 |
更多>>
From December 31, 2020 to March 31, 2021
Issuance of common stock under equity incentive plans
|
2021-03-31 |
| 2021-04-15 | 31309.79 | 未披露 | 定期报告 | 2021-03-29 |
| 2021-04-15 | 31281.79 | 未披露 | 定期报告 | 2021-02-28 |
| 2021-02-11 | 31198.97 | 未披露 | 定期报告 | 2021-02-01 |
| 2021-02-11 | 31162.70 | 未披露 |
更多>>
From December 31, 2019 to December 31, 2020
Issuance of common stock under equity incentive and stock purchase plans
|
2020-12-31 |
| 2020-11-05 | 31024.40 | 未披露 | 定期报告 | 2020-10-26 |
| 2020-11-05 | 30940.20 | 未披露 |
更多>>
From June 30, 2020 to September 30, 2020
Issuance of common stock under equity incentive and stock purchase plans
|
2020-09-30 |
| 2020-08-06 | 30899.58 | 未披露 | 定期报告 | 2020-07-27 |
| 2020-08-06 | 30888.60 | 未披露 |
更多>>
From March 31, 2020 to June 30, 2020
Issuance of common stock under equity incentive and stock purchase plans
|
2020-06-30 |
| 2020-05-05 | 30665.88 | 未披露 | 定期报告 | 2020-04-27 |
| 2020-05-05 | 30578.00 | 未披露 |
更多>>
From December 31, 2019 to March 31, 2020
Issuance of common stock under equity incentive plans, net of tax
|
2020-03-31 |
| 2020-04-09 | 30573.35 | 未披露 | 定期报告 | 2020-03-23 |
| 2020-04-09 | 30549.46 | 未披露 | 定期报告 | 2020-02-28 |
| 2020-02-25 | 30539.32 | 未披露 | 定期报告 | 2020-02-18 |
| 2020-02-25 | 30483.10 | 未披露 |
更多>>
From December 31, 2018 to December 31, 2019
Issuance of common stock under equity incentive and stock purchase plans
|
2019-12-31 |
| 2019-10-30 | 30384.63 | 未披露 | 定期报告 | 2019-10-21 |
| 2019-10-30 | 30377.60 | 未披露 |
更多>>
from June 30, 2019 to September 30, 2019
Issuance of common stock under equity incentive and stock purchase plans
|
2019-09-30 |
| 2019-07-31 | 30290.62 | 未披露 | 定期报告 | 2019-07-22 |
| 2019-07-31 | 30278.49 | 未披露 |
更多>>
from March 31, 2019 to June 30,2019
Issuance of common stock under equity incentive and stock purchase plans
|
2019-06-30 |
| 2019-05-01 | 30176.74 | 未披露 | 定期报告 | 2019-04-22 |
| 2019-05-01 | 30151.99 | 未披露 |
更多>>
from December 31, 2018 to March 31, 2019
Issuance of common stock under equity incentive and stock purchase plans
|
2019-03-31 |
| 2019-04-11 | 30134.66 | 未披露 | 定期报告 | 2019-03-25 |
| 2019-03-28 | 30099.67 | 未披露 | 定期报告 | 2019-02-28 |
| 2019-02-22 | 30012.96 | 未披露 | 定期报告 | 2019-02-12 |
| 2019-02-22 | 29987.61 | 未披露 |
更多>>
from December 31, 2017 to December 31, 2018
Issuance of common stock under equity incentive and stock purchase plans
|
2018-12-31 |
| 2018-11-01 | 29898.31 | 未披露 | 定期报告 | 2018-10-22 |
| 2018-11-01 | 29888.19 | 未披露 | 定期报告 | 2018-09-30 |
| 2018-08-01 | 29803.55 | 未披露 | 定期报告 | 2018-07-24 |
| 2018-08-01 | 29789.22 | 未披露 | 定期报告 | 2018-06-30 |
| 2018-05-02 | 29686.64 | 未披露 | 定期报告 | 2018-04-23 |
| 2018-05-02 | 29669.43 | 未披露 | 定期报告 | 2018-03-30 |
| 2018-04-12 | 29665.92 | 未披露 | 定期报告 | 2018-03-29 |
| 2018-02-26 | 29630.73 | 未披露 | 定期报告 | 2018-02-12 |
| 2018-02-26 | 29620.94 | 未披露 |
更多>>
from December 31, 2016 to December 29, 2017
Issuance of common stock under equity incentive and stock purchase plans
Issuance of common stock on warrant exercise
|
2017-12-29 |
| 2017-11-01 | 29585.32 | 未披露 | 定期报告 | 2017-10-24 |
| 2017-11-01 | 29570.06 | 未披露 | 定期报告 | 2017-09-30 |
| 2017-08-02 | 29390.47 | 未披露 | 定期报告 | 2017-07-26 |
| 2017-08-02 | 29372.76 | 未披露 | 定期报告 | 2017-06-30 |
| 2017-05-01 | 29251.23 | 未披露 | 定期报告 | 2017-04-24 |
| 2017-05-01 | 29230.23 | 未披露 | 定期报告 | 2017-03-31 |
| 2017-04-13 | 29168.73 | 未披露 | 定期报告 | 2017-03-10 |
| 2017-02-27 | 29086.66 | 未披露 | 定期报告 | 2017-02-16 |
| 2017-02-27 | 28992.38 | 未披露 |
更多>>
from December 31, 2015 to December 31, 2016
Issuance of common stock in settlement of convertible notes
Issuance of common stock under stock plans
|
2016-12-31 |
| 2016-11-03 | 28645.59 | 未披露 | 定期报告 | 2016-10-26 |
| 2016-11-03 | 28612.32 | 未披露 | 定期报告 | 2016-09-30 |
| 2016-08-03 | 23032.57 | 未披露 | 定期报告 | 2016-07-28 |
| 2016-08-03 | 23024.11 | 未披露 | 定期报告 | 2016-06-30 |
| 2016-05-04 | 22873.97 | 未披露 | 定期报告 | 2016-04-28 |
| 2016-05-04 | 22868.12 | 未披露 | 定期报告 | 2016-04-01 |
| 2016-04-13 | 22862.35 | 未披露 | 定期报告 | 2016-03-11 |
| 2016-02-29 | 22819.11 | 未披露 | 定期报告 | 2016-02-19 |
| 2016-02-29 | 22796.09 | 未披露 |
更多>>
from December 31, 2014 to December 31, 2015
Sale of shares of common stock, net
Issuance of common stock under stock plans
|
2015-12-31 |
| 2015-11-10 | 22721.66 | 未披露 | 定期报告 | 2015-10-29 |
| 2015-11-10 | 22615.44 | 未披露 | 定期报告 | 2015-10-02 |
| 2015-08-11 | 22543.11 | 未披露 | 定期报告 | 2015-08-03 |
| 2015-08-11 | 19638.12 | 未披露 | 定期报告 | 2015-07-03 |
| 2015-04-30 | 19602.66 | 未披露 | 定期报告 | 2015-04-23 |
| 2015-04-30 | 19602.09 | 未披露 | 定期报告 | 2015-03-31 |
| 2015-04-16 | 19590.89 | 未披露 | 定期报告 | 2015-03-13 |
| 2015-03-02 | 19589.58 | 未披露 |
更多>>
from December31, 2013 to December 31, 2014
Issuance of common stock under stock plans
Sale of shares of common stock
|
2014-12-31 |
| 2014-11-04 | 19521.58 | 未披露 | 定期报告 | 2014-10-29 |
| 2014-11-04 | 19517.95 | 未披露 | 定期报告 | 2014-09-26 |
| 2014-07-31 | 19511.00 | 未披露 | 定期报告 | 2014-07-24 |
| 2014-07-31 | 19508.86 | 未披露 | 定期报告 | 2014-06-27 |
| 2014-05-01 | 19469.49 | 未披露 | 定期报告 | 2014-04-24 |
| 2014-05-01 | 19465.29 | 未披露 | 定期报告 | 2014-03-28 |
| 2014-02-20 | 19461.43 | 未披露 | 定期报告 | 2014-02-19 |
| 2014-02-20 | 18453.37 | 未披露 |
更多>>
from December31, 2012 to December27, 2013
Issuance of common stock under stock plans
|
2013-12-27 |
| 2013-10-30 | 18420.44 | 未披露 | 定期报告 | 2013-10-25 |
| 2013-10-30 | 18419.41 | 未披露 | 定期报告 | 2013-09-27 |
| 2013-08-06 | 18411.72 | 未披露 | 定期报告 | 2013-07-29 |
| 2013-08-06 | 18410.43 | 未披露 | 定期报告 | 2013-06-28 |
| 2013-05-07 | 18380.18 | 未披露 | 定期报告 | 2013-04-30 |
| 2013-04-10 | 18378.91 | 未披露 | 定期报告 | 2013-03-25 |
| 2013-02-21 | 18371.84 | 未披露 | 定期报告 | 2013-02-14 |
| 2013-02-21 | 18369.72 | 未披露 |
更多>>
from December 31, 2011 to December 28, 2012
Issuance of common stock under stock plans
Sale of shares of common stock
|
2012-12-28 |
| 2012-11-07 | 18359.69 | 未披露 | 定期报告 | 2012-11-02 |
| 2012-11-07 | 18348.90 | 未披露 | 定期报告 | 2012-09-28 |
| 2012-08-02 | 14888.49 | 未披露 | 定期报告 | 2012-07-27 |
| 2012-08-02 | 14879.42 | 未披露 | 定期报告 | 2012-06-29 |
| 2012-05-03 | 14847.68 | 未披露 | 定期报告 | 2012-04-27 |
| 2012-05-03 | 14845.77 | 未披露 | 定期报告 | 2012-03-30 |
| 2012-02-22 | 14842.05 | 未披露 | 定期报告 | 2012-02-15 |
| 2012-02-22 | 13556.37 | 未披露 |
更多>>
from December 31, 2010 to December 30, 2011
Issuance of common stock under stock plans
Sale of shares of common stock
Issuance of common stock for settlement of convertible loan
|
2011-12-30 |
| 2011-10-27 | 12968.56 | 未披露 | 定期报告 | 2011-10-21 |
| 2011-08-04 | 12897.44 | 未披露 | 定期报告 | 2011-07-29 |
| 2011-05-03 | 12783.51 | 未披露 | 定期报告 | 2011-04-28 |
| 2011-02-22 | 10948.72 | 未披露 | 定期报告 | 2011-02-15 |
| 2011-02-22 | 10928.72 | 未披露 |
更多>>
Issuance of common stock under stock plans
|
2010-12-31 |
| 2010-11-04 | 10898.50 | 未披露 | 定期报告 | 2010-10-29 |
| 2010-08-05 | 10865.56 | 未披露 | 定期报告 | 2010-07-30 |
| 2010-05-11 | 10857.60 | 未披露 | 定期报告 | 2010-05-05 |
| 2010-03-10 | 10798.88 | 未披露 | 定期报告 | 2010-03-05 |
| 2010-03-10 | 10791.83 | 未披露 |
更多>>
from December 31, 2008 to December 31, 2009
Issuance of common stock under stock plans
|
2009-12-31 |
| 2009-03-10 | 10638.26 | 未披露 | 定期报告 | 2009-02-27 |
| 2009-03-10 | 10633.12 | 未披露 |
更多>>
from December 31, 2007 to December 31, 2008
Issuance of common stock under stock plans
|
2008-12-31 |
| 2008-02-25 | 10507.38 | 未披露 | 定期报告 | 2008-02-20 |
| 2008-02-25 | 10474.47 | 未披露 |
更多>>
from December 31, 2006 to December 31, 2007
Issuance of common stock under stock plans
Issuance of common stock, net of offering costs
|
2007-12-31 |
| 2007-02-27 | 9660.31 | 未披露 | 定期报告 | 2007-02-20 |
| 2007-02-27 | 9599.01 | 未披露 |
更多>>
from December 31, 2005 to December 31, 2006
Issuance of common stock under stock plans, net of repurchases
Issuance of common stock, net of offering costs
Exercise of Warrant
|
2006-12-31 |
| 2006-03-09 | 8376.76 | 未披露 | 定期报告 | 2006-02-28 |
| 2006-03-09 | 8340.47 | 未披露 |
更多>>
from December 31, 2004 to December 31, 2005
Issuance of common stock under company stock plans, net of repurchases
Issuance of common stock, net of offering costs
Issuance of common stock under the GlaxoSmithKline collaboration
|
2005-12-31 |
| 2005-03-15 | 7615.01 | 未披露 | 定期报告 | 2005-03-04 |
| 2005-03-15 | 7499.55 | 未披露 |
更多>>
from December 31, 2003 to December 31, 2004
Issuance of common stock under company stock plans, net of repurchases
Issuance of common stock for acquisition
|
2004-12-31 |
| 2004-02-20 | 7129.51 | 未披露 |
更多>>
from December 31, 2002 to December 31, 2003
Issuance of common stock under company stock plans, net of repurchases
Repayment of notes from stockholders for the exercise of stock options
Issuance of common stock, net of offerings costs
|
2003-12-31 |
| 2003-03-07 | 5964.96 | 未披露 | 定期报告 | 2003-02-28 |
| 2003-03-07 | 5938.65 | 未披露 |
更多>>
from December 31, 2001 to December 31, 2002
Issuance of common stock under company stock plans, net of repurchases
Issuance of common stock, GSK collaboration
Issuance of common stock for acquisition
|
2002-12-31 |
| 2002-03-20 | 5615.23 | 未披露 | 定期报告 | 2002-01-31 |
| 2002-03-20 | 5615.01 | 未披露 |
更多>>
from December 31, 2000 to December 31, 2001
Issuance of common stock under options, warrants and stock purchase plan net of repurchases
Issuance of common stock, BMS collaboration
Issuance of common stock for acquisition
|
2001-12-31 |
| 2001-03-15 | 4674.51 | 未披露 | 定期报告 | 2001-03-12 |
| 2001-03-15 | 4673.23 | 未披露 |
更多>>
from December 31, 1999 to December 31, 2000
Issuance of common stock under options, warrants and stock purchase plan net of repurchases
Issuance of common stock, net of offering costs
Issuance of common stock for acquisition
Conversion of preferred stock
Conversion of promissory note
|
2000-12-31 |
From December 31, 2024 to December 31, 2025
Issuance of common stock under the equity incentive plan and stock purchase plan
Repurchases of common stock
From June 30, 2025 to September 30, 2025
Issuance of common stock under the equity incentive plan
Repurchases of common stock
From March 31, 2025 to June 30, 2025
Issuance of common stock under the equity incentive plans and stock purchase plan
Repurchases of common stock
From December 31, 2024 to March 31, 2025
Issuance of common stock under the equity incentive plans
Repurchases of common stock
From December 31, 2023 to December 31, 2024
Issuance of common stock under the equity incentive plan and stock purchase plan
Repurchases of common stock
From June 30, 2024 to September 30, 2024
Issuance of common stock under the equity incentive plan
Repurchases of common stock
From March 31, 2024 to June 30, 2024
Issuance of common stock under the equity incentive plan and stock purchase plan
Repurchases of common stock
From December 31, 2023 to March 31, 2024
Issuance of common stock under equity incentive plans
Repurchases of common stock
From December 31, 2022 to December 31,2023
Issuance of common stock under equity incentive and stock purchase plans
Repurchases of common stock
From June 30, 2023 to September 30, 2023
Issuance of common stock under equity incentive plans
Repurchases of common stock
From March 31, 2023 to June 30, 2023
Issuance of common stock under equity incentive and stock purchase plans
Repurchases of common stock
From December 31, 2022 to March 31, 2023
Issuance of common stock under equity incentive and stock purchase plans
From December 31, 2021 to December 31, 2022
Issuance of common stock under equity incentive and stock purchase plans
From March 31, 2022 to June 30, 2022
Issuance of common stock under equity incentive plans and stock purchase plan
From December 31, 2021 to March 31, 2022
Issuance of common stock under equity incentive plans
From December 31, 2020 to December 31, 2021
Issuance of common stock under equity incentive and stock purchase plans
From June 30, 2021 to September 30, 2021
Issuance of common stock under equity incentive plans
From March 31, 2021 to June 30, 2021
Issuance of common stock under equity incentive and stock purchase plans
From December 31, 2020 to March 31, 2021
Issuance of common stock under equity incentive plans
From December 31, 2019 to December 31, 2020
Issuance of common stock under equity incentive and stock purchase plans
From June 30, 2020 to September 30, 2020
Issuance of common stock under equity incentive and stock purchase plans
From March 31, 2020 to June 30, 2020
Issuance of common stock under equity incentive and stock purchase plans
From December 31, 2019 to March 31, 2020
Issuance of common stock under equity incentive plans, net of tax
From December 31, 2018 to December 31, 2019
Issuance of common stock under equity incentive and stock purchase plans
from June 30, 2019 to September 30, 2019
Issuance of common stock under equity incentive and stock purchase plans
from March 31, 2019 to June 30,2019
Issuance of common stock under equity incentive and stock purchase plans
from December 31, 2018 to March 31, 2019
Issuance of common stock under equity incentive and stock purchase plans
from December 31, 2017 to December 31, 2018
Issuance of common stock under equity incentive and stock purchase plans
from December 31, 2016 to December 29, 2017
Issuance of common stock under equity incentive and stock purchase plans
Issuance of common stock on warrant exercise
from December 31, 2015 to December 31, 2016
Issuance of common stock in settlement of convertible notes
Issuance of common stock under stock plans
from December 31, 2014 to December 31, 2015
Sale of shares of common stock, net
Issuance of common stock under stock plans
from December31, 2013 to December 31, 2014
Issuance of common stock under stock plans
Sale of shares of common stock
from December31, 2012 to December27, 2013
Issuance of common stock under stock plans
from December 31, 2011 to December 28, 2012
Issuance of common stock under stock plans
Sale of shares of common stock
from December 31, 2010 to December 30, 2011
Issuance of common stock under stock plans
Sale of shares of common stock
Issuance of common stock for settlement of convertible loan
Issuance of common stock under stock plans
from December 31, 2008 to December 31, 2009
Issuance of common stock under stock plans
from December 31, 2007 to December 31, 2008
Issuance of common stock under stock plans
from December 31, 2006 to December 31, 2007
Issuance of common stock under stock plans
Issuance of common stock, net of offering costs
from December 31, 2005 to December 31, 2006
Issuance of common stock under stock plans, net of repurchases
Issuance of common stock, net of offering costs
Exercise of Warrant
from December 31, 2004 to December 31, 2005
Issuance of common stock under company stock plans, net of repurchases
Issuance of common stock, net of offering costs
Issuance of common stock under the GlaxoSmithKline collaboration
from December 31, 2003 to December 31, 2004
Issuance of common stock under company stock plans, net of repurchases
Issuance of common stock for acquisition
from December 31, 2002 to December 31, 2003
Issuance of common stock under company stock plans, net of repurchases
Repayment of notes from stockholders for the exercise of stock options
Issuance of common stock, net of offerings costs
from December 31, 2001 to December 31, 2002
Issuance of common stock under company stock plans, net of repurchases
Issuance of common stock, GSK collaboration
Issuance of common stock for acquisition
from December 31, 2000 to December 31, 2001
Issuance of common stock under options, warrants and stock purchase plan net of repurchases
Issuance of common stock, BMS collaboration
Issuance of common stock for acquisition
from December 31, 1999 to December 31, 2000
Issuance of common stock under options, warrants and stock purchase plan net of repurchases
Issuance of common stock, net of offering costs
Issuance of common stock for acquisition
Conversion of preferred stock
Conversion of promissory note