股本结构
单位：万股
| 公告日期 | 2026-03-31 | 2026-03-31 | 2025-11-13 | 2025-11-13 | 2025-08-14 | 2025-08-14 |
|---|---|---|---|---|---|---|
| 证券总股本 | 7199.62 | 7167.08 | 7090.05 | 7007.36 | 6805.58 | 6002.23 |
| 普通股本 | 7199.62 | 7167.08 | 7090.05 | 7007.36 | 6805.58 | 6002.23 |
| 优先股 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2026-03-27 | 2025-12-31 | 2025-11-12 | 2025-09-30 | 2025-08-12 | 2025-06-30 |
注释：中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本（万股） | 变动后优先股（万股） | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2026-03-31 | 7199.62 | 未披露 | 定期报告 | 2026-03-27 |
| 2026-03-31 | 7167.08 | 未披露 |
更多>>
From December 31, 2024 to December 31, 2025
Issuance of common stock - registered direct offering, net
Issuance of common stock - at-the-market equity offering facility, net
Issuance of common stock - 2026 Notes equitization, net
Issuance of common stock upon exercise of stock options
|
2025-12-31 |
| 2025-11-13 | 7090.05 | 未披露 | 定期报告 | 2025-11-12 |
| 2025-11-13 | 7007.36 | 未披露 |
更多>>
From June 30, 2025 to September 30, 2025
Issuance of common stock - registered direct offering
Issuance of common stock - at-the-market equity offering facility, net
Issuance of common stock - 2026 Notes equitization
Issuance of common stock upon exercise of stock options
|
2025-09-30 |
| 2025-08-14 | 6805.58 | 未披露 | 定期报告 | 2025-08-12 |
| 2025-07-25 | 6712.68 | 未披露 |
更多>>
Common stock offered 5,365,853 shares by the company
|
2025-07-28 |
| 2025-07-25 | 6176.09 | 未披露 | 定期报告 | 2025-07-18 |
| 2025-08-14 | 6002.23 | 未披露 |
更多>>
From March 31, 2025 to June 30, 2025
Issuance of common stock upon exercise of stock options
Issuance of common stock - at-the-market equity offering facility, net
Issuance of common stock - 2026 Notes equitization
|
2025-06-30 |
| 2025-05-30 | 5859.27 | 未披露 | 定期报告 | 2025-05-23 |
| 2025-05-15 | 5859.25 | 未披露 | 定期报告 | 2025-05-09 |
| 2025-04-30 | 5830.58 | 未披露 | 定期报告 | 2025-04-17 |
| 2025-05-15 | 5806.39 | 未披露 |
更多>>
From January 1, 2025 to March 31, 2025
Issuance of common stock upon exercise of stock options
|
2025-03-31 |
| 2025-03-31 | 5806.39 | 未披露 | 定期报告 | 2025-03-25 |
| 2025-03-31 | 5804.45 | 未披露 |
更多>>
From December 31, 2023 to December 31, 2024
Issuance of common stock upon exercise of stock options
Repurchases of common stock
|
2024-12-31 |
| 2024-11-13 | 5794.98 | 未披露 |
更多>>
From June 30, 2024 to September 30, 2024
Issuance of common stock upon exercise of stock options
|
2024-09-30 |
| 2024-08-07 | 5794.69 | 未披露 | 定期报告 | 2024-08-01 |
| 2024-08-07 | 5794.42 | 未披露 |
更多>>
From March 31, 2024 to June 30, 2024
Issuance of common stock upon exercise of stock options
|
2024-06-30 |
| 2024-04-29 | 5794.42 | 未披露 | 定期报告 | 2024-04-18 |
| 2024-05-15 | 5794.27 | 未披露 |
更多>>
From January 1, 2024 to March 31, 2024
Issuance of common stock upon exercise of stock options
Repurchases of common stock
|
2024-03-31 |
| 2024-04-01 | 5794.27 | 未披露 | 定期报告 | 2024-03-28 |
| 2024-04-01 | 6112.86 | 未披露 |
更多>>
From December 31, 2022 to December 31, 2023
Issuance of common stock upon exercise of stock options
Repurchases of common stock
Issuance of common stock upon vesting of restricted stock units
|
2023-12-31 |
| 2023-11-09 | 6286.55 | 未披露 |
更多>>
From June 30, 2023 to September 30, 2023
Exercise of stock options
|
2023-09-30 |
| 2023-08-09 | 6285.58 | 未披露 | 定期报告 | 2023-08-07 |
| 2023-08-09 | 6284.83 | 未披露 | 定期报告 | 2023-06-30 |
| 2023-03-13 | 6282.88 | 未披露 |
更多>>
From December 31, 2021 to December 31, 2022
Issuance of common stock upon exercise of stock options
Issuance of common stock upon vesting of restricted stock units
|
2022-12-31 |
| 2022-05-10 | 6273.00 | 未披露 |
更多>>
From January 1, 2022 to March 31, 2022
Exercise of stock options and warrants
|
2022-03-31 |
| 2022-03-01 | 6272.65 | 未披露 | 定期报告 | 2022-02-24 |
| 2022-03-01 | 6262.89 | 未披露 |
更多>>
From December 31, 2020 to December 31, 2021
Issuance of common stock upon exercise of stock options and warrants
Issuance of common stock upon grant of restricted stock awards
|
2021-12-31 |
| 2021-11-09 | 6254.23 | 未披露 |
更多>>
From June 30, 2021 to September 30, 2021
Exercise of stock options
|
2021-09-30 |
| 2021-08-09 | 6249.56 | 未披露 | 定期报告 | 2021-08-05 |
| 2021-08-09 | 6249.09 | 未披露 |
更多>>
From March 31, 2021 to June 30, 2021
Exercise of stock options
|
2021-06-30 |
| 2021-05-10 | 6232.84 | 未披露 | 定期报告 | 2021-05-06 |
| 2021-04-30 | 6232.51 | 未披露 | 定期报告 | 2021-04-12 |
| 2021-05-10 | 6225.20 | 未披露 |
更多>>
From January 1, 2021 To March 31, 2021
Exercise of stock options
|
2021-03-31 |
| 2021-03-01 | 6193.38 | 未披露 | 定期报告 | 2021-02-25 |
| 2021-03-01 | 6167.12 | 未披露 |
更多>>
From December 31,2019 to December 31,2020
Issuance of common stock in direct offering,net of offering costs
Issuance of common stock upon exercise of stock options
Issuance of common stock upon grant of restricted stock awards
|
2020-12-31 |
| 2020-11-09 | 6165.23 | 未披露 | 定期报告 | 2020-11-05 |
| 2020-11-09 | 6165.12 | 未披露 |
更多>>
From June 30, 2020 to September 30, 2020
Issuance of common stock in direct offering,net of offering costs
Exercise of stock options
|
2020-09-30 |
| 2020-08-14 | 6141.59 | 未披露 |
更多>>
1.Common stock offered by the company 6,900,000 shares.
2.The number of shares of common stock to be outstanding immediately after this offering, should it be completed in full using the assumptions stated above, is based on 54,515,858 shares outstanding as of June 30, 2020.
|
2020-08-14 |
| 2020-08-10 | 5451.84 | 未披露 | 定期报告 | 2020-08-06 |
| 2020-08-10 | 5451.59 | 未披露 | 定期报告 | 2020-06-30 |
| 2020-04-29 | 5451.07 | 未披露 | 定期报告 | 2020-04-13 |
| 2020-05-11 | 5450.77 | 未披露 |
更多>>
From January 1, 2020 to March 31, 2020
Exercise of stock options
|
2020-03-31 |
| 2020-03-02 | 5420.52 | 未披露 | 定期报告 | 2020-02-25 |
| 2020-03-02 | 5420.08 | 未披露 |
更多>>
From December 31, 2018 to December 31, 2019
Issuance of common stock in direct offering, net of offering costs
Issuance of common stock upon exercise of stock options
|
2019-12-31 |
| 2019-12-09 | 5334.23 | 未披露 | 定期报告 | 2019-12-09 |
| 2019-11-12 | 4974.78 | 未披露 | 定期报告 | 2019-11-08 |
| 2019-11-12 | 4952.55 | 未披露 | 定期报告 | 2019-09-30 |
| 2019-08-08 | 4928.76 | 未披露 | 定期报告 | 2019-08-05 |
| 2019-08-08 | 4919.60 | 未披露 |
更多>>
from March 31, 2019 to June 30, 2019
Exercise of stock options
|
2019-06-30 |
| 2019-05-09 | 4905.79 | 未披露 | 定期报告 | 2019-05-07 |
| 2019-04-29 | 4903.80 | 未披露 | 定期报告 | 2019-04-12 |
| 2019-05-09 | 4902.24 | 未披露 | 定期报告 | 2019-03-31 |
| 2019-03-01 | 4901.17 | 未披露 | 定期报告 | 2019-02-25 |
| 2019-03-01 | 4901.17 | 未披露 |
更多>>
from December 31, 2017 to December 31, 2018
Issuance of common stock upon exercise of stock options
|
2018-12-31 |
| 2018-11-08 | 4900.93 | 未披露 | 定期报告 | 2018-09-30 |
| 2018-08-09 | 4855.98 | 未披露 | 定期报告 | 2018-08-06 |
| 2018-08-09 | 4849.81 | 未披露 | 定期报告 | 2018-06-30 |
| 2018-05-10 | 4829.26 | 未披露 | 定期报告 | 2018-05-07 |
| 2018-05-10 | 4828.68 | 未披露 | 定期报告 | 2018-03-31 |
| 2018-03-01 | 4828.60 | 未披露 | 定期报告 | 2018-02-26 |
| 2018-03-01 | 4821.12 | 未披露 |
更多>>
from December 31, 2016 to December 31, 2017
Issuance of common stock in direct offering, net of offering costs
Issuance of common stock upon exercise of stock options
|
2017-12-31 |
| 2017-11-09 | 4800.38 | 未披露 | 定期报告 | 2017-11-06 |
| 2017-11-09 | 4798.64 | 未披露 | 定期报告 | 2017-09-30 |
| 2017-08-08 | 4480.38 | 未披露 | 定期报告 | 2017-08-04 |
| 2017-08-08 | 4444.76 | 未披露 | 定期报告 | 2017-06-30 |
| 2017-05-10 | 4393.95 | 未披露 | 定期报告 | 2017-05-02 |
| 2017-04-25 | 4393.87 | 未披露 | 定期报告 | 2017-04-12 |
| 2017-05-10 | 4393.70 | 未披露 | 定期报告 | 2017-03-31 |
| 2017-03-16 | 4382.21 | 未披露 | 定期报告 | 2017-03-07 |
| 2017-03-16 | 4381.91 | 未披露 |
更多>>
from December 31, 2015 to December 31, 2016
Issuance of common stock in direct offering, net of offering costs
Issuance of common stock upon exercise of stock options
Issuance of common stock upon exercise of warrants
Issuance of common stock under the ATM Agreement, net of offering costs
|
2016-12-31 |
| 2016-11-09 | 4291.59 | 未披露 | 定期报告 | 2016-11-02 |
| 2016-11-09 | 4291.05 | 未披露 | 定期报告 | 2016-09-30 |
| 2016-08-09 | 3929.31 | 未披露 | 定期报告 | 2016-08-04 |
| 2016-08-09 | 3927.72 | 未披露 | 定期报告 | 2016-06-30 |
| 2016-05-10 | 3913.51 | 未披露 | 定期报告 | 2016-05-02 |
| 2016-05-10 | 3911.92 | 未披露 | 定期报告 | 2016-03-31 |
| 2016-03-15 | 3825.74 | 未披露 | 定期报告 | 2016-03-07 |
| 2016-03-15 | 3804.09 | 未披露 |
更多>>
From December 31, 2014 to December 31, 2015
Issuance of common stock and pre-funded warrants, net of offering costs
Issuance of common stock upon exercise of warrants
Issuance of common stock upon exercise of stock options
|
2015-12-31 |
| 2015-11-09 | 3796.94 | 未披露 | 定期报告 | 2015-09-30 |
| 2015-08-10 | 3788.57 | 未披露 | 定期报告 | 2015-08-05 |
| 2015-08-10 | 3787.59 | 未披露 | 定期报告 | 2015-06-30 |
| 2015-05-11 | 3782.53 | 未披露 | 定期报告 | 2015-03-31 |
| 2015-03-16 | 3780.25 | 未披露 | 定期报告 | 2015-03-12 |
| 2015-03-16 | 3418.55 | 未披露 |
更多>>
from December 31, 2013 to December 31, 2014
Issuance of common stock, net of offering costs
Issuance of common stock upon exercise of warrants
Issuance of common stock upon exercise of stock options for cash
|
2014-12-31 |
| 2014-11-10 | 3407.59 | 未披露 | 定期报告 | 2014-11-06 |
| 2014-11-10 | 3402.21 | 未披露 | 定期报告 | 2014-09-30 |
| 2014-08-11 | 3399.58 | 未披露 | 定期报告 | 2014-08-05 |
| 2014-08-11 | 3399.44 | 未披露 | 定期报告 | 2014-06-30 |
| 2014-05-12 | 3391.24 | 未披露 | 定期报告 | 2014-05-07 |
| 2014-05-12 | 3390.16 | 未披露 | 定期报告 | 2014-03-31 |
| 2014-03-13 | 3039.74 | 未披露 | 定期报告 | 2014-03-11 |
| 2014-03-13 | 3035.95 | 未披露 |
更多>>
from December 31, 2012 to December 31, 2013
Issuance of common stock in direct offering, net of offering costs
Issuance of common stock utilizing At-The-Market Agreement, net of commissions
Issuance of common stock upon exercise of stock options for cash
|
2013-12-31 |
| 2013-11-07 | 3032.00 | 未披露 | 定期报告 | 2013-11-06 |
| 2013-10-17 | 3028.81 | 未披露 | 定期报告 | 2013-10-15 |
| 2013-11-07 | 2984.98 | 未披露 | 定期报告 | 2013-09-30 |
| 2013-08-09 | 2984.81 | 未披露 | 定期报告 | 2013-08-09 |
| 2013-08-09 | 2983.28 | 未披露 | 定期报告 | 2013-06-30 |
| 2013-05-09 | 2592.88 | 未披露 | 定期报告 | 2013-05-06 |
| 2013-03-18 | 2591.04 | 未披露 | 定期报告 | 2013-03-13 |
| 2013-03-18 | 2589.75 | 未披露 |
更多>>
from December 31, 2011 to December 31, 2012
Issuance of common stock for $10.25 per share in public offering, net of offering costs of $2.2 million
Issuance of common stock upon exercise of stock options for cash of $0.76 to $7.56 per share
|
2012-12-31 |
| 2012-11-09 | 2588.66 | 未披露 | 定期报告 | 2012-11-05 |
| 2012-11-09 | 2588.52 | 未披露 | 定期报告 | 2012-09-30 |
| 2012-08-07 | 2586.29 | 未披露 | 定期报告 | 2012-08-02 |
| 2012-08-07 | 2249.70 | 未披露 | 定期报告 | 2012-06-30 |
| 2012-05-10 | 2245.18 | 未披露 | 定期报告 | 2012-03-31 |
| 2012-03-15 | 2243.37 | 未披露 | 定期报告 | 2012-03-07 |
| 2012-03-15 | 2243.02 | 未披露 |
更多>>
from December 31, 2010 to December 31, 2011
Issuance of common stock upon exercise of stock options for cash of $0.52 to $2.45 per share
|
2011-12-31 |
| 2011-11-08 | 2235.82 | 未披露 | 定期报告 | 2011-11-03 |
| 2011-11-08 | 2231.38 | 未披露 | 定期报告 | 2011-09-30 |
| 2011-08-09 | 2220.61 | 未披露 | 定期报告 | 2011-06-30 |
| 2011-05-10 | 2213.78 | 未披露 | 定期报告 | 2011-03-31 |
| 2011-03-15 | 2213.72 | 未披露 | 定期报告 | 2011-03-10 |
| 2011-03-15 | 2192.08 | 未披露 |
更多>>
from dec 31 2009 to dec 31 2010
Issuance of common stock to Patobios at $8.30 per share in connection with GPCR technology purchase
Issuance of common stock upon exercise of stock options for cash of $0.52 to $6.05 per share
|
2010-12-31 |
| 2010-11-04 | 2152.00 | 未披露 | 定期报告 | 2010-11-01 |
| 2010-11-04 | 2150.47 | 未披露 | 定期报告 | 2010-09-30 |
| 2010-08-10 | 2148.75 | 未披露 | 定期报告 | 2010-08-06 |
| 2010-08-10 | 2143.45 | 未披露 | 定期报告 | 2010-06-30 |
| 2010-05-12 | 2139.61 | 未披露 | 定期报告 | 2010-05-07 |
| 2010-03-31 | 2131.62 | 未披露 | 定期报告 | 2010-03-24 |
| 2010-03-31 | 2128.56 | 未披露 |
更多>>
from December 31, 2008 to December 31, 2009
Repurchase of common stock issued to founders
Issuance of common stock upon exercise of stock options for cash at $0.35 per share
Issuance of common stock for services at $0.35 per share
|
2009-12-31 |
From December 31, 2024 to December 31, 2025
Issuance of common stock - registered direct offering, net
Issuance of common stock - at-the-market equity offering facility, net
Issuance of common stock - 2026 Notes equitization, net
Issuance of common stock upon exercise of stock options
From June 30, 2025 to September 30, 2025
Issuance of common stock - registered direct offering
Issuance of common stock - at-the-market equity offering facility, net
Issuance of common stock - 2026 Notes equitization
Issuance of common stock upon exercise of stock options
Common stock offered 5,365,853 shares by the company
From March 31, 2025 to June 30, 2025
Issuance of common stock upon exercise of stock options
Issuance of common stock - at-the-market equity offering facility, net
Issuance of common stock - 2026 Notes equitization
From January 1, 2025 to March 31, 2025
Issuance of common stock upon exercise of stock options
From December 31, 2023 to December 31, 2024
Issuance of common stock upon exercise of stock options
Repurchases of common stock
From June 30, 2024 to September 30, 2024
Issuance of common stock upon exercise of stock options
From March 31, 2024 to June 30, 2024
Issuance of common stock upon exercise of stock options
From January 1, 2024 to March 31, 2024
Issuance of common stock upon exercise of stock options
Repurchases of common stock
From December 31, 2022 to December 31, 2023
Issuance of common stock upon exercise of stock options
Repurchases of common stock
Issuance of common stock upon vesting of restricted stock units
From June 30, 2023 to September 30, 2023
Exercise of stock options
From December 31, 2021 to December 31, 2022
Issuance of common stock upon exercise of stock options
Issuance of common stock upon vesting of restricted stock units
From January 1, 2022 to March 31, 2022
Exercise of stock options and warrants
From December 31, 2020 to December 31, 2021
Issuance of common stock upon exercise of stock options and warrants
Issuance of common stock upon grant of restricted stock awards
From June 30, 2021 to September 30, 2021
Exercise of stock options
From March 31, 2021 to June 30, 2021
Exercise of stock options
From January 1, 2021 To March 31, 2021
Exercise of stock options
From December 31,2019 to December 31,2020
Issuance of common stock in direct offering,net of offering costs
Issuance of common stock upon exercise of stock options
Issuance of common stock upon grant of restricted stock awards
From June 30, 2020 to September 30, 2020
Issuance of common stock in direct offering,net of offering costs
Exercise of stock options
1.Common stock offered by the company 6,900,000 shares.
2.The number of shares of common stock to be outstanding immediately after this offering, should it be completed in full using the assumptions stated above, is based on 54,515,858 shares outstanding as of June 30, 2020.
From January 1, 2020 to March 31, 2020
Exercise of stock options
From December 31, 2018 to December 31, 2019
Issuance of common stock in direct offering, net of offering costs
Issuance of common stock upon exercise of stock options
from March 31, 2019 to June 30, 2019
Exercise of stock options
from December 31, 2017 to December 31, 2018
Issuance of common stock upon exercise of stock options
from December 31, 2016 to December 31, 2017
Issuance of common stock in direct offering, net of offering costs
Issuance of common stock upon exercise of stock options
from December 31, 2015 to December 31, 2016
Issuance of common stock in direct offering, net of offering costs
Issuance of common stock upon exercise of stock options
Issuance of common stock upon exercise of warrants
Issuance of common stock under the ATM Agreement, net of offering costs
From December 31, 2014 to December 31, 2015
Issuance of common stock and pre-funded warrants, net of offering costs
Issuance of common stock upon exercise of warrants
Issuance of common stock upon exercise of stock options
from December 31, 2013 to December 31, 2014
Issuance of common stock, net of offering costs
Issuance of common stock upon exercise of warrants
Issuance of common stock upon exercise of stock options for cash
from December 31, 2012 to December 31, 2013
Issuance of common stock in direct offering, net of offering costs
Issuance of common stock utilizing At-The-Market Agreement, net of commissions
Issuance of common stock upon exercise of stock options for cash
from December 31, 2011 to December 31, 2012
Issuance of common stock for $10.25 per share in public offering, net of offering costs of $2.2 million
Issuance of common stock upon exercise of stock options for cash of $0.76 to $7.56 per share
from December 31, 2010 to December 31, 2011
Issuance of common stock upon exercise of stock options for cash of $0.52 to $2.45 per share
from dec 31 2009 to dec 31 2010
Issuance of common stock to Patobios at $8.30 per share in connection with GPCR technology purchase
Issuance of common stock upon exercise of stock options for cash of $0.52 to $6.05 per share
from December 31, 2008 to December 31, 2009
Repurchase of common stock issued to founders
Issuance of common stock upon exercise of stock options for cash at $0.35 per share
Issuance of common stock for services at $0.35 per share