股本结构
单位：万股
| 公告日期 | 2026-03-03 | 2026-03-03 | 2025-11-04 | 2025-11-04 | 2025-08-05 | 2025-08-05 |
|---|---|---|---|---|---|---|
| 证券总股本 | 1847.31 | 1831.09 | 1815.13 | 1814.40 | 1793.73 | 1793.71 |
| 普通股本 | 1847.31 | 1831.09 | 1815.13 | 1814.40 | 1793.73 | 1793.71 |
| 优先股 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2026-02-25 | 2025-12-31 | 2025-10-30 | 2025-09-30 | 2025-07-31 | 2025-06-30 |
注释：中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本（万股） | 变动后优先股（万股） | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2026-03-03 | 1847.31 | 未披露 | 定期报告 | 2026-02-25 |
| 2026-03-03 | 1831.09 | 未披露 |
更多>>
From December 31, 2024 to December 31, 2025
Issuance of common stock upon exercise of options, net of shares withheld, and participation in Purchase Plan
Issuance of common stock upon vesting of RSUs
|
2025-12-31 |
| 2025-11-04 | 1815.13 | 未披露 | 定期报告 | 2025-10-30 |
| 2025-11-04 | 1814.40 | 未披露 |
更多>>
From June 30, 2025 to September 30, 2025
Issuance of common stock upon exercise of options
|
2025-09-30 |
| 2025-08-05 | 1793.73 | 未披露 | 定期报告 | 2025-07-31 |
| 2025-08-05 | 1793.71 | 未披露 |
更多>>
From March 31, 2025 to June 30, 2025
Issuance of common stock upon exercise of options, net of shares withheld, and participation in Purchase Plan
Issuance of common stock upon vesting of RSUs
|
2025-06-30 |
| 2025-05-06 | 1787.24 | 未披露 | 定期报告 | 2025-05-01 |
| 2025-04-10 | 1786.69 | 未披露 | 定期报告 | 2025-03-25 |
| 2025-03-04 | 1786.30 | 未披露 | 定期报告 | 2025-02-25 |
| 2025-04-10 | 1773.29 | 未披露 | 定期报告 | 2025-01-31 |
| 2025-03-04 | 1771.02 | 未披露 |
更多>>
From December 31, 2023 to December 31, 2024
Issuance of common stock upon exercise of options and participation in Purchase Plan
Issuance of common stock upon vesting of RSUs
|
2024-12-31 |
| 2024-11-07 | 1761.50 | 未披露 | 定期报告 | 2024-11-04 |
| 2024-11-07 | 1761.30 | 未披露 |
更多>>
From June 30, 2024 to September 30, 2024
Issuance of common stock upon exercise of options
Issuance of common stock upon vesting of RSUs
|
2024-09-30 |
| 2024-08-06 | 1759.50 | 未披露 | 定期报告 | 2024-08-01 |
| 2024-08-06 | 1759.41 | 未披露 |
更多>>
From March 31, 2024 to June 30, 2024
Issuance of common stock upon exercise of options and participation in Purchase Plan
Issuance of common stock upon vesting of RSUs
|
2024-06-30 |
| 2024-06-25 | 1755.83 | 未披露 |
更多>>
1-for-10 the Reverse Stock Split
|
2024-06-27 |
| 2024-06-25 | 17558.29 | 未披露 | 定期报告 | 2024-06-25 |
| 2024-05-07 | 17540.61 | 未披露 |
更多>>
From January 1, 2024 to March 31, 2024
Issuance of common stock upon exercise of options
Issuance of common stock upon vesting of restricted stock units (RSUs)
|
2024-03-31 |
| 2024-04-10 | 17540.47 | 未披露 | 定期报告 | 2024-03-25 |
| 2024-03-05 | 17537.78 | 未披露 | 定期报告 | 2024-02-28 |
| 2024-04-10 | 17488.50 | 未披露 | 定期报告 | 2024-01-31 |
| 2024-03-05 | 17482.56 | 未披露 |
更多>>
From December 31,2022 to December 31,2023
Issuance of common stock upon exercise of options and participation in Purchase Plan
Issuance of common stock upon vesting of RSUs
|
2023-12-31 |
| 2023-11-07 | 17436.95 | 未披露 | 定期报告 | 2023-11-02 |
| 2023-11-07 | 17436.72 | 未披露 |
更多>>
From June 30, 2023 to September 30, 2023
Issuance of common stock upon exercise of options
|
2023-09-30 |
| 2023-08-01 | 17436.43 | 未披露 | 定期报告 | 2023-07-27 |
| 2023-08-01 | 17435.84 | 未披露 |
更多>>
From March 31,2023 to June 30,2023
Issuance of common stock upon exercise of options and participation in Purchase Plan
Issuance of common stock upon vesting of RSUs
|
2023-06-30 |
| 2023-05-02 | 17366.68 | 未披露 | 定期报告 | 2023-04-27 |
| 2023-05-02 | 17366.59 | 未披露 |
更多>>
From January 1, 2023 to March 31, 2023
Issuance of common stock upon exercise of options
Issuance of common stock upon vesting of restricted stock units (RSUs)
|
2023-03-31 |
| 2023-03-07 | 17365.34 | 未披露 | 定期报告 | 2023-02-28 |
| 2023-03-07 | 17339.86 | 未披露 |
更多>>
From December 31, 2021 to December 31, 2022
Issuance of common stock upon exercise of options and participation in Purchase Plan
Issuance of common stock upon vesting of restricted stock units (RSUs)
|
2022-12-31 |
| 2022-08-02 | 17283.63 | 未披露 |
更多>>
From March 31, 2022 to June 30, 2022
Issuance of common stock upon exercise of options and participation in Purchase Plan
Issuance of common stock upon vesting of restricted stock units
|
2022-06-30 |
| 2022-05-03 | 17205.22 | 未披露 | 定期报告 | 2022-04-29 |
| 2022-05-03 | 17204.52 | 未披露 |
更多>>
from January 1, 2022 to March 31, 2022
Issuance of common stock upon exercise of options
Issuance of common stock upon vesting of restricted stock units
|
2022-03-31 |
| 2022-04-05 | 17198.86 | 未披露 | 定期报告 | 2022-03-21 |
| 2022-03-01 | 17168.35 | 未披露 | 定期报告 | 2022-02-24 |
| 2022-03-01 | 17160.22 | 未披露 |
更多>>
From December 31, 2020 to December 31, 2021
Issuance of common stock upon exercise of options and participation in Purchase Plan
|
2021-12-31 |
| 2021-11-02 | 17100.61 | 未披露 | 定期报告 | 2021-10-29 |
| 2021-11-02 | 17096.97 | 未披露 |
更多>>
From June 30, 2021 to September 30, 2021
Issuance of common stock upon exercise of options
|
2021-09-30 |
| 2021-08-03 | 17085.03 | 未披露 | 定期报告 | 2021-07-30 |
| 2021-08-03 | 17084.25 | 未披露 |
更多>>
From March 31, 2021 to June 30, 2021
Issuance of common stock upon exercise of options and participation in Purchase Plan
|
2021-06-30 |
| 2021-05-05 | 17016.43 | 未披露 | 定期报告 | 2021-04-30 |
| 2021-05-05 | 17013.06 | 未披露 |
更多>>
from January 1, 2021 to March 31, 2021
Issuance of common stock upon exercise of options
|
2021-03-31 |
| 2021-04-06 | 17012.06 | 未披露 | 定期报告 | 2021-03-19 |
| 2021-03-02 | 17004.18 | 未披露 | 定期报告 | 2021-02-23 |
| 2021-04-06 | 16946.32 | 未披露 | 定期报告 | 2021-01-31 |
| 2021-03-02 | 16931.68 | 未披露 |
更多>>
From December 31,2019 to December 31,2020
Issuance of common stock upon exercise of options and participation in Purchase Plan
|
2020-12-31 |
| 2020-11-05 | 16898.14 | 未披露 | 定期报告 | 2020-10-30 |
| 2020-11-05 | 16894.34 | 未披露 |
更多>>
From June 30, 2020 to September 30, 2020
Issuance of common stock upon exercise of options
|
2020-09-30 |
| 2020-08-04 | 16892.89 | 未披露 | 定期报告 | 2020-08-01 |
| 2020-08-04 | 16891.76 | 未披露 |
更多>>
From March 31, 2020 to June 30, 2020
Issuance of common stock upon participation in Purchase Plan
|
2020-06-30 |
| 2020-05-05 | 16856.95 | 未披露 |
更多>>
From December 31, 2019 to February 20, 2020
Issuance of common stock upon exercise of options
|
2020-02-20 |
| 2020-02-27 | 16798.79 | 未披露 |
更多>>
From December 31, 2018 to December 31, 2019
Issuance of common stock upon exercise of options and participation in Purchase Plan
|
2019-12-31 |
| 2019-11-05 | 16761.05 | 未披露 | 定期报告 | 2019-11-01 |
| 2019-11-05 | 16760.90 | 未披露 |
更多>>
from June 30, 2019 to August 1, 2019
Issuance of common stock upon exercise of options and participation in Purchase Plan
|
2019-08-01 |
| 2019-08-06 | 16760.44 | 未披露 |
更多>>
from March 31, 2019 to June 30, 2019
Issuance of common stock upon exercise of options and participation in Purchase Plan
|
2019-06-30 |
| 2019-05-07 | 16719.34 | 未披露 | 定期报告 | 2019-05-01 |
| 2019-05-07 | 16717.91 | 未披露 |
更多>>
from January 1, 2019 to March 28, 2019
Issuance of common stock upon exercise of options and participation in Purchase Plan
|
2019-03-28 |
| 2019-02-28 | 16717.15 | 未披露 |
更多>>
from December 31, 2017 to December 31, 2018
Issuance of common stock upon exercise of options and participation in Purchase Plan
Issuance of common stock, net of offering costs
|
2018-12-31 |
| 2018-11-06 | 16664.05 | 未披露 | 定期报告 | 2018-11-01 |
| 2018-08-08 | 16644.34 | 未披露 | 定期报告 | 2018-08-02 |
| 2018-05-01 | 16358.03 | 未披露 | 定期报告 | 2018-04-26 |
| 2018-03-29 | 14736.91 | 未披露 | 定期报告 | 2018-03-26 |
| 2018-03-23 | 14725.41 | 未披露 | 定期报告 | 2018-03-15 |
| 2018-03-06 | 14710.79 | 未披露 | 定期报告 | 2018-02-27 |
| 2018-03-06 | 14681.49 | 未披露 |
更多>>
from December 31, 2016 to December 31, 2017
Issuance of common stock upon exercise of options and participation in Purchase Plan
Issuance of common stock, net of offering costs
|
2017-12-31 |
| 2017-11-07 | 14649.11 | 未披露 | 定期报告 | 2017-11-01 |
| 2017-08-01 | 12439.30 | 未披露 | 定期报告 | 2017-07-26 |
| 2017-05-02 | 12243.44 | 未披露 | 定期报告 | 2017-04-26 |
| 2017-03-29 | 12228.69 | 未披露 | 定期报告 | 2017-03-17 |
| 2017-03-07 | 12228.59 | 未披露 | 定期报告 | 2017-03-01 |
| 2017-03-07 | 9926.94 | 未披露 |
更多>>
from December 31, 2015 to December 31, 2016
Issuance of common stock upon exercise of options and participation in Purchase Plan
Issuance of common stock, net of offering costs
|
2016-12-31 |
| 2016-11-01 | 9893.72 | 未披露 | 定期报告 | 2016-10-26 |
| 2016-08-02 | 9458.96 | 未披露 | 定期报告 | 2016-07-27 |
| 2016-05-03 | 9214.44 | 未披露 | 定期报告 | 2016-04-28 |
| 2016-03-08 | 9055.63 | 未披露 | 定期报告 | 2016-02-29 |
| 2016-03-08 | 9055.46 | 未披露 |
更多>>
from December 31, 2014 to December 31, 2015
Issuance of common stock upon exercise of options and participation in Purchase Plan
Issuance of common stock, net of offering costs
|
2015-12-31 |
| 2015-11-03 | 8852.59 | 未披露 | 定期报告 | 2015-10-29 |
| 2015-08-04 | 8850.42 | 未披露 | 定期报告 | 2015-07-30 |
| 2015-05-07 | 8814.38 | 未披露 | 定期报告 | 2015-05-04 |
| 2015-03-30 | 8804.85 | 未披露 | 定期报告 | 2015-03-18 |
| 2015-03-03 | 8804.36 | 未披露 | 定期报告 | 2015-02-25 |
| 2015-03-03 | 8804.14 | 未披露 |
更多>>
from December 31, 2013 to December 31, 2014
Issuance of common stock upon exercise of options and participation in Purchase Plan
|
2014-12-31 |
| 2014-08-05 | 8779.27 | 未披露 | 定期报告 | 2014-07-30 |
| 2014-04-08 | 8753.13 | 未披露 | 定期报告 | 2014-03-21 |
| 2014-03-04 | 8752.43 | 未披露 |
更多>>
from December 31, 2012 to December 31, 2013
Issuance of common stock upon exercise of options and participation in Purchase Plan
|
2013-12-31 |
| 2013-08-06 | 8743.03 | 未披露 | 定期报告 | 2013-07-31 |
| 2013-03-05 | 8714.06 | 未披露 |
更多>>
from December 31, 2011 to December 31, 2012
Issuance of common stock at $9.50 per share for cash, net of issuance costs
Issuance of common stock upon exercise of options and participation in Purchase Plan
|
2012-12-31 |
| 2012-11-06 | 8700.03 | 未披露 | 定期报告 | 2012-10-31 |
| 2012-11-06 | 7176.01 | 未披露 | 定期报告 | 2012-09-30 |
| 2012-08-07 | 7162.66 | 未披露 | 定期报告 | 2012-08-02 |
| 2012-08-07 | 7159.51 | 未披露 | 定期报告 | 2012-06-30 |
| 2012-05-01 | 7145.45 | 未披露 | 定期报告 | 2012-04-25 |
| 2012-05-01 | 7145.12 | 未披露 | 定期报告 | 2012-03-31 |
| 2012-03-06 | 7144.18 | 未披露 | 定期报告 | 2012-02-29 |
| 2012-03-06 | 7137.91 | 未披露 |
更多>>
from December 31, 2010 to December 31, 2011
Issuance of common stock at $8.00 per share for cash, net of issuance costs
Issuance of common stock upon exercise of options and participation in Purchase Plan
|
2011-12-31 |
| 2011-11-01 | 7124.35 | 未披露 | 定期报告 | 2011-10-26 |
| 2011-11-01 | 7123.32 | 未披露 | 定期报告 | 2011-09-30 |
| 2011-08-02 | 7122.37 | 未披露 | 定期报告 | 2011-07-27 |
| 2011-08-02 | 7120.30 | 未披露 | 定期报告 | 2011-06-30 |
| 2011-05-03 | 5229.37 | 未披露 | 定期报告 | 2011-04-28 |
| 2011-05-03 | 5227.91 | 未披露 | 定期报告 | 2011-03-31 |
| 2011-03-01 | 5227.35 | 未披露 | 定期报告 | 2011-02-23 |
| 2011-03-01 | 5227.12 | 未披露 |
更多>>
from December 31, 2009 to December 31, 2010
Issuance of common stock upon exercise of options and participation in Purchase Plan
|
2010-12-31 |
| 2010-11-02 | 5214.84 | 未披露 | 定期报告 | 2010-10-28 |
| 2010-11-02 | 5214.52 | 未披露 | 定期报告 | 2010-09-30 |
| 2010-08-03 | 5212.70 | 未披露 | 定期报告 | 2010-07-29 |
| 2010-08-03 | 5211.04 | 未披露 | 定期报告 | 2010-06-30 |
| 2010-05-04 | 5197.04 | 未披露 | 定期报告 | 2010-04-28 |
| 2010-05-04 | 5196.91 | 未披露 | 定期报告 | 2010-03-31 |
| 2010-03-02 | 5196.52 | 未披露 | 定期报告 | 2010-02-23 |
| 2010-03-02 | 5195.61 | 未披露 |
更多>>
from December 31, 2008 to December 31, 2009
Issuance of common stock at $7.25 per share for cash, net of issuance costs
Issuance of common stock upon exercise of options and participation in Purchase Plan
|
2009-12-31 |
| 2009-02-27 | 3670.09 | 未披露 | 定期报告 | 2009-02-20 |
| 2009-02-27 | 3664.64 | 未披露 |
更多>>
from December 31, 2007 to December 31, 2008
Issuance of common stock at $27.00 per share for cash, net of issuance costs
Issuance of common stock upon exercise of options and participation in Purchase Plan
|
2008-12-31 |
| 2008-03-07 | 3647.11 | 未披露 | 定期报告 | 2008-02-29 |
| 2008-03-07 | 3138.18 | 未披露 |
更多>>
from December 31, 2006 to December 31, 2007
Issuance of common stock at $9.75 per share for cash, net of issuance costs
Issuance of common stock upon exercise of options and participation in Purchase Plan
|
2007-12-31 |
| 2007-03-08 | 2518.52 | 未披露 | 定期报告 | 2007-02-27 |
| 2007-03-08 | 2518.07 | 未披露 |
更多>>
from December 31, 2005 to December 31, 2006
Issuance of common stock upon exercise of options and participation in Purchase Plan
|
2006-12-31 |
| 2006-03-08 | 2481.66 | 未披露 | 定期报告 | 2006-02-28 |
| 2006-03-08 | 2481.47 | 未披露 |
更多>>
from December 31, 2004 to December 31, 2005
Issuance of common stock at $20.75 per share for cash, net of issuance costs
Issuance of common stock upon exercise of Options, participation in Purchase Plan and net exercise of a warrant
Issuance of common stock at $27.47 per share to Serono
Issuance of common stock at $26.22 per share to Pfizer
|
2005-12-31 |
| 2005-03-16 | 1967.03 | 未披露 | 定期报告 | 2005-02-28 |
| 2005-03-16 | 1966.13 | 未披露 |
更多>>
from December 31, 2003 to December 31, 2004
Issuance of common stock at $20.00 per share for cash, net of issuance costs
Issuance of common stock upon exercise of options and participation in Purchase Plan
Issuance of common stock upon cash exercise of warrants at $5.76
Issuance of common stock upon net exercise of warrants at $5.76
Issuance of common stock upon net exercise of warrants
|
2004-12-31 |
| 2004-03-12 | 1790.35 | 未披露 | 定期报告 | 2004-02-27 |
| 2004-03-12 | 1482.85 | 未披露 |
更多>>
from December 31, 2002 to December 31, 2003
Issuance of common stock at $5.76 per share for cash, net of issuance costs
Fractional shares adjustment upon reverse split
The sales prices in the above table reflect a one-for-nine reverse split of shares of our outstanding common stock effected on June 24, 2003.
Issuance of common stock upon exercise of options and participation in Purchase Plan
|
2003-12-31 |
| 2003-03-31 | 4597.68 | 未披露 | 定期报告 | 2003-03-14 |
| 2003-03-31 | 4570.22 | 未披露 |
更多>>
from December 31, 2001 to December 31, 2002
Issuance of common stock at $4.50 per share for cash, net of issuance costs
Issuance of common stock at $4.30 per share for cash, net of issuance costs
Issuance of common stock upon exercise of options and participation in Purchase Plan
|
2002-12-31 |
| 2002-03-29 | 4529.87 | 未披露 | 定期报告 | 2002-03-15 |
| 2002-03-29 | 3773.22 | 未披露 |
更多>>
from December 31, 2000 to December 31, 2001
Issuance of common stock upon exercise of options and participation in Purchase Plan
|
2001-12-31 |
| 2001-03-30 | 3690.74 | 未披露 | 定期报告 | 2001-03-15 |
| 2001-03-30 | 3680.42 | 未披露 |
更多>>
from December 31, 1999 to December 31, 2000
Issuance of Series E preferred stock at $6.00 per share for cash, net of issuance cost
Issuance of Series E preferred stock in exchange for a technology license
Issuance of Series D preferred stock upon exercise of warrant at $2.00 per share
Conversion of preferred stock to common stock up closing of initial public offering
Issuance of common stock at $7.00 per share for cash, net of issuance costs
Issuance of common stock upon exercise of options
Issuance of common stock for services
|
2000-12-31 |
From December 31, 2024 to December 31, 2025
Issuance of common stock upon exercise of options, net of shares withheld, and participation in Purchase Plan
Issuance of common stock upon vesting of RSUs
From June 30, 2025 to September 30, 2025
Issuance of common stock upon exercise of options
From March 31, 2025 to June 30, 2025
Issuance of common stock upon exercise of options, net of shares withheld, and participation in Purchase Plan
Issuance of common stock upon vesting of RSUs
From December 31, 2023 to December 31, 2024
Issuance of common stock upon exercise of options and participation in Purchase Plan
Issuance of common stock upon vesting of RSUs
From June 30, 2024 to September 30, 2024
Issuance of common stock upon exercise of options
Issuance of common stock upon vesting of RSUs
From March 31, 2024 to June 30, 2024
Issuance of common stock upon exercise of options and participation in Purchase Plan
Issuance of common stock upon vesting of RSUs
1-for-10 the Reverse Stock Split
From January 1, 2024 to March 31, 2024
Issuance of common stock upon exercise of options
Issuance of common stock upon vesting of restricted stock units (RSUs)
From December 31,2022 to December 31,2023
Issuance of common stock upon exercise of options and participation in Purchase Plan
Issuance of common stock upon vesting of RSUs
From June 30, 2023 to September 30, 2023
Issuance of common stock upon exercise of options
From March 31,2023 to June 30,2023
Issuance of common stock upon exercise of options and participation in Purchase Plan
Issuance of common stock upon vesting of RSUs
From January 1, 2023 to March 31, 2023
Issuance of common stock upon exercise of options
Issuance of common stock upon vesting of restricted stock units (RSUs)
From December 31, 2021 to December 31, 2022
Issuance of common stock upon exercise of options and participation in Purchase Plan
Issuance of common stock upon vesting of restricted stock units (RSUs)
From March 31, 2022 to June 30, 2022
Issuance of common stock upon exercise of options and participation in Purchase Plan
Issuance of common stock upon vesting of restricted stock units
from January 1, 2022 to March 31, 2022
Issuance of common stock upon exercise of options
Issuance of common stock upon vesting of restricted stock units
From December 31, 2020 to December 31, 2021
Issuance of common stock upon exercise of options and participation in Purchase Plan
From June 30, 2021 to September 30, 2021
Issuance of common stock upon exercise of options
From March 31, 2021 to June 30, 2021
Issuance of common stock upon exercise of options and participation in Purchase Plan
from January 1, 2021 to March 31, 2021
Issuance of common stock upon exercise of options
From December 31,2019 to December 31,2020
Issuance of common stock upon exercise of options and participation in Purchase Plan
From June 30, 2020 to September 30, 2020
Issuance of common stock upon exercise of options
From March 31, 2020 to June 30, 2020
Issuance of common stock upon participation in Purchase Plan
From December 31, 2019 to February 20, 2020
Issuance of common stock upon exercise of options
From December 31, 2018 to December 31, 2019
Issuance of common stock upon exercise of options and participation in Purchase Plan
from June 30, 2019 to August 1, 2019
Issuance of common stock upon exercise of options and participation in Purchase Plan
from March 31, 2019 to June 30, 2019
Issuance of common stock upon exercise of options and participation in Purchase Plan
from January 1, 2019 to March 28, 2019
Issuance of common stock upon exercise of options and participation in Purchase Plan
from December 31, 2017 to December 31, 2018
Issuance of common stock upon exercise of options and participation in Purchase Plan
Issuance of common stock, net of offering costs
from December 31, 2016 to December 31, 2017
Issuance of common stock upon exercise of options and participation in Purchase Plan
Issuance of common stock, net of offering costs
from December 31, 2015 to December 31, 2016
Issuance of common stock upon exercise of options and participation in Purchase Plan
Issuance of common stock, net of offering costs
from December 31, 2014 to December 31, 2015
Issuance of common stock upon exercise of options and participation in Purchase Plan
Issuance of common stock, net of offering costs
from December 31, 2013 to December 31, 2014
Issuance of common stock upon exercise of options and participation in Purchase Plan
from December 31, 2012 to December 31, 2013
Issuance of common stock upon exercise of options and participation in Purchase Plan
from December 31, 2011 to December 31, 2012
Issuance of common stock at $9.50 per share for cash, net of issuance costs
Issuance of common stock upon exercise of options and participation in Purchase Plan
from December 31, 2010 to December 31, 2011
Issuance of common stock at $8.00 per share for cash, net of issuance costs
Issuance of common stock upon exercise of options and participation in Purchase Plan
from December 31, 2009 to December 31, 2010
Issuance of common stock upon exercise of options and participation in Purchase Plan
from December 31, 2008 to December 31, 2009
Issuance of common stock at $7.25 per share for cash, net of issuance costs
Issuance of common stock upon exercise of options and participation in Purchase Plan
from December 31, 2007 to December 31, 2008
Issuance of common stock at $27.00 per share for cash, net of issuance costs
Issuance of common stock upon exercise of options and participation in Purchase Plan
from December 31, 2006 to December 31, 2007
Issuance of common stock at $9.75 per share for cash, net of issuance costs
Issuance of common stock upon exercise of options and participation in Purchase Plan
from December 31, 2005 to December 31, 2006
Issuance of common stock upon exercise of options and participation in Purchase Plan
from December 31, 2004 to December 31, 2005
Issuance of common stock at $20.75 per share for cash, net of issuance costs
Issuance of common stock upon exercise of Options, participation in Purchase Plan and net exercise of a warrant
Issuance of common stock at $27.47 per share to Serono
Issuance of common stock at $26.22 per share to Pfizer
from December 31, 2003 to December 31, 2004
Issuance of common stock at $20.00 per share for cash, net of issuance costs
Issuance of common stock upon exercise of options and participation in Purchase Plan
Issuance of common stock upon cash exercise of warrants at $5.76
Issuance of common stock upon net exercise of warrants at $5.76
Issuance of common stock upon net exercise of warrants
from December 31, 2002 to December 31, 2003
Issuance of common stock at $5.76 per share for cash, net of issuance costs
Fractional shares adjustment upon reverse split
The sales prices in the above table reflect a one-for-nine reverse split of shares of our outstanding common stock effected on June 24, 2003.
Issuance of common stock upon exercise of options and participation in Purchase Plan
from December 31, 2001 to December 31, 2002
Issuance of common stock at $4.50 per share for cash, net of issuance costs
Issuance of common stock at $4.30 per share for cash, net of issuance costs
Issuance of common stock upon exercise of options and participation in Purchase Plan
from December 31, 2000 to December 31, 2001
Issuance of common stock upon exercise of options and participation in Purchase Plan
from December 31, 1999 to December 31, 2000
Issuance of Series E preferred stock at $6.00 per share for cash, net of issuance cost
Issuance of Series E preferred stock in exchange for a technology license
Issuance of Series D preferred stock upon exercise of warrant at $2.00 per share
Conversion of preferred stock to common stock up closing of initial public offering
Issuance of common stock at $7.00 per share for cash, net of issuance costs
Issuance of common stock upon exercise of options
Issuance of common stock for services