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Nivalis Therapeutics, Inc. announced today that its Board of Directors (the "Board") has determined to effect a 1-for-4 reverse stock split of the Company's common shares.The reverse stock split will take effect, and the Company's common stock will begin trading on a split-adjusted as of the opening of trading on July 25, 2017.Under the terms of the Merger Agreement, the Company issued shares of its common stock to Alpine’s stockholders, at an exchange rate of 0.4969 shares of the Company’s common stock, after taking into account the Reverse Stock Split, for each share of Alpine common stock and preferred stock outstanding immediately prior to the Merger.Immediately after the Merger, there were 13,881,645 shares of the Company’s common stock outstanding.

from December 31, 2016 to March 31, 2017 Issuance of common stock under restricted stock unit awards

from December 31, 2015 to December 31, 2016 Issuance of common stock, net of issuance costs Issuance of common stock under employee share plans and awards

from December 31, 2015 to September 30, 2016 Issuance of common stock under employee share plans and awards

from December 31, 2015 to June 30, 2016 Issuance of common stock under the employee stock purchase plan Exercise of incentive stock options

a 1-for-2.889 reverse stock split, which became effective on June 1, 2015; the conversion of all outstanding shares of our preferred stock, as of March 31, 2015, into an aggregate of 6,915,525 shares of common stock immediately prior to the closing of this offering

On June 1, 2015, we effected a 1-for-2.889 reverse stock split of our common stock. Unless otherwise expressly indicated herein, all common stock figures contained in this prospectus have been adjusted to reflect the effectiveness of this reverse stock split.

from December 31, 2010 to December 31, 2011 Issuance of common stock under employee compensation plans Repurchases of common stock

from dec 31 2009 to dec 31 2010 Issuance of common stock under employee compensation plans Repurchases of common stock

from December 31, 2008 to December 31, 2009 Issuance of common stock under employee compensation plans, net

from December 31, 2007 to December 31, 2008 Issuance of common stock under employee compensation plans, net Repurchases of common stock

from December 31, 2006 to December 31, 2007 Issuance of common stock under employee compensation plans, net Repurchases of common stock

from December 31, 2005 to December 31, 2006 Issuance of common stock under employee compensation plans, net Repurchases of common stock

from December 31, 2004 to December 31, 2005 Issuance of common stock under employee compensation plans, net Issuance of restricted common stock, net Repurchases of common stock

from December 31, 2003 to December 31, 2004 Issuance of common stock under employee compensation plans, net Issuance of restricted common stock, net Repurchases of common stock

from December 31, 2002 to December 31, 2003 Issuance of common stock under employee compensation plans and other Issuance of restricted common stock, net Repurchases of common stock

from December 31, 2001 to December 31, 2002 Issuance of common stock under employee compensation plans Issuance of common stock and assumption of stock options in connection with the acquisition of SpeedFam-IPEC Issuance of restricted common stock Repurchases of common stock

from December 31, 2000 to December 31, 2001 Shares issued under employee compensation plans Adjustment to conform fiscal year end of GaSonics Issuance of restricted stock Common stock repurchased

from December 31, 1999 to December 31, 2000 Proceeds from common stock offering, net Shares issued under employee compensation plans Issuance of restricted stock Amortization of deferred compensation net of cancellati ons of restricted stock Common stock repurchased

from December 31, 1998 to January 19, 2000 Proceeds from common stock offering, net Exercise of stock options Shares issued under employee stock Purchase plan Common stock repurchased The Company's three-for-one stock split, effective January 15, 2000.

from December 31, 1997 to December 31, 1998 Exercise of stock options Shares issued under employee stock purchase plan Common stock repurchased

from December 31, 1996 to December 31, 1997 Exercise of stock options Shares issued under employee stock purchase plan Common stock repurchased On September 22, 1997 the Company announced that its Board of Directors had approved a two-for-one split of Novellus' common stock. Each shareholder of record as of the close of business on September 29, 1997 received one additional share of common stock for every share held.

from December 31, 1995 to December 31, 1996 Exercise of stock options Shares issued under employee stock purchase plan Common stock repurchased

from December 31, 1994 to December 31, 1995 Exercise of stock options Shares issued under employee stock purchase plan Common stock repurchased

from December 31, 1993 to December 31, 1994 Exercise of stock options Shares issued under employee stock purchase plan Stock offering