| | 问：猎聘网上显示贵司正在招聘 AIDD/CADD研发人员，负责 AI 药物设计、AI模型研发，在推进 AI药物研发方面有什么具体规划和举措？（来自: 深交所互动易） | | 答：您好！此为公司创新药研发平台众生睿创的招聘信息，公司坚持研发创新是第一生产力的发展理念，把发展新质生产力作为自身发展的重要路径，公司会充分结合实际，积极使用新技术，探索新技术的无限可能。谢谢！ |
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| | 问：贵司的注射减肥药的疗效好，安全性高，给药频率低，具有一定的差异化优势。近期礼来的小分子减肥药已经研发成功，小分子减肥药具有低成本和不打针的优势，可以和注射的减肥药形成互补，请问贵司是否有开发有独特优势的小分子减肥药的计划？（来自: 深交所互动易） | | 答：您好！研发管线进度情况请查阅公司定期报告及相关公告。谢谢！ |
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| | 问：近期贵司在学术会议上公布了减肥药RAY1225的数据，请问面对投资者什么时候公开研究数据？（来自: 深交所互动易） | | 答：您好！RAY1225注射液用于肥胖/超重患者及2型糖尿病患者的II期临床试验都已完成PartA子研究的数据清理和锁定，获得顶线分析结果，达到主要终点。另外，RAY1225注射液治疗超重/肥胖参与者的III期临床试验获得组长单位北京大学人民医院和共同组长单位中山大学孙逸仙纪念医院伦理审查批件，标志着RAY1225注射液III期临床试验将全面启动。有关于RAY1225注射液的具体情况详见公司刊载在《证券时报》和巨潮资讯网（www.cninfo.com.cn）的相关公告。谢谢！ |
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| | 问：请问公司的产品是全产业链模式吗？不会受到美国贸易关税影响使部分产品停产吧？目前昂拉地韦审批到哪步了？昂拉地韦能平替奥司他韦和玛巴洛沙韦吗？（来自: 深交所互动易） | | 答：您好！公司现有产品目前主要在国内销售，美国贸易关税政策目前未对公司业务产生影响。公司拥有相对完整的产业链体系，形成从原料药到制剂生产的化学药产业链、从GAP药材种植到中药饮片与中成药生产的中药产业链，以及围绕眼健康服务的药品生产和健康服务、健康管理的生态链。目前昂拉地韦片正在审评审批进程中，并按照CDE要求正常推进中。昂拉地韦片作为国内第一个获批临床的甲型流感病毒RNA聚合酶抑制剂，临床前研究结果表明，对包括奥司他韦耐药株、高致病性禽流感病毒株和巴洛沙韦耐药株等在内的多种不同亚型流感病毒株具有强大的抑制活性。 |
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| | 问：新药审批暂停需要补充的材料是哪些？（来自: 深交所互动易） | | 答：您好！目前公司昂拉地韦片正在审评审批进程中，并按照CDE要求正常推进中。公司将及时依据信息披露规则履行信息披露责任。谢谢！ |
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| | 问：请问到目前为止第三大股东全国社保基金其持有公司股票是增加了还是减少了或不变？（来自: 深交所互动易） | | 答：您好！公司股东情况敬请留意公司定期报告。谢谢！ |
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| | 问：请问到目前为止第三大股东全国社保基金其持有公司股票是增加了还是减少了或不变？（来自: 投资者关系互动平台） | | 答：您好！公司股东情况敬请留意公司定期报告。谢谢！ |
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| | 问：昂拉地韦片新药评审被暂停，董秘一直说评审在正常的进程中，现在很多其它后面申报的药物都审批通过了，昂拉地韦片却一直处于暂停的状态，这个似乎有点不正常，请问能告知暂停的原因吗，会不会批准上市会被长期搁置？（来自: 深交所互动易） | | 答：您好！公司严格按照有关法律、法规及指导原则开展新药上市申请有关工作。目前公司昂拉地韦片正在审评审批进程中，并按照CDE要求正常推进中。公司将及时依据信息披露规则履行信息披露责任。谢谢！ |
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| | 问：昂拉地韦 23 年获得美国 FDA 同意开展临床研究，目前进展到哪一阶段？后续是否有出海的打算？（来自: 深交所互动易） | | 答：您好！公司重视药品的国外市场机会，积极推动产品在海外临床申请和注册，加快国际化推进步伐。 |
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| | 问：请问贵司的RAY1225在减肥和降糖方面表现如何？在功效方面可以与知名产品格美司鲁肽相提并论吗？（来自: 深交所互动易） | | 答：您好！RAY1225注射液是公司研发的、具有全球自主知识产权的创新结构多肽药物，具有GLP-1受体和GIP受体双重激动活性，临床上拟用于2型糖尿病及超重/肥胖等患者的治疗，在用药周期上，RAY1225注射液可以做到两周一次的给药频率。目前两项研究处于II期临床试验阶段，用于肥胖/超重患者及2型糖尿病患者的II期临床试验都于近期完成Part A子研究的数据清理和锁定，获得顶线分析结果，达到主要终点。同靶点药物替尔泊肽在中国超重或肥胖人群的III期研究（SURMOUNT-CN）中，高剂量15mg组每周给药一次，连续治疗52周，总剂量为630mg，52周体重较基线变化百分比≥5%和≥10%的参与者比例分别为85.8%和71.9%。RAY1225注射液6mg组每两周给药一次，连续治疗24周，总剂量为50mg，24周体重较基线变化百分比≥5%和≥10%的参与者比例分别为95.1%和75.6%。减重达标率数值上高于替尔泊肽。关于RAY1225注射液II期临床试验的子研究顶线分析数据具体情况详见公司刊载在《证券时报》和巨潮资讯网（www.cninfo.com.cn）的相关公告。谢谢！ |
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| | 问：品评审中心网上显示新药昂拉地韦片暂停评审了，请董秘怀着对投资人负责的态度，正面说明暂停的实际原因吗？（来自: 深交所互动易） | | 答：您好！公司严格按照有关法律、法规及指导原则开展新药上市申请有关工作。目前公司昂拉地韦片正在审评审批进程中，并按照CDE要求正常推进中。公司将及时依据信息披露规则履行信息披露责任。谢谢！ |
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| | 问：昂拉地韦评审暂停是公司主动申请暂停还是评审委员会暂停的？暂停的原因是等待企业补充资料？专家自信货会议？核对文件或工艺？等待检测结果？还是等企业确认批准文件？（来自: 深交所互动易） | | 答：您好！公司严格按照有关法律、法规及指导原则开展新药上市申请有关工作。目前公司昂拉地韦片正在审评审批进程中，并按照CDE要求正常推进中。公司将及时依据信息披露规则履行信息披露责任。谢谢！ |
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| | 问：请问审批再次暂停是需要补充什么材料还是有其它原因？（来自: 深交所互动易） | | 答：您好！公司严格按照有关法律、法规及指导原则开展新药上市申请有关工作。目前公司昂拉地韦片正在审评审批进程中，并按照CDE要求正常推进中。公司将及时依据信息披露规则履行信息披露责任。谢谢！ |
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| | 问：国家近期出台了一系列支持创新药发展的政策，公司如何抓住这一机遇？（来自: 深交所互动易） | | 答：您好！国家政策对创新药的支持为行业发展注入了强劲动力。公司将继续紧跟国家政策导向，对于有助于公司的相关政策，公司积极沟通并争取获得相关政策支持，推动新药研发进程。同时，公司专注主业，积极做好经营管理等工作，不断提升公司内在价值，通过健康的发展切实维护广大投资者利益，为股东带来更好的回报。谢谢！ |
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