股本结构
单位：万股
| 公告日期 | 2025-10-29 | 2025-10-29 | 2025-07-30 | 2025-07-30 | 2025-04-30 | 2025-04-30 |
|---|---|---|---|---|---|---|
| 证券总股本 | 16197.44 | 16113.79 | 15939.12 | 15919.68 | 15915.91 | 15904.13 |
| 普通股本 | 16197.44 | 16113.79 | 15939.12 | 15919.68 | 15915.91 | 15904.13 |
| 优先股 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2025-10-23 | 2025-09-30 | 2025-07-24 | 2025-06-30 | 2025-04-24 | 2025-03-31 |
注释：中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本（万股） | 变动后优先股（万股） | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2025-10-29 | 16197.44 | 未披露 | 定期报告 | 2025-10-23 |
| 2025-10-29 | 16113.79 | 未披露 |
更多>>
From June 30, 2025 to September 30, 2025
Issuance of common stock in connection with employee stock plans, net
|
2025-09-30 |
| 2025-07-30 | 15939.12 | 未披露 | 定期报告 | 2025-07-24 |
| 2025-07-30 | 15919.68 | 未披露 |
更多>>
From March 31, 2025 to June 30, 2025
Issuance of common stock in connection with employee stock plans, net
|
2025-06-30 |
| 2025-04-30 | 15915.91 | 未披露 | 定期报告 | 2025-04-24 |
| 2025-04-30 | 15904.13 | 未披露 |
更多>>
From December 31, 2024 to March 31, 2025
Issuance of common stock in connection with employee stock plans, net
|
2025-03-31 |
| 2025-02-19 | 15896.48 | 未披露 | 定期报告 | 2025-02-13 |
| 2025-02-19 | 15790.88 | 未披露 |
更多>>
From December 31, 2023 to December 31, 2024
Issuance of common stock in connection with employee stock plans, net
Issuance of public common stock, net
|
2024-12-31 |
| 2024-11-06 | 15789.73 | 未披露 | 定期报告 | 2024-10-31 |
| 2024-11-06 | 15781.31 | 未披露 |
更多>>
From June 30, 2024 to September 30, 2024
Issuance of common stock in connection with employee stock plans, net
Issuance of public common stock, net
|
2024-09-30 |
| 2024-09-10 | 15771.11 | 未披露 |
更多>>
Common stock offered 11,500,000 shares by the company
|
2024-09-11 |
| 2024-08-01 | 14621.11 | 未披露 | 定期报告 | 2024-07-26 |
| 2024-08-01 | 14602.52 | 未披露 |
更多>>
From March 31, 2024 to June 30, 2024
Issuance of common stock in connection with employee stock plans
|
2024-06-30 |
| 2024-05-07 | 14596.54 | 未披露 | 定期报告 | 2024-05-01 |
| 2024-04-25 | 14584.59 | 未披露 | 定期报告 | 2024-04-08 |
| 2024-05-07 | 14584.47 | 未披露 |
更多>>
From December 31, 2023 to March 31, 2024
Issuance of common stock in connection with employee stock plans
|
2024-03-31 |
| 2024-02-21 | 14575.18 | 未披露 | 定期报告 | 2024-02-15 |
| 2024-02-21 | 14434.05 | 未披露 |
更多>>
From December 31, 2022 to December 31, 2023
Issuance of common stock in connection with employee stock plans
|
2023-12-31 |
| 2023-11-02 | 14347.21 | 未披露 | 定期报告 | 2023-10-27 |
| 2023-11-02 | 14339.35 | 未披露 |
更多>>
From June 30, 2023 to September 30, 2023
Issuance of common stock in connection with employee stock plans
|
2023-09-30 |
| 2023-08-09 | 14332.62 | 未披露 | 定期报告 | 2023-08-03 |
| 2023-08-09 | 14316.74 | 未披露 |
更多>>
From March 31, 2023 to June 30, 2023
Issuance of common stock in connection with employee stock plans
|
2023-06-30 |
| 2023-05-03 | 14309.21 | 未披露 | 定期报告 | 2023-04-27 |
| 2023-04-20 | 14302.34 | 未披露 | 定期报告 | 2023-04-03 |
| 2023-05-03 | 14302.25 | 未披露 |
更多>>
From December 31, 2022 to March 31, 2023
Issuance of common stock in connection with employee stock plans
|
2023-03-31 |
| 2023-02-22 | 14295.40 | 未披露 | 定期报告 | 2023-02-16 |
| 2023-02-22 | 14205.77 | 未披露 |
更多>>
From December 31, 2021 to December 31, 2022
Issuance of common stock in connection with employee stock plans
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options
|
2022-12-31 |
| 2022-11-09 | 14205.03 | 未披露 | 定期报告 | 2022-11-03 |
| 2022-11-09 | 14201.74 | 未披露 |
更多>>
From June 30, 2022 to September 30, 2022
Issuance of common stock in connection with employee stock plans
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options
|
2022-09-30 |
| 2022-08-09 | 14194.13 | 未披露 | 定期报告 | 2022-08-03 |
| 2022-08-09 | 14183.07 | 未披露 |
更多>>
From March 31, 2022 to June 30, 2022
Issuance of common stock in connection with employee stock plans
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options
|
2022-06-30 |
| 2022-05-04 | 14179.79 | 未披露 | 定期报告 | 2022-04-28 |
| 2022-05-04 | 14175.31 | 未披露 |
更多>>
From December 31, 2021 to March 31, 2022
Issuance of common stock in connection with employee stock plans
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options
|
2022-03-31 |
| 2022-04-20 | 14169.21 | 未披露 | 定期报告 | 2022-03-01 |
| 2022-02-25 | 14168.87 | 未披露 | 定期报告 | 2022-02-16 |
| 2021-11-03 | 14121.00 | 未披露 | 定期报告 | 2021-10-27 |
| 2021-11-03 | 14118.40 | 未披露 |
更多>>
From June 30, 2021 to September 30, 2021
Issuance of common stock in connection with employee stock plans
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options
|
2021-09-30 |
| 2021-08-04 | 14114.77 | 未披露 | 定期报告 | 2021-07-28 |
| 2021-08-04 | 14102.16 | 未披露 |
更多>>
From March 31, 2021 to June 30, 2021
Issuance of common stock in connection with employee stock plans
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options
|
2021-06-30 |
| 2021-05-05 | 14096.30 | 未披露 | 定期报告 | 2021-04-29 |
| 2021-04-23 | 14092.93 | 未披露 | 定期报告 | 2021-04-05 |
| 2021-05-05 | 14092.44 | 未披露 |
更多>>
From December 31, 2020 to March 31, 2021
Issuance of common stock in connection with employee stock plans
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options
|
2021-03-31 |
| 2021-04-23 | 14086.78 | 未披露 | 定期报告 | 2021-03-01 |
| 2021-02-24 | 14086.22 | 未披露 | 定期报告 | 2021-02-18 |
| 2021-02-24 | 14036.56 | 未披露 |
更多>>
From December 31,2019 to December 31,2020
Issuance of common stock in connection with employee stock plans
Purchase of noncontrolling interest of Akcea Therapeutics, Inc., including cash payments for cancellation of Akcea Therapeutics, Inc. equity awards
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options
|
2020-12-31 |
| 2020-11-04 | 13982.31 | 未披露 | 定期报告 | 2020-10-29 |
| 2020-11-04 | 13979.39 | 未披露 |
更多>>
From June 30, 2020 to September 30, 2020
Issuance of common stock in connection with employee stock plans
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options
|
2020-09-30 |
| 2020-08-05 | 13969.70 | 未披露 | 定期报告 | 2020-07-29 |
| 2020-08-10 | 13948.94 | 未披露 |
更多>>
From March 31, 2020 to June 30, 2020
Issuance of common stock in connection with employee stock plans
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options
|
2020-06-30 |
| 2020-05-06 | 13932.10 | 未披露 | 定期报告 | 2020-04-29 |
| 2020-04-24 | 13928.75 | 未披露 | 定期报告 | 2020-04-06 |
| 2020-05-06 | 13928.22 | 未披露 |
更多>>
From December 31, 2019 to March 31, 2020
Issuance of common stock in connection with employee stock plans
Repurchases and retirements of common stock
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options
|
2020-03-31 |
| 2020-04-24 | 13923.10 | 未披露 | 定期报告 | 2020-03-03 |
| 2020-03-02 | 13921.98 | 未披露 | 定期报告 | 2020-02-20 |
| 2020-03-02 | 14033.96 | 未披露 |
更多>>
From December 31, 2018 to December 31, 2019
Issuance of common stock in connection with employee stock plans
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options
Repurchases and retirements of common stock
|
2019-12-31 |
| 2019-11-06 | 14066.33 | 未披露 | 定期报告 | 2019-10-31 |
| 2019-11-06 | 14063.64 | 未披露 |
更多>>
from June 30, 2019 to September 30, 2019
Issuance of common stock in connection with employee stock plans
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options
|
2019-09-30 |
| 2019-08-08 | 14050.03 | 未披露 | 定期报告 | 2019-08-01 |
| 2019-08-08 | 14039.31 | 未披露 |
更多>>
from March 31, 2019 to June 30, 2019
Issuance of common stock in connection with employee stock plans
Payments of tax withholdings related to vesting of employee stock awards
|
2019-06-30 |
| 2019-05-09 | 14032.30 | 未披露 | 定期报告 | 2019-05-02 |
| 2019-04-26 | 13976.11 | 未披露 | 定期报告 | 2019-04-08 |
| 2019-05-09 | 13962.39 | 未披露 |
更多>>
From December 31, 2018 to March 31, 2019
Issuance of common stock in connection with employee stock plans
Payments of tax withholdings related to vesting of employee stock awards
|
2019-03-31 |
| 2019-04-26 | 13849.41 | 未披露 | 定期报告 | 2019-03-01 |
| 2019-03-01 | 13839.78 | 未披露 | 定期报告 | 2019-02-20 |
| 2019-03-01 | 13792.88 | 未披露 |
更多>>
From December 31, 2017 to December 31, 2018
Biogen stock purchase
Issuance of common stock in connection with employee stock plans
|
2018-12-31 |
| 2018-11-06 | 13757.15 | 未披露 | 定期报告 | 2018-10-31 |
| 2018-11-06 | 13750.62 | 未披露 | 定期报告 | 2018-09-30 |
| 2018-08-07 | 13727.39 | 未披露 | 定期报告 | 2018-07-31 |
| 2018-08-07 | 13715.64 | 未披露 | 定期报告 | 2018-06-30 |
| 2018-05-07 | 12552.04 | 未披露 | 定期报告 | 2018-04-30 |
| 2018-05-07 | 12544.87 | 未披露 | 定期报告 | 2018-03-31 |
| 2018-04-11 | 12544.19 | 未披露 | 定期报告 | 2018-03-26 |
| 2018-04-11 | 12540.35 | 未披露 | 定期报告 | 2018-03-01 |
| 2018-02-28 | 12540.32 | 未披露 | 定期报告 | 2018-02-20 |
| 2018-02-28 | 12497.64 | 未披露 |
更多>>
From December 31, 2016 to December 31, 2017
Novartis stock purchase
Issuance of common stock in connection with employee stock plans
|
2017-12-31 |
| 2017-11-07 | 12479.55 | 未披露 | 定期报告 | 2017-11-01 |
| 2017-11-07 | 12461.94 | 未披露 | 定期报告 | 2017-09-30 |
| 2017-08-09 | 12435.47 | 未披露 | 定期报告 | 2017-08-02 |
| 2017-08-09 | 12414.64 | 未披露 | 定期报告 | 2017-06-30 |
| 2017-05-09 | 12396.56 | 未披露 | 定期报告 | 2017-05-02 |
| 2017-04-10 | 12388.06 | 未披露 | 定期报告 | 2017-03-31 |
| 2017-03-01 | 12374.95 | 未披露 | 定期报告 | 2017-02-21 |
| 2017-03-01 | 12163.63 | 未披露 |
更多>>
From December 31, 2015 to December 31, 2016
Issuance of common stock in connection with employee stock plans
|
2016-12-31 |
| 2016-11-09 | 12120.30 | 未披露 | 定期报告 | 2016-11-02 |
| 2016-11-09 | 12114.74 | 未披露 | 定期报告 | 2016-09-30 |
| 2016-08-09 | 12091.90 | 未披露 | 定期报告 | 2016-08-02 |
| 2016-08-09 | 12085.27 | 未披露 | 定期报告 | 2016-06-30 |
| 2016-05-05 | 12078.30 | 未披露 | 定期报告 | 2016-04-29 |
| 2016-04-15 | 12072.98 | 未披露 | 定期报告 | 2016-04-04 |
| 2016-05-05 | 12071.78 | 未披露 | 定期报告 | 2016-03-31 |
| 2016-02-26 | 12065.86 | 未披露 | 定期报告 | 2016-02-19 |
| 2016-02-26 | 12035.15 | 未披露 |
更多>>
From December 31, 2014 to December 31, 2015
Issuance of common stock in connection with employee stock plans
|
2015-12-31 |
| 2015-11-09 | 12011.77 | 未披露 | 定期报告 | 2015-11-04 |
| 2015-11-09 | 12002.83 | 未披露 | 定期报告 | 2015-09-30 |
| 2015-08-05 | 11996.23 | 未披露 | 定期报告 | 2015-07-30 |
| 2015-08-05 | 11988.16 | 未披露 | 定期报告 | 2015-06-30 |
| 2015-05-05 | 11971.33 | 未披露 | 定期报告 | 2015-04-30 |
| 2015-05-05 | 11960.23 | 未披露 | 定期报告 | 2015-03-31 |
| 2015-03-02 | 11901.83 | 未披露 | 定期报告 | 2015-02-23 |
| 2015-03-02 | 11844.27 | 未披露 |
更多>>
From December 31,2013 to December 31,2014
Issuance of common stock in connection with employee stock plans
|
2014-12-31 |
| 2014-11-07 | 11814.11 | 未披露 | 定期报告 | 2014-11-05 |
| 2014-11-07 | 11799.04 | 未披露 | 定期报告 | 2014-09-30 |
| 2014-08-04 | 11773.54 | 未披露 | 定期报告 | 2014-08-01 |
| 2014-08-04 | 11766.96 | 未披露 | 定期报告 | 2014-06-30 |
| 2014-05-06 | 11757.74 | 未披露 | 定期报告 | 2014-05-02 |
| 2014-04-25 | 11755.59 | 未披露 | 定期报告 | 2014-04-11 |
| 2014-05-06 | 11754.19 | 未披露 | 定期报告 | 2014-03-31 |
| 2014-03-03 | 11727.02 | 未披露 | 定期报告 | 2014-02-21 |
| 2014-03-03 | 11647.14 | 未披露 |
更多>>
From December 31,2012 to December 31,2013
Issuance of common stock in connection with employee stock plans
Issuance of public common stock
|
2013-12-31 |
| 2013-11-05 | 11607.44 | 未披露 | 定期报告 | 2013-11-01 |
| 2013-11-05 | 11599.82 | 未披露 | 定期报告 | 2013-09-30 |
| 2013-08-06 | 11530.78 | 未披露 | 定期报告 | 2013-08-01 |
| 2013-08-06 | 11429.20 | 未披露 | 定期报告 | 2013-06-30 |
| 2013-05-07 | 10378.04 | 未披露 | 定期报告 | 2013-05-02 |
| 2013-04-26 | 10337.85 | 未披露 | 定期报告 | 2013-04-26 |
| 2013-05-07 | 10269.52 | 未披露 | 定期报告 | 2013-03-31 |
| 2013-02-28 | 10182.67 | 未披露 | 定期报告 | 2013-02-21 |
| 2013-02-28 | 10148.11 | 未披露 |
更多>>
from December 31, 2011 to December 31, 2012
Options exercised and employee stock purchase plan issuances
|
2012-12-31 |
| 2012-11-06 | 10121.08 | 未披露 | 定期报告 | 2012-11-01 |
| 2012-11-06 | 10119.31 | 未披露 | 定期报告 | 2012-09-30 |
| 2012-08-06 | 10060.38 | 未披露 | 定期报告 | 2012-08-01 |
| 2012-08-06 | 10032.04 | 未披露 | 定期报告 | 2012-06-30 |
| 2012-05-09 | 10018.37 | 未披露 | 定期报告 | 2012-05-03 |
| 2012-05-09 | 10018.32 | 未披露 | 定期报告 | 2012-03-31 |
| 2012-02-29 | 10016.25 | 未披露 | 定期报告 | 2012-02-21 |
| 2012-02-29 | 10004.30 | 未披露 |
更多>>
from December 31, 2010 to December 31, 2011
Options exercised and employee stock purchase plan issuances
Warrants exercised
|
2011-12-31 |
| 2011-11-08 | 9972.93 | 未披露 | 定期报告 | 2011-11-01 |
| 2011-11-08 | 9972.33 | 未披露 | 定期报告 | 2011-09-30 |
| 2011-08-08 | 9966.09 | 未披露 | 定期报告 | 2011-08-01 |
| 2011-08-08 | 9961.85 | 未披露 | 定期报告 | 2011-06-30 |
| 2011-05-06 | 9959.42 | 未披露 | 定期报告 | 2011-05-02 |
| 2011-05-06 | 9958.01 | 未披露 | 定期报告 | 2011-03-31 |
| 2011-03-01 | 9957.87 | 未披露 | 定期报告 | 2011-02-22 |
| 2011-03-01 | 9939.38 | 未披露 |
更多>>
Options exercised and employee stock purchase plan issuances
Warrants exercised
|
2010-12-31 |
| 2010-11-05 | 9923.14 | 未披露 | 定期报告 | 2010-11-01 |
| 2010-11-05 | 9922.52 | 未披露 | 定期报告 | 2010-09-30 |
| 2010-08-09 | 9917.69 | 未披露 | 定期报告 | 2010-08-02 |
| 2010-08-09 | 9911.37 | 未披露 | 定期报告 | 2010-06-30 |
| 2010-05-07 | 9908.82 | 未披露 | 定期报告 | 2010-05-03 |
| 2010-05-07 | 9907.74 | 未披露 | 定期报告 | 2010-03-31 |
| 2010-03-01 | 9906.40 | 未披露 | 定期报告 | 2010-02-22 |
| 2010-03-01 | 9885.09 | 未披露 |
更多>>
from December 31, 2008 to December 31, 2009
Options exercised and employee stock purchase plan issuances
Warrants exercised
|
2009-12-31 |
| 2009-02-26 | 9759.51 | 未披露 | 定期报告 | 2009-02-19 |
| 2009-02-26 | 9717.24 | 未披露 |
更多>>
from December 31, 2007 to December 31, 2008
Options exercised and employee stock purchase plan
Warrants exercised
Issuance of common stock to Genzyme Corporation
|
2008-12-31 |
| 2008-03-13 | 9294.33 | 未披露 | 定期报告 | 2008-03-06 |
| 2008-03-13 | 8723.94 | 未披露 |
更多>>
from December 31, 2006 to December 31, 2007
Options exercised and employee stock purchase plan
Warrants exercised
Issuance of common stock for Symphony GenIsis acquisition
|
2007-12-31 |
| 2007-03-16 | 8248.50 | 未披露 | 定期报告 | 2007-03-05 |
| 2007-03-16 | 8228.37 | 未披露 |
更多>>
from December 31, 2005 to December 31, 2006
Options exercised and employee stock purchase plan
Warrants exercised
Issuance of common stock under Azimuth equity financing
|
2006-12-31 |
| 2006-03-16 | 7247.98 | 未披露 | 定期报告 | 2006-03-01 |
| 2006-03-16 | 7220.15 | 未披露 |
更多>>
from December 31, 2004 to December 31, 2005
Options exercised and employee stock purchase plan
Private Placement Offering
Conversion of Lilly debt
|
2005-12-31 |
| 2005-03-16 | 5752.79 | 未披露 | 定期报告 | 2005-03-03 |
| 2005-03-16 | 5744.73 | 未披露 |
更多>>
from December 31, 2003 to December 31, 2004
Options exercised and employee stock purchase plan
Conversion of preferred stock into common stock
|
2004-12-31 |
| 2004-03-15 | 5588.37 | 未披露 | 定期报告 | 2004-03-03 |
| 2004-03-15 | 5555.73 | 1.20 |
更多>>
from December 31, 2002 to December 31, 2003
Options exercised and employee stock purchase plan
|
2003-12-31 |
| 2003-03-31 | 5538.13 | 未披露 | 定期报告 | 2003-02-28 |
| 2003-03-31 | 5521.58 | 1.20 |
更多>>
from December 31, 2001 to December 31, 2002
Options exercised and employee stock purchase plan
Issuance of common stock
Conversion of preferred stock into common stock
|
2002-12-31 |
| 2002-04-01 | 5395.85 | 未披露 | 定期报告 | 2002-02-28 |
| 2002-04-01 | 5375.03 | 13.22 |
更多>>
from December 31, 2000 to December 31, 2001
Issuances of common stock,net of offering costs
Options exercised and employee stock purchase plan
|
2001-12-31 |
| 2001-02-28 | 4011.96 | 未披露 | 定期报告 | 2001-01-12 |
| 2001-02-28 | 4008.60 | 13.22 |
更多>>
from December 31, 1999 to December 31, 2000
Issuance of preferred stock,Series B
Issuances of common stock,net of offering costs
Options exercised and employee stock purchase plan
|
2000-12-31 |
| 2000-03-28 | 3509.42 | 未披露 | 定期报告 | 2000-03-24 |
| 2000-03-28 | 3161.30 | 12.02 |
更多>>
from December 31, 1998 to December 31, 1999
Options exercised and employee stock purchase plan
Issuance of preferred stock
Issuances of common stock, net of repurchases and offering costs
Warrants exercised
|
1999-12-31 |
| 1999-03-31 | 2716.96 | 未披露 | 定期报告 | 1999-02-26 |
| 1999-03-31 | 2705.30 | 未披露 |
更多>>
from December 31, 1997 to December 31, 1998
Options exercised and employee stock purchase plan
|
1998-12-31 |
| 1998-03-19 | 2676.07 | 未披露 | 定期报告 | 1998-02-27 |
| 1998-03-19 | 2665.50 | 未披露 |
更多>>
from December 31, 1996 to December 31, 1997
Options exercised and employee stock purchase plan
|
1997-12-31 |
| 1997-03-24 | 2623.58 | 未披露 | 定期报告 | 1997-01-31 |
| 1997-03-24 | 2620.10 | 未披露 |
更多>>
from December 31, 1995 to December 31, 1996
Options exercised and employee stock purchase plan
Issuances of common stock net of repurchases and offering costs
|
1996-12-31 |
| 1997-03-24 | 2524.90 | 未披露 |
更多>>
from December 31, 1994 to December 31, 1995
Options exercised and employee stock purchase plan
Issuances of common stock net of repurchases and offering costs
|
1995-12-31 |
From June 30, 2025 to September 30, 2025
Issuance of common stock in connection with employee stock plans, net
From March 31, 2025 to June 30, 2025
Issuance of common stock in connection with employee stock plans, net
From December 31, 2024 to March 31, 2025
Issuance of common stock in connection with employee stock plans, net
From December 31, 2023 to December 31, 2024
Issuance of common stock in connection with employee stock plans, net
Issuance of public common stock, net
From June 30, 2024 to September 30, 2024
Issuance of common stock in connection with employee stock plans, net
Issuance of public common stock, net
Common stock offered 11,500,000 shares by the company
From March 31, 2024 to June 30, 2024
Issuance of common stock in connection with employee stock plans
From December 31, 2023 to March 31, 2024
Issuance of common stock in connection with employee stock plans
From December 31, 2022 to December 31, 2023
Issuance of common stock in connection with employee stock plans
From June 30, 2023 to September 30, 2023
Issuance of common stock in connection with employee stock plans
From March 31, 2023 to June 30, 2023
Issuance of common stock in connection with employee stock plans
From December 31, 2022 to March 31, 2023
Issuance of common stock in connection with employee stock plans
From December 31, 2021 to December 31, 2022
Issuance of common stock in connection with employee stock plans
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options
From June 30, 2022 to September 30, 2022
Issuance of common stock in connection with employee stock plans
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options
From March 31, 2022 to June 30, 2022
Issuance of common stock in connection with employee stock plans
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options
From December 31, 2021 to March 31, 2022
Issuance of common stock in connection with employee stock plans
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options
From June 30, 2021 to September 30, 2021
Issuance of common stock in connection with employee stock plans
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options
From March 31, 2021 to June 30, 2021
Issuance of common stock in connection with employee stock plans
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options
From December 31, 2020 to March 31, 2021
Issuance of common stock in connection with employee stock plans
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options
From December 31,2019 to December 31,2020
Issuance of common stock in connection with employee stock plans
Purchase of noncontrolling interest of Akcea Therapeutics, Inc., including cash payments for cancellation of Akcea Therapeutics, Inc. equity awards
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options
From June 30, 2020 to September 30, 2020
Issuance of common stock in connection with employee stock plans
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options
From March 31, 2020 to June 30, 2020
Issuance of common stock in connection with employee stock plans
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options
From December 31, 2019 to March 31, 2020
Issuance of common stock in connection with employee stock plans
Repurchases and retirements of common stock
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options
From December 31, 2018 to December 31, 2019
Issuance of common stock in connection with employee stock plans
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options
Repurchases and retirements of common stock
from June 30, 2019 to September 30, 2019
Issuance of common stock in connection with employee stock plans
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options
from March 31, 2019 to June 30, 2019
Issuance of common stock in connection with employee stock plans
Payments of tax withholdings related to vesting of employee stock awards
From December 31, 2018 to March 31, 2019
Issuance of common stock in connection with employee stock plans
Payments of tax withholdings related to vesting of employee stock awards
From December 31, 2017 to December 31, 2018
Biogen stock purchase
Issuance of common stock in connection with employee stock plans
From December 31, 2016 to December 31, 2017
Novartis stock purchase
Issuance of common stock in connection with employee stock plans
From December 31, 2015 to December 31, 2016
Issuance of common stock in connection with employee stock plans
From December 31, 2014 to December 31, 2015
Issuance of common stock in connection with employee stock plans
From December 31,2013 to December 31,2014
Issuance of common stock in connection with employee stock plans
From December 31,2012 to December 31,2013
Issuance of common stock in connection with employee stock plans
Issuance of public common stock
from December 31, 2011 to December 31, 2012
Options exercised and employee stock purchase plan issuances
from December 31, 2010 to December 31, 2011
Options exercised and employee stock purchase plan issuances
Warrants exercised
Options exercised and employee stock purchase plan issuances
Warrants exercised
from December 31, 2008 to December 31, 2009
Options exercised and employee stock purchase plan issuances
Warrants exercised
from December 31, 2007 to December 31, 2008
Options exercised and employee stock purchase plan
Warrants exercised
Issuance of common stock to Genzyme Corporation
from December 31, 2006 to December 31, 2007
Options exercised and employee stock purchase plan
Warrants exercised
Issuance of common stock for Symphony GenIsis acquisition
from December 31, 2005 to December 31, 2006
Options exercised and employee stock purchase plan
Warrants exercised
Issuance of common stock under Azimuth equity financing
from December 31, 2004 to December 31, 2005
Options exercised and employee stock purchase plan
Private Placement Offering
Conversion of Lilly debt
from December 31, 2003 to December 31, 2004
Options exercised and employee stock purchase plan
Conversion of preferred stock into common stock
from December 31, 2002 to December 31, 2003
Options exercised and employee stock purchase plan
from December 31, 2001 to December 31, 2002
Options exercised and employee stock purchase plan
Issuance of common stock
Conversion of preferred stock into common stock
from December 31, 2000 to December 31, 2001
Issuances of common stock,net of offering costs
Options exercised and employee stock purchase plan
from December 31, 1999 to December 31, 2000
Issuance of preferred stock,Series B
Issuances of common stock,net of offering costs
Options exercised and employee stock purchase plan
from December 31, 1998 to December 31, 1999
Options exercised and employee stock purchase plan
Issuance of preferred stock
Issuances of common stock, net of repurchases and offering costs
Warrants exercised
from December 31, 1997 to December 31, 1998
Options exercised and employee stock purchase plan
from December 31, 1996 to December 31, 1997
Options exercised and employee stock purchase plan
from December 31, 1995 to December 31, 1996
Options exercised and employee stock purchase plan
Issuances of common stock net of repurchases and offering costs
from December 31, 1994 to December 31, 1995
Options exercised and employee stock purchase plan
Issuances of common stock net of repurchases and offering costs