股本结构
单位：万股
| 公告日期 | 2025-11-04 | 2025-11-04 | 2025-08-07 | 2025-08-07 | 2025-05-06 | 2025-05-06 |
|---|---|---|---|---|---|---|
| 证券总股本 | 8028.83 | 7993.18 | 7943.81 | 7937.81 | 7925.70 | 7922.53 |
| 普通股本 | 8028.83 | 7993.18 | 7943.81 | 7937.81 | 7925.70 | 7922.53 |
| 优先股 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2025-11-03 | 2025-09-30 | 2025-08-05 | 2025-06-30 | 2025-05-04 | 2025-03-31 |
注释：中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本（万股） | 变动后优先股（万股） | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2025-11-04 | 8028.83 | 未披露 | 定期报告 | 2025-11-03 |
| 2025-11-04 | 7993.18 | 未披露 |
更多>>
From June 30, 2025 to September 30, 2025
Exercise of options
Restricted stock vesting and issuance, net
|
2025-09-30 |
| 2025-08-07 | 7943.81 | 未披露 | 定期报告 | 2025-08-05 |
| 2025-08-07 | 7937.81 | 未披露 |
更多>>
From March 31, 2025 to June 30, 2025
Issuance of common stock in connection with an employee stock purchase plan
Restricted stock vesting and issuance, net
Exercise of options
|
2025-06-30 |
| 2025-05-06 | 7925.70 | 未披露 | 定期报告 | 2025-05-04 |
| 2025-04-30 | 7923.76 | 未披露 | 定期报告 | 2025-04-21 |
| 2025-05-06 | 7922.53 | 未披露 |
更多>>
From December 31, 2024 to March 31, 2025
Exercise of options
Restricted stock vesting and issuance, net
|
2025-03-31 |
| 2025-02-27 | 7886.94 | 未披露 | 定期报告 | 2025-02-25 |
| 2025-02-27 | 7770.42 | 未披露 |
更多>>
From December 31, 2023 to December 31, 2024
Retired Shares
Exercise of options
Restricted stock vesting and issuance, net
Issuance of common stock in connection with an employee stock purchase plan
|
2024-12-31 |
| 2024-11-07 | 7712.51 | 未披露 | 定期报告 | 2024-11-05 |
| 2024-11-07 | 7695.21 | 未披露 |
更多>>
From June 30, 2024 to September 30, 2024
Retired shares
Exercise of options
Restricted stock vesting and issuance, net
|
2024-09-30 |
| 2024-08-08 | 7692.42 | 未披露 | 定期报告 | 2024-08-06 |
| 2024-08-08 | 7690.01 | 未披露 |
更多>>
From March 31, 2024 to June 30, 2024
Exercise of options
Restricted stock vesting and issuance, net
Issuance of common stock in connection with an employee stock purchase plan
|
2024-06-30 |
| 2024-04-25 | 7669.68 | 未披露 | 定期报告 | 2024-04-23 |
| 2024-04-26 | 7669.67 | 未披露 | 定期报告 | 2024-04-22 |
| 2024-04-25 | 7665.40 | 未披露 |
更多>>
From December 31, 2023 to March 31, 2024
Exercise of options
Restricted stock vesting and issuance, net
|
2024-03-31 |
| 2024-02-29 | 7660.80 | 未披露 | 定期报告 | 2024-02-27 |
| 2024-02-29 | 7570.89 | 未披露 |
更多>>
From December 31,2022 to December 31,2023
Issuance of common stock in connection with a milestone payable
Exercise of options
Restricted stock vesting and issuance, net
Issuance of common stock in connection with an employee stock purchase plan
|
2023-12-31 |
| 2023-10-26 | 7546.31 | 未披露 | 定期报告 | 2023-10-24 |
| 2023-10-26 | 7545.90 | 未披露 |
更多>>
From June 30,2023 to September 30,2023
Exercise of options
Restricted stock vesting and issuance, net
|
2023-09-30 |
| 2023-08-03 | 7534.50 | 未披露 | 定期报告 | 2023-08-01 |
| 2023-08-03 | 7531.82 | 未披露 |
更多>>
From March 31, 2023 to June 30, 2023
Issuance of common stock in connection with an employee stock purchase plan
Issuance of common stock in connection with a milestone payable
Exercise of options
Restricted stock vesting and issuance, net
|
2023-06-30 |
| 2023-04-27 | 7419.07 | 未披露 | 定期报告 | 2023-04-25 |
| 2023-04-26 | 7402.67 | 未披露 | 定期报告 | 2023-04-13 |
| 2023-04-27 | 7401.20 | 未披露 |
更多>>
From December 31, 2022 to March 31, 2023
Exercise of options
Restricted stock vesting and issuance, net
|
2023-03-31 |
| 2023-02-21 | 7381.51 | 未披露 | 定期报告 | 2023-02-16 |
| 2023-02-21 | 7310.47 | 未披露 |
更多>>
From December 31, 2021 to December 31, 2022
Issuance of common stock related to stock purchase agreement
Exercise of options
Restricted stock vesting and issuance, net
Issuance of common stock in connection with an employee stock purchase plan
|
2022-12-31 |
| 2022-12-16 | 7299.07 | 未披露 | 定期报告 | 2022-11-30 |
| 2022-10-27 | 7188.20 | 未披露 | 定期报告 | 2022-10-25 |
| 2022-10-27 | 7185.49 | 未披露 |
更多>>
From June 30, 2022 to September 30, 2022
Exercise of options
Restricted stock vesting and issuance, net
|
2022-09-30 |
| 2022-08-04 | 7154.10 | 未披露 | 定期报告 | 2022-08-02 |
| 2022-08-04 | 7150.59 | 未披露 |
更多>>
From March 31, 2022 to June 30, 2022
Exercise of options
Restricted stock vesting and issuance, net
Issuance of common stock in connection with an employee stock purchase plan
|
2022-06-30 |
| 2022-05-03 | 7133.83 | 未披露 | 定期报告 | 2022-05-02 |
| 2022-04-28 | 7136.00 | 未披露 | 定期报告 | 2022-04-14 |
| 2022-05-03 | 7133.70 | 未披露 |
更多>>
from December 31, 2021 to March 31, 2022
Exercise of options
Restricted stock vesting and issuance, net
|
2022-03-31 |
| 2022-02-22 | 7136.25 | 未披露 | 定期报告 | 2022-02-18 |
| 2022-02-22 | 7082.82 | 未披露 |
更多>>
from December 31, 2020 to December 31, 2021
Exercise of options
Restricted stock vesting and issuance, net
Issuance of common stock in connection with an employee stock purchase plan
|
2021-12-31 |
| 2021-10-28 | 7069.79 | 未披露 | 定期报告 | 2021-10-27 |
| 2021-10-28 | 7066.50 | 未披露 |
更多>>
From June 30, 2021 to September 30, 2021
Exercise of options
Restricted stock vesting and issuance, net
|
2021-09-30 |
| 2021-07-29 | 7060.49 | 未披露 | 定期报告 | 2021-07-28 |
| 2021-07-29 | 7055.93 | 未披露 |
更多>>
From March 31, 2021 to June 30, 2021
Exercise of options
Restricted stock vesting and issuance, net
Issuance of common stock in connection with an employee stock purchase plan
|
2021-06-30 |
| 2021-05-04 | 7045.59 | 未披露 | 定期报告 | 2021-05-03 |
| 2021-04-29 | 7041.81 | 未披露 | 定期报告 | 2021-04-16 |
| 2021-05-04 | 7040.59 | 未披露 |
更多>>
from December 31, 2020 to March 31, 2021
Exercise of options
Restricted stock vesting and issuance, net
|
2021-03-31 |
| 2021-02-25 | 7032.23 | 未披露 | 定期报告 | 2021-02-23 |
| 2021-02-25 | 6971.81 | 未披露 |
更多>>
From December 31, 2019 to December 31, 2020
Issuance of common stock related to equity offerings
Issuance of common stock related to acquisition
Issuance of common stock related to rights exchange
Exercise of options
Restricted stock vesting and issuance, net
Issuance of common stock in connection with an employee stock purchase plan
|
2020-12-31 |
| 2020-10-29 | 6823.57 | 未披露 | 定期报告 | 2020-10-27 |
| 2020-10-29 | 6780.96 | 未披露 |
更多>>
From June 30, 2020 to September 30, 2020
Issuance of common stock related to equity offering
Exercise of options
Restricted stock vesting and issuance, net
|
2020-09-30 |
| 2020-08-05 | 6770.32 | 未披露 | 定期报告 | 2020-08-03 |
| 2020-08-10 | 6724.07 | 未披露 |
更多>>
From March 31, 2020 to June 30, 2020
Issuance of common stock related to equity offering
Issuance of common stock related to acquisition
Issuance of common stock related to rights exchange
Exercise of options
Restricted stock vesting and issuance, net
Issuance of common stock in connection with an employee stock purchase plan
|
2020-06-30 |
| 2020-06-19 | 6547.97 | 未披露 | 定期报告 | 2020-05-29 |
| 2020-05-07 | 6287.54 | 未披露 | 定期报告 | 2020-04-28 |
| 2020-04-27 | 6279.22 | 未披露 | 定期报告 | 2020-04-17 |
| 2020-04-30 | 6275.85 | 未披露 |
更多>>
From December 31, 2019 to March 31, 2020
Issuance of common stock related to equity offerings
Exercise of options
Restricted stock vesting and issuance, net
|
2020-03-31 |
| 2020-03-02 | 6263.26 | 未披露 | 定期报告 | 2020-02-27 |
| 2020-03-02 | 6193.59 | 未披露 |
更多>>
From December 31, 2018 to December 31, 2019
Issuance of common stock related to equity offerings
Exercise of options
Restricted stock vesting and issuance, net
Issuance of common stock in connection with an employee stock purchase plan
|
2019-12-31 |
| 2019-10-30 | 6163.10 | 未披露 | 定期报告 | 2019-10-25 |
| 2019-10-30 | 6157.90 | 未披露 |
更多>>
from June 30, 2019 to September 30, 2019
Issuance of common stock related to equity offerings
Exercise of options
Restricted stock vesting and issuance, net
|
2019-09-30 |
| 2019-09-20 | 6155.29 | 未披露 | 定期报告 | 2019-09-20 |
| 2019-09-17 | 5907.76 | 未披露 | 定期报告 | 2019-08-31 |
| 2019-08-06 | 5894.97 | 未披露 | 定期报告 | 2019-08-05 |
| 2019-08-07 | 5894.73 | 未披露 | 定期报告 | 2019-07-31 |
| 2019-08-06 | 5870.72 | 未披露 |
更多>>
from March 31, 2019 to June 30, 2019
Exercise of options
Restricted stock vesting and issuance
Issuance of common stock in connection with an employee stock purchase plan
|
2019-06-30 |
| 2019-05-02 | 5843.11 | 未披露 | 定期报告 | 2019-04-29 |
| 2019-04-25 | 5842.77 | 未披露 | 定期报告 | 2019-04-18 |
| 2019-05-02 | 5841.88 | 未披露 |
更多>>
from December 31, 2018 to March 31, 2019
Issuance of common stock related to equity offering
Exercise of options
Restricted stock vesting and issuance
|
2019-03-31 |
| 2019-03-01 | 5840.17 | 未披露 | 定期报告 | 2019-02-25 |
| 2019-03-01 | 5060.61 | 未披露 |
更多>>
from December 31, 2017 to December 31, 2018
Issuance of common stock related to equity offering
Issuance of common stock related to acquisition
Exercise of options
Restricted stock vesting and issuance
Issuance of common stock in connection with an employee stock purchase plan
|
2018-12-31 |
| 2018-11-05 | 5045.48 | 未披露 | 定期报告 | 2018-11-01 |
| 2018-11-05 | 5043.27 | 未披露 | 定期报告 | 2018-09-30 |
| 2018-08-24 | 5026.53 | 未披露 | 定期报告 | 2018-08-23 |
| 2018-08-07 | 4671.39 | 未披露 | 定期报告 | 2018-08-03 |
| 2018-08-07 | 4668.05 | 未披露 | 定期报告 | 2018-06-30 |
| 2018-05-09 | 4644.57 | 未披露 | 定期报告 | 2018-05-04 |
| 2018-04-30 | 4641.20 | 未披露 | 定期报告 | 2018-04-20 |
| 2018-05-09 | 4180.94 | 未披露 | 定期报告 | 2018-03-31 |
| 2018-03-06 | 4179.57 | 未披露 | 定期报告 | 2018-02-28 |
| 2018-03-06 | 4161.24 | 未披露 |
更多>>
from December 31, 2016 to December 31, 2017
Issuance of common stock related to acquisition
Exercise of options
Restricted stock vesting and issuance
Issuance of common stock in connection with an employee stock purchase plan
|
2017-12-31 |
| 2017-08-09 | 4138.90 | 未披露 | 定期报告 | 2017-08-04 |
| 2017-08-09 | 4130.40 | 未披露 | 定期报告 | 2017-06-30 |
| 2017-04-28 | 4124.40 | 未披露 | 定期报告 | 2017-04-20 |
| 2017-05-08 | 3431.68 | 未披露 | 定期报告 | 2017-03-31 |
| 2017-03-16 | 3455.64 | 未披露 | 定期报告 | 2017-02-24 |
| 2017-03-16 | 3416.94 | 未披露 |
更多>>
from December 31, 2015 to December 31, 2016
Exercise of options
Restricted stock vesting
|
2016-12-31 |
| 2016-11-03 | 3431.82 | 未披露 | 定期报告 | 2016-11-01 |
| 2016-11-02 | 3416.55 | 未披露 | 定期报告 | 2016-09-30 |
| 2016-08-04 | 3424.77 | 未披露 | 定期报告 | 2016-08-01 |
| 2016-08-04 | 3408.33 | 未披露 | 定期报告 | 2016-06-30 |
| 2016-04-28 | 3426.50 | 未披露 | 定期报告 | 2016-04-20 |
| 2016-05-05 | 3391.97 | 未披露 | 定期报告 | 2016-03-31 |
| 2016-02-29 | 3427.20 | 未披露 | 定期报告 | 2016-02-24 |
| 2016-02-29 | 3391.66 | 未披露 |
更多>>
from December 31, 2014 to December 31, 2015
Exercise of options
Restricted stock vesting
|
2015-12-31 |
| 2015-11-09 | 3427.17 | 未披露 | 定期报告 | 2015-11-04 |
| 2015-11-09 | 3391.51 | 未披露 | 定期报告 | 2015-09-30 |
| 2015-07-31 | 3427.15 | 未披露 | 定期报告 | 2015-07-28 |
| 2015-07-30 | 3387.30 | 未披露 | 定期报告 | 2015-06-30 |
| 2015-04-28 | 3384.83 | 未披露 | 定期报告 | 2015-04-20 |
| 2015-05-04 | 3348.33 | 未披露 | 定期报告 | 2015-03-31 |
| 2015-03-02 | 3368.89 | 未披露 | 定期报告 | 2015-02-24 |
| 2015-03-02 | 3289.84 | 未披露 |
更多>>
From December 31, 2013 to December 31, 2014
Issuance of common stock from public offerings and exercise of over allotment exercise, net of offering costs
Exercise of options
Restricted stock vesting
|
2014-12-31 |
| 2014-11-06 | 3360.25 | 未披露 | 定期报告 | 2014-11-05 |
| 2014-11-06 | 2937.33 | 未披露 | 定期报告 | 2014-09-30 |
| 2014-08-07 | 3006.99 | 未披露 | 定期报告 | 2014-08-04 |
| 2014-08-07 | 2934.06 | 未披露 | 定期报告 | 2014-06-30 |
| 2014-05-06 | 3007.45 | 未披露 | 定期报告 | 2014-05-05 |
| 2014-04-28 | 3007.68 | 未披露 | 定期报告 | 2014-04-15 |
| 2014-05-06 | 2932.60 | 未披露 | 定期报告 | 2014-03-31 |
| 2014-03-06 | 3007.68 | 未披露 | 定期报告 | 2014-03-04 |
| 2014-01-31 | 2491.35 | 未披露 | 定期报告 | 2014-01-28 |
| 2013-11-14 | 2491.71 | 未披露 | 定期报告 | 2013-11-13 |
| 2014-03-06 | 2380.33 | 未披露 |
更多>>
From December 31, 2012 to September 30, 2013
Issuance of Series One convertible preferred stock, exchange of Series A—G convertible preferred stock for Series Two and Series Three convertible preferred stock
Conversion of Series Four and Series Five convertible preferred stock
Reverse stock split
Issuance of common stock from IPO and exercise of over allotment, net of offering costs
|
2013-09-30 |
| 2013-08-13 | 2491.83 | 未披露 | 定期报告 | 2013-08-12 |
| 2013-08-13 | 2380.33 | 未披露 | 定期报告 | 2013-06-30 |
| 2013-06-20 | 2367.82 | 未披露 |
更多>>
the automatic conversion of all outstanding shares of our preferred stock into an aggregate of 14,170,956 shares of our common stock upon the closing of this offering;
gives effect to a one-for-120 reverse stock split of our common stock that was effected on March 7, 2013.
|
2013-06-20 |
| 2013-05-16 | 0.45 | 1379.60 | 定期报告 | 2013-03-31 |
| 2013-05-16 | 0.45 | 1503.83 |
更多>>
From December 31, 2011 to December 31, 2012
Conversion of Series E and E-2 convertible preferred stock to common stock
Issuance of Series One convertible preferred stock, exchange of Series A—G convertible preferred stock for Series Two and Series Three convertible preferred stock
|
2012-12-31 |
From June 30, 2025 to September 30, 2025
Exercise of options
Restricted stock vesting and issuance, net
From March 31, 2025 to June 30, 2025
Issuance of common stock in connection with an employee stock purchase plan
Restricted stock vesting and issuance, net
Exercise of options
From December 31, 2024 to March 31, 2025
Exercise of options
Restricted stock vesting and issuance, net
From December 31, 2023 to December 31, 2024
Retired Shares
Exercise of options
Restricted stock vesting and issuance, net
Issuance of common stock in connection with an employee stock purchase plan
From June 30, 2024 to September 30, 2024
Retired shares
Exercise of options
Restricted stock vesting and issuance, net
From March 31, 2024 to June 30, 2024
Exercise of options
Restricted stock vesting and issuance, net
Issuance of common stock in connection with an employee stock purchase plan
From December 31, 2023 to March 31, 2024
Exercise of options
Restricted stock vesting and issuance, net
From December 31,2022 to December 31,2023
Issuance of common stock in connection with a milestone payable
Exercise of options
Restricted stock vesting and issuance, net
Issuance of common stock in connection with an employee stock purchase plan
From June 30,2023 to September 30,2023
Exercise of options
Restricted stock vesting and issuance, net
From March 31, 2023 to June 30, 2023
Issuance of common stock in connection with an employee stock purchase plan
Issuance of common stock in connection with a milestone payable
Exercise of options
Restricted stock vesting and issuance, net
From December 31, 2022 to March 31, 2023
Exercise of options
Restricted stock vesting and issuance, net
From December 31, 2021 to December 31, 2022
Issuance of common stock related to stock purchase agreement
Exercise of options
Restricted stock vesting and issuance, net
Issuance of common stock in connection with an employee stock purchase plan
From June 30, 2022 to September 30, 2022
Exercise of options
Restricted stock vesting and issuance, net
From March 31, 2022 to June 30, 2022
Exercise of options
Restricted stock vesting and issuance, net
Issuance of common stock in connection with an employee stock purchase plan
from December 31, 2021 to March 31, 2022
Exercise of options
Restricted stock vesting and issuance, net
from December 31, 2020 to December 31, 2021
Exercise of options
Restricted stock vesting and issuance, net
Issuance of common stock in connection with an employee stock purchase plan
From June 30, 2021 to September 30, 2021
Exercise of options
Restricted stock vesting and issuance, net
From March 31, 2021 to June 30, 2021
Exercise of options
Restricted stock vesting and issuance, net
Issuance of common stock in connection with an employee stock purchase plan
from December 31, 2020 to March 31, 2021
Exercise of options
Restricted stock vesting and issuance, net
From December 31, 2019 to December 31, 2020
Issuance of common stock related to equity offerings
Issuance of common stock related to acquisition
Issuance of common stock related to rights exchange
Exercise of options
Restricted stock vesting and issuance, net
Issuance of common stock in connection with an employee stock purchase plan
From June 30, 2020 to September 30, 2020
Issuance of common stock related to equity offering
Exercise of options
Restricted stock vesting and issuance, net
From March 31, 2020 to June 30, 2020
Issuance of common stock related to equity offering
Issuance of common stock related to acquisition
Issuance of common stock related to rights exchange
Exercise of options
Restricted stock vesting and issuance, net
Issuance of common stock in connection with an employee stock purchase plan
From December 31, 2019 to March 31, 2020
Issuance of common stock related to equity offerings
Exercise of options
Restricted stock vesting and issuance, net
From December 31, 2018 to December 31, 2019
Issuance of common stock related to equity offerings
Exercise of options
Restricted stock vesting and issuance, net
Issuance of common stock in connection with an employee stock purchase plan
from June 30, 2019 to September 30, 2019
Issuance of common stock related to equity offerings
Exercise of options
Restricted stock vesting and issuance, net
from March 31, 2019 to June 30, 2019
Exercise of options
Restricted stock vesting and issuance
Issuance of common stock in connection with an employee stock purchase plan
from December 31, 2018 to March 31, 2019
Issuance of common stock related to equity offering
Exercise of options
Restricted stock vesting and issuance
from December 31, 2017 to December 31, 2018
Issuance of common stock related to equity offering
Issuance of common stock related to acquisition
Exercise of options
Restricted stock vesting and issuance
Issuance of common stock in connection with an employee stock purchase plan
from December 31, 2016 to December 31, 2017
Issuance of common stock related to acquisition
Exercise of options
Restricted stock vesting and issuance
Issuance of common stock in connection with an employee stock purchase plan
from December 31, 2015 to December 31, 2016
Exercise of options
Restricted stock vesting
from December 31, 2014 to December 31, 2015
Exercise of options
Restricted stock vesting
From December 31, 2013 to December 31, 2014
Issuance of common stock from public offerings and exercise of over allotment exercise, net of offering costs
Exercise of options
Restricted stock vesting
From December 31, 2012 to September 30, 2013
Issuance of Series One convertible preferred stock, exchange of Series A—G convertible preferred stock for Series Two and Series Three convertible preferred stock
Conversion of Series Four and Series Five convertible preferred stock
Reverse stock split
Issuance of common stock from IPO and exercise of over allotment, net of offering costs
the automatic conversion of all outstanding shares of our preferred stock into an aggregate of 14,170,956 shares of our common stock upon the closing of this offering;
gives effect to a one-for-120 reverse stock split of our common stock that was effected on March 7, 2013.
From December 31, 2011 to December 31, 2012
Conversion of Series E and E-2 convertible preferred stock to common stock
Issuance of Series One convertible preferred stock, exchange of Series A—G convertible preferred stock for Series Two and Series Three convertible preferred stock