股本结构

单位:万股
公告日期 2026-04-29 2026-04-30 2026-02-26 2026-02-26 2025-11-06 2025-11-06
证券总股本 13487.77 12046.43 11813.35 11631.71 11582.99 11578.73
普通股本 13487.77 12046.43 11813.35 11631.71 11582.99 11578.73
优先股 未披露 未披露 未披露 未披露 未披露 未披露
其他 未披露 未披露 未披露 未披露 未披露 未披露
变动日期 2026-04-30 2026-04-10 2026-02-13 2025-12-31 2025-10-31 2025-09-30
注释:中概股证券总股本=普通股股本/ 存托凭证比例

历史变动

公告日期 变动后普通股本(万股) 变动后优先股(万股) 变动原因 变动日期
2026-04-29 13487.77 未披露
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Common Stock offered 16,744,187 shares by the company
2026-04-30
2026-04-30 12046.43 未披露 定期报告 2026-04-10
2026-02-26 11813.35 未披露 定期报告 2026-02-13
2026-02-26 11631.71 未披露
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From December 31, 2024 to December 31, 2025 Issuance of common stock through at-the-market offerings, net of issuance costs of $0 Exercise of stock options Vesting of restricted stock units Issuance of shares under employee stock purchase plan
2025-12-31
2025-11-06 11582.99 未披露 定期报告 2025-10-31
2025-11-06 11578.73 未披露
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From June 30, 2025 to September 30, 2025 Issuance of common stock through at-the-market offerings, net of issuance costs of $0 Exercise of stock options Vesting of restricted stock units
2025-09-30
2025-08-07 10734.69 未披露 定期报告 2025-07-31
2025-08-07 10533.07 未披露
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From March 31, 2025 to June 30, 2025 Issuance of common stock through at-the-market offerings, net of issuance costs of $0 Issuance of shares under employee stock purchase plan Vesting of restricted stock units
2025-06-30
2025-05-08 10358.34 未披露 定期报告 2025-04-30
2025-04-30 10358.27 未披露 定期报告 2025-04-14
2025-05-08 10353.97 未披露
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From December 31, 2024 to March 31, 2025 Vesting of restricted stock units
2025-03-31
2025-02-27 10351.75 未披露 定期报告 2025-02-14
2025-02-27 10202.96 未披露
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From December 31, 2023 to December 31, 2024 Issuance of common stock through at-the-market offerings, net of issuance costs of $254 - 2022 Sale Agreement Exercise of stock options Vesting of restricted stock units Issuance of shares under employee stock purchase plan
2024-12-31
2024-11-07 10184.86 未披露 定期报告 2024-11-01
2024-11-07 10179.64 未披露
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From June 30, 2024 to September 30, 2024 Issuance of common stock through at-the-market offerings, net of issuance costs of $14 Vesting of restricted stock units Exercise of stock options
2024-09-30
2024-08-08 10157.92 未披露 定期报告 2024-08-02
2024-08-08 9828.92 未披露
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From March 31, 2024 to June 30, 2024 Issuance of common stock through at-the-market offerings, net of issuance costs of $14 Vesting of restricted stock units Exercise of stock options Issuance of shares under employee stock purchase plan
2024-06-30
2024-05-09 9647.54 未披露 定期报告 2024-05-03
2024-04-29 9643.86 未披露 定期报告 2024-04-15
2024-05-09 9633.34 未披露
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From December 31, 2023 to March 31, 2024 Issuance of common stock through at-the-market offerings, net of issuance costs of $210 Exercise of stock options Vesting of restricted stock units
2024-03-31
2024-02-22 9610.64 未披露 定期报告 2024-02-16
2024-02-22 9299.72 未披露
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From December 31, 2022 to December 31, 2023 Contingent consideration paid to Rewrite Holders Issuance of common stock through at-the-market offerings, net of issuance costs of $376 - 2022 Sale Agreement Exercise of stock options Vesting of restricted stock units Issuance of shares under employee stock purchase plan
2023-12-31
2023-11-09 8955.49 未披露 定期报告 2023-11-03
2023-11-09 8909.78 未披露
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From June 30, 2023 to September 30, 2023 Issuance of common stock through at-the-market offerings, net of issuance costs of $81 Exercise of stock options Vesting of restricted stock units
2023-09-30
2023-08-03 8849.10 未披露 定期报告 2023-07-28
2023-08-03 8834.76 未披露
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From March 31, 2023 to June 30, 2023 Exercise of stock options Issuance of shares under employee stock purchase plan Vesting of restricted stock units
2023-06-30
2023-05-04 8814.10 未披露 定期报告 2023-04-28
2023-05-01 8813.83 未披露 定期报告 2023-04-17
2023-05-04 8809.58 未披露
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From December 31, 2022 to March 31, 2023 Issuance of common stock through at-the-market offerings, net of issuance costs of $ Contingent consideration paid to Rewrite holders Exercise of stock options Vesting of restricted stock units
2023-03-31
2023-02-23 8801.79 未披露 定期报告 2023-02-17
2023-02-23 8710.30 未披露
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From December 31, 2021 to December 31, 2022 Issuance of common stock through at-the-market offerings, net of issuance costs of $164 - 2019 Sale Agreement Issuance of common stock through follow-on offerings, net of issuance costs of $253 Issuance of shares under employee stock purchase plan Issuance of common stock through at-the-market offerings, net of issuance costs of $125 - 2022 Sale Agreement Vesting of restricted stock units Exercise of stock options
2022-12-31
2022-12-01 8523.43 未披露
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Common stock offered 6,550,219 shares by the company
2022-12-02
2022-11-03 7868.40 未披露 定期报告 2022-10-31
2022-11-03 7658.79 未披露
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From June 30, 2022 to September 30, 2022 Issuance of common stock through at-the-market offerings, net of issuance costs of $54 Exercise of stock options Vesting of restricted stock units
2022-09-30
2022-08-04 7601.18 未披露 定期报告 2022-08-01
2022-08-04 7600.07 未披露
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From March 31, 2022 to June 30, 2022 Exercise of stock options Vesting of restricted stock units Issuance of shares under employee stock purchase plan
2022-06-30
2022-05-05 7585.39 未披露 定期报告 2022-04-28
2022-05-02 7562.85 未披露 定期报告 2022-04-18
2022-05-05 7562.42 未披露
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From December 31, 2021 to March 31, 2022 Issuance of common stock through at-the-market offerings, net of issuance costs of $164 Exercise of stock options Vesting of restricted stock units
2022-03-31
2022-02-24 7467.24 未披露 定期报告 2022-02-17
2022-02-24 7448.59 未披露
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From December 31, 2020 to December 31, 2021 Issuance of common stock through follow-on offerings,net of issuance costs of $284 Issuance of common stock through at-the-market offerings, net of issuance costs of $52 Exercise of stock options Vesting of restricted stock units Issuance of shares under employee stock purchase plan
2021-12-31
2021-11-04 7441.94 未披露 定期报告 2021-10-29
2021-11-04 7434.22 未披露
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From June 30, 2021 to September 30, 2021 Issuance of common stock through follow-on offering, net of issuance costs of $284 Exercise of stock options Vesting of restricted stock units
2021-09-30
2021-08-05 7348.70 未披露 定期报告 2021-07-30
2021-07-02 7264.90 未披露
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1.Common stock offered 4,137,931 shares.In addition, the Company granted the Underwriters an option exercisable for 30 days from the date of the Underwriting Agreement to purchase, at the public offering price less any underwriting discounts and commissions, up to an additional 620,689 shares, which option was exercised in full on June 30, 2021. 2.The number of shares of common stock to be outstanding immediately after this offering is based on 67,890,334 shares of common stock outstanding as of March 31, 2021.
2021-07-02
2021-08-05 6833.18 未披露
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From March 31, 2021 To June 30, 2021 Exercise of stock options Vesting of restricted units Issuance of shares under employee stock purchase plan
2021-06-30
2021-05-06 6815.36 未披露 定期报告 2021-04-30
2021-04-28 6812.00 未披露 定期报告 2021-04-26
2021-05-06 6789.03 未披露
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From December 31, 2020 To March 31, 2021 Issuance of common stock through at-the-market offerings, net of issuance costs of $52 Exercise of stock options
2021-03-31
2021-02-26 6772.63 未披露 定期报告 2021-02-19
2021-02-26 6623.41 未披露
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From December 31, 2019 to December 31, 2020 Issuance of common stock through follow-on offerings,net of issuance costs of $669 Issuance of common stock to Regeneron Issuance of common stock through at-the-market offerings, net of issuance costs of $151 Exercise of stock options Vesting of restricted stock units Issuance of shares under employee stock purchase plan
2020-12-31
2020-12-04 6358.67 未披露
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1.Common stock offered by the company 4,794,521 shares. 2.The number of shares of common stock to be outstanding immediately after this offering is based on 58,792,212 shares of common stock outstanding as of September 30, 2020.
2020-12-04
2020-11-30 5908.08 未披露 定期报告 2020-10-30
2020-11-05 5879.22 未披露
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From June 30, 2020 to September 30, 2020 Exercise of stock options
2020-09-30
2020-08-06 5874.06 未披露 定期报告 2020-07-31
2020-08-06 5872.42 未披露
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From March 31, 2020 to June 30, 2020 Issuance of common stock through follow-on offering, net of issuance costs of $369 Issuance of common stock in private placement with Regeneron Issuance of common stock through at-the-market offerings, net of issuance costs of $23 Exercise of stock options Issuance of shares under employee stock purchase plan
2020-06-30
2020-06-05 5608.23 未披露
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1.Common stock offered by us 5,479,453 shares. 2.The number of shares of our common stock to be outstanding immediately after this offering is based on 50,602,875 shares of our common stock outstanding as of March 31, 2020.
2020-06-05
2020-05-07 5138.05 未披露 定期报告 2020-05-01
2020-04-24 5135.87 未披露 定期报告 2020-04-20
2020-05-07 5060.29 未披露
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From December 31, 2019 to March 31, 2020 Issuance of common stock through at-the-market offerings, net of issuance costs of $48 Exercise of stock options
2020-03-31
2020-02-27 5050.77 未披露 定期报告 2020-02-21
2020-02-27 5019.80 未披露
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From December 31, 2018 to December 31, 2019 Issuance of common stock through at-the-market offerings, net of issuance costs of $363 Exercise of stock options Issuance of shares under employee stock purchase plan
2019-12-31
2019-10-31 4888.23 未披露 定期报告 2019-10-25
2019-10-31 4887.73 未披露
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from June 30, 2019 to September 30, 2019 Issuance of common stock through at-the-market offerings, net of issuance costs of $199 Exercise of stock options
2019-09-30
2019-08-23 4887.50 未披露 定期报告 2019-08-19
2019-08-01 4854.31 未披露 定期报告 2019-07-26
2019-08-01 4771.46 未披露
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from March 31, 2019 to June 30, 2019 Issuance of common stock through at-the-market offering, net of issuance costs of $3 Exercise of stock options Issuance of shares under employee stock purchase plan
2019-06-30
2019-05-02 4571.09 未披露 定期报告 2019-04-30
2019-05-02 4547.91 未披露
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from December 31, 2018 to March 31, 2019 Issuance of common stock through at-the-market offering, net of issuance costs of $120 Exercise of stock options
2019-03-31
2019-02-27 4522.53 未披露 定期报告 2019-02-22
2019-02-27 4522.45 未披露
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from December 31, 2017 to December 31, 2018 Issuance of common stock Exercise of stock options Issuance of shares under employee stock purchase plan Equity-based compensation
2018-12-31
2018-10-31 4341.93 未披露 定期报告 2018-10-26
2018-10-12 4336.98 未披露 定期报告 2018-10-11
2018-10-31 4238.46 未披露 定期报告 2018-09-30
2018-08-01 4320.06 未披露 定期报告 2018-07-27
2018-08-01 4318.80 未披露 定期报告 2018-06-30
2018-05-01 4308.98 未披露 定期报告 2018-04-27
2018-05-01 4309.19 未披露 定期报告 2018-03-31
2018-03-14 4238.74 未披露 定期报告 2018-02-28
2018-03-14 4238.46 未披露
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from December 31, 2016 to December 31, 2017 Issuance of common stock Exercise of stock options Issuance of shares under employee stock purchase plan Equity-based compensation
2017-12-31
2017-10-31 3608.58 未披露 定期报告 2017-10-27
2017-10-31 3608.53 未披露 定期报告 2017-09-30
2017-08-01 3611.29 未披露 定期报告 2017-07-28
2017-08-01 3606.45 未披露 定期报告 2017-06-30
2017-06-05 3602.91 未披露 定期报告 2017-05-31
2017-05-02 3602.87 未披露 定期报告 2017-04-26
2017-05-02 3602.57 未披露 定期报告 2017-03-31
2017-03-14 3602.25 未披露 定期报告 2017-02-28
2017-03-14 3601.85 未披露
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from December 31, 2015 to December 31, 2016 Conversion of convertible preferred stock Issuance of common stock, net of issuance costs of $3,367 Exercise of stock options Issuance of shares under employee stock purchase plan Equity-based compensation
2016-12-31
2016-11-01 3599.53 未披露 定期报告 2016-10-28
2016-11-01 3599.51 未披露
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From December 31, 2015 to September 30, 2016 Conversion of convertible preferred stock Issuance of common stock, net of issuance costs of $3,365 Equity-based compensation The Company’s board of directors and stockholders approved a one-for-1.7 reverse stock split of the Company’s common stock effective April 25, 2016.
2016-09-30
2016-08-04 3599.51 未披露
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The Company’s board of directors and stockholders approved a one-for-1.7 reverse stock split of the Company’s common stock effective April 25, 2016.
2016-08-02
2016-06-03 3599.63 未披露
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The Company’s Board of Directors and stockholders approved a one-for-1.7 reverse stock split of the Company’s common stock that became effective on April 25, 2016.
2016-06-02
2016-05-06 3509.63 未披露
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The Company’s Board of Directors and stockholders approved a one-for-1.7 reverse stock split of the Company’s common stock that became effective on April 25, 2016.
2016-05-06
2016-04-27 255.88 3631.66
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from December 31, 2015 to April 26, 2016 Issuance of Class A-2 Preferred Units net of issuance costs of $16 Effect of Reorganization Issuance of Series B Preferred Shares, net of issuance costs of $2,754 Equity-based compensation The Company’s Board of Directors and stockholders approved a one-for-1.7 reverse stock split of the Company’s common stock that became effective on April 25, 2016.
2016-04-26
2016-04-11 434.99 3631.66
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from December 31, 2014 to December 31, 2015 Issuance of Class A-2 Preferred Units net of issuance costs of $16 Effect of Reorganization Issuance of Series B Preferred Shares, net of issuance costs of $2,754 Equity-based compensation
2015-12-31
Common Stock offered 16,744,187 shares by the company
From December 31, 2024 to December 31, 2025 Issuance of common stock through at-the-market offerings, net of issuance costs of $0 Exercise of stock options Vesting of restricted stock units Issuance of shares under employee stock purchase plan
From June 30, 2025 to September 30, 2025 Issuance of common stock through at-the-market offerings, net of issuance costs of $0 Exercise of stock options Vesting of restricted stock units
From March 31, 2025 to June 30, 2025 Issuance of common stock through at-the-market offerings, net of issuance costs of $0 Issuance of shares under employee stock purchase plan Vesting of restricted stock units
From December 31, 2024 to March 31, 2025 Vesting of restricted stock units
From December 31, 2023 to December 31, 2024 Issuance of common stock through at-the-market offerings, net of issuance costs of $254 - 2022 Sale Agreement Exercise of stock options Vesting of restricted stock units Issuance of shares under employee stock purchase plan
From June 30, 2024 to September 30, 2024 Issuance of common stock through at-the-market offerings, net of issuance costs of $14 Vesting of restricted stock units Exercise of stock options
From March 31, 2024 to June 30, 2024 Issuance of common stock through at-the-market offerings, net of issuance costs of $14 Vesting of restricted stock units Exercise of stock options Issuance of shares under employee stock purchase plan
From December 31, 2023 to March 31, 2024 Issuance of common stock through at-the-market offerings, net of issuance costs of $210 Exercise of stock options Vesting of restricted stock units
From December 31, 2022 to December 31, 2023 Contingent consideration paid to Rewrite Holders Issuance of common stock through at-the-market offerings, net of issuance costs of $376 - 2022 Sale Agreement Exercise of stock options Vesting of restricted stock units Issuance of shares under employee stock purchase plan
From June 30, 2023 to September 30, 2023 Issuance of common stock through at-the-market offerings, net of issuance costs of $81 Exercise of stock options Vesting of restricted stock units
From March 31, 2023 to June 30, 2023 Exercise of stock options Issuance of shares under employee stock purchase plan Vesting of restricted stock units
From December 31, 2022 to March 31, 2023 Issuance of common stock through at-the-market offerings, net of issuance costs of $ Contingent consideration paid to Rewrite holders Exercise of stock options Vesting of restricted stock units
From December 31, 2021 to December 31, 2022 Issuance of common stock through at-the-market offerings, net of issuance costs of $164 - 2019 Sale Agreement Issuance of common stock through follow-on offerings, net of issuance costs of $253 Issuance of shares under employee stock purchase plan Issuance of common stock through at-the-market offerings, net of issuance costs of $125 - 2022 Sale Agreement Vesting of restricted stock units Exercise of stock options
Common stock offered 6,550,219 shares by the company
From June 30, 2022 to September 30, 2022 Issuance of common stock through at-the-market offerings, net of issuance costs of $54 Exercise of stock options Vesting of restricted stock units
From March 31, 2022 to June 30, 2022 Exercise of stock options Vesting of restricted stock units Issuance of shares under employee stock purchase plan
From December 31, 2021 to March 31, 2022 Issuance of common stock through at-the-market offerings, net of issuance costs of $164 Exercise of stock options Vesting of restricted stock units
From December 31, 2020 to December 31, 2021 Issuance of common stock through follow-on offerings,net of issuance costs of $284 Issuance of common stock through at-the-market offerings, net of issuance costs of $52 Exercise of stock options Vesting of restricted stock units Issuance of shares under employee stock purchase plan
From June 30, 2021 to September 30, 2021 Issuance of common stock through follow-on offering, net of issuance costs of $284 Exercise of stock options Vesting of restricted stock units
1.Common stock offered 4,137,931 shares.In addition, the Company granted the Underwriters an option exercisable for 30 days from the date of the Underwriting Agreement to purchase, at the public offering price less any underwriting discounts and commissions, up to an additional 620,689 shares, which option was exercised in full on June 30, 2021. 2.The number of shares of common stock to be outstanding immediately after this offering is based on 67,890,334 shares of common stock outstanding as of March 31, 2021.
From March 31, 2021 To June 30, 2021 Exercise of stock options Vesting of restricted units Issuance of shares under employee stock purchase plan
From December 31, 2020 To March 31, 2021 Issuance of common stock through at-the-market offerings, net of issuance costs of $52 Exercise of stock options
From December 31, 2019 to December 31, 2020 Issuance of common stock through follow-on offerings,net of issuance costs of $669 Issuance of common stock to Regeneron Issuance of common stock through at-the-market offerings, net of issuance costs of $151 Exercise of stock options Vesting of restricted stock units Issuance of shares under employee stock purchase plan
1.Common stock offered by the company 4,794,521 shares. 2.The number of shares of common stock to be outstanding immediately after this offering is based on 58,792,212 shares of common stock outstanding as of September 30, 2020.
From June 30, 2020 to September 30, 2020 Exercise of stock options
From March 31, 2020 to June 30, 2020 Issuance of common stock through follow-on offering, net of issuance costs of $369 Issuance of common stock in private placement with Regeneron Issuance of common stock through at-the-market offerings, net of issuance costs of $23 Exercise of stock options Issuance of shares under employee stock purchase plan
1.Common stock offered by us 5,479,453 shares. 2.The number of shares of our common stock to be outstanding immediately after this offering is based on 50,602,875 shares of our common stock outstanding as of March 31, 2020.
From December 31, 2019 to March 31, 2020 Issuance of common stock through at-the-market offerings, net of issuance costs of $48 Exercise of stock options
From December 31, 2018 to December 31, 2019 Issuance of common stock through at-the-market offerings, net of issuance costs of $363 Exercise of stock options Issuance of shares under employee stock purchase plan
from June 30, 2019 to September 30, 2019 Issuance of common stock through at-the-market offerings, net of issuance costs of $199 Exercise of stock options
from March 31, 2019 to June 30, 2019 Issuance of common stock through at-the-market offering, net of issuance costs of $3 Exercise of stock options Issuance of shares under employee stock purchase plan
from December 31, 2018 to March 31, 2019 Issuance of common stock through at-the-market offering, net of issuance costs of $120 Exercise of stock options
from December 31, 2017 to December 31, 2018 Issuance of common stock Exercise of stock options Issuance of shares under employee stock purchase plan Equity-based compensation
from December 31, 2016 to December 31, 2017 Issuance of common stock Exercise of stock options Issuance of shares under employee stock purchase plan Equity-based compensation
from December 31, 2015 to December 31, 2016 Conversion of convertible preferred stock Issuance of common stock, net of issuance costs of $3,367 Exercise of stock options Issuance of shares under employee stock purchase plan Equity-based compensation
From December 31, 2015 to September 30, 2016 Conversion of convertible preferred stock Issuance of common stock, net of issuance costs of $3,365 Equity-based compensation The Company’s board of directors and stockholders approved a one-for-1.7 reverse stock split of the Company’s common stock effective April 25, 2016.
The Company’s board of directors and stockholders approved a one-for-1.7 reverse stock split of the Company’s common stock effective April 25, 2016.
The Company’s Board of Directors and stockholders approved a one-for-1.7 reverse stock split of the Company’s common stock that became effective on April 25, 2016.
The Company’s Board of Directors and stockholders approved a one-for-1.7 reverse stock split of the Company’s common stock that became effective on April 25, 2016.
from December 31, 2015 to April 26, 2016 Issuance of Class A-2 Preferred Units net of issuance costs of $16 Effect of Reorganization Issuance of Series B Preferred Shares, net of issuance costs of $2,754 Equity-based compensation The Company’s Board of Directors and stockholders approved a one-for-1.7 reverse stock split of the Company’s common stock that became effective on April 25, 2016.
from December 31, 2014 to December 31, 2015 Issuance of Class A-2 Preferred Units net of issuance costs of $16 Effect of Reorganization Issuance of Series B Preferred Shares, net of issuance costs of $2,754 Equity-based compensation