主要股东
注:以下部分股东代表特定权益共同体,直接或间接持有上市公司股份
| 序号 | 股东名称 | 是否机构 | 持股数(股) | 持股比例 | 持股变动数(股) | 持股数变动比例 | 投票权比例 |
|---|---|---|---|---|---|---|---|
| 1 | Patrick J. Heron | 否 | 1004.28万 | 27.40% | 新增 | 新增 | -- |
| 2 | OrbiMed Private Investments VII, LP | 是 | 411.50万 | 11.20% | 新增 | 新增 | -- |
| 3 | Bain Capital Life Sciences Entities | 是 | 368.52万 | 10.10% | 新增 | 新增 | -- |
内部人交易
| 日期 | 股东名称 | 变动股数(万股) | 交易后持股数量(万股) | 交易价格 | 是否直接持有 | 内部人类型 |
|---|---|---|---|---|---|---|
| 2025-12-04 | Munshi Amit |
|
0.40 | 0.00 | 是 | -- |
| 2025-12-01 | Welgus Howard G. |
|
7.97 | 30.21 | 是 | -- |
| 2025-12-01 | Matsuda Masaru |
|
15.06 | 30.23 | 是 | SVP General Counsel and Corporate Secretary |
| 2025-11-24 | LIN SUE-JEAN |
|
4.48 | 8.63 | 是 | -- |
| 2025-11-24 | LIN SUE-JEAN |
|
5.20 | 7.51 | 是 | -- |
| 2025-11-24 | LIN SUE-JEAN |
|
2.67 | 30.78 | 是 | -- |
| 2025-11-21 | Watanabe Todd |
|
79.38 | 30.00 | 是 | President and Chief Executive Officer |
| 2025-11-21 | Watanabe Todd |
|
74.05 | 30.36 | 是 | President and Chief Executive Officer |
| 2025-11-20 | Gilbert Halley E |
|
3.87 | 7.51 | 是 | -- |
| 2025-11-20 | Gilbert Halley E |
|
2.21 | 27.55 | 是 | -- |
| 2025-11-19 | Matsuda Masaru |
|
15.30 | 27.95 | 是 | SVP General Counsel and Corporate Secretary |
| 2025-11-19 | Matsuda Masaru |
|
15.15 | 28.50 | 是 | SVP General Counsel and Corporate Secretary |
| 2025-11-13 | Leonard Keith R |
|
2.21 | 0.00 | 是 | -- |
| 2025-11-13 | Krishnamohan Neha |
|
5.04 | 8.63 | 是 | -- |
| 2025-11-13 | Krishnamohan Neha |
|
6.26 | 7.51 | 是 | -- |
| 2025-11-13 | Krishnamohan Neha |
|
2.34 | 23.19 | 是 | -- |
| 2025-11-13 | Krishnamohan Neha |
|
2.21 | 23.37 | 是 | -- |
| 2025-11-06 | Burnett Patrick |
|
11.56 | 3.64 | 是 | Executive Vice President and Chief Medical Officer |
| 2025-11-06 | Burnett Patrick |
|
9.83 | 24.18 | 是 | Executive Vice President and Chief Medical Officer |
| 2025-11-06 | Edwards Larry Todd |
|
15.02 | 25.16 | 是 | EVP Chief Commercial Officer |
| 2025-11-03 | Matsuda Masaru |
|
15.41 | 24.71 | 是 | EVP & CEO--Lifestyle |
| 2025-11-03 | Welgus Howard G. |
|
8.97 | 25.27 | 是 | -- |
| 2025-11-03 | Watanabe Todd |
|
79.50 | 24.71 | 是 | President and Chief Executive Officer |
| 2025-10-28 | Watanabe Todd |
|
80.64 | 25.03 | 是 | President and Chief Executive Officer |
| 2025-10-02 | Edwards Larry Todd |
|
17.89 | 19.99 | 是 | EVP Chief Commercial Officer |
| 2025-10-02 | Edwards Larry Todd |
|
17.93 | 20.78 | 是 | EVP Chief Commercial Officer |
| 2025-10-01 | Welgus Howard G. |
|
10.97 | 1.68 | 是 | -- |
| 2025-10-01 | Welgus Howard G. |
|
10.02 | 18.92 | 是 | -- |
| 2025-10-01 | Welgus Howard G. |
|
9.97 | 18.92 | 是 | -- |
| 2025-10-01 | Watanabe Todd |
|
87.64 | 18.91 | 是 | President and Chief Executive Officer |
| 2025-10-01 | Watanabe Todd |
|
86.72 | 20.02 | 是 | President and Chief Executive Officer |
| 2025-10-01 | Watanabe Todd |
|
84.64 | 20.04 | 是 | President and Chief Executive Officer |
| 2025-09-08 | Watanabe Todd |
|
89.19 | 17.54 | 是 | President and Chief Executive Officer |
| 2025-09-08 | Watanabe Todd |
|
89.14 | 17.52 | 是 | President and Chief Executive Officer |
| 2025-09-04 | Matsuda Masaru |
|
16.12 | 16.16 | 是 | SVP General Counsel and Corporate Secretary |
| 2025-09-02 | Welgus Howard G. |
|
11.02 | 0.00 | 是 | -- |
| 2025-09-02 | Welgus Howard G. |
|
10.02 | 15.64 | 是 | -- |
| 2025-08-08 | Burnett Patrick |
|
10.90 | 14.03 | 是 | Executive Vice President and Chief Medical Officer |
| 2025-08-04 | Matsuda Masaru |
|
19.74 | 14.33 | 是 | SVP General Counsel and Corporate Secretary |
| 2025-08-04 | Burnett Patrick |
|
11.28 | 14.33 | 是 | Executive Vice President and Chief Medical Officer |
| 2025-07-10 | Burnett Patrick |
|
13.85 | 0.00 | 是 | Executive Vice President and Chief Medical Officer |
| 2025-07-10 | Burnett Patrick |
|
11.55 | 15.05 | 是 | Executive Vice President and Chief Medical Officer |
| 2025-07-10 | Burnett Patrick |
|
12.12 | 0.00 | 是 | Executive Vice President and Chief Medical Officer |
| 2025-07-10 | Burnett Patrick |
|
11.55 | 15.07 | 是 | Executive Vice President and Chief Medical Officer |
| 2025-07-01 | Welgus Howard G. |
|
10.02 | 13.84 | 是 | -- |
| 2025-06-18 | Welgus Howard G. |
|
10.94 | 13.37 | 是 | -- |
| 2025-06-12 | CHAUDHURI BHASKAR |
|
86.78 | 0.00 | 是 | -- |
| 2025-06-12 | Gilbert Halley E |
|
2.64 | 0.00 | 是 | -- |
| 2025-06-12 | Krishnamohan Neha |
|
2.34 | 0.00 | 是 | -- |
| 2025-06-12 | Curran Terrie |
|
1.77 | 0.00 | 是 | -- |
| 2025-06-12 | Leonard Keith R |
|
2.64 | 0.00 | 是 | -- |
| 2025-06-12 | Heron Patrick J |
|
2.64 | 0.00 | 是 | -- |
| 2025-06-12 | Welgus Howard G. |
|
11.96 | 0.00 | 是 | -- |
| 2025-06-12 | LIN SUE-JEAN |
|
2.67 | 0.00 | 是 | -- |
| 2025-06-10 | Watanabe Todd Franklin |
|
91.41 | 0.00 | 是 | President and Chief Executive Officer |
| 2025-06-10 | Watanabe Todd Franklin |
|
91.31 | 0.00 | 是 | President and Chief Executive Officer |
| 2025-05-28 | Matsuda Masaru |
|
20.26 | 13.78 | 是 | SVP General Counsel and Corporate Secretary |
| 2025-05-19 | Edwards Larry Todd |
|
18.31 | 14.07 | 是 | EVP Chief Commercial Officer |
| 2025-05-08 | Burnett Patrick |
|
11.55 | 13.59 | 是 | Executive Vice President and Chief Medical Officer |
| 2025-05-06 | Vairavan Latha |
|
6.51 | 0.00 | 是 | SVP Chief Financial Officer |
| 2025-05-02 | Burnett Patrick |
|
11.93 | 15.19 | 是 | Reporting Person''s Title: Executive Vice President and Chief Medical Officer |
| 2025-05-02 | Matsuda Masaru |
|
20.44 | 15.20 | 是 | SVP General Counsel and Corporate Secretary |
| 2025-05-02 | Watanabe Todd Franklin |
|
91.38 | 15.19 | 是 | President and Chief Executive Officer |
| 2025-05-01 | Welgus Howard G. |
|
11.19 | 14.64 | 是 | -- |
| 2025-04-02 | Topper David Joseph |
|
18.28 | 15.80 | 是 | Chief Financial Officer |
| 2025-04-01 | Welgus Howard G. |
|
12.19 | 15.12 | 是 | -- |
| 2025-03-24 | Watanabe Todd Franklin |
|
92.74 | 17.52 | 是 | President and Chief Executive Officer |
| 2025-03-24 | Watanabe Todd Franklin |
|
92.52 | 17.56 | 是 | President and Chief Executive Officer |
| 2025-03-17 | Watanabe Todd Franklin |
|
92.89 | 17.61 | 是 | President and Chief Executive Officer |
| 2025-03-13 | Burnett Patrick |
|
12.19 | 14.97 | 是 | Executive Vice President, Chief Medical Officer |
| 2025-03-13 | Burnett Patrick |
|
12.69 | 0.00 | 是 | Executive Vice President, Chief Medical Officer |
| 2025-03-13 | Burnett Patrick |
|
12.19 | 15.10 | 是 | Executive Vice President, Chief Medical Officer |
| 2025-03-13 | Burnett Patrick |
|
13.42 | 0.00 | 是 | Executive Vice President, Chief Medical Officer |
| 2025-03-13 | Burnett Patrick |
|
12.19 | 15.04 | 是 | Executive Vice President, Chief Medical Officer |
| 2025-03-03 | Welgus Howard G. |
|
13.19 | 13.00 | 是 | -- |
| 2025-02-28 | Burnett Patrick |
|
16.61 | 13.28 | 是 | Executive Vice President, Chief Medical Officer |
| 2025-02-28 | Burnett Patrick |
|
15.29 | 0.00 | 是 | Executive Vice President, Chief Medical Officer |
| 2025-02-28 | Burnett Patrick |
|
16.99 | 0.00 | 是 | Executive Vice President, Chief Medical Officer |
| 2025-02-28 | Burnett Patrick |
|
16.70 | 13.03 | 是 | Executive Vice President, Chief Medical Officer |
| 2025-02-28 | Topper David Joseph |
|
19.24 | 0.00 | 是 | Chief Financial Officer |
| 2025-02-28 | Matsuda Masaru |
|
21.27 | 0.00 | 是 | General Counsel and Corporate Secretary |
| 2025-02-28 | Matsuda Masaru |
|
20.94 | 13.03 | 是 | General Counsel and Corporate Secretary |
| 2025-02-28 | Edwards Larry Todd |
|
19.06 | 0.00 | 是 | Executive Vice President, Chief Commercial Officer |
| 2025-02-28 | Edwards Larry Todd |
|
17.36 | 0.00 | 是 | Executive Vice President, Chief Commercial Officer |
| 2025-02-28 | Watanabe Todd Franklin |
|
95.51 | 0.00 | 是 | President and Chief Executive Officer |
| 2025-02-28 | Watanabe Todd Franklin |
|
93.42 | 13.03 | 是 | President and Chief Executive Officer |
| 2025-02-28 | Watanabe Todd Franklin |
|
93.01 | 13.28 | 是 | President and Chief Executive Officer |
| 2025-02-03 | Burnett Patrick |
|
11.49 | 12.70 | 是 | Executive Vice President, Chief Medical Officer |
| 2025-02-03 | Welgus Howard G. |
|
14.19 | 12.71 | 是 | -- |
| 2025-02-03 | Watanabe Todd Franklin |
|
80.41 | 12.70 | 是 | President and Chief Executive Officer |
| 2025-02-03 | Edwards Larry Todd |
|
13.56 | 12.70 | 是 | Executive Vice President Chief Commercial Officer |
| 2025-02-03 | Matsuda Masaru |
|
17.87 | 12.70 | 是 | Senior Vice President General Counsel and Corporate Secretary |
| 2025-01-02 | Welgus Howard G. |
|
15.19 | 14.67 | 是 | -- |
| 2024-12-31 | Burnett Patrick |
|
12.70 | 14.00 | 是 | Executive Vice President, Chief Medical Officer |
| 2024-12-20 | Watanabe Todd Franklin |
|
82.34 | 15.17 | 是 | President and Chief Executive Officer |
| 2024-12-02 | Welgus Howard G. |
|
16.19 | 12.51 | 是 | -- |
| 2024-11-30 | Edwards Larry Todd |
|
13.77 | 7.11 | 是 | Executive Vice President Chief Commercial Officer |
| 2024-11-22 | Burnett Patrick |
|
14.47 | 0.00 | 是 | Senior Vice President Chief Medical Officer |
| 2024-11-22 | Burnett Patrick |
|
12.87 | 10.14 | 是 | Senior Vice President Chief Medical Officer |
| 2024-11-18 | Matsuda Masaru |
|
18.31 | 0.00 | 是 | Senior Vice President General Counsel and Corporate Secretary |
| 2024-11-18 | Matsuda Masaru |
|
18.14 | 9.68 | 是 | Senior Vice President General Counsel and Corporate Secretary |
| 2024-11-14 | Burnett Patrick |
|
12.87 | 10.29 | 是 | Senior Vice President Chief Medical Officer |
| 2024-11-14 | Burnett Patrick |
|
12.88 | 0.00 | 是 | Senior Vice President Chief Medical Officer |
| 2024-11-14 | Burnett Patrick |
|
12.87 | 10.03 | 是 | Senior Vice President Chief Medical Officer |
| 2024-11-14 | Burnett Patrick |
|
12.87 | 10.29 | 是 | Senior Vice President Chief Medical Officer |
| 2024-11-14 | Burnett Patrick |
|
14.70 | 0.00 | 是 | Senior Vice President Chief Medical Officer |
| 2024-11-11 | Curran Terrie |
|
1.01 | 10.85 | 是 | -- |
| 2024-11-04 | Matsuda Masaru |
|
17.83 | 8.68 | 是 | Senior Vice President General Counsel and Corporate Secretary |
| 2024-11-04 | Burnett Patrick |
|
17.94 | 8.68 | 是 | Senior Vice President Chief Medical Officer |
| 2024-11-04 | Watanabe Todd Franklin |
|
83.24 | 8.68 | 是 | President and Chief Executive Officer |
| 2024-11-01 | Welgus Howard G. |
|
17.19 | 8.65 | 是 | -- |
| 2024-10-02 | Edwards Larry Todd |
|
13.66 | 10.01 | 是 | SVP Chief Commercial Officer |
| 2024-10-01 | Welgus Howard G. |
|
18.19 | 9.26 | 是 | -- |
| 2024-09-21 | Topper David Joseph |
|
17.00 | 0.00 | 是 | Chief Financial Officer |
| 2024-09-21 | Topper David Joseph |
|
15.84 | 9.48 | 是 | Chief Financial Officer |
| 2024-09-03 | Welgus Howard G. |
|
19.19 | 10.77 | 是 | -- |
| 2024-08-19 | Burnett Patrick |
|
19.49 | 8.29 | 是 | Senior Vice President and Chief Medical Officer |
| 2024-08-02 | Matsuda Masaru |
|
18.33 | 9.02 | 是 | Senior Vice President and General Counsel |
| 2024-08-02 | Burnett Patrick |
|
19.66 | 9.02 | 是 | Senior Vice President and Chief Medical Officer |
| 2024-08-02 | Watanabe Todd Franklin |
|
84.63 | 9.02 | 是 | President and Chief Executive Officer |
| 2024-08-01 | Welgus Howard G. |
|
18.70 | 1.68 | 是 | -- |
| 2024-08-01 | Welgus Howard G. |
|
18.03 | 9.87 | 是 | -- |
| 2024-08-01 | Welgus Howard G. |
|
17.70 | 9.87 | 是 | -- |
| 2024-07-01 | Welgus Howard G. |
|
18.60 | 1.68 | 是 | -- |
| 2024-07-01 | Welgus Howard G. |
|
19.03 | 1.68 | 是 | -- |
| 2024-07-01 | Welgus Howard G. |
|
18.03 | 9.31 | 是 | -- |
| 2024-06-14 | CHAUDHURI BHASKAR |
|
86.02 | 0.00 | 是 | -- |
| 2024-06-14 | Gilbert Halley E |
|
1.88 | 0.00 | 是 | -- |
| 2024-06-14 | LIN SUE-JEAN |
|
1.91 | 0.00 | 是 | -- |
| 2024-06-14 | Krishnamohan Neha |
|
1.57 | 0.00 | 是 | -- |
| 2024-06-14 | Curran Terrie |
|
1.88 | 0.00 | 是 | -- |
| 2024-06-14 | Heron Patrick J |
|
1.88 | 0.00 | 是 | -- |
| 2024-06-14 | Welgus Howard G. |
|
18.03 | 0.00 | 是 | -- |
| 2024-06-14 | Leonard Keith R |
|
1.88 | 0.00 | 是 | -- |
| 2024-06-04 | Welgus Howard G. |
|
17.37 | 1.68 | 是 | -- |
| 2024-06-04 | Welgus Howard G. |
|
18.02 | 1.68 | 是 | -- |
| 2024-06-04 | Welgus Howard G. |
|
17.67 | 8.00 | 是 | -- |
| 2024-06-04 | Welgus Howard G. |
|
17.02 | 8.01 | 是 | -- |
| 2024-05-31 | Matsuda Masaru |
|
18.54 | 1.69 | 是 | Senior Vice President General Counsel and Corporate Secretary |
| 2024-05-31 | Matsuda Masaru |
|
18.70 | 7.11 | 是 | Senior Vice President General Counsel and Corporate Secretary |
| 2024-05-31 | Watanabe Todd Franklin |
|
83.64 | 1.69 | 是 | President and Chief Executive Officer |
| 2024-05-31 | Watanabe Todd Franklin |
|
83.84 | 7.11 | 是 | President and Chief Executive Officer |
| 2024-05-29 | Burnett Patrick |
|
20.98 | 8.72 | 是 | SVP Chief Medical Officer |
| 2024-05-29 | Burnett Patrick |
|
23.28 | 0.00 | 是 | SVP Chief Medical Officer |
| 2024-05-29 | Burnett Patrick |
|
20.98 | 8.75 | 是 | SVP Chief Medical Officer |
| 2024-05-27 | Matsuda Masaru |
|
19.03 | 0.00 | 是 | SVP General Counsel and Corporate Secretary |
| 2024-05-27 | Matsuda Masaru |
|
18.85 | 9.01 | 是 | SVP General Counsel and Corporate Secretary |
| 2024-05-16 | Edwards Larry Todd |
|
14.80 | 0.00 | 是 | SVP Chief Commercial Officer |
| 2024-05-16 | Edwards Larry Todd |
|
14.04 | 8.98 | 是 | SVP Chief Commercial Officer |
| 2024-05-02 | Burnett Patrick |
|
25.97 | 8.74 | 是 | Senior Vice President and Chief Medical Officer |
| 2024-05-02 | Matsuda Masaru |
|
18.54 | 8.74 | 是 | Senior Vice President and General Counsel |
| 2024-05-02 | Watanabe Todd Franklin |
|
86.08 | 8.74 | 是 | President and Chief Executive Officer |
| 2024-05-01 | Moore Matthew Richard |
|
15.02 | 0.00 | 是 | SVP and Chief Business Officer |
| 2024-05-01 | Moore Matthew Richard |
|
14.55 | 8.74 | 是 | SVP and Chief Business Officer |
| 2024-04-10 | Topper David Joseph |
|
11.00 | 0.00 | 是 | Chief Financial Officer |
| 2024-03-04 | Burnett Patrick |
|
26.93 | 11.12 | 是 | Senior Vice President, Chief Medical Officer |
| 2024-03-04 | Matsuda Masaru |
|
19.04 | 11.12 | 是 | Senior Vice President and General Counsel |
| 2024-03-04 | Watanabe Todd Franklin |
|
87.45 | 11.12 | 是 | President and Chief Executive Officer |
| 2024-03-04 | Moore Matthew Richard |
|
14.60 | 11.12 | 是 | SVP and Chief Business Officer |
| 2024-02-28 | Watanabe Todd Franklin |
|
88.94 | 10.60 | 是 | President and Chief Executive Officer |
| 2024-02-13 | Smither John W |
|
0.28 | -- | 是 | Chief Financial Officer |
| 2024-02-13 | Smither John W |
|
1.14 | -- | 是 | Chief Financial Officer |
| 2024-02-13 | Watanabe Todd Franklin |
|
64.87 | -- | 是 | President and Chief Executive Officer |
| 2024-02-13 | Watanabe Todd Franklin |
|
68.18 | -- | 是 | President and Chief Executive Officer |
| 2024-02-13 | Watanabe Todd Franklin |
|
77.58 | -- | 是 | President and Chief Executive Officer |
| 2024-02-13 | Watanabe Todd Franklin |
|
89.19 | -- | 是 | President and Chief Executive Officer |
| 2024-02-13 | Matsuda Masaru |
|
19.42 | -- | 是 | Senior Vice President and General Counsel |
| 2024-02-13 | Matsuda Masaru |
|
14.86 | -- | 是 | Senior Vice President and General Counsel |
| 2024-02-13 | Matsuda Masaru |
|
16.63 | -- | 是 | Senior Vice President and General Counsel |
| 2024-02-13 | Burnett Patrick |
|
24.62 | -- | 是 | Senior Vice President, Chief Medical Officer |
| 2024-02-13 | Burnett Patrick |
|
27.41 | -- | 是 | Senior Vice President, Chief Medical Officer |
| 2024-02-13 | Burnett Patrick |
|
21.30 | -- | 是 | Senior Vice President, Chief Medical Officer |
| 2024-02-13 | Burnett Patrick |
|
22.26 | -- | 是 | Senior Vice President, Chief Medical Officer |
| 2024-02-13 | Moore Matthew Richard |
|
8.13 | -- | 是 | SVP and Chief Business Officer |
| 2024-02-13 | Moore Matthew Richard |
|
10.79 | -- | 是 | SVP and Chief Business Officer |
| 2024-02-13 | Moore Matthew Richard |
|
12.56 | -- | 是 | SVP and Chief Business Officer |
| 2024-02-13 | Moore Matthew Richard |
|
14.53 | -- | 是 | SVP and Chief Business Officer |
| 2024-02-13 | Moore Matthew Richard |
|
14.95 | -- | 是 | SVP and Chief Business Officer |
| 2024-01-12 | Watanabe Todd Franklin |
|
62.70 | 0.00 | 是 | Chief Executive Officer and President |
| 2024-01-12 | Moore Matthew Richard |
|
5.46 | 0.00 | 是 | SVP and Chief Business Officer |
| 2024-01-12 | Burnett Patrick |
|
8.50 | 0.00 | 是 | Senior Vice President, Chief Medical Officer |
| 2024-01-12 | Edwards Larry Todd |
|
8.80 | 0.00 | 是 | Chief Commercial Officer |
| 2024-01-12 | Matsuda Masaru |
|
7.46 | 0.00 | 是 | Senior Vice President and General Counsel |
| 2024-01-02 | Burnett Patrick |
|
5.70 | 3.54 | 是 | Senior Vice President, Chief Medical Officer |