股本结构

单位:万股
公告日期 2025-11-13 2025-11-13 2025-08-12 2025-08-12 2025-05-13 2025-05-13
证券总股本 11535.23 11533.67 11532.97 11465.51 11463.30 11460.39
普通股本 11535.23 11533.67 11532.97 11465.51 11463.30 11460.39
优先股 未披露 275.51 未披露 275.51 未披露 275.51
其他 未披露 未披露 未披露 未披露 未披露 未披露
变动日期 2025-11-06 2025-09-30 2025-08-05 2025-06-30 2025-05-06 2025-03-31
注释:中概股证券总股本=普通股股本/ 存托凭证比例

历史变动

公告日期 变动后普通股本(万股) 变动后优先股(万股) 变动原因 变动日期
2025-11-13 11535.23 未披露 定期报告 2025-11-06
2025-11-13 11533.67 275.51
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From June 30, 2025 to September 30, 2025 Issuance of common stock upon vesting of restricted stock units
2025-09-30
2025-08-12 11532.97 未披露 定期报告 2025-08-05
2025-08-12 11465.51 275.51
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From March 31, 2025 to June 30, 2025 Issuance of common stock upon vesting of restricted stock units Exercise of stock options, net of issuance costs
2025-06-30
2025-05-13 11463.30 未披露 定期报告 2025-05-06
2025-05-13 11460.39 275.51
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From December 31, 2024 to March 31, 2025 Issuance of common stock upon vesting of restricted stock units
2025-03-31
2025-03-05 11459.74 未披露 定期报告 2025-02-25
2025-03-05 11392.83 275.51
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From December 31, 2023 to December 31, 2024 Public offering of common stock and issuance of pre-funded warrants, net of offering costs Issuance of common stock upon vesting of restricted stock units Exercise of stock options, net of issuance costs Conversion of preferred shares to common stock
2024-12-31
2024-11-12 11389.43 未披露 定期报告 2024-11-05
2024-11-12 11388.49 276.11
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From June 30, 2024 to September 30, 2024 Issuance of common stock upon vesting of restricted stock units
2024-09-30
2024-08-13 11387.79 未披露 定期报告 2024-08-06
2024-08-13 11384.96 276.11
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From March 31, 2024 to June 30, 2024 Issuance of common stock upon vesting of restricted stock units
2024-06-30
2024-05-09 11383.20 未披露 定期报告 2024-05-02
2024-04-26 11381.67 未披露 定期报告 2024-04-09
2024-05-09 11379.89 276.11
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From December 31, 2023 to March 31, 2024 Exercise of stock options, net of issuance costs Public offering of common stock, net of issuance costs Issuance of common stock upon vesting of restricted stock units
2024-03-31
2024-03-20 11378.30 未披露
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Common stock offered 14,545,454 shares by the company
2024-03-21
2024-02-26 9923.75 未披露 定期报告 2024-02-20
2024-02-26 9862.71 276.11
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From December 31, 2022 to December 31, 2023 Exercise of stock options, net of issuance costs Conversion of preferred shares to common stock Issuance of common stock upon vesting of restricted stock units
2023-12-31
2023-11-08 9860.20 未披露 定期报告 2023-10-31
2023-11-08 9858.58 276.11
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From June 30, 2023 to September 30, 2023 Issuance of common stock upon vesting of restricted stock units
2023-09-30
2023-08-08 9856.24 未披露 定期报告 2023-08-02
2023-08-08 9852.27 276.11
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From March 31, 2023 to June 30, 2023 Exercise of stock options, net of issuance costs Conversion of preferred shares to common stock Issuance of common stock upon vesting of restricted stock units
2023-06-30
2023-05-03 9838.45 未披露 定期报告 2023-04-27
2023-04-21 9820.98 未披露 定期报告 2023-04-11
2023-05-03 9819.10 279.45
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From December 31, 2022 to March 31, 2023 Exercise of stock options, net of issuance costs Issuance of common stock upon vesting of restricted stock units
2023-03-31
2023-02-28 9816.18 未披露 定期报告 2023-02-22
2023-02-28 9729.49 279.45
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From December 31, 2021 to December 31, 2022 Exercise of stock options, net of issuance costs Issuance of common stock upon vesting of restricted stock units
2022-12-31
2022-11-03 9717.04 未披露 定期报告 2022-10-27
2022-11-03 9711.22 279.45
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From June 30, 2022 to September 30, 2022 Exercise of stock options, net of issuance costs Issuance of common stock upon vesting of restricted stock units
2022-09-30
2022-08-03 9700.03 未披露 定期报告 2022-07-28
2022-08-03 9686.28 279.45
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From March 31, 2022 to June 30, 2022 Exercise of stock options, net of issuance costs Issuance of common stock upon vesting of restricted stock units
2022-06-30
2022-05-04 9662.91 未披露 定期报告 2022-04-28
2022-04-25 9658.47 未披露 定期报告 2022-04-12
2022-05-04 9653.81 279.45
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From December 31, 2021 to March 31, 2022 Exercise of stock options, net of issuance costs Issuance of common stock upon vesting of restricted stock units
2022-03-31
2022-02-28 9642.77 未披露 定期报告 2022-02-24
2022-04-25 9635.63 未披露 定期报告 2022-01-31
2022-02-28 9572.70 279.45
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From December 31, 2020 to December 31, 2021 Exercise of stock options, net of issuance costs Issuance of common stock upon vesting of restricted stock units Public offering of common stock and issuance of pre-funded warrants, net of offering costs
2021-12-31
2021-11-04 9549.40 279.45 定期报告 2021-11-02
2021-11-04 9549.28 未披露 定期报告 2021-10-28
2021-11-04 9536.13 279.45
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From June 30, 2021 to September 30, 2021 Exercise of stock options, net of issuance costs Issuance of common stock upon vesting of restricted stock units
2021-09-30
2021-08-04 9518.45 未披露 定期报告 2021-08-02
2021-08-04 9426.51 279.45
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From March 31, 2021 to June 30, 2021 Exercise of stock options, net of issuance costs Issuance of common stock upon vesting of restricted stock units
2021-06-30
2021-05-05 9403.58 未披露 定期报告 2021-05-03
2021-04-21 9389.23 未披露 定期报告 2021-04-05
2021-05-05 9388.87 280.00 定期报告 2021-03-31
2021-02-24 9378.34 未披露 定期报告 2021-02-22
2021-04-21 9368.00 未披露 定期报告 2021-01-31
2021-01-08 9142.57 未披露
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1.Common stock offered by the company 4,421,053 shares. 2.Unless otherwise indicated, all information in this prospectus supplement relating to the number of shares of common stock to be outstanding immediately after this offering is based on 87,004,686 shares of common stock outstanding as of September 30, 2020.
2021-01-08
2021-02-24 8770.00 280.00
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From December 31,2019 to December 31,2020 Exercise of stock options, net of issuance costs Issuance of common stock upon vesting of restricted stock units Public offering of common stock, net of offering costs Private placement of common stock, net of issuance costs Issuance of stock to collaboration partner, net of issuance costs
2020-12-31
2020-11-05 8724.40 未披露 定期报告 2020-11-03
2020-11-05 8700.47 279.45
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From June 30, 2020 to September 30, 2020 Exercise of stock options, net of issuance costs
2020-09-30
2020-08-05 8684.40 未披露 定期报告 2020-08-03
2020-08-05 8680.22 279.45
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From March 31, 2020 to June 30, 2020 Exercise of stock options, net of issuance costs Issuance of common stock upon vesting of restricted stock units Public offering of common stock, net of issuance costs Private placement of common stock, net of issuance costs Issuance of stock to collaboration partner, net of issuance costs
2020-06-30
2020-06-18 8394.38 未披露 定期报告 2020-06-11
2020-05-11 7769.18 未披露 定期报告 2020-05-07
2020-05-11 7599.61 279.45
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From December 31, 2019 to March 31, 2020 Exercise of stock options, net of issuance costs Issuance of common stock upon vesting of restricted stock units
2020-03-31
2020-03-20 7593.74 未披露 定期报告 2020-03-06
2020-03-02 7593.14 未披露 定期报告 2020-02-28
2020-03-02 7573.03 279.45
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from December 31, 2018 to December 31, 2019 Exercise of stock options, net of issuance costs Issuance of common stock upon cashless warrant exercise Public offering of common stock, net of issuance costs Conversion of preferred shares to common stock Issuance of common stock upon vesting of restricted stock units
2019-12-31
2019-11-05 7559.27 未披露 定期报告 2019-11-04
2019-11-05 7541.59 279.45
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from June 30,2019 to September 30, 2019 Exercise of stock options, net of issuance costs Issuance of common stock upon cashless warrant exercise Public offering of common stock, net of issuance costs Conversion of preferred shares to common stock
2019-09-30
2019-09-16 7390.99 未披露 定期报告 2019-09-16
2019-08-06 6538.60 未披露 定期报告 2019-08-05
2019-08-06 6530.99 281.95
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from March 31, 2019 to June 30,2019 Exercise of stock options, net of issuance costs
2019-06-30
2019-05-07 6518.58 未披露 定期报告 2019-05-06
2019-05-07 6511.58 281.95
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from December 31, 2018 to March 31, 2019 Exercise of stock options, net of issuance costs Issuance of common stock upon cashless warrant exercise
2019-03-31
2019-03-22 6503.20 未披露 定期报告 2019-03-06
2019-03-05 6499.95 未披露 定期报告 2019-03-01
2019-03-22 6473.40 281.95 定期报告 2019-01-30
2019-03-05 6469.37 281.95
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from December 31, 2017 to December 31, 2018 Exercise of stock options, net of issuance costs Issuance of common stock upon cashless warrant exercises Public offerings of common stock, net of offering costs Issuance of common stock for license agreements
2018-12-31
2018-11-21 6460.29 281.95 定期报告 2018-11-19
2018-11-01 6451.88 未披露 定期报告 2018-10-30
2018-11-01 6450.33 281.95 定期报告 2018-09-30
2018-08-06 5341.92 未披露 定期报告 2018-08-03
2018-08-06 5338.84 281.95 定期报告 2018-06-30
2018-05-04 5285.84 281.95 定期报告 2018-05-01
2018-05-10 5285.77 281.95 定期报告 2018-03-31
2018-03-16 5277.21 未披露 定期报告 2018-03-05
2018-03-05 5276.92 未披露 定期报告 2018-03-02
2018-03-16 5272.21 未披露 定期报告 2018-01-30
2018-03-05 5264.86 281.95
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from December 31, 2016 to December 31, 2017 Exercise of stock options, net of issuance costs Issuance of common stock upon vesting of restricted stock units Public offering of common stock,net of offering costs
2017-12-31
2017-11-01 4168.57 未披露 定期报告 2017-10-31
2017-11-01 4145.72 281.95 定期报告 2017-09-30
2017-08-14 4141.58 281.95 定期报告 2017-06-30
2017-05-15 4140.14 281.95 定期报告 2017-03-31
2017-03-16 4138.65 281.95
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from December 31,2015 to December 31, 2016 Private placement issuance of Series A convertible preferred stock, net of offering costs Exercise of stock options, net of issuance costs Private placement issuances of common stock, net of offering costs Senior executive incentive bonuses paid in common stock On November 21, 2016, we and Redmile, entities affiliated with BVF Partners L.P., EcoR1 Capital, LLC and Franklin Advisers, Inc., and other accredited investors, certain of whom are affiliated with our directors and officers, entered into a Securities Purchase Agreement, or the Purchase Agreement, and a Registration Rights Agreement, or the Registration Rights Agreement. Pursuant to the Purchase Agreement, we sold an aggregate of 7,236,837 shares of our common stock at a price per share of $2.66, and an aggregate of 2,819,549 Preferred Shares at a price of $13.30 per share, in a private placement.
2016-12-31
2016-11-07 3414.82 未披露 定期报告 2016-09-30
2016-09-12 3414.74 未披露 定期报告 2016-09-06
2016-08-08 2889.48 未披露 定期报告 2016-08-05
2016-08-08 2888.31 未披露 定期报告 2016-06-30
2016-05-09 2886.41 未披露 定期报告 2016-05-06
2016-05-09 2886.17 未披露 定期报告 2016-03-31
2016-03-03 2886.17 未披露 定期报告 2016-03-02
2016-03-03 2871.66 未披露
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From December 31, 2014 to December 31, 2015 Exercise of stock options, net of issuance costs Senior executive incentive bonuses paid in common stock Public offering of common stock, net of $2,353 of offering costs Issuance of common stock to collaboration partner
2015-12-31
2015-11-03 2871.66 未披露 定期报告 2015-11-02
2015-11-03 2871.57 未披露 定期报告 2015-09-30
2015-08-05 2869.46 未披露 定期报告 2015-08-03
2015-08-05 2861.86 未披露 定期报告 2015-06-30
2015-05-07 2068.33 未披露 定期报告 2015-05-05
2015-05-07 2063.72 未披露 定期报告 2015-03-31
2015-03-12 2063.72 未披露 定期报告 2015-03-12
2015-03-12 2056.94 未披露
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from December 31,2013 to December 31,2014 Exercise of stock options, net of issuance costs Issuance of stock on achievement of milestone
2014-12-31
2014-11-12 2056.94 未披露 定期报告 2014-11-11
2014-10-01 2056.28 未披露 定期报告 2014-09-30
2014-08-12 2056.28 未披露 定期报告 2014-08-07
2014-08-12 2056.15 未披露 定期报告 2014-06-30
2014-05-13 2051.46 未披露 定期报告 2014-05-09
2014-04-25 2049.84 未披露 定期报告 2014-04-18
2014-05-13 2046.38 未披露 定期报告 2014-03-31
2014-03-17 2043.57 未披露 定期报告 2014-03-13
2014-03-17 2043.41 未披露
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from December 31,2012 to December 31,2013 Conversion of convertible preferred stock into common stock Initial public offering of common stock, net of $5,520 of offering costs Conversion of convertible notes into common stock Exchange of exchangeable shares into common stock
2013-12-31
2013-11-13 2035.72 未披露
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With the completion of our IPO on October 4, 2013,the conversion of all outstanding shares of convertible preferred stock into 7,229,590 shares of the Company’s common stock
2013-11-11
2013-10-01 1915.66 未披露
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the conversion of all of our outstanding shares of convertible preferred stock into 7,229,590 shares of common stock upon the completion of this offering;a one-for-6.5 reverse split of our common stock, which became effective on September 12, 2013
2013-10-01
2013-11-13 137.77 4496.77 定期报告 2013-09-30
2013-09-16 135.72 4496.77
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On September 12, 2013, the Company filed an amendment to its amended and restated certificate of incorporation, effecting a 1-for-6.5 reverse stock split of the Company’s issued and outstanding shares of common stock.
2013-09-13
2013-08-14 882.20 4496.77
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from December 31, 2012 to June 30, 2013 Exercise of stock options (unaudited) Issuance of common stock for technology (unaudited)
2013-06-30
From June 30, 2025 to September 30, 2025 Issuance of common stock upon vesting of restricted stock units
From March 31, 2025 to June 30, 2025 Issuance of common stock upon vesting of restricted stock units Exercise of stock options, net of issuance costs
From December 31, 2024 to March 31, 2025 Issuance of common stock upon vesting of restricted stock units
From December 31, 2023 to December 31, 2024 Public offering of common stock and issuance of pre-funded warrants, net of offering costs Issuance of common stock upon vesting of restricted stock units Exercise of stock options, net of issuance costs Conversion of preferred shares to common stock
From June 30, 2024 to September 30, 2024 Issuance of common stock upon vesting of restricted stock units
From March 31, 2024 to June 30, 2024 Issuance of common stock upon vesting of restricted stock units
From December 31, 2023 to March 31, 2024 Exercise of stock options, net of issuance costs Public offering of common stock, net of issuance costs Issuance of common stock upon vesting of restricted stock units
Common stock offered 14,545,454 shares by the company
From December 31, 2022 to December 31, 2023 Exercise of stock options, net of issuance costs Conversion of preferred shares to common stock Issuance of common stock upon vesting of restricted stock units
From June 30, 2023 to September 30, 2023 Issuance of common stock upon vesting of restricted stock units
From March 31, 2023 to June 30, 2023 Exercise of stock options, net of issuance costs Conversion of preferred shares to common stock Issuance of common stock upon vesting of restricted stock units
From December 31, 2022 to March 31, 2023 Exercise of stock options, net of issuance costs Issuance of common stock upon vesting of restricted stock units
From December 31, 2021 to December 31, 2022 Exercise of stock options, net of issuance costs Issuance of common stock upon vesting of restricted stock units
From June 30, 2022 to September 30, 2022 Exercise of stock options, net of issuance costs Issuance of common stock upon vesting of restricted stock units
From March 31, 2022 to June 30, 2022 Exercise of stock options, net of issuance costs Issuance of common stock upon vesting of restricted stock units
From December 31, 2021 to March 31, 2022 Exercise of stock options, net of issuance costs Issuance of common stock upon vesting of restricted stock units
From December 31, 2020 to December 31, 2021 Exercise of stock options, net of issuance costs Issuance of common stock upon vesting of restricted stock units Public offering of common stock and issuance of pre-funded warrants, net of offering costs
From June 30, 2021 to September 30, 2021 Exercise of stock options, net of issuance costs Issuance of common stock upon vesting of restricted stock units
From March 31, 2021 to June 30, 2021 Exercise of stock options, net of issuance costs Issuance of common stock upon vesting of restricted stock units
1.Common stock offered by the company 4,421,053 shares. 2.Unless otherwise indicated, all information in this prospectus supplement relating to the number of shares of common stock to be outstanding immediately after this offering is based on 87,004,686 shares of common stock outstanding as of September 30, 2020.
From December 31,2019 to December 31,2020 Exercise of stock options, net of issuance costs Issuance of common stock upon vesting of restricted stock units Public offering of common stock, net of offering costs Private placement of common stock, net of issuance costs Issuance of stock to collaboration partner, net of issuance costs
From June 30, 2020 to September 30, 2020 Exercise of stock options, net of issuance costs
From March 31, 2020 to June 30, 2020 Exercise of stock options, net of issuance costs Issuance of common stock upon vesting of restricted stock units Public offering of common stock, net of issuance costs Private placement of common stock, net of issuance costs Issuance of stock to collaboration partner, net of issuance costs
From December 31, 2019 to March 31, 2020 Exercise of stock options, net of issuance costs Issuance of common stock upon vesting of restricted stock units
from December 31, 2018 to December 31, 2019 Exercise of stock options, net of issuance costs Issuance of common stock upon cashless warrant exercise Public offering of common stock, net of issuance costs Conversion of preferred shares to common stock Issuance of common stock upon vesting of restricted stock units
from June 30,2019 to September 30, 2019 Exercise of stock options, net of issuance costs Issuance of common stock upon cashless warrant exercise Public offering of common stock, net of issuance costs Conversion of preferred shares to common stock
from March 31, 2019 to June 30,2019 Exercise of stock options, net of issuance costs
from December 31, 2018 to March 31, 2019 Exercise of stock options, net of issuance costs Issuance of common stock upon cashless warrant exercise
from December 31, 2017 to December 31, 2018 Exercise of stock options, net of issuance costs Issuance of common stock upon cashless warrant exercises Public offerings of common stock, net of offering costs Issuance of common stock for license agreements
from December 31, 2016 to December 31, 2017 Exercise of stock options, net of issuance costs Issuance of common stock upon vesting of restricted stock units Public offering of common stock,net of offering costs
from December 31,2015 to December 31, 2016 Private placement issuance of Series A convertible preferred stock, net of offering costs Exercise of stock options, net of issuance costs Private placement issuances of common stock, net of offering costs Senior executive incentive bonuses paid in common stock On November 21, 2016, we and Redmile, entities affiliated with BVF Partners L.P., EcoR1 Capital, LLC and Franklin Advisers, Inc., and other accredited investors, certain of whom are affiliated with our directors and officers, entered into a Securities Purchase Agreement, or the Purchase Agreement, and a Registration Rights Agreement, or the Registration Rights Agreement. Pursuant to the Purchase Agreement, we sold an aggregate of 7,236,837 shares of our common stock at a price per share of $2.66, and an aggregate of 2,819,549 Preferred Shares at a price of $13.30 per share, in a private placement.
From December 31, 2014 to December 31, 2015 Exercise of stock options, net of issuance costs Senior executive incentive bonuses paid in common stock Public offering of common stock, net of $2,353 of offering costs Issuance of common stock to collaboration partner
from December 31,2013 to December 31,2014 Exercise of stock options, net of issuance costs Issuance of stock on achievement of milestone
from December 31,2012 to December 31,2013 Conversion of convertible preferred stock into common stock Initial public offering of common stock, net of $5,520 of offering costs Conversion of convertible notes into common stock Exchange of exchangeable shares into common stock
With the completion of our IPO on October 4, 2013,the conversion of all outstanding shares of convertible preferred stock into 7,229,590 shares of the Company’s common stock
the conversion of all of our outstanding shares of convertible preferred stock into 7,229,590 shares of common stock upon the completion of this offering;a one-for-6.5 reverse split of our common stock, which became effective on September 12, 2013
On September 12, 2013, the Company filed an amendment to its amended and restated certificate of incorporation, effecting a 1-for-6.5 reverse stock split of the Company’s issued and outstanding shares of common stock.
from December 31, 2012 to June 30, 2013 Exercise of stock options (unaudited) Issuance of common stock for technology (unaudited)