主要股东
注:以下部分股东代表特定权益共同体,直接或间接持有上市公司股份
| 序号 | 股东名称 | 是否机构 | 持股数(股) | 持股比例 | 持股变动数(股) | 持股数变动比例 | 投票权比例 |
|---|---|---|---|---|---|---|---|
| 1 | Neil Exter | 否 | 1235.32万 | 21.70% | 新增 | 新增 | -- |
| 2 | Entities affiliated with The Column Group | 是 | 797.74万 | 14.00% | 新增 | 新增 | -- |
| 3 | Sanofi Research Invest, LLC | 是 | 336.31万 | 5.90% | 新增 | 新增 | -- |
内部人交易
| 日期 | 股东名称 | 变动股数(万股) | 交易后持股数量(万股) | 交易价格 | 是否直接持有 | 内部人类型 |
|---|---|---|---|---|---|---|
| 2025-12-16 | Horn Margaret A |
|
14.11 | 76.82 | 是 | Chief Operating Officer |
| 2025-12-16 | Anders Jack |
|
10.81 | 77.09 | 是 | Chief Financial Officer |
| 2025-12-16 | Kelsey Stephen Michael |
|
27.86 | 76.82 | 是 | President, Research and Development |
| 2025-12-16 | Cislini Jeff |
|
4.79 | 76.82 | 是 | General Counsel |
| 2025-11-25 | GOLDSMITH MARK A |
|
30.79 | 4.09 | 是 | President and Chief Executive Officer |
| 2025-11-25 | GOLDSMITH MARK A |
|
24.79 | 75.08 | 是 | President and Chief Executive Officer |
| 2025-11-25 | Anders Jack |
|
11.64 | 17.00 | 是 | Chief Financial Officer |
| 2025-11-25 | Anders Jack |
|
11.10 | 74.00 | 是 | Chief Financial Officer |
| 2025-11-18 | Cislini Jeff |
|
6.38 | 42.45 | 是 | General Counsel |
| 2025-11-18 | Cislini Jeff |
|
5.04 | 70.14 | 是 | General Counsel |
| 2025-11-18 | GOLDSMITH MARK A |
|
26.79 | 4.09 | 是 | President and Chief Executive Officer |
| 2025-11-18 | GOLDSMITH MARK A |
|
24.79 | 70.38 | 是 | President and Chief Executive Officer |
| 2025-11-12 | GOLDSMITH MARK A |
|
26.79 | 4.09 | 是 | President and Chief Executive Officer |
| 2025-11-12 | GOLDSMITH MARK A |
|
24.79 | 65.07 | 是 | President and Chief Executive Officer |
| 2025-11-11 | Anders Jack |
|
12.10 | 17.00 | 是 | Chief Financial Officer |
| 2025-11-11 | Anders Jack |
|
11.10 | 64.00 | 是 | Chief Financial Officer |
| 2025-11-07 | GOLDSMITH MARK A |
|
37.43 | 1.12 | 是 | President and Chief Executive Officer |
| 2025-11-07 | GOLDSMITH MARK A |
|
37.79 | 4.09 | 是 | President and Chief Executive Officer |
| 2025-11-07 | GOLDSMITH MARK A |
|
34.79 | 60.31 | 是 | President and Chief Executive Officer |
| 2025-11-07 | GOLDSMITH MARK A |
|
29.79 | 0.00 | 是 | President and Chief Executive Officer |
| 2025-11-07 | GOLDSMITH MARK A |
|
24.79 | 0.00 | 是 | President and Chief Executive Officer |
| 2025-10-17 | Cislini Jeff |
|
6.24 | 36.57 | 是 | General Counsel |
| 2025-10-17 | Cislini Jeff |
|
5.04 | 55.00 | 是 | General Counsel |
| 2025-10-16 | GOLDSMITH MARK A |
|
46.23 | 1.12 | 是 | President and Chief Executive Officer |
| 2025-10-16 | GOLDSMITH MARK A |
|
45.23 | 50.47 | 是 | President and Chief Executive Officer |
| 2025-10-16 | GOLDSMITH MARK A |
|
46.23 | 1.12 | 是 | President and Chief Executive Officer |
| 2025-10-16 | GOLDSMITH MARK A |
|
45.23 | 55.00 | 是 | President and Chief Executive Officer |
| 2025-10-13 | Kelsey Stephen Michael |
|
30.90 | 4.73 | 是 | President, Research and Development |
| 2025-10-13 | Kelsey Stephen Michael |
|
28.40 | 48.54 | 是 | President, Research and Development |
| 2025-09-24 | Cislini Jeff |
|
5.04 | 44.26 | 是 | General Counsel |
| 2025-09-16 | Anders Jack |
|
11.10 | 45.82 | 是 | Chief Financial Officer |
| 2025-09-16 | Cislini Jeff |
|
5.22 | 45.82 | 是 | General Counsel |
| 2025-09-16 | GOLDSMITH MARK A |
|
45.23 | 45.82 | 是 | President and Chief Executive Officer |
| 2025-09-16 | Kelsey Stephen Michael |
|
28.40 | 45.82 | 是 | President, Research and Development |
| 2025-09-16 | Horn Margaret A |
|
14.59 | 45.82 | 是 | Chief Operating Officer |
| 2025-09-16 | Wei Lin |
|
8.83 | 45.82 | 是 | Chief Medical Officer |
| 2025-09-11 | Kelsey Stephen Michael |
|
38.94 | 4.73 | 是 | President, Research and Development |
| 2025-09-11 | Kelsey Stephen Michael |
|
34.54 | 43.58 | 是 | President, Research and Development |
| 2025-09-11 | Kelsey Stephen Michael |
|
28.94 | 44.48 | 是 | President, Research and Development |
| 2025-09-11 | Kelsey Stephen Michael |
|
31.44 | 4.73 | 是 | President, Research and Development |
| 2025-09-11 | Kelsey Stephen Michael |
|
29.07 | 45.92 | 是 | President, Research and Development |
| 2025-09-11 | Kelsey Stephen Michael |
|
28.94 | 46.93 | 是 | President, Research and Development |
| 2025-09-02 | Anders Jack |
|
11.61 | 2.68 | 是 | Chief Financial Officer |
| 2025-09-02 | Anders Jack |
|
11.81 | 4.73 | 是 | Chief Financial Officer |
| 2025-09-02 | Anders Jack |
|
11.33 | 40.02 | 是 | Chief Financial Officer |
| 2025-09-02 | Anders Jack |
|
11.65 | 4.73 | 是 | Chief Financial Officer |
| 2025-09-02 | Anders Jack |
|
11.86 | 17.00 | 是 | Chief Financial Officer |
| 2025-09-02 | Anders Jack |
|
11.33 | 40.17 | 是 | Chief Financial Officer |
| 2025-06-30 | GOLDSMITH MARK A |
|
46.57 | 0.54 | 是 | President and Chief Executive Officer |
| 2025-06-26 | ANDERSON ELIZABETH M |
|
2.32 | 0.00 | 是 | -- |
| 2025-06-26 | Borellini Flavia |
|
2.50 | 0.00 | 是 | -- |
| 2025-06-26 | Borisy Alexis |
|
233.89 | 0.00 | 是 | -- |
| 2025-06-26 | Kim Lorence H. |
|
7.31 | 0.00 | 是 | -- |
| 2025-06-26 | Patel Sushil |
|
2.31 | 0.00 | 是 | -- |
| 2025-06-26 | Horning Sandra |
|
9.66 | 0.00 | 是 | -- |
| 2025-06-20 | Cislini Jeff |
|
5.41 | 39.61 | 是 | General Counsel |
| 2025-06-16 | Anders Jack |
|
11.33 | 39.83 | 是 | Chief Financial Officer |
| 2025-06-16 | Kelsey Stephen Michael |
|
28.94 | 39.83 | 是 | President, Research and Development |
| 2025-06-16 | GOLDSMITH MARK A |
|
42.87 | 39.83 | 是 | President and Chief Executive Officer |
| 2025-06-16 | Wei Lin |
|
9.05 | 39.83 | 是 | Chief Medical Officer |
| 2025-06-16 | Cislini Jeff |
|
5.60 | 39.83 | 是 | General Counsel |
| 2025-06-16 | Horn Margaret A |
|
15.07 | 39.83 | 是 | Chief Operating Officer |
| 2025-03-20 | Cislini Jeff |
|
5.77 | 38.71 | 是 | General Counsel |
| 2025-03-17 | Horn Margaret A |
|
15.35 | 39.04 | 是 | Chief Operating Officer |
| 2025-03-17 | Kelsey Stephen Michael |
|
29.31 | 39.04 | 是 | President, Research and Development |
| 2025-03-17 | Wang Xiaolin |
|
10.23 | 0.00 | 是 | EVP, Clinical Development |
| 2025-03-17 | Anders Jack |
|
11.50 | 39.04 | 是 | Chief Financial Officer |
| 2025-03-17 | GOLDSMITH MARK A |
|
44.16 | 39.04 | 是 | President and Chief Executive Officer |
| 2025-03-17 | Cislini Jeff |
|
5.98 | 39.04 | 是 | General Counsel |
| 2025-03-01 | Cislini Jeff |
|
6.12 | 0.00 | 是 | General Counsel |
| 2025-03-01 | Horn Margaret A |
|
15.66 | 0.00 | 是 | Chief Operating Officer |
| 2025-03-01 | GOLDSMITH MARK A |
|
45.33 | 0.00 | 是 | President and Chief Executive Officer |
| 2025-03-01 | Kelsey Stephen Michael |
|
29.63 | 0.00 | 是 | President, Research and Development |
| 2025-03-01 | Anders Jack |
|
11.69 | 0.00 | 是 | Chief Financial Officer |
| 2025-03-01 | Wang Xiaolin |
|
10.50 | 0.00 | 是 | -- |
| 2025-03-01 | Wei Lin |
|
9.17 | 0.00 | 是 | Chief Medical Officer |
| 2025-01-21 | Cislini Jeff |
|
3.92 | 40.50 | 是 | General Counsel |
| 2024-12-18 | GOLDSMITH MARK A |
|
35.59 | 0.49 | 是 | President and Chief Executive Officer |
| 2024-12-16 | Horn Margaret A |
|
12.80 | 45.40 | 是 | Chief Operating Officer |
| 2024-12-16 | GOLDSMITH MARK A |
|
32.51 | 45.40 | 是 | President and Chief Executive Officer |
| 2024-12-16 | Kelsey Stephen Michael |
|
25.97 | 45.40 | 是 | President, Research and Development |
| 2024-12-16 | Cislini Jeff |
|
4.16 | 45.40 | 是 | General Counsel |
| 2024-12-16 | Anders Jack |
|
9.65 | 45.40 | 是 | Chief Financial Officer |
| 2024-11-15 | Cislini Jeff |
|
4.31 | 55.13 | 是 | General Counsel |
| 2024-11-13 | Kelsey Stephen Michael |
|
26.73 | 58.49 | 是 | President, Research and Development |
| 2024-11-13 | Kelsey Stephen Michael |
|
26.44 | 59.45 | 是 | President, Research and Development |
| 2024-11-13 | Kelsey Stephen Michael |
|
28.11 | 4.09 | 是 | President, Research and Development |
| 2024-11-06 | Cislini Jeff |
|
5.16 | 36.57 | 是 | General Counsel |
| 2024-11-06 | Cislini Jeff |
|
4.56 | 60.00 | 是 | General Counsel |
| 2024-11-01 | GOLDSMITH MARK A |
|
30.93 | 4.09 | 是 | President and Chief Executive Officer |
| 2024-11-01 | GOLDSMITH MARK A |
|
30.02 | 55.56 | 是 | President and Chief Executive Officer |
| 2024-11-01 | GOLDSMITH MARK A |
|
33.68 | 0.49 | 是 | President and Chief Executive Officer |
| 2024-11-01 | GOLDSMITH MARK A |
|
30.02 | 55.02 | 是 | President and Chief Executive Officer |
| 2024-11-01 | GOLDSMITH MARK A |
|
35.11 | 4.09 | 是 | President and Chief Executive Officer |
| 2024-10-31 | Patel Sushil |
|
1.99 | 54.14 | 是 | -- |
| 2024-10-31 | Patel Sushil |
|
2.49 | 24.84 | 是 | -- |
| 2024-10-14 | Kelsey Stephen Michael |
|
26.70 | 49.38 | 是 | President, Research and Development |
| 2024-10-14 | Kelsey Stephen Michael |
|
28.11 | 4.09 | 是 | President, Research and Development |
| 2024-10-14 | Kelsey Stephen Michael |
|
26.44 | 50.08 | 是 | President, Research and Development |
| 2024-10-11 | GOLDSMITH MARK A |
|
33.02 | 4.09 | 是 | President and Chief Executive Officer |
| 2024-10-11 | GOLDSMITH MARK A |
|
30.02 | 50.36 | 是 | President and Chief Executive Officer |
| 2024-10-11 | Horn Margaret A |
|
13.23 | 50.34 | 是 | Chief Operating Officer |
| 2024-10-11 | Anders Jack |
|
10.89 | 2.68 | 是 | Chief Financial Officer |
| 2024-10-11 | Anders Jack |
|
9.89 | 50.30 | 是 | Chief Financial Officer |
| 2024-10-11 | Horn Margaret A |
|
17.70 | 4.09 | 是 | Chief Operating Officer |
| 2024-10-11 | Horn Margaret A |
|
18.23 | 4.09 | 是 | Chief Operating Officer |
| 2024-10-11 | Cislini Jeff |
|
5.16 | 36.57 | 是 | General Counsel |
| 2024-10-11 | Cislini Jeff |
|
4.56 | 50.17 | 是 | General Counsel |
| 2024-10-08 | Weber Barbara |
|
1.31 | 48.02 | 是 | -- |
| 2024-10-01 | GOLDSMITH MARK A |
|
31.02 | 4.09 | 是 | President and Chief Executive Officer |
| 2024-10-01 | GOLDSMITH MARK A |
|
30.22 | 44.80 | 是 | President and Chief Executive Officer |
| 2024-10-01 | GOLDSMITH MARK A |
|
30.02 | 45.46 | 是 | President and Chief Executive Officer |
| 2024-09-16 | Kelsey Stephen Michael |
|
26.44 | 44.19 | 是 | President, Research and Development |
| 2024-09-16 | Horn Margaret A |
|
13.23 | 44.19 | 是 | Chief Operating Officer |
| 2024-09-16 | Anders Jack |
|
9.89 | 44.19 | 是 | Chief Financial Officer |
| 2024-09-16 | Cislini Jeff |
|
4.56 | 44.19 | 是 | General Counsel |
| 2024-09-16 | GOLDSMITH MARK A |
|
30.02 | 44.19 | 是 | President and Chief Executive Officer |
| 2024-09-13 | Kelsey Stephen Michael |
|
28.57 | 4.09 | 是 | President, Research and Development |
| 2024-09-13 | Kelsey Stephen Michael |
|
27.98 | 42.75 | 是 | President, Research and Development |
| 2024-09-13 | Kelsey Stephen Michael |
|
26.91 | 43.65 | 是 | President, Research and Development |
| 2024-08-21 | Weber Barbara |
|
1.83 | 44.83 | 是 | -- |
| 2024-08-13 | Kelsey Stephen Michael |
|
28.57 | 4.09 | 是 | President, Research and Development |
| 2024-08-13 | Kelsey Stephen Michael |
|
26.91 | 42.98 | 是 | President, Research and Development |
| 2024-08-05 | Clyburn Frank |
|
0.69 | 0.00 | 是 | -- |
| 2024-08-01 | GOLDSMITH MARK A |
|
32.19 | 4.09 | 是 | President and Chief Executive Officer |
| 2024-08-01 | GOLDSMITH MARK A |
|
31.51 | 45.60 | 是 | President and Chief Executive Officer |
| 2024-08-01 | GOLDSMITH MARK A |
|
31.19 | 46.48 | 是 | President and Chief Executive Officer |
| 2024-07-15 | Kelsey Stephen Michael |
|
28.57 | 4.09 | 是 | President, Research and Development |
| 2024-07-15 | Kelsey Stephen Michael |
|
28.46 | 43.99 | 是 | President, Research and Development |
| 2024-07-15 | Kelsey Stephen Michael |
|
28.25 | 44.94 | 是 | President, Research and Development |
| 2024-07-15 | Kelsey Stephen Michael |
|
27.68 | 46.08 | 是 | President, Research and Development |
| 2024-07-15 | Kelsey Stephen Michael |
|
27.30 | 47.02 | 是 | President, Research and Development |
| 2024-07-15 | Kelsey Stephen Michael |
|
26.91 | 48.06 | 是 | President, Research and Development |
| 2024-07-12 | GOLDSMITH MARK A |
|
33.69 | 4.09 | 是 | President and Chief Executive Officer |
| 2024-07-12 | GOLDSMITH MARK A |
|
31.19 | 45.05 | 是 | President and Chief Executive Officer |
| 2024-07-09 | Patel Sushil |
|
2.21 | 16.80 | 是 | -- |
| 2024-07-09 | Patel Sushil |
|
1.99 | 44.00 | 是 | -- |
| 2024-07-09 | Cislini Jeff |
|
4.71 | 40.83 | 是 | General Counsel |
| 2024-06-26 | Cislini Jeff |
|
4.95 | 38.47 | 是 | General Counsel |
| 2024-06-24 | Kelsey Stephen Michael |
|
28.55 | 4.09 | 是 | President, Research and Development |
| 2024-06-24 | Kelsey Stephen Michael |
|
26.91 | 39.06 | 是 | President, Research and Development |
| 2024-06-24 | Kelsey Stephen Michael |
|
26.93 | 4.09 | 是 | President, Research and Development |
| 2024-06-24 | Kelsey Stephen Michael |
|
26.91 | 39.00 | 是 | President, Research and Development |
| 2024-06-20 | Kim Lorence H. |
|
6.99 | 0.00 | 是 | -- |
| 2024-06-20 | ANDERSON ELIZABETH M |
|
2.01 | 0.00 | 是 | -- |
| 2024-06-20 | Weber Barbara |
|
2.01 | 0.00 | 是 | -- |
| 2024-06-20 | Borellini Flavia |
|
2.19 | 0.00 | 是 | -- |
| 2024-06-20 | Borisy Alexis |
|
233.57 | 0.00 | 是 | -- |
| 2024-06-20 | Horning Sandra |
|
9.34 | 0.00 | 是 | -- |
| 2024-06-20 | Patel Sushil |
|
1.99 | 0.00 | 是 | -- |
| 2024-06-17 | Kelsey Stephen Michael |
|
26.91 | 37.39 | 是 | President, Research and Development |
| 2024-06-17 | Wei Lin |
|
7.09 | 37.39 | 是 | Chief Medical Officer |
| 2024-06-17 | Cislini Jeff |
|
5.15 | 37.39 | 是 | General Counsel |
| 2024-06-17 | GOLDSMITH MARK A |
|
31.19 | 37.39 | 是 | President and Chief Executive Officer |
| 2024-06-17 | Horn Margaret A |
|
13.67 | 37.39 | 是 | Chief Operating Officer |
| 2024-06-17 | Anders Jack |
|
10.12 | 37.39 | 是 | Chief Financial Officer |
| 2024-06-03 | GOLDSMITH MARK A |
|
32.98 | 4.09 | 是 | President and Chief Executive Officer |
| 2024-06-03 | GOLDSMITH MARK A |
|
32.89 | 39.09 | 是 | President and Chief Executive Officer |
| 2024-06-03 | GOLDSMITH MARK A |
|
32.32 | 39.99 | 是 | President and Chief Executive Officer |
| 2024-06-03 | GOLDSMITH MARK A |
|
32.23 | 40.93 | 是 | President and Chief Executive Officer |
| 2024-05-21 | Cislini Jeff |
|
5.37 | 38.67 | 是 | General Counsel |
| 2024-05-21 | Cislini Jeff |
|
5.29 | 39.51 | 是 | General Counsel |
| 2024-05-03 | Anders Jack |
|
11.20 | 2.68 | 是 | Chief Financial Officer |
| 2024-05-03 | Anders Jack |
|
10.20 | 40.03 | 是 | Chief Financial Officer |
| 2024-04-10 | Patel Sushil |
|
1.79 | 16.80 | 是 | -- |
| 2024-04-10 | Patel Sushil |
|
1.57 | 37.00 | 是 | -- |
| 2024-04-10 | GOLDSMITH MARK A |
|
45.29 | 35.48 | 是 | President and Chief Executive Officer |
| 2024-03-27 | Cislini Jeff |
|
5.52 | 30.38 | 是 | General Counsel |
| 2024-03-27 | Cislini Jeff |
|
5.44 | 31.52 | 是 | General Counsel |
| 2024-03-18 | GOLDSMITH MARK A |
|
46.04 | 31.58 | 是 | President and Chief Executive Officer |
| 2024-03-18 | Horn Margaret A |
|
13.96 | 31.58 | 是 | Chief Operating Officer |
| 2024-03-18 | Kelsey Stephen Michael |
|
27.09 | 31.58 | 是 | President, Research and Development |
| 2024-03-18 | Anders Jack |
|
10.20 | 31.58 | 是 | Chief Financial Officer |
| 2024-03-18 | Cislini Jeff |
|
5.59 | 31.58 | 是 | General Counsel |
| 2024-03-11 | Horn Margaret A |
|
15.82 | 4.09 | 是 | Chief Operating Officer |
| 2024-03-11 | Horn Margaret A |
|
14.25 | 34.02 | 是 | Chief Operating Officer |
| 2024-03-11 | Horn Margaret A |
|
15.04 | 4.09 | 是 | Chief Operating Officer |
| 2024-03-11 | Horn Margaret A |
|
14.25 | 34.07 | 是 | Chief Operating Officer |
| 2024-03-01 | Kelsey Stephen Michael |
|
27.30 | 0.00 | 是 | President, Research and Development |
| 2024-03-01 | Wang Xiaolin |
|
8.45 | 0.00 | 是 | -- |
| 2024-03-01 | Anders Jack |
|
10.32 | 0.00 | 是 | Chief Financial Officer |
| 2024-03-01 | Cislini Jeff |
|
5.71 | 0.00 | 是 | General Counsel |
| 2024-03-01 | Horn Margaret A |
|
14.25 | 0.00 | 是 | Chief Operating Officer |
| 2024-03-01 | GOLDSMITH MARK A |
|
46.62 | 0.00 | 是 | President and Chief Executive Officer |
| 2024-01-22 | Cislini Jeff |
|
3.61 | 27.00 | 是 | General Counsel |
| 2024-01-08 | Kelsey Stephen Michael |
|
22.16 | 29.01 | 是 | President, Research and Development |
| 2024-01-02 | Kelsey Stephen Michael |
|
22.50 | 29.10 | 是 | President, Research and Development |