股本结构
单位：万股
| 公告日期 | 2025-10-30 | 2025-10-30 | 2025-08-07 | 2025-08-07 | 2025-06-12 | 2025-05-08 |
|---|---|---|---|---|---|---|
| 证券总股本 | 21327.35 | 21258.30 | 21137.48 | 21111.07 | 18995.14 | 18213.89 |
| 普通股本 | 21327.35 | 21258.30 | 21137.48 | 21111.07 | 18995.14 | 18213.89 |
| 优先股 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2025-10-24 | 2025-09-30 | 2025-08-01 | 2025-06-30 | 2025-06-13 | 2025-05-02 |
注释：中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本（万股） | 变动后优先股（万股） | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2025-10-30 | 21327.35 | 未披露 | 定期报告 | 2025-10-24 |
| 2025-10-30 | 21258.30 | 未披露 |
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From June 30, 2025 to September 30, 2025
Exercise of stock options and ESPP share issuance
Issuance of common stock for vesting of RSUs
Issuance of common stock for vesting of PSUs
|
2025-09-30 |
| 2025-08-07 | 21137.48 | 未披露 | 定期报告 | 2025-08-01 |
| 2025-08-07 | 21111.07 | 未披露 |
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From March 31, 2025 to June 30, 2025
Issuance of common stock upon conversion of convertible notes
Exercise of stock options and ESPP share issuance
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
|
2025-06-30 |
| 2025-06-12 | 18995.14 | 未披露 |
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Common stock offered 7,812,500 shares by the company
|
2025-06-13 |
| 2025-05-08 | 18213.89 | 未披露 | 定期报告 | 2025-05-02 |
| 2025-05-08 | 18190.01 | 未披露 |
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From December 31, 2024 to March 31, 2025
Exercise of stock options and ESPP share issuance
Issuance of common stock for vesting of RSUs
|
2025-03-31 |
| 2025-04-04 | 18182.00 | 未披露 | 定期报告 | 2025-03-07 |
| 2025-02-20 | 18099.94 | 未披露 | 定期报告 | 2025-02-14 |
| 2025-02-20 | 17938.26 | 未披露 |
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From December 31, 2023 to December 31, 2024
Issuance of common stock for vesting of RSUs
Net proceeds from issuance of common stock
Deferred payments for Business Acquisition and Vertuis Bio, Inc.
Exercise of stock options and ESPP shares
Issuance of common stock upon conversion of convertible notes
|
2024-12-31 |
| 2024-10-31 | 17890.27 | 未披露 | 定期报告 | 2024-10-25 |
| 2024-10-31 | 17884.70 | 未披露 |
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From June 30, 2024 to September 30, 2024
Exercise of stock options and ESPP shares
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
Deferred payments for Business Acquisition and Vertuis Bio, Inc.
Issuance of common stock upon conversion of convertible notes
|
2024-09-30 |
| 2024-08-08 | 17184.91 | 未披露 | 定期报告 | 2024-08-02 |
| 2024-08-08 | 16666.66 | 未披露 |
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From March 31, 2024 to June 30, 2024
Exercise of stock options and ESPP shares
Issuance of common stock for vesting of RSUs
Net proceeds from issuance of common stock
|
2024-06-30 |
| 2024-05-30 | 16122.59 | 未披露 |
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Common stock offered 12,621,359 shares by the company
|
2024-05-31 |
| 2024-05-09 | 14860.45 | 未披露 | 定期报告 | 2024-05-06 |
| 2024-05-09 | 14856.09 | 未披露 |
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From December 31, 2023 to March 31, 2024
Exercise of stock options and ESPP shares issuance
Issuance of common stock for vesting of RSUs
|
2024-03-31 |
| 2024-04-01 | 14855.52 | 未披露 | 定期报告 | 2024-03-12 |
| 2024-02-22 | 14849.16 | 未披露 | 定期报告 | 2024-02-19 |
| 2024-02-22 | 14797.80 | 未披露 |
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From December 31, 2022 to December 31, 2023
Exercise of stock options and ESPP shares issuance
Deferred payment for Business Acquisition
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
Issuance of common stock for asset acquisitions
|
2023-12-31 |
| 2023-10-26 | 14306.21 | 未披露 | 定期报告 | 2023-10-23 |
| 2023-10-26 | 14304.92 | 未披露 |
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From June 30, 2023 to September 30, 2023
Deferred payments for Business Acquisition
Issuance of common stock for vesting of RSUs
Exercise of stock options and ESPP shares issuance
|
2023-09-30 |
| 2023-08-03 | 14380.00 | 未披露 | 定期报告 | 2023-07-31 |
| 2023-08-03 | 14275.05 | 未披露 |
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From March 31, 2023 to June 30, 2023
Net proceeds from issuance of common stock
Issuance of common stock for asset acquisition
Exercise of stock options and ESPP shares
Issuance of common stock for vesting of RSUs
|
2023-06-30 |
| 2023-05-04 | 13643.28 | 未披露 | 定期报告 | 2023-05-01 |
| 2023-05-04 | 13642.92 | 未披露 |
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From December 31, 2022 to March 31, 2023
Exercise of stock options and ESPP shares
Issuance of common stock for vesting of RSUs
Issuance of common stock for asset acquisition
|
2023-03-31 |
| 2023-03-31 | 13642.85 | 未披露 | 定期报告 | 2023-03-14 |
| 2023-02-23 | 13640.54 | 未披露 | 定期报告 | 2023-02-20 |
| 2023-02-23 | 13565.37 | 未披露 |
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From December 31, 2021 to December 31, 2022
Issuance of common stock for vesting of RSUs
Deferred payment for Business Acquisition
Exercise of stock options and ESPP shares issuance
Net proceeds from issuance of common stock
|
2022-12-31 |
| 2022-10-27 | 13547.68 | 未披露 | 定期报告 | 2022-10-24 |
| 2022-10-19 | 13372.53 | 未披露 |
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Common stock offered 13,750,000 shares by the company
|
2022-10-21 |
| 2022-10-27 | 12172.62 | 未披露 |
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From June 30, 2022 to September 30, 2022
Exercise of stock options and ESPP shares issuance
Net proceeds from issuance of common stock
Deferred payments for Business Acquisition
Issuance of common stock for vesting of RSUs
|
2022-09-30 |
| 2022-08-04 | 11997.53 | 未披露 | 定期报告 | 2022-08-01 |
| 2022-08-04 | 11986.50 | 未披露 |
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From March 31, 2022 to June 30, 2022
Exercise of stock options and ESPP shares issuance
Issuance of common stock for vesting of RSUs
|
2022-06-30 |
| 2022-05-05 | 11951.72 | 未披露 | 定期报告 | 2022-05-02 |
| 2022-05-05 | 11934.60 | 未披露 |
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From December 31, 2021 to March 31, 2022
Exercise of stock options and ESPP shares issuance
Issuance of common stock for vesting of RSUs
|
2022-03-31 |
| 2022-04-01 | 11893.86 | 未披露 | 定期报告 | 2022-03-18 |
| 2022-02-17 | 11890.46 | 未披露 | 定期报告 | 2022-02-14 |
| 2022-02-17 | 11873.83 | 未披露 |
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From December 31, 2020 to December 31, 2021
Exercise of stock options and ESPP shares issuance
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
Issuance of common stock for business acquisition
|
2021-12-31 |
| 2021-10-28 | 11837.21 | 未披露 | 定期报告 | 2021-10-25 |
| 2021-10-28 | 11835.56 | 未披露 |
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From June 30, 2021 to September 30, 2021
Exercise of stock options and ESPP shares issuance
Issuance of common stock for vesting of RSUs
Issuance of common stock for business acquisition
|
2021-09-30 |
| 2021-08-05 | 11524.67 | 未披露 | 定期报告 | 2021-08-02 |
| 2021-08-05 | 11523.93 | 未披露 |
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From March 31, 2021 to June 30, 2021
Exercise of stock options and ESPP shares issuance
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
|
2021-06-30 |
| 2021-05-13 | 11477.87 | 未披露 |
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1.The closing of the previously announced registered underwritten public offering (the “Equity Offering”) of 11,500,000 shares of its common stock (the “Shares”), including 1,500,000 Shares issued pursuant to the exercise in full of the underwriters’ option to purchase additional Shares,at a price to the public of $25.00 per share before deducting underwriting discounts and commissions, and the previously announced registered underwritten public offering (the “Notes Offering”) of $575 million aggregate principal amount of its 0.75% convertible senior notes due 2028 (the “Notes”), including $75 million aggregate principal amount of Notes purchased pursuant to the exercise in full of the underwriters’ option to purchase additional Notes, solely to cover over-allotments.
|
2021-05-13 |
| 2021-05-06 | 10349.20 | 未披露 | 定期报告 | 2021-05-03 |
| 2021-05-06 | 10327.87 | 未披露 |
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From December 31, 2020 to March 31, 2021
Exercise of stock options and ESPP shares issuance
Issuance of common stock for vesting of RSUs
|
2021-03-31 |
| 2021-04-01 | 10327.02 | 未披露 | 定期报告 | 2021-03-19 |
| 2021-02-25 | 10304.33 | 未披露 | 定期报告 | 2021-02-22 |
| 2021-02-25 | 10276.31 | 未披露 |
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From December 31, 2019 to December 31, 2020
Exercise of stock options and ESPP shares issuance
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
|
2020-12-31 |
| 2020-10-29 | 10186.77 | 未披露 | 定期报告 | 2020-10-26 |
| 2020-10-29 | 10180.37 | 未披露 |
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From June 30, 2020 to September 30, 2020
Exercise of stock options and ESPP shares
Issuance of common stock for vesting of RSUs
|
2020-09-30 |
| 2020-08-06 | 10148.10 | 未披露 | 定期报告 | 2020-08-03 |
| 2020-08-06 | 10143.41 | 未披露 |
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From March 31, 2020 to June 30, 2020
Exercise of stock options and ESPP shares
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
|
2020-06-30 |
| 2020-05-21 | 10104.48 | 未披露 | 定期报告 | 2020-05-10 |
| 2020-05-07 | 10101.45 | 未披露 |
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1.Common stock offered by us 9,700,000 shares
2.Except as otherwise indicated herein, the number of shares of our common stock to be outstanding immediately after this offering is based on 89,859,549 shares of our common stock outstanding as of March 31, 2020.
3.The Company also granted the Underwriters an option to purchase up to an additional 1,455,000 shares of Common Stock within 30 days after May 4, 2020, which the Underwriters exercised in full on May 5, 2020.
|
2020-05-07 |
| 2020-04-30 | 8987.83 | 未披露 | 定期报告 | 2020-04-27 |
| 2020-04-30 | 8985.95 | 未披露 |
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From January 1, 2020 to March 18, 2020
Exercise of stock options and ESPP shares
Issuance of common stock for vesting of RSUs
|
2020-03-18 |
| 2020-02-25 | 8977.57 | 未披露 | 定期报告 | 2020-02-21 |
| 2020-02-25 | 8968.24 | 未披露 |
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From December 31, 2018 to December 31, 2019
Exercise of stock options and ESPP shares
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
|
2019-12-31 |
| 2019-10-30 | 8934.37 | 未披露 | 定期报告 | 2019-10-28 |
| 2019-10-30 | 8931.07 | 未披露 |
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from July 1, 2019 to September 30, 2019
Exercise of stock options and ESPP shares
Issuance of common stock for vesting of RSUs
|
2019-09-30 |
| 2019-08-01 | 8920.76 | 未披露 | 定期报告 | 2019-07-29 |
| 2019-08-01 | 8920.75 | 未披露 |
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From April 1, 2019 To June 30, 2019
Exercise of stock options and ESPP shares
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
|
2019-06-30 |
| 2019-05-24 | 8865.41 | 未披露 | 定期报告 | 2019-05-24 |
| 2019-05-07 | 7766.63 | 未披露 | 定期报告 | 2019-05-02 |
| 2019-05-07 | 7759.64 | 未披露 |
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from January 1, 2019 to March 31, 2019
Exercise of stock options and ESPP shares
Issuance of common stock for vesting of RSUs
|
2019-03-31 |
| 2019-04-04 | 7759.15 | 未披露 | 定期报告 | 2019-03-22 |
| 2019-02-22 | 7753.86 | 未披露 | 定期报告 | 2019-02-15 |
| 2019-02-22 | 7730.75 | 未披露 |
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from December 31, 2017 to December 31, 2018
Exercise of stock options and ESPP shares
Issuance of common stock for vesting of RSUs
|
2018-12-31 |
| 2018-10-30 | 7709.02 | 未披露 | 定期报告 | 2018-10-26 |
| 2018-10-30 | 7708.57 | 未披露 | 定期报告 | 2018-09-30 |
| 2018-08-02 | 7704.09 | 未披露 | 定期报告 | 2018-07-31 |
| 2018-08-02 | 7703.88 | 未披露 | 定期报告 | 2018-06-30 |
| 2018-04-05 | 7662.31 | 未披露 | 定期报告 | 2018-03-23 |
| 2018-02-23 | 7661.79 | 未披露 | 定期报告 | 2018-02-01 |
| 2018-02-23 | 7661.05 | 未披露 |
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from December 31, 2016 to December 31, 2017
Exercise of stock options
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
|
2017-12-31 |
| 2017-08-03 | 6237.79 | 未披露 | 定期报告 | 2017-07-31 |
| 2017-08-03 | 6237.64 | 未披露 | 定期报告 | 2017-06-30 |
| 2017-05-19 | 6216.67 | 未披露 | 定期报告 | 2017-05-17 |
| 2017-05-03 | 6209.01 | 未披露 | 定期报告 | 2017-04-28 |
| 2017-05-03 | 6208.78 | 未披露 | 定期报告 | 2017-03-31 |
| 2017-04-07 | 6208.58 | 未披露 | 定期报告 | 2017-03-24 |
| 2017-02-23 | 6202.35 | 未披露 | 定期报告 | 2017-02-01 |
| 2017-02-23 | 6201.99 | 未披露 |
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From December 31, 2015 to December 31, 2016
Exercise of stock options
Issuance of common stock for vesting of RSUs
|
2016-12-31 |
| 2016-05-05 | 6187.79 | 未披露 | 定期报告 | 2016-05-01 |
| 2016-05-05 | 6187.29 | 未披露 | 定期报告 | 2016-03-31 |
| 2016-04-13 | 6187.02 | 未披露 | 定期报告 | 2016-03-28 |
| 2016-02-25 | 6185.75 | 未披露 | 定期报告 | 2016-02-01 |
| 2016-02-25 | 6181.40 | 未披露 |
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From December 31, 2014 to December 31, 2015
Exercise of stock options
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
|
2015-12-31 |
| 2015-11-06 | 6180.37 | 未披露 | 定期报告 | 2015-09-30 |
| 2015-08-06 | 6176.03 | 未披露 | 定期报告 | 2015-07-31 |
| 2015-08-06 | 6174.39 | 未披露 | 定期报告 | 2015-06-30 |
| 2015-04-15 | 6150.18 | 未披露 | 定期报告 | 2015-04-07 |
| 2015-05-07 | 5000.18 | 未披露 | 定期报告 | 2015-03-31 |
| 2015-03-30 | 4999.86 | 未披露 | 定期报告 | 2015-03-25 |
| 2015-02-27 | 4999.41 | 未披露 | 定期报告 | 2015-02-02 |
| 2015-02-27 | 4980.61 | 未披露 |
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from December 31, 2013 to December 31, 2014
Exercise of stock options
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
|
2014-12-31 |
| 2014-11-06 | 4966.50 | 未披露 | 定期报告 | 2014-10-31 |
| 2014-11-06 | 4960.55 | 未披露 | 定期报告 | 2014-09-30 |
| 2014-08-06 | 3928.30 | 未披露 | 定期报告 | 2014-07-31 |
| 2014-08-06 | 3927.64 | 未披露 | 定期报告 | 2014-06-30 |
| 2014-05-08 | 3927.25 | 未披露 | 定期报告 | 2014-04-30 |
| 2014-05-08 | 3926.89 | 未披露 | 定期报告 | 2014-03-31 |
| 2014-03-06 | 3926.38 | 未披露 | 定期报告 | 2014-02-27 |
| 2014-03-06 | 3913.77 | 未披露 |
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from December 31, 2012 to December 31, 2013
Exercise of stock options
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
Exercise of warrants
|
2013-12-31 |
| 2013-11-05 | 3910.99 | 未披露 | 定期报告 | 2013-10-31 |
| 2013-11-05 | 3910.09 | 未披露 | 定期报告 | 2013-09-30 |
| 2013-08-06 | 3901.24 | 未披露 | 定期报告 | 2013-07-31 |
| 2013-08-06 | 3199.98 | 未披露 | 定期报告 | 2013-06-30 |
| 2013-05-07 | 3179.54 | 未披露 | 定期报告 | 2013-04-30 |
| 2013-05-07 | 3157.19 | 未披露 | 定期报告 | 2013-03-31 |
| 2013-04-29 | 3157.18 | 未披露 | 定期报告 | 2013-03-28 |
| 2013-03-18 | 3156.33 | 未披露 | 定期报告 | 2013-02-28 |
| 2013-03-18 | 3148.82 | 未披露 |
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from December 31, 2011 to December 31, 2012
Exercise of stock options
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
|
2012-12-31 |
| 2012-11-07 | 3135.26 | 未披露 | 定期报告 | 2012-11-02 |
| 2012-11-07 | 3117.90 | 未披露 | 定期报告 | 2012-09-30 |
| 2012-05-08 | 2487.49 | 未披露 | 定期报告 | 2012-03-31 |
| 2012-03-13 | 2486.38 | 未披露 | 定期报告 | 2012-03-09 |
| 2011-08-08 | 2483.33 | 未披露 | 定期报告 | 2011-06-30 |
| 2011-05-10 | 2482.81 | 未披露 | 定期报告 | 2011-03-31 |
| 2011-03-16 | 2482.81 | 未披露 | 定期报告 | 2011-03-10 |
| 2011-03-16 | 1565.37 | 917.46 |
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stock upon issuance of restricted stock awards
Issuance of 2,593,882 shares of common stock upon merger
Issuance of 9,174,589 shares of preferred stock upon merger
On March 1, 2011, at a special meeting, our shareholders approved a one for 10 reverse stock split of our common stock, which became effective at 5:00 pm EST on March 2, 2011
|
2011-03-03 |
| 2010-11-03 | 13034.58 | 未披露 | 定期报告 | 2010-09-30 |
| 2010-08-04 | 13029.58 | 未披露 | 定期报告 | 2010-08-01 |
| 2010-03-16 | 13020.81 | 未披露 |
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from December 31, 2008 to December 31, 2009
Issuance of 2,927,450 shares of common stock for warrant exercises
Issuance of 3,253,136 shares of common stock upon issuance of restricted stock awards
Issuance of 533,650 shares of common stock upon exercise of stock options
Issuance of 999,853 shares of common stock upon conversion of notes
|
2009-12-31 |
| 2009-03-31 | 12249.40 | 未披露 |
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from December 31, 2007 to December 31, 2008
Issuance of 349,698 shares of common stock from Employee Stock Purchase Plan
Issuance of 240,000 shares of common stock for consulting services
|
2008-12-31 |
| 2008-03-12 | 12190.43 | 未披露 |
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from December 31, 2006 to December 31, 2007
Issuance of 186,870 shares of common stock from Employee Stock Purchase Plan
Issuance of 116,573 shares of common stock upon conversion of notes
Issuance of 20,255,367 shares of common stock for cash, net of offering costs of $1,266,135
|
2007-12-31 |
| 2007-03-16 | 10132.81 | 未披露 |
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from December 31, 2005 to December 31, 2006
Issuance of 23,000,000 shares of common stock for cash, net of offering costs of $421,000
Issuance of 6,572,621 shares of common stock upon exercise of warrants
Issuance of 4,912,971 shares of common stock upon conversion of notes
Issuance of 280,234 shares of common stock from Employee Stock Purchase Plan
|
2006-12-31 |
| 2006-03-06 | 7715.07 | 未披露 | 定期报告 | 2006-02-28 |
| 2006-03-06 | 6652.58 | 未披露 |
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from December 31, 2004 to December 31, 2005
Issuance of 3,011,303 shares of common stock upon exercise of warrants
Issuance of 18,287,848 shares of common stock upon conversion of notes
Issuance of 169,823 shares of common stock from Employee Stock Purchase Plan
Issuance of 163,322 shares of common stock upon exercise of stock options
|
2005-12-31 |
| 2005-03-16 | 4489.35 | 未披露 |
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from December 31, 2003 to December 31, 2004
Issuance of 6,455,551 shares of common stock and 3,227,775 warrants for cash, net of offering costs of $602,472
|
2004-12-31 |
| 2004-03-12 | 3839.50 | 未披露 |
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from December 31, 2002 to December 31, 2003
Stock re-purchase from Taisho
Stock issued for consulting services
Issuance of 5,146,846 shares of common stock and 1,544,046 warrants for cash, net of offering costs of $972,593
Issuance of 53,171 shares of common stock upon exercise of stock options
|
2003-12-31 |
| 2003-03-28 | 3318.63 | 未披露 |
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from December 31, 2001 to December 31, 2002
Issuance of 56,289 shares of common stock from Employee Stock Purchase Plan
Issuance of 198,282 shares of common stock upon exercise of stock options
|
2002-12-31 |
| 2002-03-25 | 3295.16 | 未披露 | 定期报告 | 2002-02-28 |
| 2002-03-25 | 3293.18 | 未披露 |
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from December 31, 2000 to December 31, 2001
Issuance of 115,962 shares of common stock upon exercise of stock options
|
2001-12-31 |
| 2001-03-22 | 3281.90 | 未披露 | 定期报告 | 2001-02-28 |
| 2001-03-22 | 3279.74 | 未披露 |
更多>>
from December 31,1999 to December 31,2000
Issuance of 14,470,553 shares of common stock in connection with the acquisition of Insmed Pharmaceuticals, Inc
Issuance of 792,298 shares of common stock upon exercise of stock options
Issuance of 93,413 shares of common stock to Taisho Pharmaceuticals Co. Ltd
Issuance of 1,408,169 shares of common stock and 1,725,330 warrants for cash, net of offering costs of $1,775
Issuance of 9,527,385 shares of common stock in connection with the acquisition of Celtrix Pharmaceuticals, Inc
Issuance of 5,500,000 shares of common stock for cash, net of offering costs of $4,746
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2000-12-31 |
From June 30, 2025 to September 30, 2025
Exercise of stock options and ESPP share issuance
Issuance of common stock for vesting of RSUs
Issuance of common stock for vesting of PSUs
From March 31, 2025 to June 30, 2025
Issuance of common stock upon conversion of convertible notes
Exercise of stock options and ESPP share issuance
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
Common stock offered 7,812,500 shares by the company
From December 31, 2024 to March 31, 2025
Exercise of stock options and ESPP share issuance
Issuance of common stock for vesting of RSUs
From December 31, 2023 to December 31, 2024
Issuance of common stock for vesting of RSUs
Net proceeds from issuance of common stock
Deferred payments for Business Acquisition and Vertuis Bio, Inc.
Exercise of stock options and ESPP shares
Issuance of common stock upon conversion of convertible notes
From June 30, 2024 to September 30, 2024
Exercise of stock options and ESPP shares
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
Deferred payments for Business Acquisition and Vertuis Bio, Inc.
Issuance of common stock upon conversion of convertible notes
From March 31, 2024 to June 30, 2024
Exercise of stock options and ESPP shares
Issuance of common stock for vesting of RSUs
Net proceeds from issuance of common stock
Common stock offered 12,621,359 shares by the company
From December 31, 2023 to March 31, 2024
Exercise of stock options and ESPP shares issuance
Issuance of common stock for vesting of RSUs
From December 31, 2022 to December 31, 2023
Exercise of stock options and ESPP shares issuance
Deferred payment for Business Acquisition
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
Issuance of common stock for asset acquisitions
From June 30, 2023 to September 30, 2023
Deferred payments for Business Acquisition
Issuance of common stock for vesting of RSUs
Exercise of stock options and ESPP shares issuance
From March 31, 2023 to June 30, 2023
Net proceeds from issuance of common stock
Issuance of common stock for asset acquisition
Exercise of stock options and ESPP shares
Issuance of common stock for vesting of RSUs
From December 31, 2022 to March 31, 2023
Exercise of stock options and ESPP shares
Issuance of common stock for vesting of RSUs
Issuance of common stock for asset acquisition
From December 31, 2021 to December 31, 2022
Issuance of common stock for vesting of RSUs
Deferred payment for Business Acquisition
Exercise of stock options and ESPP shares issuance
Net proceeds from issuance of common stock
Common stock offered 13,750,000 shares by the company
From June 30, 2022 to September 30, 2022
Exercise of stock options and ESPP shares issuance
Net proceeds from issuance of common stock
Deferred payments for Business Acquisition
Issuance of common stock for vesting of RSUs
From March 31, 2022 to June 30, 2022
Exercise of stock options and ESPP shares issuance
Issuance of common stock for vesting of RSUs
From December 31, 2021 to March 31, 2022
Exercise of stock options and ESPP shares issuance
Issuance of common stock for vesting of RSUs
From December 31, 2020 to December 31, 2021
Exercise of stock options and ESPP shares issuance
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
Issuance of common stock for business acquisition
From June 30, 2021 to September 30, 2021
Exercise of stock options and ESPP shares issuance
Issuance of common stock for vesting of RSUs
Issuance of common stock for business acquisition
From March 31, 2021 to June 30, 2021
Exercise of stock options and ESPP shares issuance
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
1.The closing of the previously announced registered underwritten public offering (the “Equity Offering”) of 11,500,000 shares of its common stock (the “Shares”), including 1,500,000 Shares issued pursuant to the exercise in full of the underwriters’ option to purchase additional Shares,at a price to the public of $25.00 per share before deducting underwriting discounts and commissions, and the previously announced registered underwritten public offering (the “Notes Offering”) of $575 million aggregate principal amount of its 0.75% convertible senior notes due 2028 (the “Notes”), including $75 million aggregate principal amount of Notes purchased pursuant to the exercise in full of the underwriters’ option to purchase additional Notes, solely to cover over-allotments.
From December 31, 2020 to March 31, 2021
Exercise of stock options and ESPP shares issuance
Issuance of common stock for vesting of RSUs
From December 31, 2019 to December 31, 2020
Exercise of stock options and ESPP shares issuance
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
From June 30, 2020 to September 30, 2020
Exercise of stock options and ESPP shares
Issuance of common stock for vesting of RSUs
From March 31, 2020 to June 30, 2020
Exercise of stock options and ESPP shares
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
1.Common stock offered by us 9,700,000 shares
2.Except as otherwise indicated herein, the number of shares of our common stock to be outstanding immediately after this offering is based on 89,859,549 shares of our common stock outstanding as of March 31, 2020.
3.The Company also granted the Underwriters an option to purchase up to an additional 1,455,000 shares of Common Stock within 30 days after May 4, 2020, which the Underwriters exercised in full on May 5, 2020.
From January 1, 2020 to March 18, 2020
Exercise of stock options and ESPP shares
Issuance of common stock for vesting of RSUs
From December 31, 2018 to December 31, 2019
Exercise of stock options and ESPP shares
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
from July 1, 2019 to September 30, 2019
Exercise of stock options and ESPP shares
Issuance of common stock for vesting of RSUs
From April 1, 2019 To June 30, 2019
Exercise of stock options and ESPP shares
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
from January 1, 2019 to March 31, 2019
Exercise of stock options and ESPP shares
Issuance of common stock for vesting of RSUs
from December 31, 2017 to December 31, 2018
Exercise of stock options and ESPP shares
Issuance of common stock for vesting of RSUs
from December 31, 2016 to December 31, 2017
Exercise of stock options
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
From December 31, 2015 to December 31, 2016
Exercise of stock options
Issuance of common stock for vesting of RSUs
From December 31, 2014 to December 31, 2015
Exercise of stock options
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
from December 31, 2013 to December 31, 2014
Exercise of stock options
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
from December 31, 2012 to December 31, 2013
Exercise of stock options
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
Exercise of warrants
from December 31, 2011 to December 31, 2012
Exercise of stock options
Net proceeds from issuance of common stock
Issuance of common stock for vesting of RSUs
stock upon issuance of restricted stock awards
Issuance of 2,593,882 shares of common stock upon merger
Issuance of 9,174,589 shares of preferred stock upon merger
On March 1, 2011, at a special meeting, our shareholders approved a one for 10 reverse stock split of our common stock, which became effective at 5:00 pm EST on March 2, 2011
from December 31, 2008 to December 31, 2009
Issuance of 2,927,450 shares of common stock for warrant exercises
Issuance of 3,253,136 shares of common stock upon issuance of restricted stock awards
Issuance of 533,650 shares of common stock upon exercise of stock options
Issuance of 999,853 shares of common stock upon conversion of notes
from December 31, 2007 to December 31, 2008
Issuance of 349,698 shares of common stock from Employee Stock Purchase Plan
Issuance of 240,000 shares of common stock for consulting services
from December 31, 2006 to December 31, 2007
Issuance of 186,870 shares of common stock from Employee Stock Purchase Plan
Issuance of 116,573 shares of common stock upon conversion of notes
Issuance of 20,255,367 shares of common stock for cash, net of offering costs of $1,266,135
from December 31, 2005 to December 31, 2006
Issuance of 23,000,000 shares of common stock for cash, net of offering costs of $421,000
Issuance of 6,572,621 shares of common stock upon exercise of warrants
Issuance of 4,912,971 shares of common stock upon conversion of notes
Issuance of 280,234 shares of common stock from Employee Stock Purchase Plan
from December 31, 2004 to December 31, 2005
Issuance of 3,011,303 shares of common stock upon exercise of warrants
Issuance of 18,287,848 shares of common stock upon conversion of notes
Issuance of 169,823 shares of common stock from Employee Stock Purchase Plan
Issuance of 163,322 shares of common stock upon exercise of stock options
from December 31, 2003 to December 31, 2004
Issuance of 6,455,551 shares of common stock and 3,227,775 warrants for cash, net of offering costs of $602,472
from December 31, 2002 to December 31, 2003
Stock re-purchase from Taisho
Stock issued for consulting services
Issuance of 5,146,846 shares of common stock and 1,544,046 warrants for cash, net of offering costs of $972,593
Issuance of 53,171 shares of common stock upon exercise of stock options
from December 31, 2001 to December 31, 2002
Issuance of 56,289 shares of common stock from Employee Stock Purchase Plan
Issuance of 198,282 shares of common stock upon exercise of stock options
from December 31, 2000 to December 31, 2001
Issuance of 115,962 shares of common stock upon exercise of stock options
from December 31,1999 to December 31,2000
Issuance of 14,470,553 shares of common stock in connection with the acquisition of Insmed Pharmaceuticals, Inc
Issuance of 792,298 shares of common stock upon exercise of stock options
Issuance of 93,413 shares of common stock to Taisho Pharmaceuticals Co. Ltd
Issuance of 1,408,169 shares of common stock and 1,725,330 warrants for cash, net of offering costs of $1,775
Issuance of 9,527,385 shares of common stock in connection with the acquisition of Celtrix Pharmaceuticals, Inc
Issuance of 5,500,000 shares of common stock for cash, net of offering costs of $4,746