股本结构
单位：万股
| 公告日期 | 2026-04-21 | 2026-04-21 | 2026-02-25 | 2026-02-25 | 2026-02-25 | 2025-10-30 |
|---|---|---|---|---|---|---|
| 证券总股本 | 12562.87 | 12535.05 | 13590.48 | 12534.95 | 12529.48 | 10710.11 |
| 普通股本 | 12562.87 | 12535.05 | 13590.48 | 12534.95 | 12529.48 | 10710.11 |
| 优先股 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2026-04-16 | 2026-03-01 | 2026-02-23 | 2026-02-19 | 2025-12-31 | 2025-09-30 |
注释：中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本（万股） | 变动后优先股（万股） | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2026-04-21 | 12562.87 | 未披露 | 定期报告 | 2026-04-16 |
| 2026-04-21 | 12535.05 | 未披露 | 定期报告 | 2026-03-01 |
| 2026-02-25 | 13590.48 | 未披露 | 定期报告 | 2026-02-23 |
| 2026-02-25 | 12534.95 | 未披露 | 定期报告 | 2026-02-19 |
| 2026-02-25 | 12529.48 | 未披露 | 定期报告 | 2025-12-31 |
| 2025-10-28 | 12167.35 | 未披露 |
更多>>
Common Stock offered 13,700,000 shares by the company
|
2025-11-03 |
| 2025-10-28 | 10797.35 | 未披露 | 定期报告 | 2025-10-23 |
| 2025-10-30 | 10710.11 | 未披露 |
更多>>
From June 30, 2025 to September 30, 2025
Issuance of common stock
|
2025-09-30 |
| 2025-08-06 | 10643.10 | 未披露 | 定期报告 | 2025-08-01 |
| 2025-08-06 | 10640.00 | 未披露 |
更多>>
From March 31, 2025 to June 30, 2025
Issuance of common stock in connection with our equity award programs
|
2025-06-30 |
| 2025-04-22 | 10588.51 | 未披露 | 定期报告 | 2025-04-21 |
| 2025-05-06 | 10590.00 | 未披露 |
更多>>
From December 31, 2024 to March 31, 2025
Issuance of common stock in connection with our equity award programs
Issuance of common stock
|
2025-03-31 |
| 2025-02-25 | 10584.14 | 未披露 | 定期报告 | 2025-02-19 |
| 2025-02-25 | 9220.00 | 未披露 |
更多>>
From December 31, 2023 to December 31, 2024
Issuance of common stock in connection with our equity award programs
Issuance of common stock
|
2024-12-31 |
| 2024-11-06 | 9151.16 | 未披露 | 定期报告 | 2024-10-30 |
| 2025-02-18 | 9150.15 | 未披露 |
更多>>
From June 30, 2024 to September 30, 2024
Issuance of common stock in connection with our equity award programs
|
2024-09-30 |
| 2024-08-08 | 9142.75 | 未披露 | 定期报告 | 2024-08-01 |
| 2024-08-08 | 9130.00 | 未披露 |
更多>>
From March 31, 2024 to June 30, 2024
Issuance of common stock in connection with our equity award programs
|
2024-06-30 |
| 2024-05-08 | 9095.30 | 未披露 | 定期报告 | 2024-05-01 |
| 2024-04-23 | 9095.28 | 未披露 | 定期报告 | 2024-04-09 |
| 2024-05-08 | 9090.00 | 未披露 |
更多>>
From December 31, 2023 to March 31, 2024
Issuance of common stock
Issuance of common stock in connection with our equity award programs
|
2024-03-31 |
| 2024-04-23 | 9086.85 | 未披露 | 定期报告 | 2024-03-01 |
| 2024-02-21 | 9086.48 | 未披露 | 定期报告 | 2024-02-14 |
| 2024-02-21 | 9085.98 | 未披露 | 定期报告 | 2024-02-01 |
| 2024-02-21 | 7550.00 | 未披露 |
更多>>
From December 31, 2022 to December 31, 2023
Issuance of common stock in connection with equity award programs
Issuance of common stock
|
2023-12-31 |
| 2023-11-07 | 7485.56 | 未披露 | 定期报告 | 2023-11-01 |
| 2023-11-07 | 7480.00 | 未披露 |
更多>>
From June 30, 2023 to September 30, 2023
Issuance of common stock
Issuance of common stock in connection with equity award programs
|
2023-09-30 |
| 2023-08-07 | 7450.37 | 未披露 | 定期报告 | 2023-08-02 |
| 2023-08-07 | 7450.00 | 未披露 |
更多>>
From March 31, 2023 to June 30, 2023
Issuance of common stock and rights to purchase additional shares in accordance with the Second Stock Purchase Agreement Amendment
Issuance of common stock in connection with the company's equity award programs
|
2023-06-30 |
| 2023-05-09 | 7310.56 | 未披露 | 定期报告 | 2023-05-03 |
| 2023-04-21 | 7307.79 | 未披露 | 定期报告 | 2023-04-18 |
| 2023-05-09 | 7310.00 | 未披露 |
更多>>
From December 31, 2022 to March 31, 2023
Issuance of common stock in connection with the company's equity award programs
|
2023-03-31 |
| 2023-04-21 | 7301.92 | 未披露 | 定期报告 | 2023-03-01 |
| 2023-02-28 | 7301.13 | 未披露 | 定期报告 | 2023-02-17 |
| 2023-02-28 | 7291.51 | 未披露 |
更多>>
From December 31, 2021 to December 31, 2022
Issuance of common stock in connection with the company's equity award programs
|
2022-12-31 |
| 2022-11-02 | 7240.77 | 未披露 | 定期报告 | 2022-10-28 |
| 2022-11-02 | 7235.24 | 未披露 |
更多>>
From June 30, 2022 to September 30, 2022
Issuance of common stock upon exercise of stock options and vesting of restricted stock
|
2022-09-30 |
| 2022-08-03 | 7216.00 | 未披露 | 定期报告 | 2022-07-29 |
| 2022-08-03 | 7208.55 | 未披露 |
更多>>
From March 31, 2022 to June 30, 2022
Issuance of common stock under Employee Stock Purchase Plan
Issuance of common stock upon exercise of stock options and vesting of restricted stock
|
2022-06-30 |
| 2022-05-09 | 7171.86 | 未披露 | 定期报告 | 2022-04-29 |
| 2022-04-20 | 7170.90 | 未披露 | 定期报告 | 2022-04-18 |
| 2022-05-09 | 7162.23 | 未披露 |
更多>>
From December 31, 2021 to March 31, 2022
Issuance of common stock upon exercise of stock options and vesting of restricted stock
Vesting of early exercised stock options
|
2022-03-31 |
| 2022-04-20 | 7124.34 | 未披露 | 定期报告 | 2022-03-01 |
| 2022-02-23 | 7106.19 | 未披露 | 定期报告 | 2022-02-12 |
| 2022-02-23 | 7078.17 | 未披露 |
更多>>
From December 31, 2020 to December 31, 2021
Issuance of common stock and rights to purchase additional shares in accordance with Amended and Restated Gilead Purchase Agreement, net of $55 offering costs
Issuance of common stock upon exercise of stock options and vesting of restricted stock
Vesting of early exercised stock options
Issuance of common stock under Employee Stock Purchase Plan
|
2021-12-31 |
| 2021-11-08 | 7024.95 | 未披露 | 定期报告 | 2021-10-29 |
| 2021-11-08 | 7024.16 | 未披露 |
更多>>
From June 30, 2021 to September 30, 2021
Issuance of common stock upon exercise of stock options and vesting of restricted stock
Vesting of early exercised stock options
|
2021-09-30 |
| 2021-08-05 | 7139.40 | 未披露 | 定期报告 | 2021-07-30 |
| 2021-08-05 | 7137.41 | 未披露 |
更多>>
From March 31, 2021 to June 30, 2021
Issuance of common stock upon exercise of stock options and vesting of restricted stock
Vesting of early exercised stock options
Issuance of common stock under Employee Stock Purchase Plan
|
2021-06-30 |
| 2021-05-05 | 7099.59 | 未披露 | 定期报告 | 2021-04-30 |
| 2021-04-20 | 7099.11 | 未披露 | 定期报告 | 2021-04-09 |
| 2021-05-05 | 7096.55 | 未披露 |
更多>>
from December 31, 2020 to March 31, 2021
Issuance of common stock and rights to purchase additional shares in accordance with Amended and Restated Gilead Purchase Agreement, net of $55 offering costs
Issuance of common stock upon exercise of stock options and vesting of restricted stock
Vesting of early exercised stock options
|
2021-03-31 |
| 2021-04-20 | 7088.72 | 未披露 | 定期报告 | 2021-03-01 |
| 2021-02-25 | 7087.62 | 未披露 | 定期报告 | 2021-02-12 |
| 2021-02-25 | 6511.47 | 未披露 |
更多>>
From December 31, 2019 to December 31, 2020
Issuance of common stock in public offering, net of $21,629 offering costs(2,200,000 shares and $56,738, net of $3,762 offering costs, from a related party)
Issuance of common stock and rights to purchase additional shares in accordance with Gilead Stock Purchase Agreement, net of $1,931 offering costs
Issuance of common stock upon exercise of stock options and vesting of restricted stock
Vesting of early exercised stock options
Issuance of common stock under Employee Stock Purchase Plan
|
2020-12-31 |
| 2020-11-05 | 6492.33 | 未披露 | 定期报告 | 2020-10-31 |
| 2020-11-05 | 6492.41 | 未披露 |
更多>>
From June 30, 2020 to September 30, 2020
Issuance of common stock and rights to purchase additional shares in accordance with Gilead Purchase Agreement, net of $1,931,000 offering costs
Issuance of common stock upon exercise of stock options
Vesting of early exercised stock options and restricted stock
|
2020-09-30 |
| 2020-08-06 | 6490.63 | 未披露 | 定期报告 | 2020-07-31 |
| 2020-08-06 | 5894.09 | 未披露 |
更多>>
From March 31, 2020 to June 30, 2020
Issuance of common stock in public offering, net of $21,629 offering costs
Issuance of common stock upon exercise of stock options
Vesting of early exercised stock options and restricted stock
Issuance of common stock under Employee Stock Purchase Plan
|
2020-06-30 |
| 2020-06-02 | 5698.28 | 未披露 |
更多>>
1.Common stock offered by us 11,000,000 shares
2.The number of shares of common stock to be outstanding after the offering is based on the number of shares outstanding as of March 31, 2020
|
2020-06-02 |
| 2020-05-05 | 4604.60 | 未披露 | 定期报告 | 2020-04-30 |
| 2020-04-21 | 4598.47 | 未披露 | 定期报告 | 2020-04-09 |
| 2020-05-05 | 4598.28 | 未披露 |
更多>>
From December 31, 2019 to March 31, 2020
Issuance of common stock upon exercise of stock options
Vesting of early exercised stock options and restricted stock
|
2020-03-31 |
| 2020-03-05 | 4597.42 | 未披露 | 定期报告 | 2020-02-28 |
| 2020-03-05 | 4592.50 | 未披露 |
更多>>
from December 31, 2018 to December 31, 2019
Issuance of common stock upon exercise of stock options, net of amounts related to unvested shares
Vesting of early exercised stock options and restricted stock
Issuance of common stock under Employee Stock Purchase Plan
|
2019-12-31 |
| 2019-11-05 | 4585.90 | 未披露 | 定期报告 | 2019-10-30 |
| 2019-11-05 | 4584.30 | 未披露 |
更多>>
from June 30, 2019 to September 30, 2019
Issuance of common stock upon exercise of stock options
Vesting of early exercised stock options and restricted stock
|
2019-09-30 |
| 2019-08-06 | 4584.92 | 未披露 | 定期报告 | 2019-07-30 |
| 2019-08-06 | 4585.42 | 未披露 |
更多>>
fro March 31, 2019 to June 30, 2019
Issuance of common stock upon exercise of stock options
Vesting of early exercised stock options and restricted stock
Issuance of common stock under Employee Stock Purchase Plan
|
2019-06-30 |
| 2019-05-02 | 4453.50 | 未披露 | 定期报告 | 2019-04-29 |
| 2019-04-22 | 4451.33 | 未披露 | 定期报告 | 2019-04-15 |
| 2019-05-02 | 4453.46 | 未披露 |
更多>>
from December 31, 2018 to March 31, 2019
Issuance of common stock upon exercise of stock options
Vesting of early exercised stock options and restricted stock
|
2019-03-31 |
| 2019-03-05 | 4453.46 | 未披露 | 定期报告 | 2019-03-01 |
| 2019-03-05 | 4453.79 | 未披露 |
更多>>
from December 31, 2017 to December 31, 2018
Conversion of preferred stock to common stock
Issuance of common stock upon IPO
Issuance of common stock upon exercise of stock options, net of amounts related to unvested shares
Vesting of early exercised stock options and restricted stock
Issuance of common stock under Employee Stock Purchase Plan
|
2018-12-31 |
| 2018-11-08 | 4445.37 | 未披露 | 定期报告 | 2018-09-30 |
| 2018-08-06 | 4445.67 | 未披露 | 定期报告 | 2018-06-30 |
| 2018-05-09 | 4445.43 | 未披露 | 定期报告 | 2018-03-31 |
| 2018-03-16 | 4255.05 | 未披露 |
更多>>
1.Shares of common stock offering 8,000,000 shares
2.The number of shares of common stock to be outstanding after this offering is based on 34,550,472 shares of common stock outstanding as of December 31, 2017
3.a 1-for-3.96 reverse stock split of our common stock and preferred stock effected on March 9, 2018
|
2018-03-15 |
| 2018-03-05 | 409.09 | 未披露 | 定期报告 | 2017-12-31 |
Common Stock offered 13,700,000 shares by the company
From June 30, 2025 to September 30, 2025
Issuance of common stock
From March 31, 2025 to June 30, 2025
Issuance of common stock in connection with our equity award programs
From December 31, 2024 to March 31, 2025
Issuance of common stock in connection with our equity award programs
Issuance of common stock
From December 31, 2023 to December 31, 2024
Issuance of common stock in connection with our equity award programs
Issuance of common stock
From June 30, 2024 to September 30, 2024
Issuance of common stock in connection with our equity award programs
From March 31, 2024 to June 30, 2024
Issuance of common stock in connection with our equity award programs
From December 31, 2023 to March 31, 2024
Issuance of common stock
Issuance of common stock in connection with our equity award programs
From December 31, 2022 to December 31, 2023
Issuance of common stock in connection with equity award programs
Issuance of common stock
From June 30, 2023 to September 30, 2023
Issuance of common stock
Issuance of common stock in connection with equity award programs
From March 31, 2023 to June 30, 2023
Issuance of common stock and rights to purchase additional shares in accordance with the Second Stock Purchase Agreement Amendment
Issuance of common stock in connection with the company's equity award programs
From December 31, 2022 to March 31, 2023
Issuance of common stock in connection with the company's equity award programs
From December 31, 2021 to December 31, 2022
Issuance of common stock in connection with the company's equity award programs
From June 30, 2022 to September 30, 2022
Issuance of common stock upon exercise of stock options and vesting of restricted stock
From March 31, 2022 to June 30, 2022
Issuance of common stock under Employee Stock Purchase Plan
Issuance of common stock upon exercise of stock options and vesting of restricted stock
From December 31, 2021 to March 31, 2022
Issuance of common stock upon exercise of stock options and vesting of restricted stock
Vesting of early exercised stock options
From December 31, 2020 to December 31, 2021
Issuance of common stock and rights to purchase additional shares in accordance with Amended and Restated Gilead Purchase Agreement, net of $55 offering costs
Issuance of common stock upon exercise of stock options and vesting of restricted stock
Vesting of early exercised stock options
Issuance of common stock under Employee Stock Purchase Plan
From June 30, 2021 to September 30, 2021
Issuance of common stock upon exercise of stock options and vesting of restricted stock
Vesting of early exercised stock options
From March 31, 2021 to June 30, 2021
Issuance of common stock upon exercise of stock options and vesting of restricted stock
Vesting of early exercised stock options
Issuance of common stock under Employee Stock Purchase Plan
from December 31, 2020 to March 31, 2021
Issuance of common stock and rights to purchase additional shares in accordance with Amended and Restated Gilead Purchase Agreement, net of $55 offering costs
Issuance of common stock upon exercise of stock options and vesting of restricted stock
Vesting of early exercised stock options
From December 31, 2019 to December 31, 2020
Issuance of common stock in public offering, net of $21,629 offering costs(2,200,000 shares and $56,738, net of $3,762 offering costs, from a related party)
Issuance of common stock and rights to purchase additional shares in accordance with Gilead Stock Purchase Agreement, net of $1,931 offering costs
Issuance of common stock upon exercise of stock options and vesting of restricted stock
Vesting of early exercised stock options
Issuance of common stock under Employee Stock Purchase Plan
From June 30, 2020 to September 30, 2020
Issuance of common stock and rights to purchase additional shares in accordance with Gilead Purchase Agreement, net of $1,931,000 offering costs
Issuance of common stock upon exercise of stock options
Vesting of early exercised stock options and restricted stock
From March 31, 2020 to June 30, 2020
Issuance of common stock in public offering, net of $21,629 offering costs
Issuance of common stock upon exercise of stock options
Vesting of early exercised stock options and restricted stock
Issuance of common stock under Employee Stock Purchase Plan
1.Common stock offered by us 11,000,000 shares
2.The number of shares of common stock to be outstanding after the offering is based on the number of shares outstanding as of March 31, 2020
From December 31, 2019 to March 31, 2020
Issuance of common stock upon exercise of stock options
Vesting of early exercised stock options and restricted stock
from December 31, 2018 to December 31, 2019
Issuance of common stock upon exercise of stock options, net of amounts related to unvested shares
Vesting of early exercised stock options and restricted stock
Issuance of common stock under Employee Stock Purchase Plan
from June 30, 2019 to September 30, 2019
Issuance of common stock upon exercise of stock options
Vesting of early exercised stock options and restricted stock
fro March 31, 2019 to June 30, 2019
Issuance of common stock upon exercise of stock options
Vesting of early exercised stock options and restricted stock
Issuance of common stock under Employee Stock Purchase Plan
from December 31, 2018 to March 31, 2019
Issuance of common stock upon exercise of stock options
Vesting of early exercised stock options and restricted stock
from December 31, 2017 to December 31, 2018
Conversion of preferred stock to common stock
Issuance of common stock upon IPO
Issuance of common stock upon exercise of stock options, net of amounts related to unvested shares
Vesting of early exercised stock options and restricted stock
Issuance of common stock under Employee Stock Purchase Plan
1.Shares of common stock offering 8,000,000 shares
2.The number of shares of common stock to be outstanding after this offering is based on 34,550,472 shares of common stock outstanding as of December 31, 2017
3.a 1-for-3.96 reverse stock split of our common stock and preferred stock effected on March 9, 2018