股本结构
单位：万股
| 公告日期 | 2025-10-30 | 2025-10-30 | 2025-07-31 | 2025-07-31 | 2025-05-08 | 2025-05-08 |
|---|---|---|---|---|---|---|
| 证券总股本 | 5909.66 | 5909.56 | 5908.91 | 5908.06 | 5893.45 | 5893.40 |
| 普通股本 | 5909.66 | 5909.56 | 5908.91 | 5908.06 | 5893.45 | 5893.40 |
| 优先股 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2025-10-23 | 2025-09-30 | 2025-07-24 | 2025-06-30 | 2025-05-01 | 2025-03-31 |
注释：中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本（万股） | 变动后优先股（万股） | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2025-10-30 | 5909.66 | 未披露 | 定期报告 | 2025-10-23 |
| 2025-10-30 | 5909.56 | 未披露 |
更多>>
From June 30, 2025 to September 30, 2025
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2025-09-30 |
| 2025-07-31 | 5908.91 | 未披露 | 定期报告 | 2025-07-24 |
| 2025-07-31 | 5908.06 | 未披露 |
更多>>
From March 31, 2025 to June 30, 2025
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2025-06-30 |
| 2025-05-08 | 5893.45 | 未披露 | 定期报告 | 2025-05-01 |
| 2025-05-08 | 5893.40 | 未披露 |
更多>>
From December 31, 2024 to March 31, 2025
Issuance of common stock from the exercise of stock options and settlement of restricted stock units, net of shares withheld for taxes
|
2025-03-31 |
| 2025-02-14 | 5831.60 | 未披露 | 定期报告 | 2025-02-07 |
| 2025-02-14 | 5831.06 | 未披露 |
更多>>
From December 31, 2023 to December 31, 2024
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2024-12-31 |
| 2024-11-07 | 5830.81 | 未披露 | 定期报告 | 2024-10-31 |
| 2024-11-07 | 5830.61 | 未披露 |
更多>>
From June 30, 2024 to September 30, 2024
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2024-09-30 |
| 2024-08-01 | 5828.98 | 未披露 | 定期报告 | 2024-07-25 |
| 2024-08-01 | 5828.73 | 未披露 |
更多>>
From March 31, 2024 to June 30, 2024
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2024-06-30 |
| 2024-05-09 | 5819.83 | 未披露 | 定期报告 | 2024-05-02 |
| 2024-04-29 | 5819.78 | 未披露 | 定期报告 | 2024-04-22 |
| 2024-05-09 | 5819.65 | 未披露 |
更多>>
From December 31, 2023 to March 31, 2024
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2024-03-31 |
| 2024-02-08 | 5753.75 | 未披露 | 定期报告 | 2024-02-01 |
| 2024-02-08 | 5753.45 | 未披露 |
更多>>
From December 31, 2022 to December 31,2023
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2023-12-31 |
| 2023-11-09 | 5753.20 | 未披露 | 定期报告 | 2023-11-02 |
| 2023-11-09 | 5752.95 | 未披露 |
更多>>
From June 30, 2023 to September 30, 2023
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2023-09-30 |
| 2023-07-28 | 5750.87 | 未披露 | 定期报告 | 2023-07-20 |
| 2023-07-28 | 5749.69 | 未披露 |
更多>>
From March 31, 2023 to June 30, 2023
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2023-06-30 |
| 2023-05-03 | 5744.41 | 未披露 | 定期报告 | 2023-04-27 |
| 2023-04-24 | 5744.36 | 未披露 | 定期报告 | 2023-04-17 |
| 2023-05-03 | 5744.10 | 未披露 |
更多>>
From December 31, 2022 to March 31, 2023
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2023-03-31 |
| 2023-02-09 | 5678.53 | 未披露 | 定期报告 | 2023-02-02 |
| 2023-02-09 | 5678.38 | 未披露 |
更多>>
From December 31, 2021 to December 31, 2022
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2022-12-31 |
| 2022-11-03 | 5659.00 | 未披露 | 定期报告 | 2022-10-27 |
| 2022-11-03 | 5658.85 | 未披露 |
更多>>
From June 30, 2022 to September 30, 2022
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2022-09-30 |
| 2022-08-04 | 5656.15 | 未披露 | 定期报告 | 2022-07-28 |
| 2022-08-04 | 5655.25 | 未披露 |
更多>>
From March 31, 2022 to June 30, 2022
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2022-06-30 |
| 2022-05-06 | 5648.97 | 未披露 | 定期报告 | 2022-04-29 |
| 2022-04-25 | 5648.92 | 未披露 | 定期报告 | 2022-04-18 |
| 2022-05-06 | 5648.67 | 未披露 |
更多>>
From December 31, 2021 to March 31, 2022
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2022-03-31 |
| 2022-02-24 | 5590.69 | 未披露 | 定期报告 | 2022-02-17 |
| 2022-02-24 | 5590.09 | 未披露 |
更多>>
From December 31, 2020 to December 31, 2021
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2021-12-31 |
| 2021-11-04 | 5571.22 | 未披露 | 定期报告 | 2021-10-28 |
| 2021-11-04 | 5570.87 | 未披露 |
更多>>
From June 30, 2021 to September 30, 2021
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2021-09-30 |
| 2021-07-29 | 5563.82 | 未披露 | 定期报告 | 2021-07-22 |
| 2021-07-29 | 5562.77 | 未披露 |
更多>>
From March 31, 2021 to June 30, 2021
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2021-06-30 |
| 2021-05-06 | 5556.42 | 未披露 | 定期报告 | 2021-04-29 |
| 2021-04-22 | 5556.22 | 未披露 | 定期报告 | 2021-04-15 |
| 2021-05-06 | 5556.02 | 未披露 |
更多>>
From December 31, 2020 to March 31, 2021
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2021-03-31 |
| 2021-02-11 | 5488.27 | 未披露 | 定期报告 | 2021-02-04 |
| 2021-02-11 | 5486.51 | 未披露 |
更多>>
From December 31, 2019 to December 31, 2020
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2020-12-31 |
| 2020-10-29 | 5469.17 | 未披露 | 定期报告 | 2020-10-22 |
| 2020-10-29 | 5468.97 | 未披露 |
更多>>
From June 30, 2020 to September 30, 2020
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2020-09-30 |
| 2020-08-06 | 5465.14 | 未披露 | 定期报告 | 2020-07-30 |
| 2020-08-06 | 5462.83 | 未披露 |
更多>>
From March 31, 2020 to June 30, 2020
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2020-06-30 |
| 2020-05-07 | 5455.05 | 未披露 | 定期报告 | 2020-04-30 |
| 2020-04-22 | 5424.26 | 未披露 | 定期报告 | 2020-04-17 |
| 2020-05-07 | 5413.23 | 未披露 |
更多>>
From December 31, 2019 to March 31, 2020
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2020-03-31 |
| 2020-02-26 | 5364.86 | 未披露 | 定期报告 | 2020-02-18 |
| 2020-02-26 | 5354.96 | 未披露 |
更多>>
From December 31, 2018 to December 31, 2019
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2019-12-31 |
| 2019-11-07 | 5333.71 | 未披露 | 定期报告 | 2019-10-31 |
| 2019-11-07 | 5333.32 | 未披露 |
更多>>
from June 30, 2019 to September 30, 2019
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2019-09-30 |
| 2019-08-01 | 5327.39 | 未披露 | 定期报告 | 2019-07-25 |
| 2019-08-01 | 5326.48 | 未披露 |
更多>>
from March 31, 2019 to June 30,2019
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2019-06-30 |
| 2019-04-25 | 5296.37 | 未披露 | 定期报告 | 2019-04-17 |
| 2019-05-03 | 5296.27 | 未披露 |
更多>>
From December 31, 2018 To March 31, 2019
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2019-03-31 |
| 2019-02-19 | 5264.28 | 未披露 | 定期报告 | 2019-02-12 |
| 2019-02-19 | 5247.76 | 未披露 |
更多>>
From December 31, 2017 To December 31, 2018
Net proceeds from public offering of common stock
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2018-12-31 |
| 2018-11-07 | 5244.99 | 未披露 | 定期报告 | 2018-10-25 |
| 2018-11-07 | 5240.07 | 未披露 |
更多>>
from December 31, 2017 to September 30, 2018
Net proceeds from public offering of common stock
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2018-09-30 |
| 2018-08-02 | 5237.94 | 未披露 | 定期报告 | 2018-07-19 |
| 2018-08-02 | 5237.59 | 未披露 |
更多>>
from December 31, 2017 to June 30, 2018
Net proceeds from public offering of common stock
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2018-06-30 |
| 2018-05-02 | 5211.07 | 未披露 | 定期报告 | 2018-04-19 |
| 2018-05-02 | 5210.97 | 未披露 |
更多>>
from December 31, 2017 to March 31, 2018
Net proceeds from public offering of common stock
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2018-03-31 |
| 2018-02-15 | 4543.79 | 未披露 | 定期报告 | 2018-02-01 |
| 2018-02-15 | 4493.81 | 未披露 |
更多>>
From December 31,2016 To December 31, 2017
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2017-12-31 |
| 2017-11-08 | 4492.75 | 未披露 | 定期报告 | 2017-10-30 |
| 2017-11-08 | 4492.27 | 未披露 |
更多>>
From December 31,2016 To September 30, 2017
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2017-09-30 |
| 2017-08-03 | 4485.83 | 未披露 | 定期报告 | 2017-07-26 |
| 2017-08-03 | 4484.59 | 未披露 |
更多>>
From December 31, 2016 to June 30, 2017
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2017-06-30 |
| 2017-04-27 | 4455.23 | 未披露 | 定期报告 | 2017-04-21 |
| 2017-05-03 | 4454.63 | 未披露 |
更多>>
from December 31, 2016 to March 31, 2017
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2017-03-31 |
| 2017-02-17 | 4434.64 | 未披露 | 定期报告 | 2017-02-06 |
| 2017-02-17 | 4400.06 | 未披露 |
更多>>
from December 31, 2015 to December 31, 2016
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2016-12-31 |
| 2016-11-03 | 4394.67 | 未披露 | 定期报告 | 2016-10-24 |
| 2016-11-03 | 4393.05 | 未披露 |
更多>>
From December 31, 2015 to September 30, 2016
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2016-09-30 |
| 2016-07-28 | 4328.43 | 未披露 | 定期报告 | 2016-07-21 |
| 2016-07-28 | 4328.22 | 未披露 |
更多>>
From December 31, 2015 to June 30, 2016
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2016-06-30 |
| 2016-05-05 | 4315.30 | 未披露 | 定期报告 | 2016-04-30 |
| 2016-04-28 | 4314.49 | 未披露 | 定期报告 | 2016-04-22 |
| 2016-05-05 | 4310.92 | 未披露 |
更多>>
From December 31, 2015 to March 31, 2016
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2016-03-31 |
| 2016-02-12 | 4310.30 | 未披露 | 定期报告 | 2016-01-31 |
| 2015-11-04 | 4281.53 | 未披露 |
更多>>
from December 31, 2014 to September 30, 2015
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
Shares withheld upon settlement of equity awards
|
2015-09-30 |
| 2015-07-31 | 4228.54 | 未披露 | 定期报告 | 2015-07-24 |
| 2015-07-31 | 4227.04 | 未披露 |
更多>>
from December 31,2014 to June 30,2015
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
Shares withheld upon settlement of equity awards
|
2015-06-30 |
| 2015-04-29 | 4179.85 | 未披露 | 定期报告 | 2015-04-20 |
| 2015-05-07 | 4179.34 | 未披露 |
更多>>
From December 31, 2014 to March 31, 2015
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
Shares withheld upon settlement of equity awards
|
2015-03-31 |
| 2015-03-13 | 4164.10 | 未披露 | 定期报告 | 2015-03-06 |
| 2015-03-13 | 4148.64 | 未披露 |
更多>>
From December 31, 2013 to December 31, 2014
Net proceeds from public offering of common stock
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
Shares withheld upon settlement of restricted stock units
Issuance of common stock to Novartis Pharma AG
|
2014-12-31 |
| 2014-10-27 | 3390.11 | 未披露 |
更多>>
from December 31, 2013 to September 30, 2014
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
Shares withheld upon settlement of restricted stock units
|
2014-09-30 |
| 2014-08-08 | 3387.78 | 未披露 |
更多>>
from December 31, 2013 to June 30, 2014
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
Shares withheld upon settlement of restricted stock units
|
2014-06-30 |
| 2014-05-08 | 3387.37 | 未披露 |
更多>>
from December 31,2013 to March 31, 2014
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
Shares withheld upon settlement of restricted stock units
|
2014-03-31 |
| 2014-04-07 | 3386.65 | 未披露 | 定期报告 | 2014-03-28 |
| 2014-02-25 | 3350.19 | 未披露 | 定期报告 | 2014-02-20 |
| 2014-02-25 | 3333.85 | 未披露 |
更多>>
From December 31, 2012 to December 31, 2013
Net proceeds from public offering of common stock
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
Shares withheld upon settlement of restricted stock units
|
2013-12-31 |
| 2013-11-08 | 3319.01 | 未披露 |
更多>>
From December 31, 2012 to August 31, 2013
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
Shares withheld upon settlement of restricted stock units
Net proceeds from public offering of common stock
|
2013-08-31 |
| 2013-07-31 | 2848.32 | 未披露 |
更多>>
From December 31, 2012 to June 30, 2013
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
Shares withheld upon settlement of restricted stock units
|
2013-06-30 |
| 2013-05-10 | 2834.68 | 未披露 |
更多>>
from December 31,2012 to March 31,2013
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
Shares withheld upon settlement of restricted stock units
|
2013-03-31 |
| 2013-02-26 | 2834.27 | 未披露 | 定期报告 | 2013-02-20 |
| 2013-02-26 | 2824.17 | 未披露 |
更多>>
from December 31, 2011 to December 31, 2012
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
|
2012-12-31 |
| 2012-11-08 | 2822.67 | 未披露 |
更多>>
from December 31, 2011 to march 7,2012
Issuance of common stock from exercised stock options and settlement of restricted stock units
|
2012-03-07 |
| 2011-11-07 | 2811.70 | 未披露 | 定期报告 | 2011-11-02 |
| 2011-11-07 | 2811.06 | 未披露 |
更多>>
from December 31, 2010 to September 30, 2011
Issuance of common stock from exercised stock options/restricted stock units
|
2011-09-30 |
| 2011-03-10 | 2810.34 | 未披露 | 定期报告 | 2011-03-04 |
| 2011-03-10 | 2804.14 | 未披露 |
更多>>
from December 31, 2009 to December 31, 2010
Issuance of common stock from exercised stock options and restricted stock units
|
2010-12-31 |
| 2010-11-08 | 2804.14 | 未披露 | 定期报告 | 2010-11-05 |
| 2010-11-08 | 2801.18 | 未披露 |
更多>>
from December 31, 2009 to September 30, 2010
Issuance of common stock from exercised stock options/restricted stock units
|
2010-09-30 |
| 2010-08-06 | 2799.96 | 未披露 |
更多>>
from December 31, 2009 to June 30, 2010
Issuance of common stock from exercised stock options/restricted stock units
|
2010-06-30 |
| 2010-05-10 | 2787.95 | 未披露 | 定期报告 | 2010-05-05 |
| 2010-05-10 | 2786.45 | 未披露 |
更多>>
from December 31, 2009 to March 31, 2010
Issuance of common stock from exercised stock options/restricted stock units
|
2010-03-31 |
| 2010-03-15 | 2786.02 | 未披露 | 定期报告 | 2010-03-12 |
| 2010-03-15 | 2756.86 | 未披露 |
更多>>
from December 31, 2008 to December 31, 2009
Issuance of common stock from exercised stock options and restricted stock units
|
2009-12-31 |
| 2009-03-13 | 2665.35 | 未披露 |
更多>>
from December 31, 2007 to December 31, 2008
Employee stock-based compensation
|
2008-12-31 |
| 2008-03-13 | 2665.27 | 未披露 |
更多>>
from December 31, 2006 to December 31, 2007
Issuance of common stock from exercised stock options
Follow-on offering of common stock, net of issuance costs
|
2007-12-31 |
| 2007-03-16 | 2654.85 | 未披露 | 定期报告 | 2007-03-09 |
| 2007-03-16 | 2212.85 | 未披露 |
更多>>
from December 31, 2005 to December 31, 2006
Conversion of preferred stock upon initial public offering
Initial public offering of common stock, net of issuance costs
Issuance of common stock from exercised stock options
Exercise of warrants
|
2006-12-31 |
From June 30, 2025 to September 30, 2025
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From March 31, 2025 to June 30, 2025
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From December 31, 2024 to March 31, 2025
Issuance of common stock from the exercise of stock options and settlement of restricted stock units, net of shares withheld for taxes
From December 31, 2023 to December 31, 2024
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From June 30, 2024 to September 30, 2024
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From March 31, 2024 to June 30, 2024
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From December 31, 2023 to March 31, 2024
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From December 31, 2022 to December 31,2023
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From June 30, 2023 to September 30, 2023
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From March 31, 2023 to June 30, 2023
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From December 31, 2022 to March 31, 2023
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From December 31, 2021 to December 31, 2022
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From June 30, 2022 to September 30, 2022
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From March 31, 2022 to June 30, 2022
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From December 31, 2021 to March 31, 2022
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From December 31, 2020 to December 31, 2021
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From June 30, 2021 to September 30, 2021
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From March 31, 2021 to June 30, 2021
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From December 31, 2020 to March 31, 2021
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From December 31, 2019 to December 31, 2020
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From June 30, 2020 to September 30, 2020
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From March 31, 2020 to June 30, 2020
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From December 31, 2019 to March 31, 2020
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From December 31, 2018 to December 31, 2019
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
from June 30, 2019 to September 30, 2019
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
from March 31, 2019 to June 30,2019
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From December 31, 2018 To March 31, 2019
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From December 31, 2017 To December 31, 2018
Net proceeds from public offering of common stock
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
from December 31, 2017 to September 30, 2018
Net proceeds from public offering of common stock
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
from December 31, 2017 to June 30, 2018
Net proceeds from public offering of common stock
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
from December 31, 2017 to March 31, 2018
Net proceeds from public offering of common stock
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From December 31,2016 To December 31, 2017
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From December 31,2016 To September 30, 2017
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From December 31, 2016 to June 30, 2017
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
from December 31, 2016 to March 31, 2017
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
from December 31, 2015 to December 31, 2016
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From December 31, 2015 to September 30, 2016
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From December 31, 2015 to June 30, 2016
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
From December 31, 2015 to March 31, 2016
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
from December 31, 2014 to September 30, 2015
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
Shares withheld upon settlement of equity awards
from December 31,2014 to June 30,2015
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
Shares withheld upon settlement of equity awards
From December 31, 2014 to March 31, 2015
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
Shares withheld upon settlement of equity awards
From December 31, 2013 to December 31, 2014
Net proceeds from public offering of common stock
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
Shares withheld upon settlement of restricted stock units
Issuance of common stock to Novartis Pharma AG
from December 31, 2013 to September 30, 2014
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
Shares withheld upon settlement of restricted stock units
from December 31, 2013 to June 30, 2014
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
Shares withheld upon settlement of restricted stock units
from December 31,2013 to March 31, 2014
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
Shares withheld upon settlement of restricted stock units
From December 31, 2012 to December 31, 2013
Net proceeds from public offering of common stock
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
Shares withheld upon settlement of restricted stock units
From December 31, 2012 to August 31, 2013
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
Shares withheld upon settlement of restricted stock units
Net proceeds from public offering of common stock
From December 31, 2012 to June 30, 2013
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
Shares withheld upon settlement of restricted stock units
from December 31,2012 to March 31,2013
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
Shares withheld upon settlement of restricted stock units
from December 31, 2011 to December 31, 2012
Issuance of common stock from the exercise of stock options and settlement of restricted stock units
from December 31, 2011 to march 7,2012
Issuance of common stock from exercised stock options and settlement of restricted stock units
from December 31, 2010 to September 30, 2011
Issuance of common stock from exercised stock options/restricted stock units
from December 31, 2009 to December 31, 2010
Issuance of common stock from exercised stock options and restricted stock units
from December 31, 2009 to September 30, 2010
Issuance of common stock from exercised stock options/restricted stock units
from December 31, 2009 to June 30, 2010
Issuance of common stock from exercised stock options/restricted stock units
from December 31, 2009 to March 31, 2010
Issuance of common stock from exercised stock options/restricted stock units
from December 31, 2008 to December 31, 2009
Issuance of common stock from exercised stock options and restricted stock units
from December 31, 2007 to December 31, 2008
Employee stock-based compensation
from December 31, 2006 to December 31, 2007
Issuance of common stock from exercised stock options
Follow-on offering of common stock, net of issuance costs
from December 31, 2005 to December 31, 2006
Conversion of preferred stock upon initial public offering
Initial public offering of common stock, net of issuance costs
Issuance of common stock from exercised stock options
Exercise of warrants