股本结构
单位：万股
| 公告日期 | 2025-10-28 | 2025-10-28 | 2025-07-30 | 2025-07-30 | 2025-05-05 | 2025-05-05 |
|---|---|---|---|---|---|---|
| 证券总股本 | 9970.57 | 9970.00 | 9918.15 | 9900.00 | 9896.58 | 9900.00 |
| 普通股本 | 9970.57 | 9970.00 | 9918.15 | 9900.00 | 9896.58 | 9900.00 |
| 优先股 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2025-10-21 | 2025-09-30 | 2025-07-24 | 2025-06-30 | 2025-04-30 | 2025-03-31 |
注释：中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本（万股） | 变动后优先股（万股） | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2025-10-28 | 9970.57 | 未披露 | 定期报告 | 2025-10-21 |
| 2025-10-28 | 9970.00 | 未披露 |
更多>>
From June 30, 2025 to September 30, 2025
Issuances of common stock under stock plans
|
2025-09-30 |
| 2025-07-30 | 9918.15 | 未披露 | 定期报告 | 2025-07-24 |
| 2025-07-30 | 9900.00 | 未披露 |
更多>>
From March 31, 2025 to June 30, 2025
Issuances of common stock under stock plans
Repurchases of common stock
|
2025-06-30 |
| 2025-05-05 | 9896.58 | 未披露 | 定期报告 | 2025-04-30 |
| 2025-05-05 | 9900.00 | 未披露 |
更多>>
From December 31,2024 to March 31, 2025
Issuances of common stock under stock plans
Repurchases of common stock
|
2025-03-31 |
| 2025-04-09 | 9893.82 | 未披露 | 定期报告 | 2025-03-24 |
| 2025-02-10 | 9970.35 | 未披露 | 定期报告 | 2025-02-05 |
| 2025-02-10 | 9940.00 | 未披露 |
更多>>
From December 31, 2023 to December 31, 2024
Issuances of common stock under stock plans
Repurchases of common stock under accelerated buyback agreements
|
2024-12-31 |
| 2024-10-30 | 10124.69 | 未披露 | 定期报告 | 2024-10-24 |
| 2024-10-30 | 10120.00 | 未披露 |
更多>>
From June 30, 2024 to September 30, 2024
Issuances of common stock under stock plans
|
2024-09-30 |
| 2024-08-01 | 10097.62 | 未披露 | 定期报告 | 2024-07-26 |
| 2024-08-01 | 10090.00 | 未披露 |
更多>>
From March 31, 2024 to June 30, 2024
Issuances of common stock under stock plans
|
2024-06-30 |
| 2024-05-01 | 10063.72 | 未披露 | 定期报告 | 2024-04-25 |
| 2024-05-01 | 10060.00 | 未披露 |
更多>>
From December 31, 2023 to March 31, 2024
Issuances of common stock under stock plans
|
2024-03-31 |
| 2024-04-10 | 10058.05 | 未披露 | 定期报告 | 2024-03-25 |
| 2024-02-09 | 9950.75 | 未披露 | 定期报告 | 2024-02-05 |
| 2024-02-09 | 9870.00 | 未披露 |
更多>>
From December 31,2022 to December 31,2023
Issuances of common stock under stock plans
|
2023-12-31 |
| 2023-10-31 | 9825.19 | 未披露 | 定期报告 | 2023-10-25 |
| 2023-10-31 | 9820.00 | 未披露 |
更多>>
From June 30, 2023 to September 30, 2023
Issuances of common stock under stock plans
|
2023-09-30 |
| 2023-08-01 | 9765.25 | 未披露 | 定期报告 | 2023-07-26 |
| 2023-08-01 | 9760.00 | 未披露 |
更多>>
From March 31, 2023 to June 30, 2023
Issuances of common stock under stock plans
|
2023-06-30 |
| 2023-05-03 | 9757.48 | 未披露 | 定期报告 | 2023-04-26 |
| 2023-05-03 | 9750.00 | 未披露 |
更多>>
From December 31, 2022 to March 31, 2023
Issuances of common stock under stock plans
|
2023-03-31 |
| 2023-04-05 | 9752.56 | 未披露 | 定期报告 | 2023-03-20 |
| 2023-04-05 | 9752.51 | 未披露 | 定期报告 | 2023-03-15 |
| 2023-02-09 | 9658.79 | 未披露 | 定期报告 | 2023-01-31 |
| 2023-02-09 | 9650.00 | 未披露 |
更多>>
From December 31, 2021 to December 31, 2022
Issuances of common stock under stock plans
|
2022-12-31 |
| 2022-11-01 | 9613.44 | 未披露 | 定期报告 | 2022-10-28 |
| 2022-11-01 | 9610.00 | 未披露 |
更多>>
From June 30, 2022 to September 30, 2022
Issuances of common stock under stock plans
|
2022-09-30 |
| 2022-08-04 | 9563.93 | 未披露 | 定期报告 | 2022-07-28 |
| 2022-08-04 | 9560.00 | 未披露 |
更多>>
From March 31, 2022 to June 30, 2022
Issuances of common stock under stock plans
|
2022-06-30 |
| 2022-05-04 | 9557.67 | 未披露 | 定期报告 | 2022-04-28 |
| 2022-05-04 | 9550.00 | 未披露 |
更多>>
From December 31, 2021 to March 31, 2022
Issuances of common stock under stock plans
|
2022-03-31 |
| 2022-04-07 | 9550.92 | 未披露 | 定期报告 | 2022-03-15 |
| 2022-02-11 | 9524.27 | 未披露 | 定期报告 | 2022-02-07 |
| 2022-02-11 | 9490.00 | 未披露 |
更多>>
From December 31, 2020 to December 31, 2021
Issuances of common stock under stock plans
|
2021-12-31 |
| 2021-11-01 | 9486.67 | 未披露 | 定期报告 | 2021-10-27 |
| 2021-11-01 | 9480.00 | 未披露 |
更多>>
From June 30, 2021 to September 30, 2021
Issuances of common stock under stock plans
|
2021-09-30 |
| 2021-08-03 | 9464.64 | 未披露 | 定期报告 | 2021-07-28 |
| 2021-08-03 | 9460.00 | 未披露 |
更多>>
From March 31, 2021 to June 30, 2021
Issuances of common stock under stock plans
|
2021-06-30 |
| 2021-05-05 | 9454.60 | 未披露 | 定期报告 | 2021-04-29 |
| 2021-05-05 | 9450.00 | 未披露 |
更多>>
From December 31,2020 to March 31, 2021
Issuances of common stock under stock plans
|
2021-03-31 |
| 2021-04-09 | 9453.57 | 未披露 | 定期报告 | 2021-03-23 |
| 2021-02-05 | 9394.36 | 未披露 | 定期报告 | 2021-01-29 |
| 2021-02-05 | 9350.00 | 未披露 |
更多>>
From December 31,2019 to December 31,2020
Issuance of common stock for vested restricted stock units
Issuance of common stock for stock option exercises
Issuance of common stock for employee stock purchase plan
|
2020-12-31 |
| 2020-11-09 | 9342.92 | 未披露 | 定期报告 | 2020-11-04 |
| 2020-11-09 | 9340.00 | 未披露 |
更多>>
From June 30, 2020 to September 30, 2020
Issuance of common stock for stock options
Issuance of common stock for employee stock purchase plan
|
2020-09-30 |
| 2020-08-03 | 9325.49 | 未披露 | 定期报告 | 2020-07-28 |
| 2020-08-03 | 9320.00 | 未披露 |
更多>>
from March 31, 2020 to June 30, 2020
Issuance of common stock for vested restricted stock options
Issuance of common stock for stock option
|
2020-06-30 |
| 2020-05-06 | 9286.51 | 未披露 | 定期报告 | 2020-04-30 |
| 2020-05-06 | 9280.00 | 未披露 |
更多>>
from December 31, 2019 to March 31, 2020
Issuance of common stock for vested restricted stock units
Issuance of common stock for stock option exercises
|
2020-03-31 |
| 2020-04-09 | 9277.94 | 未披露 | 定期报告 | 2020-03-15 |
| 2020-02-07 | 9229.24 | 未披露 | 定期报告 | 2020-01-31 |
| 2020-02-07 | 9227.20 | 未披露 |
更多>>
from December 31, 2018 to December 31, 2019
Issuance of common stock for vested restricted stock units
Issuance of common stock for stock option exercises
Issuance of common stock for employee stock purchase plan
|
2019-12-31 |
| 2019-11-04 | 9209.35 | 未披露 | 定期报告 | 2019-10-29 |
| 2019-11-04 | 9208.00 | 未披露 |
更多>>
from June 30, 2019 to September 30, 2019
Issuance of common stock for vested restricted stock units
Issuance of common stock for stock option exercises
Issuance of common stock for employee stock purchase plan
|
2019-09-30 |
| 2019-07-29 | 9157.94 | 未披露 | 定期报告 | 2019-07-24 |
| 2019-07-29 | 9153.60 | 未披露 |
更多>>
from March 31, 2019 to June 30,2019
Issuance of common stock for vested restricted stock units
Issuance of common stock for stock option exercises
|
2019-06-30 |
| 2019-04-29 | 9128.69 | 未披露 | 定期报告 | 2019-04-24 |
| 2019-04-29 | 9128.40 | 未披露 |
更多>>
from December 31, 2018 to March 31, 2019
Issuance of common stock for vested restricted stock units
Issuance of common stock for stock option exercises
Issuance of common stock for employee stock purchase plan
|
2019-03-31 |
| 2019-04-17 | 9128.43 | 未披露 | 定期报告 | 2019-03-29 |
| 2019-04-17 | 9126.65 | 未披露 | 定期报告 | 2019-03-15 |
| 2019-02-08 | 9082.13 | 未披露 | 定期报告 | 2019-02-01 |
| 2019-02-08 | 9079.71 | 未披露 |
更多>>
from December 31, 2017 to December 31, 2018
Issuance of common stock for vested restricted stock units
Issuance of common stock for stock option exercises
|
2018-12-31 |
| 2018-11-05 | 9068.22 | 未披露 | 定期报告 | 2018-10-30 |
| 2018-11-05 | 9067.32 | 未披露 | 定期报告 | 2018-09-30 |
| 2018-07-31 | 9046.94 | 未披露 | 定期报告 | 2018-07-25 |
| 2018-07-31 | 9040.32 | 未披露 | 定期报告 | 2018-06-30 |
| 2018-04-30 | 8989.79 | 未披露 | 定期报告 | 2018-04-25 |
| 2018-04-04 | 8988.21 | 未披露 | 定期报告 | 2018-03-29 |
| 2018-04-04 | 8970.89 | 未披露 | 定期报告 | 2018-02-28 |
| 2018-02-13 | 8927.35 | 未披露 | 定期报告 | 2018-02-02 |
| 2018-02-13 | 8879.39 | 未披露 |
更多>>
from December 31, 2016 to December 31, 2017
Issuance of common stock for restricted share units vested
Issuance of common stock for option exercises
|
2017-12-31 |
| 2017-11-01 | 8849.30 | 未披露 | 定期报告 | 2017-10-27 |
| 2017-11-01 | 8846.20 | 未披露 | 定期报告 | 2017-09-30 |
| 2017-08-03 | 8822.17 | 未披露 | 定期报告 | 2017-07-27 |
| 2017-08-03 | 8821.69 | 未披露 | 定期报告 | 2017-06-30 |
| 2017-05-09 | 8807.50 | 未披露 | 定期报告 | 2017-05-03 |
| 2017-05-09 | 8751.99 | 未披露 | 定期报告 | 2017-03-31 |
| 2017-02-14 | 8711.43 | 未披露 | 定期报告 | 2017-02-01 |
| 2017-02-14 | 8688.33 | 未披露 |
更多>>
from DECEMBER 31, 2015 to DECEMBER 31, 2016
Issuance of common stock for restricted share units vested
Issuance of common stock for option exercises
|
2016-12-31 |
| 2016-11-02 | 8687.13 | 未披露 | 定期报告 | 2016-10-27 |
| 2016-11-02 | 8686.61 | 未披露 | 定期报告 | 2016-09-30 |
| 2016-08-03 | 8675.16 | 未披露 | 定期报告 | 2016-06-30 |
| 2016-05-05 | 8665.60 | 未披露 | 定期报告 | 2016-04-29 |
| 2016-05-02 | 8662.47 | 未披露 | 定期报告 | 2016-04-12 |
| 2016-05-05 | 8657.31 | 未披露 | 定期报告 | 2016-03-31 |
| 2016-02-11 | 8645.30 | 未披露 | 定期报告 | 2016-02-01 |
| 2016-02-11 | 8626.26 | 未披露 |
更多>>
from December 31, 2014 to December 31, 2015
Issuance of common stock for restricted share units vested
Issuance of common stock for option exercises
Issuance of common stock, net of offering costs
|
2015-12-31 |
| 2015-10-29 | 8619.66 | 未披露 | 定期报告 | 2015-10-23 |
| 2015-10-29 | 8588.41 | 未披露 | 定期报告 | 2015-09-30 |
| 2015-07-29 | 8587.32 | 未披露 | 定期报告 | 2015-07-24 |
| 2015-07-29 | 8575.04 | 未披露 | 定期报告 | 2015-06-30 |
| 2015-04-30 | 8541.78 | 未披露 | 定期报告 | 2015-04-24 |
| 2015-04-30 | 8537.23 | 未披露 | 定期报告 | 2015-03-31 |
| 2015-02-09 | 7716.33 | 未披露 | 定期报告 | 2015-01-26 |
| 2015-02-09 | 7646.59 | 未披露 |
更多>>
from December 31, 2013 to December 31, 2014
Issuance of common stock for restricted share units vested
Issuance of common stock for option exercises
Issuance of common stock, net of offering costs
|
2014-12-31 |
| 2014-11-04 | 7600.52 | 未披露 | 定期报告 | 2014-10-27 |
| 2014-11-04 | 7599.64 | 未披露 | 定期报告 | 2014-09-30 |
| 2014-08-06 | 7591.94 | 未披露 | 定期报告 | 2014-07-31 |
| 2014-08-06 | 7591.90 | 未披露 | 定期报告 | 2014-06-30 |
| 2014-05-01 | 7586.30 | 未披露 | 定期报告 | 2014-04-25 |
| 2014-05-01 | 7585.87 | 未披露 | 定期报告 | 2014-03-31 |
| 2014-02-25 | 6780.23 | 未披露 | 定期报告 | 2014-02-20 |
| 2014-02-11 | 6779.37 | 未披露 | 定期报告 | 2014-01-24 |
| 2014-02-11 | 6735.12 | 未披露 |
更多>>
from DECEMBER 31, 2012 to DECEMBER 31, 2013
Issuance of common stock for option exercises
|
2013-12-31 |
| 2013-10-29 | 6734.34 | 未披露 | 定期报告 | 2013-10-23 |
| 2013-10-29 | 6734.32 | 未披露 | 定期报告 | 2013-09-30 |
| 2013-07-26 | 6706.23 | 未披露 | 定期报告 | 2013-07-19 |
| 2013-07-26 | 6699.81 | 未披露 | 定期报告 | 2013-06-30 |
| 2013-05-02 | 6673.24 | 未披露 | 定期报告 | 2013-04-26 |
| 2013-04-19 | 6671.20 | 未披露 | 定期报告 | 2013-04-01 |
| 2013-05-02 | 6671.24 | 未披露 | 定期报告 | 2013-03-31 |
| 2013-02-08 | 6650.93 | 未披露 | 定期报告 | 2013-01-31 |
| 2013-02-08 | 6644.69 | 未披露 |
更多>>
from DECEMBER 31, 2011 to DECEMBER 31, 2012
Issuance of common stock for restricted share units vested
Issuance of common stock for option exercises
Issuance of common stock, net of offering costs
|
2012-12-31 |
| 2012-11-20 | 6638.68 | 未披露 | 定期报告 | 2012-11-16 |
| 2012-10-31 | 6638.47 | 未披露 | 定期报告 | 2012-10-25 |
| 2012-10-31 | 6638.11 | 未披露 | 定期报告 | 2012-09-30 |
| 2012-07-31 | 6632.52 | 未披露 | 定期报告 | 2012-07-24 |
| 2012-07-31 | 6632.02 | 未披露 | 定期报告 | 2012-06-30 |
| 2012-05-02 | 6630.72 | 未披露 | 定期报告 | 2012-04-27 |
| 2012-05-02 | 6630.63 | 未披露 | 定期报告 | 2012-03-31 |
| 2012-02-09 | 6623.95 | 未披露 | 定期报告 | 2012-01-31 |
| 2012-02-09 | 5526.27 | 未披露 |
更多>>
from DECEMBER 31, 2010 to DECEMBER 31, 2011
Issuance of common stock for restricted share units vested
Issuance of common stock for option exercises
|
2011-12-31 |
| 2011-10-31 | 5525.67 | 未披露 | 定期报告 | 2011-10-26 |
| 2011-10-31 | 5525.40 | 未披露 | 定期报告 | 2011-09-30 |
| 2011-07-29 | 5523.92 | 未披露 | 定期报告 | 2011-07-22 |
| 2011-07-29 | 5523.69 | 未披露 | 定期报告 | 2011-06-30 |
| 2011-05-03 | 5520.06 | 未披露 | 定期报告 | 2011-04-29 |
| 2011-05-03 | 5519.11 | 未披露 | 定期报告 | 2011-03-31 |
| 2011-02-10 | 5488.71 | 未披露 | 定期报告 | 2011-02-01 |
| 2011-02-10 | 5488.21 | 未披露 |
更多>>
from dec 31 2009 to dec 31 2010
Issuance of common stock for restricted share units vested
Issuance of common stock for option exercises
Issuance of common stock, net of offering costs
|
2010-12-31 |
| 2010-10-29 | 5486.25 | 未披露 | 定期报告 | 2010-10-25 |
| 2010-10-29 | 5484.97 | 未披露 | 定期报告 | 2010-09-30 |
| 2010-07-29 | 5484.22 | 未披露 | 定期报告 | 2010-07-23 |
| 2010-07-29 | 5484.10 | 未披露 | 定期报告 | 2010-06-30 |
| 2010-04-29 | 5483.19 | 未披露 | 定期报告 | 2010-04-26 |
| 2010-04-29 | 5482.36 | 未披露 | 定期报告 | 2010-03-31 |
| 2010-02-08 | 4406.19 | 未披露 | 定期报告 | 2010-01-29 |
| 2010-02-08 | 4399.16 | 未披露 |
更多>>
from DECEMBER 31, 2008 to DECEMBER 31, 2009
Issuance of common stock for restricted share units vested
Issuance of common stock, net of offering costs
|
2009-12-31 |
| 2009-02-04 | 3867.38 | 未披露 | 定期报告 | 2009-01-23 |
| 2009-02-04 | 3859.88 | 未披露 |
更多>>
from DECEMBER 31, 2007 to DECEMBER 31, 2008
Issuance of common stock for restricted share units vested
Issuance of common stock for option exercises
|
2008-12-31 |
| 2008-02-11 | 3827.40 | 未披露 |
更多>>
from DECEMBER 31, 2006 to DECEMBER 31, 2007
Issuance of common stock for restricted share units vested
Issuance of common stock for option exercises
|
2007-12-31 |
| 2007-02-09 | 3790.60 | 未披露 |
更多>>
from DECEMBER 31, 2005 to DECEMBER 31, 2006
Issuance of common stock for exercise of warrants
Issuance of common stock for option exercises
Issuance of common stock pursuant to the Employee Stock Purchase Plan
|
2006-12-31 |
| 2006-02-07 | 3720.86 | 未披露 | 定期报告 | 2006-01-26 |
| 2006-02-07 | 3713.25 | 未披露 |
更多>>
from DECEMBER 31, 2004 to DECEMBER 31, 2005
Issuance of common stock for option exercises
Issuance of common stock pursuant to the Employee Stock Purchase Plan
|
2005-12-31 |
| 2005-02-16 | 3659.75 | 未披露 | 定期报告 | 2005-02-11 |
| 2005-02-16 | 3653.28 | 未披露 |
更多>>
from DECEMBER 31, 2003 to DECEMBER 31, 2004
Issuance of common stock for option exercises
Issuance of common stock pursuant to the Employee Stock Purchase Plan
Issuance of common stock, related to royalty stream purchase
Issuance of common stock for exercise of warrants
|
2004-12-31 |
| 2004-03-15 | 3533.44 | 未披露 | 定期报告 | 2004-02-27 |
| 2004-03-15 | 3531.19 | 未披露 |
更多>>
from DECEMBER 31, 2002 to DECEMBER 31, 2003
Issuance of common stock for option exercises
Issuance of common stock pursuant to the Employee Stock Purchase Plan
Issuance of common stock, net of offering costs
Common shares issued as a stock bonus
Issuance of common stock for exercise of warrants
|
2003-12-31 |
| 2003-03-04 | 3071.95 | 未披露 | 定期报告 | 2003-02-21 |
| 2003-03-04 | 3066.23 | 未披露 |
更多>>
from DECEMBER 31, 2001 to DECEMBER 31, 2002
Issuance of common stock for option exercises
Issuance of common stock pursuant to the Employee Stock Purchase Plan
|
2002-12-31 |
| 2002-03-26 | 3039.96 | 未披露 | 定期报告 | 2002-03-15 |
| 2002-03-26 | 3034.77 | 未披露 |
更多>>
from DECEMBER 31, 2000 to DECEMBER 31, 2001
Issuance of common stock from exercise of warrants
Issuance of common stock for notes
Issuance of common stock from option exercises
Issuance of common stock pursuant to the Employee Stock Purchase Plan
Issuance of common stock, net of offering costs
|
2001-12-31 |
| 2001-03-30 | 2542.87 | 未披露 | 定期报告 | 2001-03-23 |
| 2001-03-30 | 2531.45 | 未披露 |
更多>>
from DECEMBER 31, 1999 to DECEMBER 31, 2000
Issuance of common stock for warrants
Issuance of common stock for stock purchase agreement
Issuance of common stock for option exercises
Issuance of common stock pursuant to the Employee Stock Purchase Plan
Issuance of common stock, net of offering costs
|
2000-12-31 |
| 2000-03-30 | 2183.05 | 未披露 | 定期报告 | 2000-03-15 |
| 2000-03-30 | 2160.80 | 未披露 |
更多>>
from DECEMBER 31, 1998 to DECEMBER 31, 1999
Issuance of common stock for option exercises
Issuance of common stock pursuant to the Employee Stock Purchase Plan
Issuance of common stock, net of offering costs
|
1999-12-31 |
| 1999-03-31 | 1896.06 | 未披露 | 定期报告 | 1999-03-15 |
| 1999-03-31 | 1893.09 | 未披露 |
更多>>
from DECEMBER 31, 1997 to DECEMBER 31, 1998
Issuance of common stock for warrants
Issuance of common stock for option exercises
Issuance of common stock pursuant to the Employee Stock Purchase Plan
Issuance of common stock in exchange for NPI Preferred Stock
Issuance of common stock for NNL Acquisition
Issuance of common stock for milestone achievement
|
1998-12-31 |
| 1998-04-10 | 1770.78 | 未披露 | 定期报告 | 1998-02-27 |
| 1998-04-10 | 1768.68 | 未披露 |
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from December 31, 1996 to December 31,1997
Issuance of Common Stock for warrants
Issuance of Common Stock for stock options
Issuance of Common Stock under the Employee Stock Purchase Plan
Issuance of Common Stock in exchange for investment in NPI
|
1997-12-31 |
| 1997-03-31 | 1684.63 | 未披露 | 定期报告 | 1997-02-28 |
| 1997-03-31 | 1677.66 | 未披露 |
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from December 31, 1995 to December 31, 1996
Issuance of Common Stock for cash
|
1996-12-31 |
From June 30, 2025 to September 30, 2025
Issuances of common stock under stock plans
From March 31, 2025 to June 30, 2025
Issuances of common stock under stock plans
Repurchases of common stock
From December 31,2024 to March 31, 2025
Issuances of common stock under stock plans
Repurchases of common stock
From December 31, 2023 to December 31, 2024
Issuances of common stock under stock plans
Repurchases of common stock under accelerated buyback agreements
From June 30, 2024 to September 30, 2024
Issuances of common stock under stock plans
From March 31, 2024 to June 30, 2024
Issuances of common stock under stock plans
From December 31, 2023 to March 31, 2024
Issuances of common stock under stock plans
From December 31,2022 to December 31,2023
Issuances of common stock under stock plans
From June 30, 2023 to September 30, 2023
Issuances of common stock under stock plans
From March 31, 2023 to June 30, 2023
Issuances of common stock under stock plans
From December 31, 2022 to March 31, 2023
Issuances of common stock under stock plans
From December 31, 2021 to December 31, 2022
Issuances of common stock under stock plans
From June 30, 2022 to September 30, 2022
Issuances of common stock under stock plans
From March 31, 2022 to June 30, 2022
Issuances of common stock under stock plans
From December 31, 2021 to March 31, 2022
Issuances of common stock under stock plans
From December 31, 2020 to December 31, 2021
Issuances of common stock under stock plans
From June 30, 2021 to September 30, 2021
Issuances of common stock under stock plans
From March 31, 2021 to June 30, 2021
Issuances of common stock under stock plans
From December 31,2020 to March 31, 2021
Issuances of common stock under stock plans
From December 31,2019 to December 31,2020
Issuance of common stock for vested restricted stock units
Issuance of common stock for stock option exercises
Issuance of common stock for employee stock purchase plan
From June 30, 2020 to September 30, 2020
Issuance of common stock for stock options
Issuance of common stock for employee stock purchase plan
from March 31, 2020 to June 30, 2020
Issuance of common stock for vested restricted stock options
Issuance of common stock for stock option
from December 31, 2019 to March 31, 2020
Issuance of common stock for vested restricted stock units
Issuance of common stock for stock option exercises
from December 31, 2018 to December 31, 2019
Issuance of common stock for vested restricted stock units
Issuance of common stock for stock option exercises
Issuance of common stock for employee stock purchase plan
from June 30, 2019 to September 30, 2019
Issuance of common stock for vested restricted stock units
Issuance of common stock for stock option exercises
Issuance of common stock for employee stock purchase plan
from March 31, 2019 to June 30,2019
Issuance of common stock for vested restricted stock units
Issuance of common stock for stock option exercises
from December 31, 2018 to March 31, 2019
Issuance of common stock for vested restricted stock units
Issuance of common stock for stock option exercises
Issuance of common stock for employee stock purchase plan
from December 31, 2017 to December 31, 2018
Issuance of common stock for vested restricted stock units
Issuance of common stock for stock option exercises
from December 31, 2016 to December 31, 2017
Issuance of common stock for restricted share units vested
Issuance of common stock for option exercises
from DECEMBER 31, 2015 to DECEMBER 31, 2016
Issuance of common stock for restricted share units vested
Issuance of common stock for option exercises
from December 31, 2014 to December 31, 2015
Issuance of common stock for restricted share units vested
Issuance of common stock for option exercises
Issuance of common stock, net of offering costs
from December 31, 2013 to December 31, 2014
Issuance of common stock for restricted share units vested
Issuance of common stock for option exercises
Issuance of common stock, net of offering costs
from DECEMBER 31, 2012 to DECEMBER 31, 2013
Issuance of common stock for option exercises
from DECEMBER 31, 2011 to DECEMBER 31, 2012
Issuance of common stock for restricted share units vested
Issuance of common stock for option exercises
Issuance of common stock, net of offering costs
from DECEMBER 31, 2010 to DECEMBER 31, 2011
Issuance of common stock for restricted share units vested
Issuance of common stock for option exercises
from dec 31 2009 to dec 31 2010
Issuance of common stock for restricted share units vested
Issuance of common stock for option exercises
Issuance of common stock, net of offering costs
from DECEMBER 31, 2008 to DECEMBER 31, 2009
Issuance of common stock for restricted share units vested
Issuance of common stock, net of offering costs
from DECEMBER 31, 2007 to DECEMBER 31, 2008
Issuance of common stock for restricted share units vested
Issuance of common stock for option exercises
from DECEMBER 31, 2006 to DECEMBER 31, 2007
Issuance of common stock for restricted share units vested
Issuance of common stock for option exercises
from DECEMBER 31, 2005 to DECEMBER 31, 2006
Issuance of common stock for exercise of warrants
Issuance of common stock for option exercises
Issuance of common stock pursuant to the Employee Stock Purchase Plan
from DECEMBER 31, 2004 to DECEMBER 31, 2005
Issuance of common stock for option exercises
Issuance of common stock pursuant to the Employee Stock Purchase Plan
from DECEMBER 31, 2003 to DECEMBER 31, 2004
Issuance of common stock for option exercises
Issuance of common stock pursuant to the Employee Stock Purchase Plan
Issuance of common stock, related to royalty stream purchase
Issuance of common stock for exercise of warrants
from DECEMBER 31, 2002 to DECEMBER 31, 2003
Issuance of common stock for option exercises
Issuance of common stock pursuant to the Employee Stock Purchase Plan
Issuance of common stock, net of offering costs
Common shares issued as a stock bonus
Issuance of common stock for exercise of warrants
from DECEMBER 31, 2001 to DECEMBER 31, 2002
Issuance of common stock for option exercises
Issuance of common stock pursuant to the Employee Stock Purchase Plan
from DECEMBER 31, 2000 to DECEMBER 31, 2001
Issuance of common stock from exercise of warrants
Issuance of common stock for notes
Issuance of common stock from option exercises
Issuance of common stock pursuant to the Employee Stock Purchase Plan
Issuance of common stock, net of offering costs
from DECEMBER 31, 1999 to DECEMBER 31, 2000
Issuance of common stock for warrants
Issuance of common stock for stock purchase agreement
Issuance of common stock for option exercises
Issuance of common stock pursuant to the Employee Stock Purchase Plan
Issuance of common stock, net of offering costs
from DECEMBER 31, 1998 to DECEMBER 31, 1999
Issuance of common stock for option exercises
Issuance of common stock pursuant to the Employee Stock Purchase Plan
Issuance of common stock, net of offering costs
from DECEMBER 31, 1997 to DECEMBER 31, 1998
Issuance of common stock for warrants
Issuance of common stock for option exercises
Issuance of common stock pursuant to the Employee Stock Purchase Plan
Issuance of common stock in exchange for NPI Preferred Stock
Issuance of common stock for NNL Acquisition
Issuance of common stock for milestone achievement
from December 31, 1996 to December 31,1997
Issuance of Common Stock for warrants
Issuance of Common Stock for stock options
Issuance of Common Stock under the Employee Stock Purchase Plan
Issuance of Common Stock in exchange for investment in NPI
from December 31, 1995 to December 31, 1996
Issuance of Common Stock for cash