股本结构

单位:万股
公告日期 2025-11-05 2025-11-05 2025-08-06 2025-08-06 2025-06-06 2025-06-06
证券总股本 6076.51 6074.00 6065.88 6064.00 6051.10 6165.25
普通股本 6076.51 6074.00 6065.88 6064.00 6051.10 6165.25
优先股 未披露 未披露 未披露 未披露 未披露 未披露
其他 未披露 400.00 未披露 400.00 未披露 未披露
变动日期 2025-10-29 2025-09-30 2025-07-30 2025-06-30 2025-05-29 2025-05-12
注释:中概股证券总股本=普通股股本/ 存托凭证比例

历史变动

公告日期 变动后普通股本(万股) 变动后优先股(万股) 变动原因 变动日期
2025-11-05 6076.51 未披露 定期报告 2025-10-29
2025-11-05 6074.00 未披露
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From June 30, 2025 to September 30, 2025 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units Issuance of ordinary shares in conjunction with vesting of performance-based restricted stock units
2025-09-30
2025-08-06 6065.88 未披露 定期报告 2025-07-30
2025-08-06 6064.00 未披露
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From March 31, 2025 to June 30, 2025 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
2025-06-30
2025-06-06 6051.10 未披露 定期报告 2025-05-29
2025-06-06 6165.25 未披露 定期报告 2025-05-12
2025-05-07 6163.28 未披露 定期报告 2025-04-30
2025-04-25 6163.23 未披露 定期报告 2025-04-15
2025-04-25 6162.40 未披露 定期报告 2025-04-01
2025-05-07 6162.30 未披露
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From December 31, 2024 to March 31, 2025 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units Issuance of ordinary shares in conjunction with vesting of performance-based restricted stock units
2025-03-31
2025-02-26 6073.25 未披露 定期报告 2025-02-19
2025-02-26 6063.10 未披露
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From December 31, 2023 to December 31, 2024 Issuance of ordinary shares in conjunction with vesting of performance-based restricted stock units Issuance of ordinary shares in conjunction with vesting of restricted stock units Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Shares repurchased
2024-12-31
2024-11-07 6045.46 未披露 定期报告 2024-10-31
2024-11-07 6044.30 未披露
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From June 30, 2024 to September 30, 2024 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
2024-09-30
2024-08-01 6175.35 未披露 定期报告 2024-07-25
2024-08-01 6174.50 未披露
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From March 31, 2024 to June 30, 2024 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
2024-06-30
2024-06-14 6306.24 未披露 定期报告 2024-05-29
2024-06-14 6303.98 未披露 定期报告 2024-05-01
2024-05-02 6303.96 未披露 定期报告 2024-04-25
2024-04-26 6303.95 未披露 定期报告 2024-04-15
2024-04-26 6302.78 未披露 定期报告 2024-04-01
2024-05-02 6302.80 未披露
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From December 31, 2023 to March 31, 2024 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units Issuance of ordinary shares in conjunction with vesting of performance-based restricted stock units
2024-03-31
2024-02-28 6234.53 未披露 定期报告 2024-02-21
2024-02-28 6225.50 未披露
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From December 31, 2022 to December 31, 2023 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Shares repurchased Issuance of ordinary shares in conjunction with vesting of restricted stock units
2023-12-31
2023-11-08 6295.69 未披露 定期报告 2023-11-01
2023-11-08 6294.50 未披露
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From June 30, 2023 to September 30, 2023 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
2023-09-30
2023-08-09 6313.48 未披露 定期报告 2023-08-02
2023-06-16 6413.95 未披露 定期报告 2023-06-07
2023-05-10 6400.48 未披露 定期报告 2023-05-03
2023-06-16 6400.29 未披露 定期报告 2023-05-01
2023-05-01 6400.11 未披露 定期报告 2023-04-15
2023-05-10 6398.70 未披露
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From December 31, 2022 to March 31, 2023 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units
2023-03-31
2023-03-01 6333.14 未披露 定期报告 2023-02-22
2023-03-01 6321.40 未披露
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From December 31, 2021 to December 31, 2022 Issuance of ordinary shares in conjunction with vesting of restricted stock units Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan
2022-12-31
2022-11-09 6296.63 未披露 定期报告 2022-11-02
2022-11-09 6289.00 未披露
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From June 30, 2022 to September 30, 2022 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units
2022-09-30
2022-08-03 6268.07 未披露 定期报告 2022-07-27
2022-08-03 6262.30 未披露
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From March 31, 2022 to June 30, 2022 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units
2022-06-30
2022-06-13 6244.25 未披露 定期报告 2022-06-01
2022-06-13 6231.96 未披露 定期报告 2022-05-01
2022-05-04 6231.87 未披露 定期报告 2022-04-27
2022-05-02 6231.11 未披露 定期报告 2022-04-15
2022-05-04 6224.40 未披露
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from December 31, 2021 to March 31, 2022 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units
2022-03-31
2022-03-01 6173.88 未披露 定期报告 2022-02-22
2022-03-01 6163.30 未披露
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From December 31, 2020 to December 31, 2021 Issuance of ordinary shares in connection with the acquisition of GW Pharmaceuticals plc Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units
2021-12-31
2021-11-09 6146.96 未披露 定期报告 2021-11-02
2021-11-09 6138.00 未披露
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From June 30, 2021 to September 30, 2021 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units
2021-09-30
2021-08-30 6136.40 未披露 定期报告 2021-08-19
2021-08-03 6114.86 未披露 定期报告 2021-07-27
2021-08-03 6111.50 未披露
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From March 31, 2021 to June 30, 2021 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units
2021-06-30
2021-06-11 6097.51 未披露 定期报告 2021-06-02
2021-05-04 5689.59 未披露 定期报告 2021-04-27
2021-04-23 5689.17 未披露 定期报告 2021-04-15
2021-05-04 5687.30 未披露
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from December 31, 2020 to March 31, 2021 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units
2021-03-31
2021-02-23 5632.54 未披露 定期报告 2021-02-16
2021-02-23 5617.10 未披露
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From December 31,2019 to December 31,2020 Stock issued under directors deferred compensation plan Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
2020-12-31
2020-11-02 5571.40 未披露 定期报告 2020-10-27
2020-11-02 5559.20 未披露
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From June 30, 2020 to September 30, 2020 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units
2020-09-30
2020-08-04 5545.86 未披露 定期报告 2020-07-28
2020-08-04 5545.60 未披露
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From March 31, 2020 to June 30, 2020 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
2020-06-30
2020-06-12 5534.69 未披露 定期报告 2020-06-03
2020-06-12 5532.54 未披露 定期报告 2020-05-01
2020-05-05 5533.04 未披露 定期报告 2020-04-28
2020-04-24 5534.70 未披露 定期报告 2020-04-16
2020-05-05 5536.80 未披露
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From December 31, 2019 to March 31, 2020 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
2020-03-31
2020-02-25 5613.33 未披露 定期报告 2020-02-18
2020-02-25 5614.00 未披露
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from December 31, 2018 to December 31, 2019 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
2019-12-31
2019-11-05 5657.27 未披露 定期报告 2019-10-31
2019-11-05 5661.90 未披露
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from June 30, 2019 to September 30, 2019 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
2019-09-30
2019-08-06 5662.11 未披露 定期报告 2019-07-31
2019-08-06 5662.60 未披露
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from March 31, 2019 to June 30, 2019 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
2019-06-30
2019-06-14 5663.56 未披露 定期报告 2019-06-05
2019-06-14 5658.48 未披露 定期报告 2019-05-13
2019-05-07 5666.07 未披露 定期报告 2019-04-30
2019-04-26 5676.85 未披露 定期报告 2019-04-18
2019-05-07 5690.30 未披露
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from December 31, 2018 to March 31, 2019 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
2019-03-31
2019-02-26 5705.57 未披露 定期报告 2019-02-19
2019-02-26 5750.40 未披露
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from December 31, 2017 to December 31, 2018 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
2018-12-31
2018-11-06 6032.16 未披露 定期报告 2018-10-31
2018-08-07 6040.91 未披露 定期报告 2018-07-31
2018-06-15 6028.67 未披露 定期报告 2018-06-06
2018-06-15 6001.90 未披露 定期报告 2018-05-14
2018-05-08 5999.62 未披露 定期报告 2018-04-30
2018-04-24 5999.85 未披露 定期报告 2018-04-17
2018-02-27 5980.34 未披露 定期报告 2018-02-20
2018-02-27 5989.80 未披露
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from December 31, 2016 to December 31, 2017 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
2017-12-31
2017-11-07 5995.05 未披露 定期报告 2017-10-31
2017-08-08 6006.50 未披露 定期报告 2017-07-31
2017-06-20 6009.10 未披露 定期报告 2017-06-07
2017-06-20 6006.36 未披露 定期报告 2017-05-18
2017-05-09 6002.88 未披露 定期报告 2017-05-02
2017-04-25 6001.66 未披露 定期报告 2017-04-18
2017-02-28 5974.22 未披露 定期报告 2017-02-21
2017-02-28 5982.00 未披露
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from December 31, 2015 to December 31, 2016 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
2016-12-31
2016-11-08 5989.23 未披露 定期报告 2016-10-31
2016-08-09 6053.21 未披露 定期报告 2016-08-02
2016-06-20 6048.60 未披露 定期报告 2016-06-07
2016-05-10 6042.18 未披露 定期报告 2016-05-03
2016-04-22 6044.47 未披露 定期报告 2016-04-18
2016-04-22 6049.28 未披露 定期报告 2016-03-31
2016-02-23 6118.46 未披露 定期报告 2016-02-17
2016-02-23 6130.50 未披露
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from December 31, 2014 to December 31, 2015 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
2015-12-31
2015-11-09 6149.78 未披露 定期报告 2015-10-30
2015-08-05 6133.93 未披露 定期报告 2015-07-31
2015-06-10 6122.47 未披露 定期报告 2015-06-01
2015-05-07 6106.70 未披露 定期报告 2015-05-01
2015-02-24 6065.72 未披露 定期报告 2015-02-18
2015-02-24 6064.30 未披露
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from December 31, 2013 to December 31, 2014 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units Issuance of ordinary shares in conjunction with exercise of warrants Shares issued under directors deferred compensation plan Shares repurchased
2014-12-31
2014-11-04 6049.17 未披露 定期报告 2014-10-28
2014-08-05 6022.11 未披露 定期报告 2014-07-29
2014-06-12 5945.09 未披露 定期报告 2014-05-27
2014-05-08 5939.19 未披露 定期报告 2014-05-01
2014-02-25 5806.84 未披露 定期报告 2014-02-19
2014-02-25 5785.40 未披露
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from December 31, 2012 to December 31, 2013 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units Issuance of ordinary shares in conjunction with exercise of warrants Shares repurchased
2013-12-31
2013-11-05 5778.97 未披露 定期报告 2013-10-29
2013-08-06 5815.35 未披露 定期报告 2013-07-22
2013-06-12 5862.70 未披露 定期报告 2013-06-04
2013-05-07 5885.04 未披露 定期报告 2013-03-31
2013-02-26 5803.75 未披露 定期报告 2013-02-20
2013-02-26 5801.40 未披露
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from December 31, 2011 to December 31, 2012 Merger with Azur Pharma Shares issued under directors deferred compensation plan Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with exercise of warrants
2012-12-31
2012-11-09 5788.82 未披露 定期报告 2012-11-02
2012-08-07 5753.66 未披露 定期报告 2012-07-31
2012-06-14 5690.10 未披露 定期报告 2012-05-25
2012-05-08 5673.29 未披露 定期报告 2012-04-30
2012-02-28 5624.38 未披露 定期报告 2012-02-21
2012-02-28 4246.80 未披露
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FROM December 31, 2010 TO December 31, 2011 Stock issued/issuable under directors deferred compensation plan Issuance of common stock in conjunction with exercise of stock options Issuance of common stock in conjunction with vesting of restricted stock units Issuance of common stock under employee stock purchase plan Issuance of common stock in conjunction with exercise of warrants
2011-12-31
2011-11-08 4215.73 未披露 定期报告 2011-10-24
2011-08-03 4173.93 未披露 定期报告 2011-07-25
2011-05-09 4074.18 未披露 定期报告 2011-04-29
2011-03-08 4029.46 未披露 定期报告 2011-02-28
2011-03-08 3995.93 未披露
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Issuance of common stock in conjunction with exercise of stock options Issuance of common stock in conjunction with vesting of restricted stock units Issuance of common stock under employee stock purchase plan Issuance of common stock in conjunction with offering, net of issuance costs Issuance of common stock in conjunction with cashless exercise of warrants Issuance of common stock in conjunction with exercise of warrants
2010-12-31
2010-11-05 3891.85 未披露 定期报告 2010-11-01
2010-08-11 3885.58 未披露 定期报告 2010-08-02
2010-05-06 3153.94 未披露 定期报告 2010-04-30
2010-03-04 3126.94 未披露 定期报告 2010-02-26
2010-03-04 3125.53 未披露
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from December 31, 2008 to December 31, 2009 Stock issued/issuable under directors deferred compensation plan Issuance of common stock in conjunction with exercise of stock options for cash and restricted stock units Issuance of common stock for cash under employee stock purchase plan Issuance of common stock and warrants for cash in conjunction with private placement offering, net of issuance costs
2009-12-31
2009-03-26 2892.54 未披露 定期报告 2009-03-20
2009-03-26 2892.51 未披露
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from December 31, 2007 to December 31, 2008 Stock issued/issuable under directors deferred compensation plan Issuance of common stock upon exercise of stock options for cash & restricted stock units Issuance of common stock for cash under employee stock purchase plan Issuance of common stock and warrants for cash upon registered direct public offering, net of issuance costs
2008-12-31
2008-03-31 2462.26 未披露 定期报告 2008-03-25
2008-03-31 2462.08 未披露
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from December 31, 2006 to December 31, 2007 Conversion of convertible preferred stock to common stock and common stock subject to repurchase upon initial public offering Issuance of common stock for cash upon initial public offering, net of issuance costs of $10,512 Issuance of common stock for cash upon exercise of stock options Issuance of common stock for cash under employee stock purchase plan
2007-12-31
From June 30, 2025 to September 30, 2025 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units Issuance of ordinary shares in conjunction with vesting of performance-based restricted stock units
From March 31, 2025 to June 30, 2025 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
From December 31, 2024 to March 31, 2025 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units Issuance of ordinary shares in conjunction with vesting of performance-based restricted stock units
From December 31, 2023 to December 31, 2024 Issuance of ordinary shares in conjunction with vesting of performance-based restricted stock units Issuance of ordinary shares in conjunction with vesting of restricted stock units Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Shares repurchased
From June 30, 2024 to September 30, 2024 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
From March 31, 2024 to June 30, 2024 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
From December 31, 2023 to March 31, 2024 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units Issuance of ordinary shares in conjunction with vesting of performance-based restricted stock units
From December 31, 2022 to December 31, 2023 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Shares repurchased Issuance of ordinary shares in conjunction with vesting of restricted stock units
From June 30, 2023 to September 30, 2023 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
From December 31, 2022 to March 31, 2023 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units
From December 31, 2021 to December 31, 2022 Issuance of ordinary shares in conjunction with vesting of restricted stock units Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan
From June 30, 2022 to September 30, 2022 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units
From March 31, 2022 to June 30, 2022 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units
from December 31, 2021 to March 31, 2022 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units
From December 31, 2020 to December 31, 2021 Issuance of ordinary shares in connection with the acquisition of GW Pharmaceuticals plc Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units
From June 30, 2021 to September 30, 2021 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units
From March 31, 2021 to June 30, 2021 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units
from December 31, 2020 to March 31, 2021 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units
From December 31,2019 to December 31,2020 Stock issued under directors deferred compensation plan Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
From June 30, 2020 to September 30, 2020 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units
From March 31, 2020 to June 30, 2020 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
From December 31, 2019 to March 31, 2020 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
from December 31, 2018 to December 31, 2019 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
from June 30, 2019 to September 30, 2019 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
from March 31, 2019 to June 30, 2019 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
from December 31, 2018 to March 31, 2019 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
from December 31, 2017 to December 31, 2018 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
from December 31, 2016 to December 31, 2017 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
from December 31, 2015 to December 31, 2016 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
from December 31, 2014 to December 31, 2015 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units Shares repurchased
from December 31, 2013 to December 31, 2014 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units Issuance of ordinary shares in conjunction with exercise of warrants Shares issued under directors deferred compensation plan Shares repurchased
from December 31, 2012 to December 31, 2013 Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with vesting of restricted stock units Issuance of ordinary shares in conjunction with exercise of warrants Shares repurchased
from December 31, 2011 to December 31, 2012 Merger with Azur Pharma Shares issued under directors deferred compensation plan Issuance of ordinary shares in conjunction with exercise of share options Issuance of ordinary shares under employee stock purchase plan Issuance of ordinary shares in conjunction with exercise of warrants
FROM December 31, 2010 TO December 31, 2011 Stock issued/issuable under directors deferred compensation plan Issuance of common stock in conjunction with exercise of stock options Issuance of common stock in conjunction with vesting of restricted stock units Issuance of common stock under employee stock purchase plan Issuance of common stock in conjunction with exercise of warrants
Issuance of common stock in conjunction with exercise of stock options Issuance of common stock in conjunction with vesting of restricted stock units Issuance of common stock under employee stock purchase plan Issuance of common stock in conjunction with offering, net of issuance costs Issuance of common stock in conjunction with cashless exercise of warrants Issuance of common stock in conjunction with exercise of warrants
from December 31, 2008 to December 31, 2009 Stock issued/issuable under directors deferred compensation plan Issuance of common stock in conjunction with exercise of stock options for cash and restricted stock units Issuance of common stock for cash under employee stock purchase plan Issuance of common stock and warrants for cash in conjunction with private placement offering, net of issuance costs
from December 31, 2007 to December 31, 2008 Stock issued/issuable under directors deferred compensation plan Issuance of common stock upon exercise of stock options for cash & restricted stock units Issuance of common stock for cash under employee stock purchase plan Issuance of common stock and warrants for cash upon registered direct public offering, net of issuance costs
from December 31, 2006 to December 31, 2007 Conversion of convertible preferred stock to common stock and common stock subject to repurchase upon initial public offering Issuance of common stock for cash upon initial public offering, net of issuance costs of $10,512 Issuance of common stock for cash upon exercise of stock options Issuance of common stock for cash under employee stock purchase plan