股本结构
单位：万股
| 公告日期 | 2025-11-13 | 2025-11-13 | 2025-09-24 | 2025-08-12 | 2025-08-12 | 2025-05-13 |
|---|---|---|---|---|---|---|
| 证券总股本 | 668.26 | 666.29 | 665.42 | 617.00 | 612.75 | 611.52 |
| 普通股本 | 668.26 | 666.29 | 665.42 | 617.00 | 612.75 | 611.52 |
| 优先股 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2025-10-31 | 2025-09-30 | 2025-09-25 | 2025-07-31 | 2025-06-30 | 2025-03-31 |
注释：中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本（万股） | 变动后优先股（万股） | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2025-11-13 | 668.26 | 未披露 | 定期报告 | 2025-10-31 |
| 2025-11-13 | 666.29 | 未披露 |
更多>>
From June 30, 2025 to September 30, 2025
Issuance of common stock upon public offering, net of commissions, fees and expenses of $7,857,468
Repurchase of common stock
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
Issuance of common stock upon exercise of stock options
|
2025-09-30 |
| 2025-09-24 | 665.42 | 未披露 |
更多>>
1.Common stock offered 1,034,433 shares by the company
2.Common stock repurchased 550,229 shares by the company
|
2025-09-25 |
| 2025-08-12 | 617.00 | 未披露 | 定期报告 | 2025-07-31 |
| 2025-08-12 | 612.75 | 未披露 |
更多>>
From March 31, 2025 to June 30, 2025
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
Issuance of common stock upon exercise of stock options
|
2025-06-30 |
| 2025-05-13 | 611.52 | 未披露 |
更多>>
From January 1, 2025 to March 31, 2025
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
Issuance of common stock upon exercise of stock options
|
2025-03-31 |
| 2025-03-31 | 611.26 | 未披露 | 定期报告 | 2025-03-14 |
| 2025-01-15 | 610.25 | 未披露 | 定期报告 | 2025-01-15 |
| 2025-03-31 | 610.26 | 未披露 |
更多>>
From December 31, 2023 to December 31, 2024
Issuance of common stock to Alexion Pharmaceuticals, Inc, a wholly owned subsidiary of AstraZeneca PLC
Issuance of common stock under a Capital on DemandTM Sales Agreement with Jones Trading Institutional Services LLC, net of commissions, fees and expenses of $107,806
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
Impact of reverse stock split fractional share round up
Issuance of common stock and concurrent private placement of pre-funded warrants upon registered offering, net of commissions, fees and expenses of $2,621,880
Exercise of stock options
Issuance of common stock upon public offering, net of commissions, fees and expenses of $1,489,702
|
2024-12-31 |
| 2024-12-23 | 607.65 | 未披露 |
更多>>
Common Stock Offered 798,655 shares by the company
|
2024-12-23 |
| 2024-11-08 | 527.78 | 未披露 | 定期报告 | 2024-10-31 |
| 2024-10-29 | 527.78 | 未披露 |
更多>>
Common Stock Offered 1,181,540 shares by the company
|
2024-10-30 |
| 2024-10-28 | 396.11 | 未披露 | 定期报告 | 2024-10-25 |
| 2024-11-08 | 352.51 | 未披露 |
更多>>
From June 30, 2024 to September 30, 2024
Impact of reverse stock split fractional share round up
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
|
2024-09-30 |
| 2024-08-09 | 350.00 | 未披露 |
更多>>
1-for-5 reverse stock split of its outstanding shares of common stock
|
2024-08-13 |
| 2024-08-09 | 1760.00 | 未披露 | 定期报告 | 2024-08-09 |
| 2024-08-09 | 1760.18 | 未披露 |
更多>>
From March 31, 2024 to June 30, 2024
Exercise of stock options
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
|
2024-06-30 |
| 2024-07-22 | 1756.82 | 未披露 | 定期报告 | 2024-06-14 |
| 2024-05-09 | 1748.42 | 未披露 |
更多>>
From January 1, 2024 to March 31, 2024
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
Issuance of common stock under a Capital on Demand[TM] Sales Agreement with JonesTrading Institutional Services, LLC, net of commissions, fees and offering costs of $81,932
|
2024-03-31 |
| 2024-03-28 | 1745.49 | 未披露 | 定期报告 | 2024-03-08 |
| 2024-03-28 | 1490.45 | 未披露 |
更多>>
From December 31, 2022 to December 31, 2023
Issuance of common stock under a Capital on DemandTM Sales Agreement with JonesTrading Institutional Services LLC, net of commissions, fees and expenses of $98,230
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
|
2023-12-31 |
| 2023-11-09 | 1486.64 | 未披露 | 定期报告 | 2023-11-07 |
| 2023-11-09 | 1419.84 | 未披露 |
更多>>
From June 30, 2023 to September 30, 2023
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
Issuance of common stock under a Capital on DemandTM Sales Agreement with JonesTrading Institutional Services, LLC, net of commissions, fees and offering costs of $8,218
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
|
2023-09-30 |
| 2023-08-10 | 1415.79 | 未披露 | 定期报告 | 2023-07-28 |
| 2023-08-10 | 1389.81 | 未披露 |
更多>>
From March 31, 2023 to June 30, 2023
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
Issuance of common stock under a Capital on DemandTM Sales Agreement with JonesTrading Institutional Services, LLC, net of commissions, fees and offering costs of $26,522
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
|
2023-06-30 |
| 2023-05-11 | 1322.21 | 未披露 |
更多>>
From January 1, 2023 to March 31, 2023
Issuance of common stock under a Capital on DemandTM Sales Agreement with JonesTrading Institutional Services, LLC, net of commissions, fees and offering costs of $37,661
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
|
2023-03-31 |
| 2023-03-23 | 1319.32 | 未披露 | 定期报告 | 2023-03-10 |
| 2023-03-23 | 1294.66 | 未披露 |
更多>>
From December 31, 2021 to December 31, 2022
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
Issuance of common stock upon exercise of stock options
Issuance of common stock under a Capital on DemandTM Sales Agreement with JonesTrading Institutional Services LLC, net of commissions, fees and expenses of $87,611
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
|
2022-12-31 |
| 2022-12-21 | 1292.03 | 未披露 | 定期报告 | 2022-12-15 |
| 2022-11-10 | 1285.57 | 未披露 |
更多>>
From June 30, 2022 to September 30, 2022
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
Issuance of common stock upon exercise of stock options
|
2022-09-30 |
| 2022-08-11 | 1272.58 | 未披露 | 定期报告 | 2022-07-29 |
| 2022-08-11 | 1270.07 | 未披露 |
更多>>
From March 31, 2022 to June 30, 2022
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
Issuance of common stock upon exercise of stock options
|
2022-06-30 |
| 2022-05-12 | 1262.16 | 未披露 | 定期报告 | 2022-04-30 |
| 2022-05-12 | 1262.06 | 未披露 |
更多>>
From January 1, 2022 to March 31, 2022
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
|
2022-03-31 |
| 2022-03-24 | 1260.45 | 未披露 | 定期报告 | 2022-03-11 |
| 2022-03-24 | 1259.81 | 未披露 |
更多>>
From December 31, 2020 to December 31, 2021
Issuance of common stock under a Capital on DemandTM Sales Agreement with JonesTrading Institutional Services LLC, net of commissions and fees of $338,153
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
Issuance of common stock upon exercise of stock options
|
2021-12-31 |
| 2021-11-12 | 1259.06 | 未披露 |
更多>>
From June 30, 2021 to September 30, 2021
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
|
2021-09-30 |
| 2021-08-12 | 1258.27 | 未披露 |
更多>>
From March 31, 2021 to June 30, 2021
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
|
2021-06-30 |
| 2021-05-13 | 1256.99 | 未披露 |
更多>>
From January 1, 2021 To March 31, 2021
Issuance of common stock under a Capital on DemandTM Sales Agreement with JonesTrading Institutional Services LLC, net of commissions and fees of $338,153
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
Issuance of common stock upon exercise of stock options
|
2021-03-31 |
| 2021-03-25 | 1256.69 | 未披露 | 定期报告 | 2021-03-05 |
| 2021-03-25 | 1145.35 | 未披露 |
更多>>
from December 31, 2019 to December 31, 2020
Issuance of common stock under a Capital on DemandTM Sales Agreement with JonesTrading Institutional Services LLC, net of commissions and fees of $253,035
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
|
2020-12-31 |
| 2020-11-12 | 1145.22 | 未披露 |
更多>>
From June 30, 2020 to September 30, 2020
Issuance of common stock under a Capital on DemandTM Sales Agreement with Jones Trading Institutional Services LLC, net of commissions and fees of $207,326
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
|
2020-09-30 |
| 2020-08-06 | 1073.64 | 未披露 | 定期报告 | 2020-07-31 |
| 2020-08-06 | 1073.60 | 未披露 |
更多>>
From March 31, 2020 to June 30, 2020
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
|
2020-06-30 |
| 2020-05-07 | 1063.41 | 未披露 | 定期报告 | 2020-05-01 |
| 2020-04-29 | 1062.28 | 未披露 | 定期报告 | 2020-04-15 |
| 2020-05-07 | 1062.28 | 未披露 |
更多>>
From January 1, 2020 to March 31, 2020
Issuance of common stock under a Capital on DemandTM Sales Agreement with Jones Trading Institutional Services LLC, net of $16,284 in commissions
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
|
2020-03-31 |
| 2020-03-27 | 1062.15 | 未披露 | 定期报告 | 2020-03-13 |
| 2020-03-27 | 1058.76 | 未披露 |
更多>>
from December 31, 2018 to December 31, 2019
Issuance of common stock at $8 per share for cash, net of $1,400,492 issuance costs
Issuance of common stock upon exercise of stock options
|
2019-12-31 |
| 2019-12-19 | 1042.10 | 未披露 |
更多>>
1.Common Stock offered by us 1,111,112 shares
2.The number of shares of our Common Stock to be outstanding after this offering is based on an aggregate of 9,309,854 shares of our Common Stock outstanding as of December 13, 2019
|
2019-12-19 |
| 2019-08-15 | 929.14 | 未披露 | 定期报告 | 2019-06-30 |
From June 30, 2025 to September 30, 2025
Issuance of common stock upon public offering, net of commissions, fees and expenses of $7,857,468
Repurchase of common stock
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
Issuance of common stock upon exercise of stock options
1.Common stock offered 1,034,433 shares by the company
2.Common stock repurchased 550,229 shares by the company
From March 31, 2025 to June 30, 2025
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
Issuance of common stock upon exercise of stock options
From January 1, 2025 to March 31, 2025
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
Issuance of common stock upon exercise of stock options
From December 31, 2023 to December 31, 2024
Issuance of common stock to Alexion Pharmaceuticals, Inc, a wholly owned subsidiary of AstraZeneca PLC
Issuance of common stock under a Capital on DemandTM Sales Agreement with Jones Trading Institutional Services LLC, net of commissions, fees and expenses of $107,806
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
Impact of reverse stock split fractional share round up
Issuance of common stock and concurrent private placement of pre-funded warrants upon registered offering, net of commissions, fees and expenses of $2,621,880
Exercise of stock options
Issuance of common stock upon public offering, net of commissions, fees and expenses of $1,489,702
Common Stock Offered 798,655 shares by the company
Common Stock Offered 1,181,540 shares by the company
From June 30, 2024 to September 30, 2024
Impact of reverse stock split fractional share round up
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
1-for-5 reverse stock split of its outstanding shares of common stock
From March 31, 2024 to June 30, 2024
Exercise of stock options
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
From January 1, 2024 to March 31, 2024
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
Issuance of common stock under a Capital on Demand[TM] Sales Agreement with JonesTrading Institutional Services, LLC, net of commissions, fees and offering costs of $81,932
From December 31, 2022 to December 31, 2023
Issuance of common stock under a Capital on DemandTM Sales Agreement with JonesTrading Institutional Services LLC, net of commissions, fees and expenses of $98,230
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
From June 30, 2023 to September 30, 2023
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
Issuance of common stock under a Capital on DemandTM Sales Agreement with JonesTrading Institutional Services, LLC, net of commissions, fees and offering costs of $8,218
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
From March 31, 2023 to June 30, 2023
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
Issuance of common stock under a Capital on DemandTM Sales Agreement with JonesTrading Institutional Services, LLC, net of commissions, fees and offering costs of $26,522
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
From January 1, 2023 to March 31, 2023
Issuance of common stock under a Capital on DemandTM Sales Agreement with JonesTrading Institutional Services, LLC, net of commissions, fees and offering costs of $37,661
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
From December 31, 2021 to December 31, 2022
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
Issuance of common stock upon exercise of stock options
Issuance of common stock under a Capital on DemandTM Sales Agreement with JonesTrading Institutional Services LLC, net of commissions, fees and expenses of $87,611
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
From June 30, 2022 to September 30, 2022
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
Issuance of common stock upon exercise of stock options
From March 31, 2022 to June 30, 2022
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
Issuance of common stock upon exercise of stock options
From January 1, 2022 to March 31, 2022
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
From December 31, 2020 to December 31, 2021
Issuance of common stock under a Capital on DemandTM Sales Agreement with JonesTrading Institutional Services LLC, net of commissions and fees of $338,153
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
Issuance of common stock upon exercise of stock options
From June 30, 2021 to September 30, 2021
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
From March 31, 2021 to June 30, 2021
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
From January 1, 2021 To March 31, 2021
Issuance of common stock under a Capital on DemandTM Sales Agreement with JonesTrading Institutional Services LLC, net of commissions and fees of $338,153
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
Issuance of common stock to employees pursuant to vested restricted stock units, net of taxes
Issuance of common stock upon exercise of stock options
from December 31, 2019 to December 31, 2020
Issuance of common stock under a Capital on DemandTM Sales Agreement with JonesTrading Institutional Services LLC, net of commissions and fees of $253,035
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
From June 30, 2020 to September 30, 2020
Issuance of common stock under a Capital on DemandTM Sales Agreement with Jones Trading Institutional Services LLC, net of commissions and fees of $207,326
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
From March 31, 2020 to June 30, 2020
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
From January 1, 2020 to March 31, 2020
Issuance of common stock under a Capital on DemandTM Sales Agreement with Jones Trading Institutional Services LLC, net of $16,284 in commissions
Issuance of common stock to non-employee directors pursuant to vested restricted stock units
from December 31, 2018 to December 31, 2019
Issuance of common stock at $8 per share for cash, net of $1,400,492 issuance costs
Issuance of common stock upon exercise of stock options
1.Common Stock offered by us 1,111,112 shares
2.The number of shares of our Common Stock to be outstanding after this offering is based on an aggregate of 9,309,854 shares of our Common Stock outstanding as of December 13, 2019