股本结构
单位：万股
| 公告日期 | 2025-11-06 | 2025-07-31 | 2025-07-31 | 2025-05-01 | 2025-04-24 | 2025-05-01 |
|---|---|---|---|---|---|---|
| 证券总股本 | 4754.22 | 4753.42 | 4753.41 | 4752.61 | 4757.18 | 4757.18 |
| 普通股本 | 4754.22 | 4753.42 | 4753.41 | 4752.61 | 4757.18 | 4757.18 |
| 优先股 | 20.00 | 未披露 | 20.00 | 未披露 | 20.00 | 20.00 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2025-09-30 | 2025-07-29 | 2025-06-30 | 2025-04-29 | 2025-04-04 | 2025-03-31 |
注释：中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本（万股） | 变动后优先股（万股） | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2025-11-06 | 4754.22 | 20.00 |
更多>>
From June 30, 2025 to September 30, 2025
Stock-based compensation and ESPP activity, net of taxes withheld
|
2025-09-30 |
| 2025-07-31 | 4753.42 | 未披露 | 定期报告 | 2025-07-29 |
| 2025-07-31 | 4753.41 | 20.00 |
更多>>
From March 31, 2025 to June 30, 2025
Stock-based compensation and ESPP activity, net of taxes withheld
|
2025-06-30 |
| 2025-05-01 | 4752.61 | 未披露 | 定期报告 | 2025-04-29 |
| 2025-04-24 | 4757.18 | 20.00 | 定期报告 | 2025-04-04 |
| 2025-05-01 | 4757.18 | 20.00 |
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From December 31, 2024 to March 31, 2025
Stock-based compensation and ESPP activity, net of taxes withheld
|
2025-03-31 |
| 2025-02-20 | 4746.91 | 未披露 | 定期报告 | 2025-02-18 |
| 2025-02-20 | 4746.89 | 20.00 |
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From December 31, 2023 to December 31, 2024
Stock-based compensation and ESPP activity, net of taxes withheld
|
2024-12-31 |
| 2024-10-30 | 4746.14 | 未披露 | 定期报告 | 2024-10-28 |
| 2024-10-30 | 4746.13 | 20.00 |
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From June 30, 2024 to September 30, 2024
Stock-based compensation and ESPP activity, net of taxes withheld
|
2024-09-30 |
| 2024-08-01 | 4745.21 | 未披露 | 定期报告 | 2024-07-25 |
| 2024-08-01 | 4744.86 | 20.00 |
更多>>
From March 31, 2024 to June 30, 2024
Stock-based compensation and ESPP activity, net of taxes withheld
|
2024-06-30 |
| 2024-05-02 | 4743.95 | 未披露 | 定期报告 | 2024-04-29 |
| 2024-04-25 | 4743.93 | 20.00 | 定期报告 | 2024-04-05 |
| 2024-05-02 | 4743.93 | 20.00 |
更多>>
From December 31, 2023 to March 31, 2024
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to employees under an ESPP
|
2024-03-31 |
| 2024-02-22 | 4736.56 | 未披露 | 定期报告 | 2024-02-16 |
| 2024-02-22 | 4736.54 | 20.00 |
更多>>
From December 31, 2022 to December 31, 2023
Issuance of common stock to employees
Shares withheld for employee taxes
Cancellation of restricted stock awards
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2023-12-31 |
| 2023-11-02 | 4735.81 | 未披露 | 定期报告 | 2023-11-01 |
| 2023-11-02 | 4735.49 | 20.00 |
更多>>
From June 30, 2023 to September 30, 2023
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2023-09-30 |
| 2023-08-03 | 4734.64 | 未披露 | 定期报告 | 2023-08-02 |
| 2023-08-03 | 4734.13 | 20.00 |
更多>>
From March 31, 2023 to June 30, 2023
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2023-06-30 |
| 2023-05-03 | 4733.41 | 未披露 | 定期报告 | 2023-05-02 |
| 2023-04-20 | 4733.19 | 20.00 | 定期报告 | 2023-04-10 |
| 2023-05-03 | 4733.18 | 20.00 |
更多>>
From December 31, 2022 to March 31, 2023
Issuance of common stock to employees
Shares withheld for employee taxes
Cancellation of restricted stock awards
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2023-03-31 |
| 2023-02-23 | 4725.43 | 未披露 | 定期报告 | 2023-02-21 |
| 2023-02-23 | 4777.04 | 20.00 |
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From December 31, 2021 to December 31, 2022
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to employees under an ESPP
|
2022-12-31 |
| 2022-11-03 | 4723.66 | 未披露 | 定期报告 | 2022-11-01 |
| 2022-11-03 | 4776.29 | 20.00 |
更多>>
From SEPTEMBER 30, 2021 to SEPTEMBER 30, 2022
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to employees under an ESPP
Issuance of common stock to Board of Directors and Scientific Advisory Board
|
2022-09-30 |
| 2022-08-04 | 4722.91 | 未披露 | 定期报告 | 2022-08-02 |
| 2022-08-04 | 4774.98 | 20.00 |
更多>>
From March 31, 2022 to June 30, 2022
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to employees under an ESPP
|
2022-06-30 |
| 2022-05-05 | 4721.43 | 未披露 | 定期报告 | 2022-05-03 |
| 2022-04-21 | 4720.70 | 20.00 | 定期报告 | 2022-04-01 |
| 2022-05-05 | 4773.42 | 20.00 |
更多>>
From DECEMBER 31, 2021 to March 31, 2022
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2022-03-31 |
| 2022-02-23 | 4849.64 | 未披露 | 定期报告 | 2022-02-21 |
| 2022-02-23 | 4770.03 | 20.00 |
更多>>
From December 31, 2020 to December 31, 2021
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2021-12-31 |
| 2021-11-04 | 4712.57 | 未披露 | 定期报告 | 2021-11-02 |
| 2021-11-04 | 4769.53 | 20.00 |
更多>>
From June 30, 2021 to September 30, 2021
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2021-09-30 |
| 2021-08-05 | 4711.99 | 未披露 | 定期报告 | 2021-08-03 |
| 2021-08-05 | 4768.84 | 20.00 |
更多>>
From March 31, 2021 to June 30, 2021
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2021-06-30 |
| 2021-05-06 | 4713.97 | 未披露 | 定期报告 | 2021-05-04 |
| 2021-04-22 | 4712.70 | 未披露 | 定期报告 | 2021-04-05 |
| 2021-05-06 | 4768.51 | 20.00 |
更多>>
From December 31, 2020 to March 31, 2021
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2021-03-31 |
| 2021-02-18 | 4710.93 | 未披露 | 定期报告 | 2021-02-16 |
| 2021-02-18 | 4764.78 | 20.00 |
更多>>
From December 31,2019 to December 31,2020
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2020-12-31 |
| 2020-10-29 | 4710.44 | 未披露 | 定期报告 | 2020-10-27 |
| 2020-10-29 | 4764.33 | 20.00 |
更多>>
From JUNE 30, 2020 to SEPTEMBER 30, 2020
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2020-09-30 |
| 2020-08-06 | 4710.03 | 未披露 | 定期报告 | 2020-08-05 |
| 2020-08-06 | 4762.69 | 20.00 |
更多>>
from March 31, 2020 to June 30,2020
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2020-06-30 |
| 2020-05-07 | 4710.58 | 未披露 | 定期报告 | 2020-05-05 |
| 2020-04-23 | 4714.97 | 未披露 | 定期报告 | 2020-04-03 |
| 2020-05-07 | 4754.46 | 20.00 |
更多>>
from December 31, 2019 to March 31, 2020
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2020-03-31 |
| 2020-02-20 | 4718.78 | 未披露 | 定期报告 | 2020-02-18 |
| 2020-02-20 | 4748.65 | 20.00 |
更多>>
from December 31, 2018 to December 31, 2019
Issuance of common stock to employees
Shares withheld for employee taxes
Common shares repurchased
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2019-12-31 |
| 2019-10-30 | 4711.06 | 未披露 | 定期报告 | 2019-10-28 |
| 2019-10-30 | 4748.21 | 20.00 |
更多>>
from June 30, 2019 to September 30, 2019
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2019-09-30 |
| 2019-08-01 | 4710.65 | 未披露 | 定期报告 | 2019-07-29 |
| 2019-08-01 | 4746.59 | 20.00 |
更多>>
from March 31, 2019 to June 30,2019
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2019-06-30 |
| 2019-05-02 | 4720.94 | 未披露 | 定期报告 | 2019-04-29 |
| 2019-04-25 | 4716.09 | 未披露 | 定期报告 | 2019-04-05 |
| 2019-05-02 | 4739.47 | 20.00 |
更多>>
from December 31, 2018 to March 31, 2019
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2019-03-31 |
| 2019-02-21 | 4711.04 | 未披露 | 定期报告 | 2019-02-18 |
| 2019-02-21 | 4731.99 | 20.00 |
更多>>
from JANUARY 1, 2018 to DECEMBER 31, 2018
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2018-12-31 |
| 2018-11-01 | 4710.10 | 未披露 | 定期报告 | 2018-10-29 |
| 2018-11-01 | 4731.09 | 20.00 |
更多>>
from DECEMBER 31, 2017 to SEPTEMBER 30, 2018
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
Common shares repurchased
|
2018-09-30 |
| 2018-08-09 | 4709.41 | 未披露 | 定期报告 | 2018-08-06 |
| 2018-08-09 | 4728.91 | 20.00 |
更多>>
from DECEMBER 31, 2017 to JUNE 30, 2018
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
Common shares repurchased
|
2018-06-30 |
| 2018-05-03 | 4708.61 | 未披露 | 定期报告 | 2018-04-30 |
| 2018-04-26 | 4713.88 | 20.00 | 定期报告 | 2018-04-05 |
| 2018-05-03 | 4721.24 | 20.00 |
更多>>
from December 31, 2017 to MARCH 31, 2018
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
Common shares repurchased
|
2018-03-31 |
| 2018-02-22 | 4705.05 | 未披露 | 定期报告 | 2018-02-20 |
| 2018-02-22 | 4711.82 | 20.00 |
更多>>
From DECEMBER 31, 2016 To DECEMBER 31, 2017
Exercise of common stock options
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2017-12-31 |
| 2017-11-02 | 4704.06 | 未披露 | 定期报告 | 2017-10-30 |
| 2017-11-02 | 4710.82 | 20.00 |
更多>>
From DECEMBER 31, 2016 To SEPTEMBER 30, 2017
Exercise of common stock options
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2017-09-30 |
| 2017-08-03 | 4703.11 | 未披露 | 定期报告 | 2017-08-02 |
| 2017-08-03 | 4708.66 | 20.00 |
更多>>
From DECEMBER 31, 2016 to JUNE 30, 2017
Exercise of common stock options
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2017-06-30 |
| 2017-05-04 | 4702.83 | 未披露 | 定期报告 | 2017-05-03 |
| 2017-04-26 | 4706.87 | 20.00 | 定期报告 | 2017-04-06 |
| 2017-05-04 | 4700.70 | 20.00 |
更多>>
from December 31, 2016 to March 31, 2017
Exercise of common stock options
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2017-03-31 |
| 2017-02-23 | 4698.10 | 未披露 | 定期报告 | 2017-02-22 |
| 2017-02-23 | 4691.31 | 20.00 |
更多>>
from December 31, 2015 to December 31, 2016
Exercise of common stock options
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
|
2016-12-31 |
| 2016-11-03 | 4696.91 | 未披露 | 定期报告 | 2016-11-02 |
| 2016-11-03 | 4695.67 | 20.00 |
更多>>
From December 31,2015 to September 30,2016
Exercise of common stock options
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
|
2016-09-30 |
| 2016-08-04 | 4695.66 | 未披露 | 定期报告 | 2016-08-02 |
| 2016-08-04 | 4694.47 | 20.00 |
更多>>
from December 31, 2015 to June 30, 2016
Exercise of common stock options
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2016-06-30 |
| 2016-05-05 | 4684.76 | 未披露 | 定期报告 | 2016-05-03 |
| 2016-04-21 | 4688.94 | 20.00 | 定期报告 | 2016-04-08 |
| 2016-05-05 | 4678.99 | 20.00 |
更多>>
from December 31, 2015 to March 31, 2016
Exercise of common stock options
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2016-03-31 |
| 2016-02-25 | 4682.42 | 未披露 | 定期报告 | 2016-02-23 |
| 2016-02-25 | 4677.44 | 20.00 |
更多>>
From December 31, 2014 to December 31, 2015
Exercise of common stock options, net of tendered shares
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2015-12-31 |
| 2015-11-05 | 4671.19 | 未披露 | 定期报告 | 2015-11-03 |
| 2015-11-05 | 4749.49 | 20.00 |
更多>>
from DECEMBER 31, 2014 to SEPTEMBER 30, 2015
Exercise of common stock options
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2015-09-30 |
| 2015-08-06 | 4645.38 | 未披露 | 定期报告 | 2015-08-04 |
| 2015-08-06 | 4609.99 | 20.00 |
更多>>
from December 31, 2014 to June 30, 2015
Exercise of common stock options
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2015-06-30 |
| 2015-05-07 | 4636.55 | 未披露 | 定期报告 | 2015-05-05 |
| 2015-04-23 | 4586.94 | 未披露 | 定期报告 | 2015-04-08 |
| 2015-05-07 | 4602.17 | 20.00 |
更多>>
from December 31, 2014 to March 31, 2015
Exercise of common stock options, net of tendered shares
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2015-03-31 |
| 2015-02-26 | 4575.30 | 未披露 | 定期报告 | 2015-02-24 |
| 2015-02-26 | 4570.40 | 20.00 |
更多>>
from December 31,2013 to December 31,2014
Exercise of common stock options, net of tendered shares
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
Repurchase of common stock
|
2014-12-31 |
| 2014-11-06 | 4566.95 | 未披露 | 定期报告 | 2014-11-04 |
| 2014-11-06 | 4582.83 | 20.00 |
更多>>
from December 31, 2013 to September 30, 2014
Exercise of common stock options
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
Repurchase of common stock
|
2014-09-30 |
| 2014-08-07 | 4646.37 | 未披露 | 定期报告 | 2014-08-05 |
| 2014-08-07 | 4626.35 | 20.00 |
更多>>
from December 31, 2013 to June 30, 2014
Exercise of common stock options
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
Repurchase of common stock
|
2014-06-30 |
| 2014-05-08 | 4649.40 | 未披露 | 定期报告 | 2014-05-05 |
| 2014-04-25 | 4645.01 | 未披露 | 定期报告 | 2014-04-09 |
| 2014-05-08 | 4648.80 | 20.00 |
更多>>
from DECEMBER 31, 2013 to MARCH 31, 2014
Exercise of common stock options
Stock-based employee compensation, net of shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2014-03-31 |
| 2014-02-28 | 4643.87 | 未披露 | 定期报告 | 2014-02-24 |
| 2014-02-28 | 4642.37 | 20.00 |
更多>>
from December 31,2012 to December 31,2013
Exercise of common stock options, net of tendered shares
Stock-based employee compensation, net of shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
Repurchase of common stock
|
2013-12-31 |
| 2013-11-07 | 4628.33 | 未披露 | 定期报告 | 2013-11-04 |
| 2013-11-07 | 4626.93 | 20.00 |
更多>>
from January 1, 2013 to September 30, 2013
Exercise of common stock options, net of tendered shares
Repurchase of common stock
Stock-based employee compensation, net of shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock under an Employee Stock Purchase Plan
|
2013-09-30 |
| 2013-08-08 | 4622.40 | 未披露 | 定期报告 | 2013-08-02 |
| 2013-08-08 | 4620.70 | 20.00 |
更多>>
From December 31, 2012 to June 30, 2013
Exercise of common stock options, net of tendered shares
Stock-based employee compensation, net of shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock under an Employee Stock Purchase Plan
Repurchase of common stock
|
2013-06-30 |
| 2013-05-09 | 4614.78 | 未披露 | 定期报告 | 2013-05-07 |
| 2013-04-24 | 4617.64 | 未披露 | 定期报告 | 2013-04-10 |
| 2013-05-09 | 4618.57 | 20.00 |
更多>>
from January 1, 2013 to March 31,2013
Exercise of common stock options, net of tendered shares
Stock-based employee compensation, net of shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock under an Employee Stock Purchase Plan
Repurchase of common stock
|
2013-03-31 |
| 2013-02-27 | 4621.17 | 未披露 | 定期报告 | 2013-02-22 |
| 2013-02-27 | 4635.55 | 20.00 |
更多>>
from DECEMBER 31, 2011 to DECEMBER 31, 2012
Exercise of common stock options, net of tendered shares
Stock-based employee compensation, net of shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
|
2012-12-31 |
| 2012-11-07 | 4650.74 | 未披露 | 定期报告 | 2012-11-02 |
| 2012-11-07 | 4653.78 | 20.00 |
更多>>
From JANUARY 1, 2012 to September 30, 2012
Exercise of common stock options, net of tendered shares
Stock-based employee compensation, net of shares withheld for taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock under an Employee Stock Purchase Plan
|
2012-09-30 |
| 2012-08-08 | 4645.31 | 20.00 |
更多>>
from JANUARY 1, 2012 to June 30, 2012
Exercise of common stock options
Stock-based employee compensation, net of shares withheld for taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock under an Employee Stock Purchase Plan
|
2012-06-30 |
| 2012-05-09 | 4640.51 | 未披露 | 定期报告 | 2012-05-07 |
| 2012-05-09 | 4633.68 | 20.00 |
更多>>
from JANUARY 1, 2012 to March 31, 2012
Exercise of common stock options
Stock-based employee compensation, net of shares withheld for taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock under an Employee Stock Purchase Plan
|
2012-03-31 |
| 2012-02-28 | 4614.45 | 未披露 | 定期报告 | 2012-02-23 |
| 2012-02-28 | 4611.33 | 20.00 |
更多>>
from DECEMBER 31, 2010 to DECEMBER 31, 2011
Exercise of common stock options and warrants, net of tendered shares
Stock-based employee compensation, net of shares withheld for employee taxes
Stock-based non-employee compensation
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock in connection with materials and license agreements
Issuance of common stock to employees under an ESPP
Issuance of common stock through a public offering, net of expenses of $14,871,186
|
2011-12-31 |
| 2011-11-08 | 4602.61 | 未披露 | 定期报告 | 2011-11-02 |
| 2011-11-08 | 4606.20 | 20.00 | 定期报告 | 2011-09-30 |
| 2011-08-09 | 4555.70 | 未披露 | 定期报告 | 2011-08-02 |
| 2011-08-09 | 4555.22 | 20.00 | 定期报告 | 2011-06-30 |
| 2011-05-09 | 4536.25 | 未披露 | 定期报告 | 2011-05-04 |
| 2011-05-09 | 4535.33 | 20.00 |
更多>>
Exercise of common stock options and warrants, net of tendered shares
Stock-based employee compensation, net of shares withheld for taxes
Stock-based non-employee compensation
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock in connection with materials agreements
Issuance of common stock under an Employee Stock Purchase Plan
Issuance of common stock through a public offering, net of expenses of $14,768,708
|
2011-03-31 |
| 2011-03-16 | 3945.15 | 未披露 | 定期报告 | 2011-03-09 |
| 2011-03-16 | 3893.66 | 20.00 |
更多>>
from DECEMBER 31, 2009 to DECEMBER 31, 2010
Exercise of common stock options and warrants, net of tendered shares
Stock-based employee compensation, net of shares withheld for employee taxes
Stock-based non-employee compensation
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock in connection with materials and license agreements
Issuance of common stock to employees under an Employee Stock Purchase Plan
|
2010-12-31 |
| 2010-11-04 | 3852.28 | 未披露 | 定期报告 | 2010-11-01 |
| 2010-11-04 | 3831.52 | 20.00 |
更多>>
from JANUARY 1, 2010 to SEPTEMBER 30, 2010
Exercise of common stock options and warrants, net
Stock-based employee compensation, net of shares withheld for taxes
Stock-based non-employee compensation
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock in connection with materials and license agreements
Issuance of common stock under an Employee Stock Purchase Plan
|
2010-09-30 |
| 2010-08-09 | 3819.03 | 未披露 | 定期报告 | 2010-08-02 |
| 2010-08-09 | 3819.71 | 20.00 |
更多>>
from JANUARY 1, 2010 to JUNE 30, 2010
Exercise of common stock options and warrants
Stock-based employee compensation, net of shares withheld for taxes
Stock-based non-employee compensation
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock in connection with materials and license agreements
Issuance of common stock under an Employee Stock Purchase Plan
|
2010-06-30 |
| 2010-03-15 | 3703.37 | 未披露 | 定期报告 | 2010-03-10 |
| 2010-03-15 | 3681.84 | 20.00 |
更多>>
from DECEMBER 31, 2008 to DECEMBER 31, 2009
Exercise of common stock options and warrants
Stock-based employee compensation, net of shares withheld for employee taxes
Stock-based non-employee compensation
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock in connection with materials and license agreements
Issuance of common stock to employees under an Employee Stock Purchase Plan
|
2009-12-31 |
| 2009-03-12 | 3630.88 | 未披露 | 定期报告 | 2009-03-09 |
| 2009-03-12 | 3613.20 | 20.00 |
更多>>
from DECEMBER 31, 2007 to DECEMBER 31, 2008
Exercise of common stock options and warrants
Stock-based employee compensation, net of shares withheld for employee taxes
Stock-based non-employee compensation
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock in connection with the development and license agreements
|
2008-12-31 |
| 2008-03-14 | 3579.58 | 未披露 | 定期报告 | 2008-03-07 |
| 2008-03-14 | 3556.32 | 20.00 |
更多>>
from DECEMBER 31, 2006 to DECEMBER 31, 2007
Issuance of common stock through a public offering, net of expenses of $2,599,977
Exercise of common stock options and warrants
Stock-based employee compensation
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock and options in connection with the development and license agreements
|
2007-12-31 |
| 2007-03-15 | 3153.56 | 未披露 | 定期报告 | 2007-03-08 |
| 2007-03-15 | 3138.54 | 20.00 |
更多>>
from DECEMBER 31, 2005 to DECEMBER 31, 2006
Exercise of common stock options
Exercise of common stock warrants
Stock-based employee compensation
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock, options and warrants in connection with the Development Agreement
|
2006-12-31 |
| 2006-03-09 | 3007.87 | 未披露 | 定期报告 | 2006-03-06 |
| 2006-03-09 | 2954.55 | 20.00 |
更多>>
from DECEMBER 31, 2004 to DECEMBER 31, 2005
Exercise of common stock options and warrants
Issuance of common stock to employees
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock, options and warrants in connection with the Development Agreements
|
2005-12-31 |
| 2005-03-14 | 2807.74 | 未披露 | 定期报告 | 2005-03-08 |
| 2005-03-14 | 2790.34 | 20.00 |
更多>>
from DECEMBER 31, 2003 to DECEMBER 31, 2004
Exercise of common stock options and warrants
Issuance of common stock through direct offerings, net of expenses of $2,077,750
Issuance of common stock to employees
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock, options and warrants in connection with the Development Agreements
Issuance of common stock upon conversion of Series B Preferred Stock
|
2004-12-31 |
| 2004-03-01 | 2478.17 | 未披露 | 定期报告 | 2004-02-20 |
| 2004-03-01 | 2419.68 | 50.00 |
更多>>
from DECEMBER 31, 2002 to DECEMBER 31, 2003
Exercise of Common Stock options and warrants
Issuance of Common Stock through direct offerings, net of expenses of $1,270,643
Issuance of Common Stock to employees
Issuance of Common Stock and options to non-employees
Issuance of Common Stock, options and warrants in connection with the Development Agreements
|
2003-12-31 |
| 2003-03-31 | 2186.40 | 未披露 | 定期报告 | 2003-03-26 |
| 2003-03-31 | 2152.54 | 50.00 |
更多>>
from DECEMBER 31, 2001 to DECEMBER 31, 2002
Exercise of Common Stock options and warrants
Issuance of Common Stock through direct offerings, net of expenses of $519,288
Issuance of Common Stock in connection with the executive employee bonus
Issuance of Common Stock, options and warrants in connection with the Development Agreements
Issuance of Common Stock upon conversion of Convertible Notes
Issuance of Common Stock in connection with License Agreement
|
2002-12-31 |
| 2002-04-01 | 1845.93 | 未披露 | 定期报告 | 2002-03-18 |
| 2002-04-01 | 1809.31 | 50.00 |
更多>>
from DECEMBER 31, 2000 to DECEMBER 31, 2001
Exercise of Common Stock options and warrants
Issuance of Common Stock upon conversion of Convertible Preferred Stock
Issuance of Common Stock and warrants through private placement
Issuance of Common Stock for purchase of equipment
Issuance of Common Stock options to non-employees
Issuance of Common Stock, options and warrants in connection with the Development Agreements
|
2001-12-31 |
| 2001-03-29 | 1678.59 | 未披露 | 定期报告 | 2001-03-20 |
| 2001-03-29 | 1644.03 | 50.00 |
更多>>
from DECEMBER 31, 1999 to DECEMBER 31, 2000
Issuance of Common Stock, Preferred Stock Series B, and warrants in connection with the purchase of intangibles
Exercise of Common Stock options and warrants
Issuance of Common Stock and warrants through private placement, net of expenses of $311,313
Issuance of Common Stock for purchase of equipment
Issuance of Common Stock, Preferred Stock Series B, and warrants in connection with the purchase of intangibles
|
2000-12-31 |
| 2000-03-30 | 1488.82 | 未披露 | 定期报告 | 2000-03-17 |
| 2000-03-30 | 1371.46 | 20.00 |
更多>>
from December 31, 1998 to December 31, 1999
Exercise of Common Stock options and warrants
Issuance of Common Stock and warrants through private placement, net of expenses of $488,220
Issuance of Common Stock for purchase of equipment
Issuance of Common Stock in connection with the executive employee bonus
|
1999-12-31 |
| 1999-03-31 | 1034.81 | 未披露 | 定期报告 | 1999-03-17 |
| 1999-03-31 | 1031.29 | 20.00 |
更多>>
from DECEMBER 31, 1997 to DECEMBER 31, 1998
Exercise of private placement warrants
Exercise of Common Stock options and public warrants
|
1998-12-31 |
| 1998-03-31 | 1030.23 | 20.00 |
更多>>
from DECEMBER 31, 1996 to DECEMBER 31, 1997
Exercise of private placement warrants
Issuance of Common Stock and warrants in connection with 1997 Sponsored Research Agreement
Exercise of Common Stock options and warrants
|
1997-12-31 |
| 1997-03-31 | 893.73 | 20.00 |
更多>>
from DECEMBER 31, 1995 to DECEMBER 31, 1996
Issuance of Common Stock in Initial Public Offering on April 11, 1996
|
1996-12-31 |
From June 30, 2025 to September 30, 2025
Stock-based compensation and ESPP activity, net of taxes withheld
From March 31, 2025 to June 30, 2025
Stock-based compensation and ESPP activity, net of taxes withheld
From December 31, 2024 to March 31, 2025
Stock-based compensation and ESPP activity, net of taxes withheld
From December 31, 2023 to December 31, 2024
Stock-based compensation and ESPP activity, net of taxes withheld
From June 30, 2024 to September 30, 2024
Stock-based compensation and ESPP activity, net of taxes withheld
From March 31, 2024 to June 30, 2024
Stock-based compensation and ESPP activity, net of taxes withheld
From December 31, 2023 to March 31, 2024
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to employees under an ESPP
From December 31, 2022 to December 31, 2023
Issuance of common stock to employees
Shares withheld for employee taxes
Cancellation of restricted stock awards
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
From June 30, 2023 to September 30, 2023
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
From March 31, 2023 to June 30, 2023
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
From December 31, 2022 to March 31, 2023
Issuance of common stock to employees
Shares withheld for employee taxes
Cancellation of restricted stock awards
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
From December 31, 2021 to December 31, 2022
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to employees under an ESPP
From SEPTEMBER 30, 2021 to SEPTEMBER 30, 2022
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to employees under an ESPP
Issuance of common stock to Board of Directors and Scientific Advisory Board
From March 31, 2022 to June 30, 2022
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to employees under an ESPP
From DECEMBER 31, 2021 to March 31, 2022
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
From December 31, 2020 to December 31, 2021
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
From June 30, 2021 to September 30, 2021
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
From March 31, 2021 to June 30, 2021
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
From December 31, 2020 to March 31, 2021
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
From December 31,2019 to December 31,2020
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
From JUNE 30, 2020 to SEPTEMBER 30, 2020
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
from March 31, 2020 to June 30,2020
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
from December 31, 2019 to March 31, 2020
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
from December 31, 2018 to December 31, 2019
Issuance of common stock to employees
Shares withheld for employee taxes
Common shares repurchased
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
from June 30, 2019 to September 30, 2019
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
from March 31, 2019 to June 30,2019
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
from December 31, 2018 to March 31, 2019
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
from JANUARY 1, 2018 to DECEMBER 31, 2018
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
from DECEMBER 31, 2017 to SEPTEMBER 30, 2018
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
Common shares repurchased
from DECEMBER 31, 2017 to JUNE 30, 2018
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
Common shares repurchased
from December 31, 2017 to MARCH 31, 2018
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
Common shares repurchased
From DECEMBER 31, 2016 To DECEMBER 31, 2017
Exercise of common stock options
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
From DECEMBER 31, 2016 To SEPTEMBER 30, 2017
Exercise of common stock options
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
From DECEMBER 31, 2016 to JUNE 30, 2017
Exercise of common stock options
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
from December 31, 2016 to March 31, 2017
Exercise of common stock options
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
from December 31, 2015 to December 31, 2016
Exercise of common stock options
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
From December 31,2015 to September 30,2016
Exercise of common stock options
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
from December 31, 2015 to June 30, 2016
Exercise of common stock options
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
from December 31, 2015 to March 31, 2016
Exercise of common stock options
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
From December 31, 2014 to December 31, 2015
Exercise of common stock options, net of tendered shares
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
from DECEMBER 31, 2014 to SEPTEMBER 30, 2015
Exercise of common stock options
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
from December 31, 2014 to June 30, 2015
Exercise of common stock options
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
from December 31, 2014 to March 31, 2015
Exercise of common stock options, net of tendered shares
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
from December 31,2013 to December 31,2014
Exercise of common stock options, net of tendered shares
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
Repurchase of common stock
from December 31, 2013 to September 30, 2014
Exercise of common stock options
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
Repurchase of common stock
from December 31, 2013 to June 30, 2014
Exercise of common stock options
Issuance of common stock to employees
Shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
Repurchase of common stock
from DECEMBER 31, 2013 to MARCH 31, 2014
Exercise of common stock options
Stock-based employee compensation, net of shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
from December 31,2012 to December 31,2013
Exercise of common stock options, net of tendered shares
Stock-based employee compensation, net of shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
Repurchase of common stock
from January 1, 2013 to September 30, 2013
Exercise of common stock options, net of tendered shares
Repurchase of common stock
Stock-based employee compensation, net of shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock under an Employee Stock Purchase Plan
From December 31, 2012 to June 30, 2013
Exercise of common stock options, net of tendered shares
Stock-based employee compensation, net of shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock under an Employee Stock Purchase Plan
Repurchase of common stock
from January 1, 2013 to March 31,2013
Exercise of common stock options, net of tendered shares
Stock-based employee compensation, net of shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock under an Employee Stock Purchase Plan
Repurchase of common stock
from DECEMBER 31, 2011 to DECEMBER 31, 2012
Exercise of common stock options, net of tendered shares
Stock-based employee compensation, net of shares withheld for employee taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock to employees under an ESPP
From JANUARY 1, 2012 to September 30, 2012
Exercise of common stock options, net of tendered shares
Stock-based employee compensation, net of shares withheld for taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock under an Employee Stock Purchase Plan
from JANUARY 1, 2012 to June 30, 2012
Exercise of common stock options
Stock-based employee compensation, net of shares withheld for taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock under an Employee Stock Purchase Plan
from JANUARY 1, 2012 to March 31, 2012
Exercise of common stock options
Stock-based employee compensation, net of shares withheld for taxes
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock under an Employee Stock Purchase Plan
from DECEMBER 31, 2010 to DECEMBER 31, 2011
Exercise of common stock options and warrants, net of tendered shares
Stock-based employee compensation, net of shares withheld for employee taxes
Stock-based non-employee compensation
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock in connection with materials and license agreements
Issuance of common stock to employees under an ESPP
Issuance of common stock through a public offering, net of expenses of $14,871,186
Exercise of common stock options and warrants, net of tendered shares
Stock-based employee compensation, net of shares withheld for taxes
Stock-based non-employee compensation
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock in connection with materials agreements
Issuance of common stock under an Employee Stock Purchase Plan
Issuance of common stock through a public offering, net of expenses of $14,768,708
from DECEMBER 31, 2009 to DECEMBER 31, 2010
Exercise of common stock options and warrants, net of tendered shares
Stock-based employee compensation, net of shares withheld for employee taxes
Stock-based non-employee compensation
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock in connection with materials and license agreements
Issuance of common stock to employees under an Employee Stock Purchase Plan
from JANUARY 1, 2010 to SEPTEMBER 30, 2010
Exercise of common stock options and warrants, net
Stock-based employee compensation, net of shares withheld for taxes
Stock-based non-employee compensation
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock in connection with materials and license agreements
Issuance of common stock under an Employee Stock Purchase Plan
from JANUARY 1, 2010 to JUNE 30, 2010
Exercise of common stock options and warrants
Stock-based employee compensation, net of shares withheld for taxes
Stock-based non-employee compensation
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock in connection with materials and license agreements
Issuance of common stock under an Employee Stock Purchase Plan
from DECEMBER 31, 2008 to DECEMBER 31, 2009
Exercise of common stock options and warrants
Stock-based employee compensation, net of shares withheld for employee taxes
Stock-based non-employee compensation
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock in connection with materials and license agreements
Issuance of common stock to employees under an Employee Stock Purchase Plan
from DECEMBER 31, 2007 to DECEMBER 31, 2008
Exercise of common stock options and warrants
Stock-based employee compensation, net of shares withheld for employee taxes
Stock-based non-employee compensation
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock in connection with the development and license agreements
from DECEMBER 31, 2006 to DECEMBER 31, 2007
Issuance of common stock through a public offering, net of expenses of $2,599,977
Exercise of common stock options and warrants
Stock-based employee compensation
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock and options in connection with the development and license agreements
from DECEMBER 31, 2005 to DECEMBER 31, 2006
Exercise of common stock options
Exercise of common stock warrants
Stock-based employee compensation
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock, options and warrants in connection with the Development Agreement
from DECEMBER 31, 2004 to DECEMBER 31, 2005
Exercise of common stock options and warrants
Issuance of common stock to employees
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock, options and warrants in connection with the Development Agreements
from DECEMBER 31, 2003 to DECEMBER 31, 2004
Exercise of common stock options and warrants
Issuance of common stock through direct offerings, net of expenses of $2,077,750
Issuance of common stock to employees
Issuance of common stock to Board of Directors and Scientific Advisory Board
Issuance of common stock, options and warrants in connection with the Development Agreements
Issuance of common stock upon conversion of Series B Preferred Stock
from DECEMBER 31, 2002 to DECEMBER 31, 2003
Exercise of Common Stock options and warrants
Issuance of Common Stock through direct offerings, net of expenses of $1,270,643
Issuance of Common Stock to employees
Issuance of Common Stock and options to non-employees
Issuance of Common Stock, options and warrants in connection with the Development Agreements
from DECEMBER 31, 2001 to DECEMBER 31, 2002
Exercise of Common Stock options and warrants
Issuance of Common Stock through direct offerings, net of expenses of $519,288
Issuance of Common Stock in connection with the executive employee bonus
Issuance of Common Stock, options and warrants in connection with the Development Agreements
Issuance of Common Stock upon conversion of Convertible Notes
Issuance of Common Stock in connection with License Agreement
from DECEMBER 31, 2000 to DECEMBER 31, 2001
Exercise of Common Stock options and warrants
Issuance of Common Stock upon conversion of Convertible Preferred Stock
Issuance of Common Stock and warrants through private placement
Issuance of Common Stock for purchase of equipment
Issuance of Common Stock options to non-employees
Issuance of Common Stock, options and warrants in connection with the Development Agreements
from DECEMBER 31, 1999 to DECEMBER 31, 2000
Issuance of Common Stock, Preferred Stock Series B, and warrants in connection with the purchase of intangibles
Exercise of Common Stock options and warrants
Issuance of Common Stock and warrants through private placement, net of expenses of $311,313
Issuance of Common Stock for purchase of equipment
Issuance of Common Stock, Preferred Stock Series B, and warrants in connection with the purchase of intangibles
from December 31, 1998 to December 31, 1999
Exercise of Common Stock options and warrants
Issuance of Common Stock and warrants through private placement, net of expenses of $488,220
Issuance of Common Stock for purchase of equipment
Issuance of Common Stock in connection with the executive employee bonus
from DECEMBER 31, 1997 to DECEMBER 31, 1998
Exercise of private placement warrants
Exercise of Common Stock options and public warrants
from DECEMBER 31, 1996 to DECEMBER 31, 1997
Exercise of private placement warrants
Issuance of Common Stock and warrants in connection with 1997 Sponsored Research Agreement
Exercise of Common Stock options and warrants
from DECEMBER 31, 1995 to DECEMBER 31, 1996
Issuance of Common Stock in Initial Public Offering on April 11, 1996